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At least 19 recordsLinked to original sources
PubMed2004

Potential for enlarging DNA memory: the validity of experimental operations of scaled-up nested primer molecular memory.

DNA is an attractive memory unit because of its immense information density. Here, we describe a memory model made of DNA, called Nested Primer Molecular Memory (NPMM). NPMM consists of many DNA strands, and each DNA strand consists of two areas: a data area and a data address area. When the address of target data is specified, only the target data can be extracted from NPMM. In this paper, we evaluate the validity of the basic operations of NPMM and then discuss the feasibility of scaled-up NPMM through some laboratory experiments. In the latter, we deal with scaled-up NPMM simulated by the Concentration Scaling method.

Algorithms↗
PubMed1997

Application of M-JPEG compression hardware to dynamic stimulus production.

Inexpensive circuit boards have appeared on the market which transform a normal micro-computer's disk drive into a video disk capable of playing extended video sequences in real time. This technology enables the performance of experiments which were previously impossible, or at least prohibitively expensive. The new technology achieves this capability using special-purpose hardware to compress and decompress individual video frames, enabling a video stream to be transferred over relatively low-bandwidth disk interfaces. This paper will describe the use of such devices for visual psychophysics and present the technical issues that must be considered when evaluating individual products.

Computer Storage Devices↗
PubMed1981

What pathologists should know and be able to do in laboratory data processing and computers: peripheral devices and storages.

This article is the second in a five-part educational series on laboratory data processing and computers. The authors describe the major components of peripheral storage and the limitations of input/output devices, and analyze in terms of laboratory workflow the type and placement of input/output devices. Preceding the article are competency areas and performance objectives, defined by the Laboratory Computer Applications and Data Processing Committee. Following the article are questions with which readers can test their understanding of the material. Next month the authors will focus on software.

Computers↗
PubMed1987

A computer method for the acquisition and analysis of patch-clamp single-channel currents.

The method we present instructs the computer to deliver sets of programmed membrane voltages and allows the acquisition of large amounts of digitized data, compact storage, ready identification of records and rapid, interactive analysis of channel current data. A typical cycle of analysis including amplitude determination and kinetic measurements for 10 s of continuous data digitized at 5 kHz requires 5-20 min depending on the complexity of the observed channel activity. This procedure is compatible with such storage protocols as that described by Bezanilla [Biophys. J., 47 (1985) 437-441], although there are obvious benefits to using standard computer storage devices such as hard disks, floppy disks, and Bernoulli Boxes. The programs described in this report are available from the authors.

Animals↗
PubMed1995

Design of the EPC-9, a computer-controlled patch-clamp amplifier. 1. Hardware.

The EPC-9 patch-clamp amplifier is a digitally controlled analog device for recording currents in membrane patches and in small cells. It has neither front-panel controls nor internal trim adjustments; instead all gain, range-changing, transient cancellation, calibration and other functions are computer controlled. Novel aspects of the circuit design of this instrument are discussed, with special reference to the issues of allowing computer control of all functions.

Computer Storage Devices↗
PubMed2000

"Permanent" records: experience with data migration in radiology information system and picture archiving and communication system replacement.

In the replacement of both a radiology information system (RIS) and a picture archiving and communication system (PACS) archive, data were migrated from the prior system to the new system. We report on the process, the time and resources required, and the fidelity of data transfer. We find that for two PACS archives, both organized according to the Digital Imaging and Communications in Medicine (DICOM) information model, data may be transferred with full fidelity, but the time required for transfer is significant. Transfer from off-line backup media was found to be faster than transfer from our robotic tape library. In contrast, the RIS replacement required extensive labor to translate prior data between dissimilar information models, and some data were inevitably lost in the translation. Standards for RIS information models are needed to promote the migration of data without loss of content.

Computer Storage Devices↗
PubMed1993

The operational impact of architectural alternatives for radiological imaging workstations.

Characteristics of workstations for use in digital radiological imaging have been investigated for many years. However, much of this investigation has focused on the workstation in isolation, and has often been directed almost entirely at user interface issues. Certainly these issues are critical, but with the increasing use of commercial workstations it is important to look at the workstation in the context of the medical information environment and examine some important underlying characteristics required to meet the demands of digital radiology. This article examines the role of storage components in these workstations both architecturally and operationally. Both aspects are viewed with consideration of their impact on the internals of the workstation and its interaction with the external information system. By considering these aspects of the workstation it is apparent that local storage and image preloading are required to support diagnostic viewing. Additional operational and architectural strategies are required to efficiently manage information within the workstation.

Computer Communication Networks↗
PubMedDate not supplied

Digital image management and communication in medicine.

With the rapid development of digital imaging modalities in medicine, there is an increasing need for an efficient management and archival of medical images in digital form. Picture Archiving and Communication Systems (PACS) are becoming an essential component of medical imaging equipment, allowing for medical images to be accessed and stored directly in digital form. This paper describes a hospital-wide PACS currently under development at the University Hospital of Geneva, based on an open architecture, regrouping equipment from different vendors in a distributed topology. The image archival is organized in multiple locations geographically distributed in the hospital. The PACS database is fully integrated with the concurrent Radiology Information System (RIS) and Hospital Information System (HIS). A standard image storage format called the PAPYRUS format was developed for the storage of medical images from a variety of imaging modalities. To provide a more uniform user interface on a variety of different workstations, a common platform for image display and manipulation called OSIRIS was developed.

Computer Communication Networks↗
PubMed2004

MITIS: a WWW-based medical system for managing and processing gynecological-obstetrical-radiological data.

In this paper a World Wide Web (WWW)-based medical system, called MITIS, is designed and developed for the management and processing of obstetrical, gynecological and radiological medical data. The system records all the necessary medical information in terms of patient data, examinations, and operations and provides the user-expert with advanced image processing tools for the manipulation, processing and storage of ultrasound and mammographic images. The system can be installed in a hospital's Local Area Network (LAN) where it can access picture archival and communication systems (PACS) servers (if available), or any other server within the radiology department, for image archiving and retrieval, based on the digital imaging and communication in medicine (DICOM) 3.0 protocol, over TCP/IP and also it is accessible to external physicians via the hospital's Internet connection. MITIS is composed as a set of independent WWW modules (ISAPI server extension dlls) and a Win32 application (COM+ server) for mammography image processing and evaluation.

Algorithms↗
PubMed2002

Handheld computing in dentistry.

Handheld computer sales are increasing rapidly in the United States and worldwide. The convenience and communication features will continue to improve and become commonplace in our lives. Using a handheld computer in the dental environment is efficient and potentially aids the dentist in delivering a higher standard of care to patients.

Computer Storage Devices↗
PubMed2006

Fast maximum intensity projections of large medical data sets by exploiting hierarchical memory architectures.

Maximum intensity projections (MIPs) are an important visualization technique for angiographic data sets. Efficient data inspection requires frame rates of at least five frames per second at preserved image quality. Despite the advances in computer technology, this task remains a challenge. On the one hand, the sizes of computed tomography and magnetic resonance images are increasing rapidly. On the other hand, rendering algorithms do not automatically benefit from the advances in processor technology, especially for large data sets. This is due to the faster evolving processing power and the slower evolving memory access speed, which is bridged by hierarchical cache memory architectures. In this paper, we investigate memory access optimization methods and use them for generating MIPs on general-purpose central processing units (CPUs) and graphics processing units (GPUs), respectively. These methods can work on any level of the memory hierarchy, and we show that properly combined methods can optimize memory access on multiple levels of the hierarchy at the same time. We present performance measurements to compare different algorithm variants and illustrate the influence of the respective techniques. On current hardware, the efficient handling of the memory hierarchy for CPUs improves the rendering performance by a factor of 3 to 4. On GPUs, we observed that the effect is even larger, especially for large data sets. The methods can easily be adjusted to different hardware specifics, although their impact can vary considerably. They can also be used for other rendering techniques than MIPs, and their use for more general image processing task could be investigated in the future.

Computer Storage Devices↗
PubMed1997

Value of automatic processing and reliability of stored data in an implanted pacemaker: initial results in 59 patients.

Stored data in implantable pacemakers have rarely been used as a diagnostic tool because of the complexity. Our group has developed software called AIDA, providing an automatic interpretation of data stored in memories of the Chorus (ELA medical) pacemaker. We compared the results of AIDA analysis to surface ECG Holter interpretation in 59 patients (age 75 +/- 9 years). In 33 cases, neither AIDA nor the Holter found any anomaly. Eleven patients demonstrated episodes of supraventricular tachycardia (SVT), confirmed by AIDA in ten patients; AIDA failure was due to nonsustained episodes of SVT not inducing mode switch. Loss of atrial sensing, pacemaker-mediated tachycardia, and ventricular extrasystoles were detected by AIDA in ten patients. Traditional Holter missed three cases. This initial study confirms that stored pacemaker data, automatically interpreted can provide reliable information over a 24-hour period.

Aged↗