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Results for “Catastrophization”

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At least 19 recordsLinked to original sources
PubMed2026

The Effect of Pain Catastrophizing on Acupuncture Treatment for Chronic Pain in Cancer Survivors.

CONTEXT: Pain catastrophizing (PC) predicts worse pain outcomes in cancer survivors. However, little is known whether PC influences pain outcomes of nonpharmacological treatments such as acupuncture. OBJECTIVES: This study aimed to assess the impact of PC on acupuncture efficacy for chronic pain in cancer survivors. METHODS: This secondary analysis of PEACE trial used two-sample t-test and Pearson's chi-squared test to analyze the pain outcomes of cancer survivors who received electroacupuncture (EA) or battlefield acupuncture (BFA). PC was measured using Pain Catastrophizing Scale (PCS). The Brief Pain Inventory (BPI) was used to measure pain severity and interference at the primary endpoint (week 12). RESULTS: Among 266 participants, 41 (15.41%) had a high baseline PC. Among those receiving EA, high PC patients had greater reductions in pain severity (-3.9 vs. -2.1, P = 0.006) and pain interference (-3.8 vs. -2.6, P = 0.04) than low PC. PC was not associated with pain outcomes in BFA group (P > 0.05 for both severity and interference). Among patients with high PC, a greater proportion were responders in the EA group than those in BFA group (83.3% vs. 43.5%, P = 0.009). Among low PC patients, there was no significant difference in the proportion of responders between the EA and BFA groups (66.1% vs. 64.5%, P = 0.8). CONCLUSION: We found that cancer survivors with high baseline PC had greater pain reductions with EA than BFA and compared to low PC patients. These findings suggest that EA may serve as a targeted treatment option for vulnerable patients with high PC and further support precision pain management.

Humans↗
PubMed1977

Impact of a natural catastrophe on life events.

A major earthquake struck Peru in May 1970. This post-quake study compares the impact of this natural catastrophe on the residents of two different cities; one was 90 percent levelled by the quake and one was untouched. A relatively homogeneous population of Peruvians obtained from the two cities completed two paper-and-pencil tests, the Social Readjustment Rating Questionnaire (SRRQ) and the Schedule of Recent Experience (SRE). Both questionnaires were adapted from the SRRQ which had been translated for studies in Spain and EL Salvador. The data from the SRRQ generated two Peruvian Social Readjustment Rating Scales (SRRS), one for each of the cities studied. The differences in the two scales were striking. The lowest intra-cultural correlation yet observed on four studies was obtained. Comparison with a United States population yielded no significant relationships (rs = 0.15), the first time this has occurred in nine intercultural studies. A comparison of the profile of items generated by their subjective magnitude estimations indicated striking qualitative and quantitative differences between the two populations. The SRE generated frequency of occurrence of items and life change magnitudes in five proscribed time intervals. Significant differences in these two quantitative indices (including the health change items) were observed in the two populations in some of the time intervals and not in others. The data formulated suggest that the occurrence of a natural catastrophe--an earthquake which devastated one city--accounted for much of the difference observed between the populations of the two cities.

Adult↗
PubMed1977

Treat decision making in catastrophic illness.

Through conceptual discussion and consideration of a case study, this paper examines how physicians respond to the availability of an innovative treatment of a serious illness. It is argued that the unusual economic environment of the delivery of catastrophic illness care works with the "social contract" in medicine to encourage the use of innovative therapies, even before their efficacy has been demonstrated and often irrespective of their costs, in striking contrast with the conventional innovation adoption process. The primary constraint on catastrophic illness treatment may well be the technology or the state of knowledge. In the case of the management of leukemias in Connecticut, decisions to use drug therapies appear to have been based on a treatment trend rather than on the inherent merits of the therapies. The trend seems to have spread from the treatment of one leukemia, which responded significantly, to the management of three other leukemias. The influence on treatment decisions of a few indiviudal varibles differed across the leukemia. For example, treatment decisions in the acute leukemias were unrelated to the patient's economic status, whereas receipt of chemotherapy for one of the chronic leukemias was significantly positively correlated with economic status.

Acute Disease↗
PubMed1978

Applications of catastrophe theory to optometry.

Catastrophe theory, a recently developed area of mathematics, is used to model two aspects of visual behavior. Visual behavior measured in a patient undergoing phorometry and the visual behavior of some patients with anomalous retinal correspondence undergoing the Walraven technique are characterized as catastrophes.

Humans↗
PubMed2026

Targeting KIFC1 to disrupt centrosome clustering and trigger anaphase catastrophe in small-cell lung cancer.

Supernumerary centrosomes are a hallmark of cancer. To maintain viability, cancer cells cluster these centrosomes during mitosis, enabling bipolar division similar to that of normal cells. Disruption of this centrosome clustering leads to multipolar anaphase and apoptosis (anaphase catastrophe), which selectively eliminates cancer cells harboring supernumerary centrosomes. In this context, because the motor protein KIFC1 contributes to centrosome clustering, we investigated whether targeting of this mechanism through KIFC1 inhibition could be exploited in small-cell lung cancer (SCLC), an aggressive malignancy with limited treatment options and poor prognosis. Through in silico and in vitro analyses, as well as IHC of clinical samples, we found that KIFC1 is overexpressed and that centrosome amplification occurs more frequently in SCLC compared with normal tissues and other cancer types. Pharmacological and genetic inhibition of KIFC1 disrupted the clustering of supernumerary centrosomes, triggered multipolar mitosis, and exerted antineoplastic effects in SCLC cells, with minimal effects on noncancerous cells. These findings were validated and extended in vivo using SCLC xenograft models. Finally, cotargeting KIFC1 and the centrosome duplication regulator PLK4 further enhanced growth suppression in SCLC cells. Together, these results suggest that disrupting centrosome clustering and triggering anaphase catastrophe via KIFC1 inhibition may represent a promising therapeutic strategy for SCLC.

Humans↗
PubMed1978

Qualitative change from quantitative change: mathematical catastrophe theory in relation to psychoanalysis.

The relation of qualitative change to quantitative change is important to psychoanalytic theory. Until recently no tools were available for dealing with the problem, but the development of catastrophe theory has provided methods for studying it. Psychoanalytic investigators might benefit from the methods of catastrophe theory, and dilemmas arising from the supposed impossibility of relating quantity to quality are seen to allow of solution.

Adaptation, Psychological↗
PubMed1978

Disseminated melanoma presenting as a catastrophic event.

The possibility of a patient with malignant melanoma having a catastrophic event as the presenting sign of tumor dissemination cannot be dismissed. Should such an event occur, it would pose not only a risk to the patient, but also a potential risk to others. Since 1971, 712 patients with malignant melanoma have been evaluated. Twenty patients presented with brain metastases and an additional 12 patients developed brain metastases simultaneously with other organ involvement. Four patients (0.6%) had a catastrophic event, such as a stroke or seizure, with no antecedent symptoms. Microstaging of a primary melanoma by the methods of Clark and Breslow, in addition to the recognition of the presence or absence of regional lymph node metastases, provides reliable information for predicting the probability of tumor dissemination. Patients with deep primary melanomas or with lymph node metastases should be advised regarding their participation in potentially hazardous occupations or recreations.

Adult↗
PubMed1977

Can the singularity of chronic peptic ulcers be described by catastrophe theory and explained by biofeedback?

The damaging effect of hydrochloric acid within the lumen of the stomach and duodenum should be diffuse, but chronic peptic ulcers are discrete and usually single. The search for localizing effects on acid attack, or localized defects in mucosal defense have so far been fruitless. If attacking forces increase, or mucosal defense diminishes to the point where ulceration occurs, mucosal breakdown should be progressive. In chronic peptic ulceration, however, the process usually seems to be self-limiting. The catastrophe theory of René Thom may describe the progressive change in the forces that leads to eventual breakdown in mucosal continuity. Possibly this catastrophe triggers off biofeedback mechanisms that hold in check further progress of the ulcer.

Chronic Disease↗
PubMed2025

The Use of APC/C Antagonists to Promote Mitotic Catastrophe in Cancer Cells.

The multiprotein subunit E3 ubiquitin ligase Anaphase-Promoting Complex/Cyclosome (APC/C) plays a key role in the control of mitosis progression. APC/C is the ultimate effector of the Spindle Assembly Checkpoint (SAC), the signaling system of higher organisms including the human that monitors the proper attachment of chromosomes to microtubules during cell division. Defects in this process result in genome instability, aneuploidy, premature aging, and cancer. APC/C roles in the SAC require its activation by the protein Cdc20. Interfering with APC/C activation by Cdc20 impairs APC/C substrate recognition, resulting in a delayed mitotic exit and eventually inducing cell death. This may be advantageous for the treatment of cancer and malignancies associated with SAC dysregulation. Here we describe a protocol to interfere with mitotic exit through the use of commercially available (Apcin, proTAME) as well as innovative small molecules we have developed that function as antagonists of APC/C activation by Cdc20. We show that the use of these molecules alone and in combination is effective to promote mitotic catastrophe and suppress cell expansion in 2D and 3D (spheroids) cancer cells of different tissue origin, including breast, cervical, and ovarian cancer.

Humans↗
PubMedDate not supplied

Ribosome editing and the error catastrophe hypothesis of cellular aging.

Ribosome editing involves the dissociation during protein synthesis of inappropriate peptidyl-tRNA's, ones whose structure does not correctly complement the codon of the mRNA. This process is one of three stages in protein biosynthesis in which the frequency of errors in cellular proteins is controlled. These stages are reviewed and the implications of ribosome editing are described. A model for stability of the translation apparatus is criticized. Calculations using a revision of the model and experimentally reasonable values for the various parameters show varying time courses for error catastrophes.

Cell Survival↗
PubMed1979

Catastrophe theory: a model interaction between neurochemical and environmental influences in the control of schizophrenia.

Catastrophe theory is a new mathematical technique relating variables in a novel, discontinuous way. It suggests ways in which neurochemical and environmental influences could interact so that very small changes in either variable may produce rapid changes in intensity of psychosis that are characteristic of schizophrenia. Other behavioural and pharmacological characteristics of schizophrenia previously considered paradoxical may be similarly explicable, and the model predicts factors most likely to generate relapse.

Acute Disease↗
PubMedDate not supplied

Catastrophic necrosis of the neck.

This case report illuminates the high possibility of catastrophic complications in the lateral neck, the vagaries associated with the preoperative therapeutic information, the technical effort to gain maximum surgical security, and the overwhelming complications associated with chemotherapy, irradiation, and surgical intervention.

Adult↗
PubMedDate not supplied

A behavioral approach to post-catastrophic illness work phobias.

Two patients developed work phobias following major catastrophic physical illness. A combined approach to addressing their specific fears of returning to premorbid levels of work function utilized deep muscle relaxation, imagery based desensitization, social reinforcement, and shaping techniques. A significant increase in adaptive function and decrease in depressive symptomatology resulted in both cases within six weeks after initiation of treatment.

Adult↗
PubMed1977

[The role of the dental officer in catastrophic situations with large numbers of casualties].

During and after military operations, the dental officer helps the medical officer with his knowledge and experience in treating maxillo-facial injuries. According to experience of past wars, head injuries are likely to amount to 10% of all casualties. If the number of casualties is very high, the dental officer will give all general medical assistance which he is qualified to give by his training. To enable him to fulfill all his tasks, the armed forces will give him special training in catastrophe medicine.

Disasters↗
PubMed1979

[Survival of the mutant clone. III. Catastrophic selection. The inadequacy of the selection coefficient for assessing clone fate].

Majorant estimations of the probabilities pr for the surviving of the clone of the dividing cells have been obtained in the catastrophic situation (monotonous diminishing of the clone almost to zero during the period of time from t=0 to t=T, T approximately 100 generation). At t=0 the clone consisted of 10(6) individuals. Average selection coefficient (s) was found to determine pr only roughly, that is the clone with s greater than --0.09 survives almost in all cases, whereas the clone with s greater than --0.13 becomes extinct practically always. Within this interval ps-inversion can be observed, i.e. preferential surviving of the clone with a worse s value. Results of three communications lead to the conclusion that the mutants with small selective advantage practically cannot be selected.

Cell Survival↗
PubMed1978

Fortuitous rupture of aortic aneurysm: a catastrophic event affording time for surgical cure.

The rupture of an aortic aneurysm is generally a fatal event, but occasionally the rupture will occur into an adjacent vascular structure, thereby preventing exsanguination and affording temporary survival. Three cases are presented illustrating the fortuitous nature of the rupture of an aortic aneurysm into a vascular structure. The first patient had an atherosclerotic abdominal aortic aneurysm that ruptured into the inferior vena cava and was successfully repaired. The second case demonstrates the formation of a fistula from the aorta to the left pulmonary artery in a patient with a syphilitic thoracic aortic aneurysm. In the third patient a dissecting aneurysm of the aortic root that communicated with the right ventricle after coronary bypass surgery was successfully repaired. Rarely, aortic aneurysms will rupture fortuitously into vascular capacitance structures. These three cases emphasize the need for early accurate diagnosis and the institution of appropriate surgical measures.

Aged↗