PubMed Health⌕ Search

SEARCH · PubMed Health

Results for “Conjunctival Neoplasms”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 19 recordsLinked to original sources
PubMed1994

Application of impression cytology to the diagnosis of conjunctival neoplasms.

Conjunctival impression cytology using cellulose acetate filter paper was employed to obtain multiple samples of conjunctival epithelium from 192 normal and abnormal eyes. Modifications of an established technique were used and the impressions were stained by the Papanicolaou method and mounted on glass slides. The impressions were examined for their effectiveness in demonstrating the morphological characteristics of normal epithelium and the features of the more common conjunctival neoplasms. The technique was found to be successful at both removing cells and preserving cytologic features. It also had several advantages over other collection techniques. Overlapping cells were not a detrimental feature of the preparations from this study.

Conjunctiva↗
PubMed2005

[Drug therapy for corneo-conjunctival neoplasm].

BACKGROUND: The goal of therapy for corneo-conjunctival neoplasm is lesion removal, with the most widespread procedure being complete tumor resection with or without associated chemotherapy lines. As this sort of procedure entails a high relapse rate (9-52%) the use of adjuvant therapies to reduce the occurence of relapse becomes a need. The administration of a number of topically administered drugs has been used for adjuvant therapy, including mitomycin C, 5-fluorouracil and interferon a 2b. OBJECTIVE: To determine the clinical experience published regarding the effectiveness of the various drug therapies for cor-neo-conjunctival neoplasm. SEARCH STRATEGY: Information reported on this topic in the Medline database (1966-2004) was searched using corneo-conjunctival neoplasm, 5-fluorouracil, mitomycin C, and interferon ca2b as key words. SELECTION CRITERIA: All papers quoting dosage for drugs used,treatment length, adverse effect development, and clinical response obtained were included. PRIMARY RESULTS: Papers reporting the use of 5-fluorouracil re few when compared to those quoting other drugs, with a response rate of 88% and a relapse rate of 20%. The use of mitomycin C is widely described in the medical literature with a response rate of 90% and a relapse rate of 13%, but in association with the development of adverse effects in a high percentage of patients. Interferon ca 2b is the last drug to be incorporated in the treatment of these ocular lesions, with a response rate of 100% and a low incidence of adverse effects, with a relapse rate of 4%. CONCLUSIONS: Mitomycin C is an effective drug, but its use is associated with a high number of adverse events, some of which may lead to therapy discontinuation. Interferon ct 2b has efficacy outcomes comparable to mitomycin C and a lower incidence of adverse effects, which are mostly mild in nature. The use of 5-fluorouracil is relegated to a second-tier status.

Antineoplastic Agents↗
PubMed1995

[777 cases of the primary conjunctival neoplasms].

PURPOSE: To make a histopathologic analysis of the primary conjuctival neoplasms. METHODS: The light microscopic findings of 777 cases of the primary conjunctival neoplasms were reported. The histochemical and immunohistochemical technologies were used. RESULTS: In a series of 777 primary conjunctival neoplasms, 669(86.1%) were benign and 108 (13.9%) were malignant. The pigmented nevi (247 cases) were the most common in the benign tumors, while the squamous cell carcinoma (58 cases) were the most common tumors among the malignant ones. CONCLUSIONS: The biological characteristics of the benign and malignant tumors can be referred as differential diagnosis. There is the spindle cell and mucoepidermoid type in the squamous cell carcinoma of the conjunctiva. Postoperative recurrent factor of the malignant melanoma of the conjunctiva is numerous.

Carcinoma, Squamous Cell↗
PubMed2000

Localized infection by Serratia marcescens simulating a conjunctival neoplasm.

PURPOSE: To report a Serratia marcescens infection that clinically simulated a conjunctival neoplasm. METHOD: Case report. RESULTS: A healthy 80-year-old man without contact lenses presented with a pink-yellow conjunctival mass that resembled a solid neoplasm. Stains and cultures of material that exuded from the mass during surgery revealed S. marcescens. Histopathology disclosed an epithelial-lined cyst with macrophages containing S. marcescens. CONCLUSION: Although S. marcescens usually affects the eye as a keratoconjunctivitis in patients with contact lenses, it can also present as a mass simulating a neoplasm in a patient who does not wear contact lenses.

Aged↗
PubMed2000

[The TNM classification system in malignant conjunctival neoplasms].

The authors submit a review of histological findings and classification according to the TNM-classification of conjunctival tumours in patients under dispensary care at the First Ophthalmological Clinic of the Faculty Hospital and Medical Clinic of the Comenius University in Bratislava during a 10-year period (1989-1998). They included in the group 75 patients with clinically assessed conjunctival tumours (0.4% of the hospitalized patients). As to histological findings, 61 times (80.3%) a benign process was involved (naevus of the conjunctiva 12x) and 14x (19.7%) a malignant tumour, (7x times a primary malignant melanoma of the conjunctiva, 3x carcinoma). The authors recorded two relapses (one malignant melanoma of the conjunctiva, one melanoma penetrating into the orbit). The mean age of the patients was 47 years (from 1 to 82 years). In malignant melanoma of the conjunctiva stage T1 was detected in as many as 3/4 of the patients (6 times), whereby stage pT1, 2 was found in 7 patients. In carcinoma the authors did not detect stage T1, only stage T2 in 2 patients, T3 (pT3) in one patient.

Adolescent↗
PubMed2002

Pigmented conjunctival neoplasms.

Pigmented lesions of the conjunctiva are not rare. They may be acquired, congenital, benign or malignant. In the present paper, the author provides a brief review, in a non-exhaustive manner, of the common melanocytic pigmentations, with more emphasis on the malignant and pre-malignant variants.

Conjunctival Diseases↗
PubMed2004

Adjunctive treatment with interferon alpha-2b may decrease the risk of papilloma-associated conjunctival intraepithelial neoplasm recurrence.

PURPOSE: To report a case of bilateral papilloma virus-positive conjunctival intraepithelial neoplasm and the treatment results of using adjunctive interferon alpha-2b. METHODS: Case report and literature review. RESULTS: A 73-year-old man underwent subtotal excisional biopsy of the 270-degree gelatinous limbal lesion of the right eye to avoid creating a limbal deficiency and cicatricial change. Total excisional biopsy of the temporal elevated leukoplakic limbal lesion was performed on his left eye. Histology examination showed bilateral intraepithelial neoplasia, and human papilloma virus-16 and -18 were detected by polymerase chain reaction in both lesions. Two supplemental perilesional injections of interferon alpha-2b in the right eye were given, and the residual mass decreased in size gradually and completed clinical resolution 7 weeks following initial surgery. Although no recurrence was noticed in the right eye, recurrence of the conjunctival intraepithelial neoplasm lesion was noticed in the left eye. CONCLUSION: Adjunctive therapy might lower CIN recurrence rate, especially in extensive lesions, when surgical excision cannot ensure a tumor-free margin. Our bilateral case provided a good control example for the recurrence with or without adjunctive therapy.

Aged↗
PubMed2006

Survey of 447 patients with conjunctival neoplastic lesions in Farabi Eye Hospital, Tehran, Iran.

PURPOSE: The current study was undertaken to determine the frequency of specific primary conjunctival neoplastic lesions in a patient population treated at an ocular service over a 15-year period. MATERIALS AND METHODS: We analyzed the data of all primary cases of conjunctival neoplasia diagnosed from 1990 to 2004 in the pathology department of Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran. RESULTS: Of 3,242 conjunctival specimens, 447 were identified as primary conjunctival neoplasms. The patient group comprised 270 (60.4%) males and 177 (39.6%) females, with an age range of 1 to 90 years. The mean age was 38 years and the median was 32 years. The most common primary conjunctival neoplastic lesion was nevus (38.7%), followed by squamous cell carcinoma, (25.1%), papilloma (7.8%), dysplasia (5.6%), and hemangioma (5.1%), respectively. Of 447 lesions, 261 (58.4%) were benign, 134 (30%) were malignant, and 52 (11.6%) were precancerous. CONCLUSION: As in previously published studies, benign lesions were the most frequent, but the percent of malignant lesions was much higher than that described in other reports. The high percentage of squamous cell carcinoma that we observed can likely be attributed to elevated sun exposure and ultraviolet light in Iran. The characterization of precancerous lesions in this study emphasizes their potential to transform into malignant lesions and the need for sufficient early management and follow up.

Adolescent↗
PubMedDate not supplied

B-cell conjunctival lymphoma in a cat.

A bilateral conjunctival neoplasm was surgically removed from a 13-year-old Domestic Short-haired female cat and examined by histopathology. The neoplasm was infiltrative, nonencapsulated and composed of large sheets of densely packed, round to polygonal cells. Neoplastic cells were variably sized with scant to modest amounts of cytoplasm and oval to round nuclei. On immunohistochemistry the neoplastic cells stained positively for BLA.36 and negative for CD-3 antibodies. On the basis of histopathology and immunohistochemical findings, a diagnosis of conjunctival B-cell lymphoma was made. This is the first case with immunohistochemical characterization of conjunctival lymphoma in a cat.

Animals↗