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At least 19 recordsLinked to original sources
PubMed2003

Mucoepidermoid carcinoma (adenosquamous carcinoma) treated with Mohs micrographic surgery.

BACKGROUND: Mucoepidermoid carcinoma (MEC), sometimes referred to as adenosquamous carcinoma (ASC), is a common malignant tumor of the salivary glands that can also develop from the esophagus, lacrimal passages, lung, upper respiratory tract, pancreas, prostate and thyroid. Rarely, MEC will present primarily in the skin. CASE: We present a case of primary MEC of the lower eyelid treated successfully with Mohs micrographic surgery. RESULTS: Mohs micrographic surgery was performed because of the highly aggressive and unpredictable nature of this tumor. The tumor was completely excised using Mohs with negative margins achieved in three stages. The patient has been disease free for 3 years since the surgery. CONCLUSION: We offer Mohs as an option for treating MEC.

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PubMed2005

Clinicopathological features of head and neck adenosquamous carcinoma.

Adenosquamous carcinoma is a rare tumour which is characterized pathologically by the simultaneous presence of distinct areas of squamous cell carcinoma and adenocarcinoma. The origin of adenosquamous carcinoma is controversial; however, it is generally considered to be aggressive and associated with a dismal prognosis. In the present study, the medical and pathological records of 4 patients with head and neck adenosquamous carcinoma are reviewed. In 1 patient, the tumour arose from an area of carcinoma in situ of surface epithelium. The origin from surface epithelium was not evident in any of the others. Perineural invasion was present in 3 patients. Three patients had evidence of cervical metastases. One patient died of postoperative complications, 1 suffered from local recurrence and developed distant metastases and 2 were alive with no evidence of disease over 30 months later. Adenosquamous carcinoma is an aggressive tumour; however, with appropriate treatment, some patients may remain well beyond 2 years.

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PubMed2006

[A case of successful treatment by low-dose 5-fluorouracil and cisplatin for liver metastases of esophageal adenosquamous carcinoma].

Adenosquamous carcinoma of the esophagus is an uncommon type of esophageal tumor. In the present case, a 54-year-old man without symptoms was diagnosed with esophageal squamous cell carcinoma, based on endoscopic examination of a biopsy specimen. Endoscopy and barium roentgenography revealed a superficial plateau-type lesion, 2 cm in length, in the lower esophagus. Esophagectomy with lymphadenectomy was performed via a right thoraco-abdominal approach. The histological diagnosis was adenosquamous carcinoma with no lymph node metastasis. Three years after the surgery, multiple liver metastases were detected by computed tomography. The patient was treated with a combination of low-dose 5-fluorouracil(350 mg/body/day) and low-dose cisplatin (7 mg/body/day). Because the first course of chemotherapy was very effective and the number of liver metastases was reduced,a further 6 courses were administered. After 6 courses of chemotherapy, no liver metastases were detected. Based on the present findings, we recommend low-dose 5-fluorouracil/cisplatin therapy for liver metastasis from esophageal adenosquamous carcinoma.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1999

Adenosquamous carcinoma of the mouth: a rare variant of squamous cell carcinoma.

Adenosquamous carcinoma is a rare tumour in the oral cavity and is characterised histologically by carcinomatous change in surface epithelium, in association with adenocarcinoma affecting the ducts of minor salivary glands. Only a dozen cases have previously been reported in the oral cavity, but all have shown an aggressive course with 60% of patients dying of disease. We report three further cases and review the literature, which suggests that this lesion should be regarded as a high-grade variant of squamous cell carcinoma.

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PubMed1994

Squamous cell carcinoma of the oesophagus with mucin-secreting component (muco-epidermoid carcinoma and adenosquamous carcinoma): a clinicopathologic study and a review of literature.

The clinicopathological features of 11 cases of primary oesophageal squamous cell carcinomas with mucin-secreting component (eight muco-epidermoid and three adenosquamous carcinomas) are presented. The incidence was 2.2% of all resected primary oesophageal tumors. The mean age was 64 years and the male to female ratio was 4.5:1. The mean diameter of these tumours was 4 cm. Twenty-seven per cent of these tumours were in the upper, 46% in the middle and 27% in the lower portion of the oesophagus. The age, sex and site distribution of these tumors were similar to those of squamous cell carcinomas. The medium survival of these patients was 15 months. The world literature concerning this rare entity was reviewed and compared with the findings of the present study. No major racial differences were noted. In addition, the classification of this group of tumours was also discussed.

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PubMed1980

Squamous cell carcinomas and adenosquamous carcinomas originating from the thyroid gland.

Three cases of squamous cell carcinoma and 3 cases of mixed squamous and glandular carcinoma were reported. Pathologic differential diagnosis of these rare primary tumors of the thyroid gland were discussed. All except 1 case occurred in elderly patients; their clinical behavior was more aggressive than that of differentiated carcinoma. It is suggested that the tumor be treated more vigorously at its initial stage.

Adenocarcinoma↗
PubMed2000

Transition from squamous cell carcinoma to adenocarcinoma in adenosquamous carcinoma of the lung.

The heterogeneity of tumor cells is frequently observed in lung cancer, but the clonality of these cells has not yet been established. The distinct components of 12 lung adenosquamous carcinomas were compared by genetic alterations of p53 and K-ras, chromosomal abnormalities at 9p21 and 9q31-32, and immunohistochemical reactions. The immunoreactivity of p53 was consistent in both adenocarcinomatous and squamous cell carcinomatous components as well as in the transitional areas, retaining the morphological characteristics of the distinct components. The same p53 mutation was found in both components of each tumor with p53 overexpression. No K-ras mutations were detected in any of the tumors examined. Three of the four tumors with chromosomal abnormalities detected, one at 9p21 and two at 9q31-32, had coincident abnormalities between the distinct components, whereas one tumor deleted homozygously at 9p21 (D9S259) in the adenocarcinomatous component with loss of heterozygosity in the other component. The expression of squamous cell carcinoma-related antigen in adenocarcinomatous components was significantly higher than that of lung adenocarcinomas (57 +/- 5.8% vs. 1.0 +/- 0.5%, P < 0.0001), whereas Mucin 1 expression is less in these components (9.0 +/- 4.9% vs. 55 +/- 8.2%, P = 0.003). These results suggest monoclonal transition from squamous cell carcinoma to adenocarcinoma in lung adenosquamous carcinoma.

Adenocarcinoma↗
PubMed1992

In situ hybridization for human papillomavirus DNA in uterine adenosquamous carcinoma with glassy cell features ("glassy cell carcinoma").

Eighteen uterine adenosquamous carcinomas that showed focal glassy cell features (33% to 85% of tumor histology) or predominant glassy cell features (greater than 85% of tumor histology) were studied by in situ hybridization for human papillomavirus (HPV). Viral DNA was present in neoplastic cells in five cases: type 18 in four cases (two cervical adenosquamous carcinomas with predominant glassy cell features, two cervical adenosquamous carcinomas with focal glassy cell features) and type 16 in one case (cervical adenosquamous carcinoma with predominant glassy cell features). Positive intranuclear staining for HPV DNA was present within areas of squamous and glandular differentiation and within areas with glassy cell features. The mean age of HPV(+) patients was less than HPV(-) patients (mean, 57 years, compared to 67 years). No significant association between HPV status and prognosis or glassy cell features was detected. Human papillomavirus types 16 and 18 are associated with adenosquamous carcinoma with predominant glassy cell features or focal glassy cell features, "glassy cell carcinoma." Automated colorimetric in situ hybridization is an effective method to detect HPV DNA.

Adenocarcinoma↗
PubMed1997

Cytological aspects of uterine cervical adenocarcinoma, adenosquamous carcinoma and combined adenocarcinoma-squamous carcinoma: appraisal of diagnostic criteria for in situ versus invasive lesions.

This paper reports the cytological findings based on air-dried smears in a retrospective series of 143 cases of endocervical adenocarcinoma, combined adenocarcinoma-squamous carcinoma and adenosquamous carcinoma drawn from the files of the BC Cancer Registry. Cervical cytology smears were available before biopsy in 131 patients, but in 18 cases the cytology showed no abnormality. Malignant changes or high-grade atypia of glandular and/or squamous cells (defined as moderate or severe dyskaryosis) were detected in 103 cases. In 46 cases, only a high-grade squamous abnormality was detected. Low-grade glandular and/or squamous lesions were detected in nine cases and one showed atypical endometrial-type glands. The cervical smears of 64 cases were reviewed in detail to determine the important cytomorphological criteria of in situ and invasive adenocarcinoma in air-dried smears, the technique used for preparing PAP smears in British Columbia. Endocervical cells were absent in four cases. Numerous (> 10) groups of glandular cells were present in 51 cases. Important clues to the diagnosis of adenocarcinoma included crowding of nuclei, stratification of nuclei, loss of polarity, syncytial balls and papillary groups of glandular cells, nuclear enlargement, nuclear pleomorphism, and the presence of free-lying atypical glandular cells. Nuclear hyperchromatism, chromatin pattern, nuclear borders, nuclear membranes, and numbers and morphology of nucleoli were not helpful criteria in our material. Criteria enabling reliable distinction between in situ and invasive adenocarcinoma and/or mixed adenocarcinoma-squamous carcinoma could not be established.

Adenocarcinoma↗
PubMed1993

Histochemistry of mucin secreting components in mucoepidermoid and adenosquamous carcinoma of the oesophagus.

AIMS: To determine the direction of differentiation of the mucin secreting components in a rare group of oesophageal tumours--oesophageal squamous cell carcinomas with prominent mucin secreting components (mucoepidermoid carcinomas and adenosquamous carcinomas). METHODS: In a review of 617 cases of primary carcinoma of the oesophagus, 16 cases of squamous cell carcinoma with prominent mucin secreting components were studied using a battery of histochemical techniques. RESULTS: The mucin produced by these tumours was mixed and included a variable content of enzyme labile sialomucin (positive for mucicarmine, periodic acid Schiff, and alcian blue, and sensitive to sialidase digestion and negative for high iron diamine-alcian blue). Retrospective analysis of endoscopic biopsy specimens taken from these tumours showed that mucin was present in five (42%) cases. CONCLUSIONS: The glandular component of this group of tumours histochemically differentiated in the direction of oesophageal glands: examination of the mucin secreting component in squamous cell carcinoma in resected specimens is therefore required for recording the true incidence of this type of tumour.

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PubMed1996

A clinicopathologic study of resected cases of adenosquamous carcinoma of the lung.

Adenosquamous carcinoma of the lung is an uncommon form of the lung cancer. Owing to the infrequent occurrence of this disease, no series reported to date (and to our knowledge) has been of adequate size for definitive statistical analysis. In this study, survival curves and background factors affecting prognosis in those with resected adenosquamous carcinoma of the lung were reviewed. In the period from 1973 to 1994, a total of 1,284 patients with primary lung cancer, including 44 cases (3.4%) of adenosquamous carcinoma, were surgically treated in our department. The cumulative 5-year postoperative survival rate, for all cases of adenosquamous carcinoma of the lung was 18.5%. When the survival rates were compared by histologic type, the outcomes of patients with adenosquamous carcinoma were statistically worse than for patients with squamous cell carcinoma and adenocarcinoma, owing to the highly aggressive pathologic stage of adenosquamous carcinoma. The background factors most closely associated with the survival rate in those with adenosquamous carcinoma, using Cox's proportional hazard model, were gender and the degree of nodal involvement. Five-year survival was obtained in seven patients as follows: T1N0M0 in one patient, T2N0M0 in three, T2N1M0 in two, and T3N0M0 in one. Of these seven patients, all had received complete resections, and five were N0 cases. Although our series is small, this study suggest that adenosquamous carcinoma of the lung is an aggressive tumor that grows rapidly.

Adenocarcinoma↗
PubMed1999

[Clinical analysis of patients operated for adenocarcinoma and adenosquamous carcinoma of uterine cervix].

OBJECTIVES: The aim of our study was clinical analysis of patients with operated adenocarcinoma and adenosquamous carcinoma of uterine cervix. STUDY DESIGN: The mean age, number of pregnancies and labours, the incidence of adenocarcinoma and carcinoma adenosquamous in the stage Ib and IIa, and also in 2 following decades (1972-81 and 1982-91), the influence of positive lymph nodes on the survival have been estimated. MATERIALS AND METHODS: Between 1972 and 1991 at the 2nd Department of Obstetrics and Gynecology, Medical University of Gdańsk, 499 radical hysterectomies were performed in the patients with cervical cancer stage Ia, Ib and IIa. In this group there were 41 (8.2%) patients selected with adenocarcinoma and 16 (3.2%) with carcinoma adenosquamous. In the group of 18 pregnant women (3.6% of the whole group) there was diagnosed 1 case of adenocarcinoma and 1 case of carcinoma adenosquamous. The incidence of both-adenocarcinoma and carcinoma adenosquamous amounted to 11.4%. RESULTS: The number of pregnancies and labours was similar to other histological types. Nulliparas made up respectively 10.5% adenocarcinoma and 6.25% carcinoma adenosquamous. The incidence of adenocarcinoma stage Ib has been found to be more than twice higher than the incidence of adenocarcinoma stage IIa (9.0% and 3.8% respectively). The percentage of carcinoma adenosquamous in those two clinical stages was similar. The three times decrease in the incidence of adenocarcinoma, and the four times increase in the incidence of carcinoma adenosquamous has been found in the years 1982-91 in comparison to 1972-81. It was also stated that an adenouse type, comparing to other histological types, most often occurs without any clinical symptoms--in 23.1% a course of the disease was asymptomatic. As for an adenosqamous type the figures were lower--12.5%. In the patients with adenocarcinoma the incidence of positive pelvic nodes in the stage Ib-IIa was 34%. The incidence of positive lymph nodes in the patients with carcinoma adenosqamous and adenocarcinoma was lower and similar--25% and 23.7% respectively. The analysis of the 5-year survival showed 69.8% in patients with adenocarcinoma stage Ib-IIa and 66.3% in patients with carcinoma adenosquamous the (same stages). The difference is not statistically significant (p = 0.8).

Adenocarcinoma↗
PubMed1978

Association of carcinoma of the breast with adenosquamous carcinoma of endometrium.

Numerous investigators have alluded to an association of cancer of the endometrium and breast. There is no available information relating the histologic forms of cancer of the endometrium to breast cancer. We found ten cases of adenosquamous carcinoma of the endometrium in one tumor registry in a ten year period, 1967-1977. Five of these cases also had breast carcinoma. In three of these cases the breast carcinoma was discovered two to three years after hysterectomy; in one case both tumors were discovered at the same time, and in one case the breast carcinoma antedated the diagnosis of endometrial malignancy by approximately one year. These observations, although from a small number of cases, warrant an expansion of this study in order to determine whether patients with adenosquamous carcinoma of the uterus have a higher risk of developing breast cancer.

Adenocarcinoma↗
PubMed1984

Adenosquamous carcinoma of the liver arising in biliary cystadenocarcinoma: clinical, radiologic, and pathologic features with review of the literature.

Primary biliary cystadenoma, cystadenocarcinoma, squamous carcinoma, and adenosquamous carcinoma of the liver are rare tumors. We describe a middle-aged woman with recurrent fever and a clinical diagnosis of hepatic abscess who proved at laparotomy to have adenosquamous carcinoma of the liver arising in a biliary cystadenocarcinoma. The pathologic features of the tumor and findings on ultrasonography, angiography, and computed tomography are described in detail. The pathogenetic relationships of this unusual tumor to chronic biliary inflammation, biliary cystadenoma, and cystadenocarcinoma and to bile duct malformations (von Meyenburg complexes) are considered.

Adenocarcinoma↗
PubMed1986

Human papillomavirus deoxyribonucleic acid in adenocarcinoma and adenosquamous carcinoma of the uterine cervix.

This report describes the detection of human papillomavirus type 16 or 18 deoxyribonucleic acid (DNA) in nine of 15 invasive tumors of the cervix, including three squamous carcinomas, four adenosquamous carcinomas, one glassy cell carcinoma, and one adenocarcinoma. The viral DNA was identified by Southern blotting and DNA hybridization. Human papillomaviruses may play an etiologic role in the development of at least some adenocarcinomas and adenosquamous carcinomas as well as most squamous tumors of the cervix.

Adenocarcinoma↗
PubMed2007

Identical epidermal growth factor receptor mutations in adenocarcinomatous and squamous cell carcinomatous components of adenosquamous carcinoma of the lung.

BACKGROUND: Adenosquamous carcinoma of the lung is composed of adenocarcinomatous and squamous cell carcinomatous components. The epidermal growth factor receptor (EGFR) mutations occur mostly in adenocarcinomas and rarely in squamous cell carcinoma of lung. Attempts to investigate the EGFR mutation status in each component of adenosquamous carcinoma and to characterize the patients according to mutation status may help to understand the histogenesis of adenosquamous carcinoma. METHODS: The mutation status of EGFR kinase domain from exon 18 to 21 was investigated in 25 Korean patients with adenosquamous carcinoma by polymerase chain reaction-single strand conformation polymorphism using the tissues of each component from the adenosquamous carcinoma tumor. Clinicopathologic characteristics of the patients according to the status of EGFR mutations were compared. RESULTS: EGFR mutations were identified in 11 (44%) patients: 9 mutations were in exon 19, 1 in exon 20, and 1 in exon 21. EGFR mutations were significantly more frequent (P = .005) in women (n = 8, 80%) than men (n = 3, 20%). Never-smokers (n = 8, 62%) had EGFR mutations more commonly than smokers (n = 3, 25%; P = .111). Identical EGFR mutations in both components of adenosquamous carcinoma were confirmed by nucleotide sequencing. CONCLUSIONS: The frequency of EGFR mutation and clinicopathologic characteristics of the EGFR mutants in adenosquamous carcinoma are similar to those of Asian patients with adenocarcinomas. Identical EGFR mutations in both components suggest the possibility of monoclonality in the histogenesis of adenosquamous carcinoma.

Adenocarcinoma↗
PubMed2005

Primary adenosquamous carcinoma of the jejunum.

Adenosquamous carcinomas of the small intestine are extremely rare, with only three documented jejunal and three ileal cases being reported in the English-language medical literature. Presented herein is a case of primary jejunal adenosquamous carcinoma in an 80-year-old woman. The jejunal carcinoma consisted predominantly of a squamous component throughout the tumor but peritoneal nodules carrying metastases from the adenocarcinoma element were noted, making it the first case of jejunal adenosquamous carcinoma with metastases from the adenocarcinoma component. The finding that metastases could arise from the minor component of a jejunal adenosquamous carcinoma indicates that an accurate diagnosis must be based upon thorough examination of both the primary and the metastases, not just mesenteric nodule biopsy alone. Histological foci of closely intermingled squamous and glandular components with apparent morphological transition were noted, indicating the pathogenetic possibility that the squamous component might arise by transformation from the glandular element. The squamous component was strongly positive with immunostaining for p63 (nuclear staining) and for cytokeratin 10/13 (cytoplasmic staining), while the adenocarcinoma element was negative. The immunohistochemical results suggest that p63 and cytokeratin 10/13 might be useful in identifying squamous differentiation in jejunal carcinoma.

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