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At least 19 recordsLinked to original sources

Conjuctivitis and keratoconjunctivitis associated with primary immunodeficiency diseases.

Nineteen patients with a variety of well-defined primary immunodeficiency diseases were examined for ocular abnormalities. Eight patients with low levels, or absence, of all the major serum immunoglobulins had conjunctivitis or keratoconjunctivitis associated with bacterial infection. The remaining 11 patients, who had at least one immunoglobulin class present in normal concentration in the serum, showed no inflammatory ocular lesion. Absence of only IgA, the major tear immunoglobulin, did not predispose the eye to these lesions.

Adolescent↗

Conjuctions of visually based categories: overextension and compensation.

The degree to which overextension effects found with conjunctions of semantic categories, such as sports and games (J. A. Hampton, 1988), would generalize to categories of visual stimuli was tested in 4 experiments. Overextension occurs when participants categorize a stimulus in the conjunction of 2 categories but fail to categorize the same stimulus as belonging to 1 of the 2 constituent categories considered individually. Stimuli for the present experiments were ambiguous colored letter shapes and cartoon faces that could vary along dimensions of happiness and either apparent intelligence or apparent age. Overextension was found with both stimulus sets, thus showing that the phenomenon is not restricted to categorization in superordinate semantic categories. There was also evidence that typicality in 1 category could compensate for borderline membership of the other. More overextension was found for faces than for letters, and there was evidence for asymmetric compensation between category dimensions.

Adult↗

Retrospective survey of a link between cat and dog antigens and allergic conjuctivitis.

This retrospective 3-year study was designed to determine (a) which antigen positive patients were found in greater numbers, (b) whether the patients who were positive for cat or dog antigen-specific IgE were also positive for other antigens, and (c) whether the number of patients with allergic conjunctivitis increased during a particular time of the year. A total of 762 patients were diagnosed with allergic conjunctivitis including 107 cat-positive and/or dog-positive patients. Cat-positive patients were more prevalent than dog-positive patients, (p < 0.001). All but 2 patients were positive for other antigens, indicating a strong link between the animal antigens and other antigens. Cat and dog allergy increased in spring and early summer.

Adolescent↗

Modeling synaptic plasticity in conjuction with the timing of pre- and postsynaptic action potentials.

We present a spiking neuron model that allows for an analytic calculation of the correlations between pre- and postsynaptic spikes. The neuron model is a generalization of the integrate-and-fire model and equipped with a probabilistic spike-triggering mechanism. We show that under certain biologically plausible conditions, pre- and postsynaptic spike trains can be described simultaneously as an inhomogeneous Poisson process. Inspired by experimental findings, we develop a model for synaptic long-term plasticity that relies on the relative timing of pre- and post-synaptic action potentials. Being given an input statistics, we compute the stationary synaptic weights that result from the temporal correlations between the pre- and postsynaptic spikes. By means of both analytic calculations and computer simulations, we show that such a mechanism of synaptic plasticity is able to strengthen those input synapses that convey precisely timed spikes at the expense of synapses that deliver spikes with a broad temporal distribution. This may be of vital importance for any kind of information processing based on spiking neurons and temporal coding.

Action Potentials↗

Transfer between contextual conditional discriminations: an examination of how stimulus conjuctions are represented.

In 2 experiments, when rats were placed in 1 pair of contexts, A and B, 2 relationships were in force (X --> food and Y --> no food), and when they were placed in another pair of contexts, C and D, the complementary relationships were operative (Y --> food and X --> no food). In Experiment 1, rats then received a 2nd discrimination that was either contextually congruent (in A and B, Y --> food and X --> no food; in C and D, X --> food and Y --> no food) or contextually incongruent (in A and D, Y --> food and X --> no food; in C and B, X --> food and Y --> no food) with the 1st discrimination. In Experiment 2, the 1st discrimination, involving X and Y, was interleaved with a 2nd discrimination, involving V and W, that was again either congruent (in A and B, V --> food and W --> no food) or incongruent (in A and D, V --> food and W --> no food) with the 1st discrimination. The congruent discriminations were acquired more readily than were the incongruent discriminations.

Animals↗