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At least 19 recordsLinked to original sources
PubMed1977

Influence of sunscreening agents on color stability of tablets coated with certified dyes III: FD&C Yellow No. 6.

The influence of a protective coating of six sunscreening agents (glyceryl p-aminobenzoate, benzocaine, cinoxate, homosalate, n-octyl salicylate, and amyl salicylate) upon the photostability of FD&C Yellow No. 6 used to color coat tablets was studied. The alcohol film, modified sugar-, and film-coating methods were used to apply the sunscreening agents. Tablets were exposed to 1000 foot-candles of light for various times, after which reflectance measurements and visual observations were recorded. FD&C Yellow No. 6 did not follow the Kubelka-Munk equation. The order of relative stability was FD&C Yellow No. 6 greater than erythrosine sodium (FD&C Red No. 3) greater than FD&C Blue No. 1. The greatest protection against fading was afforded by benzocaine.

Azo Compounds↗
PubMed1977

Food, drug, and cosmetic dyes: biological effects related to lipid solubility.

Food, drug, and cosmetic dyes of the xanthane type (analogs of fluorescein) were applied to isolated molluscan ganglia and changes in the electrophysiological properties of identified neurons were monitored. The synthetic coloring agents increased the resting membrane potential and conductance of the neurons in a dose-dependent manner by increasing the potassium permeability of the membrane relative to that of other ions. The relative activity of these anionic dyes was highly correlated with their lipid solubility. The structure-activity study of the effects of the dyes on molluscan neurophysiology provides a basis for estimating the toxicity and brain uptake of the dyes in vertebrates, and predicting their effects on metabolism and blood clotting.

Animals↗
PubMed1978

The use of chromium-51 sodium chromate for the detection of food and chemical sensitivities.

Both antibody mediated lysis of human RBC's and toxic hemolysis were found to occur with chemicals used as coloring agents for foods, drugs and cosmetics. Because of the strong chromaticity of these dyes, chromium-51 sodium chromate was bound to the hemoglobin of target human RBC's and its efflux was used as an indicator of lysis instead of spectrophotometry, which had been used with food antigens. The major antibody effect was noted when treatment of the target RBC's with antiIgG resulted in a marked inhibition of lysis, indicating that IgG is a lysis-promoting factor (LPF) in this system. Weaker effects were noted by treatment of the target RBC's with monospecific antisera for the other four classes of immunoglobulin and for alpha2-macroglobulin. No neutralizing effects were observed by pre-incubation of the dyes with autologous serum prior to the addition of RBC's.

Chromates↗
PubMed1978

Production of a novel red pigment, rubrolone, by Streptomyces echinoruber sp. nov. I. Taxonomy, fermentation and partial purification.

A taxonomic study of Streptomyces X-14077 (NRRL 8144), which produces a water-soluble purple-red pigment complex, revealed it to be a new species which has been named Streptomyces echinoruber sp. nov. The pigment complex was produced in deep culture fermentation and isolated by solvent extraction and concentration. The major pigment component, rubrolone, has low toxicity and may have potential as a food coloring agent. It appears to be devoid of antibiotic activity.

Animals↗
PubMed1979

Home remedies.

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Adolescent↗