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PubMedDate not supplied

[Etiological connection between juvenile rheumatoid arthritis and the chronic form of coxsackie virus infection].

Coxsackie group enteroviruses, mainly Coxsackie A13 virus, were detected in involved joints of 76% children with rheumatoid arthritis, adenoviruses (mainly adenovirus 5) in 68%, and rubella virus in 52%. Mixed virus infection was diagnosed in 80% patients. At least one of the above viruses was detected in 23 out of 25 examinees (92%). The authors discuss the contribution of different viruses to the etiology of juvenile rheumatoid arthritis and consider that chronic Coxsackie virus infection is the most probable primary etiological factor of this disease.

Adenoviruses, Human↗
PubMed1989

Incidence of Coxsackie virus infection in patients with dilated cardiomyopathy.

A total of 127 patients, divided into two groups, were examined; one was made up by patients with dilated cardiomyopathy (D-CMP) (n: 32), the other one by patients with myocarditis and pericarditis ("other cardiopathies") (n: 95). A control group of healthy subjects (n: 278) consisted of blood donors. Infection with Coxsackie viruses (B1, B2, B3, B4, B5, B6, A7, A9) was followed up serologically using virus-neutralizing antibodies and/or IgM class virus-specific antibodies. Actual Coxsackie virus infection was demonstrated in almost half of patients. Seventeen (53.1%) out of the 32 D-CMP patients (with a negative history of Coxsackie virus infection) had a positive serological finding. The most frequently isolated Coxsackie virus was, B4. In the group of "other cardiopathies", a positive serological finding was in 42 patients (44.2%) with the incidence of B1 and B4 viruses being the highest and identical. Compared with data obtained in healthy controls, the incidence of Coxsackie virus infection in the two follow-up groups of patients was statistically highly significant (p less than 0.001).

Adult↗
PubMed1987

Coxsackie virus infection in association with heart affection in man.

The frequency of actual infections by selected types of coxsackie virus (B1-B6, A7, A9) has been followed up in adult patients hospitalized for reason of heart disease. Criteria of actual coxsackie virus infection have been defined, including a significant rise of titer of virus neutralizing antibodies and/or presence of virus-specific IgM antibodies. An actual coxsackie virus infection has been found in 71 (46.3%) out of 153 patients. Most frequently coxsackie B1 virus infection (24 times) and B4 (17 times) could be proved. In sera of patients with actual coxsackie virus infection, a higher proportion of infection with some types of coxsackie viruses, along with the presence of antibodies against a larger number of coxsackie virus types has been found, as compared to sera from patients without actual coxsackie virus infection, and/or, in sera of healthy blood donors (control group). The role of repeated infections with different types of coxsackie virus in the etiology of heart disease has been discussed.

Antibodies, Viral↗
PubMed2006

Rhabdomyolysis following recent severe coxsackie virus infection in patient with chronic renal failure: one case report and a review of the literature.

Coxsackie virus infection may be life-threatening, although in most cases, it is asymptomatic. Coxsackie virus infection can cause rhabdomyolysis. This study reports a 39-year-old female patient with chronic renal failure who presented with fever, myalgia, anuria, edema, vomiting, diarrhea, exacerbation of renal function, elevation of serum CK, CK-MB, CK-MM, myoglobin, and liver function abnormality. Serology for Coxsackie virus IgM antibody was positive at first, and IgG antibody became positive 4 weeks later. Muscle biopsy showed skeletal muscle denaturalization and necrosis. She underwent hemodialysis three times per week and then kidney transplantation. No evidence suggests relapse of Coxsackie virus infection 5 months after transplantation. As illustrated with the present case, serological testing may reveal an early, quick, and simple diagnosis in a case of rhabdomyolysis after a viral illness.

Adult↗
PubMedDate not supplied

[Chronic congenital Coxsackie virus infection in the etiology of allergic disease in children].

The authors prove the involvement of congenital Coxsackie virus infection in the etiology of allergic diseases in children: 1) indications of high risk of vertical transmission of viruses of this group from mothers with persistent infection to children are more incident in the history of mothers whose children develop allergies in comparison with healthy age-matched children (83 vs. 38.8%); 2) Coxsackie viruses are detected in sick children more often than in healthy ones (58.1-81.1 vs. 7.4%); 3) the persistence of Coxsackie A and B viruses is confirmed in the majority of patients examined over time; 4) in the mothers examined in parallel with their sick children Coxsackie viruses were detected virtually as often as in their children; and 5) reduction of endogenous chronic Coxsackie infection by energy metabolism correction in the risk group women during pregnancy prevents the development of allergic diseases in their children.

Child↗
PubMed1951

The sparing effect of Coxsackie virus infection on experimental poliomyelitis.

Young mice infected with Group B Coxsackie virus were rendered markedly resistant to poliomyelitis virus given from 4 to 10 days later. A sparing effect was detectable in somewhat older mice and in young mice inoculated with poliomyelitis after shorter intervals, but in both cases few mice survived. Interference was manifest by survival, by prolongation of the course of poliomyelitis, and by a decreased frequency of poliomyelitis.

Animals↗
PubMed1979

Type 1 diabetes and Coxsackie virus infection.

The role played by viruses in the aetiopathogenesis of type 1 diabetes mellitus has been studied by several authors; in particular the importance of Coxsackie virus B4 infection has been stated by some authors and not confirmed by others. 43 diabetic children were studied at the time of the diagnosis of the disease. No viruses could be isolated from stools; the titres of anti-Coxsackie viruses B1 to 6 complement fixing antibodies and anti-Coxsackie virus B4 neutralizing antibodies, compared to controls, indicated that Coxsackie virus infection was not associated with the onset of diabetes in these children. A cross-reaction with anti-Coxsackie viruses sera and a human pancreas demonstrated that there are not antigens in common between these viruses and the human pancreas.

Adolescent↗
PubMed1974

Antiviral activity of N-phenyl-N'-aryl- or alkylthiourea derivatives in Coxsackie virus infections in mice.

The effect of five derivatives of N-phenyl-N'-aryl- or alkylthiourea-inhibitors of the multiplication of Coxsackie virus B1 and other picornaviruses in vitro-was tested in experimental infections with Coxsackie viruses B1, B3, A6, and A7 in newborn mice. Under the action of N-phenyl-N'-3-hydroxyphenylthiourea (no. 23) and N-phenyl-N'-4-carboxy-5-hydroxyphenylthiourea (no. 20) a two- to threefold reduction in mortality was observed, as well as an appreciable delay in the course of the disease (mean effective dose, lengthening by 2 to 6 days) after infection with Coxsackie viruses B1, B3, and A7. The infection with Coxsackie virus A6 was affected only by compound no. 23 and, at that, to a low degree. If the antiviral effect is to be obtained, the compounds must be applied daily (once subcutaneously) from the 24th to the 144th h after virus inoculation, a period which corresponds to the incubation period and the beginning of the manifested infection. On the basis of these data, as well as of the relatively high selectivity (therapeutic index of 3 to 20), the two indicated substances may be considered to be reliable antiviral chemotherapeutic agents.

Animals↗
PubMed1989

[The role of coxsackie virus infection in the development of type 1 diabetes mellitus and its effect on the postinitial course of the disease in childhood].

The authors present the results of a three-year investigation of Coxsackie viruses in children diabetics. In paired serum samples of 66 newly diagnosed patients of virus neutralizing antibodies against eight types of Coxsackie viruses were estimated. Concurrently specific antibodies of class IgM were assessed and compared with a control group of 218 healthy children. Infection with Coxsackie viruses, in particular types B2, B4 and B5, were found in 38 diabetics (in 57.6%) as compared with 6% in healthy children. The findings indicate an evidence that diabetics with Coxsackie infection at the betics. The prospective three-year investigation provided evidence that diabetics with Coxsackie infection at the time of manifestation of the disease had a worse postinitial course. Their C-peptide levels were significantly lower (p less than 0.05). The frequency and intensity of partial remission were significantly worse in the group of diabetics who had just overcome a Coxsackie virus infection (p less than 0.02).

Adolescent↗