Penile carcinoma in circumcised males.
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The effectiveness of continuous stimulation in lowering arousal level, as indexed by state and heart rate, was studied in 30 uncircumcised males, 30 circumcised males, and 30 female subjects. The continuous-stimulation effect was shown to be directly related to auditory stimulus intensity. It is more complexly related to preexisting stress, operationally defined as subjects' circumcision status.
The availability of age-standardized cancer incidences for different parts of the world has enabled a thorough and meaningful analysis of the geographical distribution of cancer of the uterine cervix. The high morbidity and mortality from cervical cancer reported for most European countries and North America at the beginning of this century has, in recent years, been superseded by those for Asian, African, Latin American and Caribbean countries with the provision of additional data. Striking differences in cervical cancer incidences have been observed among various ethnic groups in Africa which seem to reflect variations in the intensity of certain environmental influences. Cervix cancer is uncommon in the white population of North America and Europe with the exception of West Germany, Denmark, Sweden and Yugoslavia. In the United States, the highest incidence occurs in Puerto Rican women of New York City and the Latin population of the South. The very low incidence in Jewish women is virtually the same in New York City as in Israel. This world-wide survey has shown that poor sexual hygiene rather than lack of male circumcision per se is a more important aetiological factor in cervical cancer.
Sixty-six circumcised men and 69 uncircumcised men, both heterosexual and homosexual, had specimens taken from the coronal sulcus and meatus of the penis. Yeasts were isolated at similar rates in both the circumcised (14%) and uncircumcised (17%) men. The circumcised men had significantly fewer symptoms (P = 0-0058). Therefore the female partners of both circumcised and uncircumcised men are exposed to similar rates of yeast infection despite the absence of symptoms in circumcised men. Eighty per cent of the female contacts of yeast-positive men had yeast infection while 32% of the contacts of yeast-negative men were affected. This difference was statistically significant (0-05 greater than P greater than 0-025). Men with non-specific genital infection seemed more likely to carry yeasts than men with gonorrhoea or normal men.
Results of questioning young parents--582 by direct questioning and 624 by questionnaires--about their knowledge of male circumcision are presented. 61% of those directly questioned and 24% of parents polled by questionnaire did not know what circumcision means. The older the parent and the higher their professional qualifications, the greater their knowledge. Reasons for circumcision were divided into four categories: surgical, hygienic, prophylaxis of cancer and cosmetic. Health education about genital hygiene and circumcision is necessary.
In human studies, the possible long-term effects on behavior of early physical insult or pharmacological agents have received little attention. We present both circumstantial and direct evidence that circumcision of male infants leads to behavioral changes. In some American studies using circumcised infants, reported gender differences may instead be the result of the altered behavior of circumcised males. We suggest that circumcision requires more study in its own right, and that it requires description if not control in all neonatal and infancy studies.
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In polygynous societies in which the family consists of husband, wives, and children only, if each cowife lives in a separate quarter with her children, males are more likely to be circumcised or segregated at puberty. These customs are interpreted as the measures to rectify boys' mother-oriented personality development because of limited contact with their fathers due to their mother's separate quarters. Circumcision and segregation can be explained better in terms of the son's insufficient contact with the father rather than a very close relationship with the mother due to the long postpartum sexual taboo.
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Very often penile cancer occurs histologically as a squamous cell carcinoma. Its treatment is based on radiation therapy and surgery and depends on the stage of the tumor, age of patient, and anatomy and pathology of the lymph system of the male genitalia. In evaluation of 69 cases, the problems of therapy and prognosis are discussed. Preventive circumcision for the purpose of facilitating genital hygiene is reputed to be the operative prophylaxis.
Eight hundred forty consecutive male patients were examined for the presence of pearly penile papules. The age, race and presence or absence of circumcision were recorded. Two hundred fifty-three (30.1%) of patients had lesions, and there was a significantly increased incidence of pearly penile papules in Negroes and uncircumcised men. A significantly greater proportion of Negroes were uncircumcised, possibly explaining the racial difference. The incidence of papules was greatest in young adults and tended to decrease with increasing age. A higher percentage of men over 40 had pearly penile papules than previously reported.
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The more common injuries to the skin of the male external genital organs are described; some of these mutilations are unique to the African continent. The extent of trauma ranges from small penile skin defects after circumcision to complete avulsion of the skin of the penis and scrotum. The techniques of reconstruction are described.
Conventional circumcision techniques may result in bleeding, limited control of the mucosal collar, and the need for dressings. We describe a modified bipolar technique enabling near-bloodless dissection with precise mucosal trimming. Following bipolar division of the preputial skin, the inner mucosa is separated using two forceps and retracted proximally, creating a protective plane for safe skin adjustment. The mucosal collar is trimmed with scissors. The wound is closed with sutures and 2-octyl cyanoacrylate, avoiding dressings. This technique has been performed in 55 consecutive cases (median age: 2 years and 2 months; range: 0 days-17 years and 5 months) with no reported complications over a median follow-up of 2 years and 7 months (range: 3 months-4 years and 1 month).
INTRODUCTION: Circumcision is a common surgical intervention, and pain is the most common complaint. Poorly managed pain can increase morbidity and reduce patient and parent satisfaction. Ketorolac, a non-steroidal anti-inflammatory drug (NSAID), provides analgesia and may be effective in reducing pain after circumcision in pediatric patients. STUDY OBJECTIVES: The primary objective was to determine the effect of pre-operative intravenous ketorolac versus normal saline placebo on parental perception of postoperative pain at 24 h. We also explored the effect of ketorolac on postoperative pain scores, incidence of bleeding, incidence of vomiting, and analgesic use. MATERIALS AND METHODS: A prospective, randomized, single-blinded trial was conducted at a single tertiary children's hospital. Patients aged 1-17 presenting for circumcision were included and randomized to either normal saline injectate or ketorolac (0.5 mg/kg, maximum 30 mg). Postoperative delirium and pain scores were recorded in the post-anesthetic care unit. Parents completed the parents' postoperative pain measure (PPPM) at 24 h. The CONSORT criteria and checklist were used to guide reporting of this randomized controlled trial. RESULTS: A total of 100 participants were included. 50 participants were in each group. Mean (SD) PPPM score 24 h after normal saline and ketorolac was 6.1 (3.4) and 5.5 (3.3), respectively for a mean difference of -0.55 points [95% CI: -1.9 to 0.83; p = 0.427]. The mean (95% CI) fixed effect size of ketorolac on post anesthetic care unit reported Face, Leg, Activity, Cry, Consolability score was -0.17 (-0.77 to 0.43, p = 0.585) points, while the mean (95% CI) effect size of ketorolac on numerical rating scale was -1.2 (-2.2 to -0.18, p = 0.026) points. DISCUSSION: Pre-operative intravenous ketorolac, compared to normal saline placebo, did not result in a difference in parental perception of postoperative pain at 24 h after circumcision surgery. As part of exploratory analyses, those receiving ketorolac had modestly lower mean immediate postoperative pain scores, likely not of clinical importance. Ketorolac has often been avoided due to concerns of increased bleeding risk, however it is important to consider that there is no substantial evidence to support this. This is the first study to our knowledge evaluating the effect of ketorolac in pediatric circumcision patients. While the PPPM score is a family centered outcome, it is an indirect measurement of pediatric pain. CONCLUSIONS: Pre-operative intravenous ketorolac was not associated with lower parental reported pain scores at 24 h compared to normal saline placebo after pediatric circumcision surgery. CLINICAL TRIAL REGISTRATION: NCT02973958.
A form-fitting glans condom has been developed for use in small uncircumcised males with neurogenic bladders to avoid the problems inherent with diapers. The method to make the glans condom and early successful use in 19 of 33 patients are noted.
Forty-five cases of genetic males were assigned and habilitated as females, 43 because of a congenitally defective penis (micropenis with or without hypospadias), and two because of infantile ablatio penis. One of the latter has an identical twin brother as a control. Now 9 years old, she has differentiated a female gender identity in marked contrast to the male gender identity of her brother. Some of the other patients are now adolescent or adult in age. They demonstrate that the twin can expect to be feminine in erotic expression and sexual life. Maintained on estrogen therapy, she will have normal feminine physique and a sexually attractive appearance. She will be able to establish motherhood by adoption.
A one-year epidemiologic study of penile venereal edema in a clinic for sexually transmitted diseases identified 25 cases, a rate of 1.7 per 1,000 male visits. Twenty-four patients had coexisting urethritis (36%), infected penile lesions (36%), or both (24%). Men with penile edema were significantly more likely to have gonococcal urethritis (40%), genital scabies (12%), genital herpes (12%), and inguinal adenopathy (52%) than men without penile edema. Penile edema is self-limited and seems to resolve along with the underlying penile disease. Lymphatic involvement may be the final common factor.