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At least 19 recordsLinked to original sources
PubMed1962

Pathogenesis of Coccidioides immitis in monkeys.

Converse, J. L. (U. S. Army Chemical Corps, Fort Detrick, Frederick, Md.), E. P. Lowe, M. W. Castleberry, G. P. Blundell, and A. R. Besemer. Pathogenesis of Coccidioides immitis in monkeys. J. Bacteriol. 83:871-878. 1962.-Respiratory exposure to arthrospores from the submerged growth of Coccidioides immitis, strain Cash, in liquid medium resulted in similar pathogenesis in monkeys to that of strain Silveira arthrospores harvested from solid medium. Infectivity of 100% was noted with doses of 50 to 10,000 arthrospores. The disease was characterized by loss of appetite and weight, malaise, and extreme respiratory distress accompanied by coughing, with the immediate cause of death being acute coccidioidal pneumonia. The pathological picture was one of extensive, progressive, destructive pulmonary disease in the higher dose levels and few, small, self-contained, fibrous lesions, with little destruction of lung tissue, in the low doses. This was correlated in general with the findings of serial X rays and serological tests. The presence of the parasitic phase (spherule and endospore) of the organism was noted in large numbers within the pulmonary lesions and bronchial exudates and was substantiated by cultural methods. Occasionally, hyphal elements of the saprophytic growth phase were noted around the periphery of residual cavitated areas of the lungs.

Animals↗
PubMed1962

Immunization of mice against coccidioidomycosis.

Converse, J. L. (U. S. Army Chemical Corps, Frederick, Md.), M. W. Castleberry, A. R. Besemer, and E. M. Snyder. Immunization of mice against coccidioidomycosis. J. Bacteriol. 84:46-52. 1962-The observed lower virulence of Coccidioides immitis arthrospores of the M-11 strain compared with the Cash strain was ascribed to the lower ability of the M-11 spores to invade the lungs and brain. Endospores of strain M-11, grown in synthetic medium, were equally as virulent by the intraperitoneal route as arthrospores of strain Cash. Immunization of mice with viable strain M-11 arthrospores protected approximately 50% of the animals against challenge with strain Cash arthrospores. This was evidenced by lower mortality over a 5-month period and lack of gross pathological lesions in killed animals. Although fewer lesions resulted after the use of a viable vaccine, higher survival was obtained with formaldehyde-killed arthrospores. Either preparation tended to confine the infection to the peritoneal cavity.

Animals↗