Studies on the effects of ephedrine in the presence of cocaine.
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The application of high hydrostatic pressure to toad sciatic nerve causes a gain in sodium and a loss of potassium which are not affected by cocaine. However, cocaine action is enhanced by high pressure when counteracting veratrine depolarization and when blocking the action potential. Various effects of elevated pressure on the after-potentials are presented and the role of ions in these processes is discussed.
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Cocaine augments appreciably the effects of small doses of acetylcholine on the heart rate, blood pressure, and the nictitating membrane in intact, anesthetized animals. This phenomenon assigns cocaine, thus far only known as a potentiator of adrenergic stimulation, a more general role of potentiator of both adrenergic and cholinergic neurohumors.
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