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At least 19 recordsLinked to original sources
PubMed1992

Steroids and "the pill": early steroid research at Searle.

The announcement from the Mayo Clinic in 1949 of the dramatic effectiveness of cortisone in the treatment of rheumatoid arthritis stimulated tremendous interest in steroid chemistry, endocrinology, and related areas of medicine. Shortly thereafter, G. D. Searle & Co. initiated a major effort in steroid research, the objective of which was to discover better steroid drugs than those available at that time or steroids that could be used for conditions for which no compounds were previously available. This effort was remarkably successful and resulted in the introduction of several important pioneering drugs. These included norethandrolone, marketed in 1956 as Nilevar, the first anabolic agent with a favorable separation between protein building and virilization, and spironolactone, introduced in 1959 as Aldactone, the first steroid antialdosterone antihypertensive agent. Of special importance was the research that culminated in the discovery of Enovid. This substance, a combination of the progestin norethynodrel and the estrogen mestranol was first approved in 1957 for the treatment of a variety of disorders associated with the menstrual cycle. The era of oral contraception began in May 1960, when Enovid was approved by the Food and Drug Administration for ovulation inhibition, and was immediately thereafter introduced for such use.

Contraceptives, Oral, Hormonal↗
PubMed1991

Norplant.

Explore the source record for details and available documents.

Drug Implants↗
PubMed1990

The evolution of oral contraceptives. Maximizing efficacy, minimizing risks.

No single pharmacologic agent has been more widely studied than the oral contraceptive (OC). Scientific efforts have been directed primarily toward maximizing the benefits of OCs--which remain the most effective, reversible form of birth control--while minimizing their potential risks, specifically thromboembolic disorders and cardiovascular disease. Decreases in the dose of estrogen from the 100 micrograms--150 micrograms levels of the 1960s to the 30 micrograms--50 micrograms formulations of today have been accompanied by dramatic reductions in the risk of thromboembolic events. In healthy women not predisposed to these conditions, the risk of thromboembolism is now considered very small. Similar reductions in the doses of progestin have also resulted in decreases in the incidence of stroke and myocardial infarction. Evidence suggests that not only dose but androgenic activity of a progestin may negatively impact on risk of cardiovascular disease. Thus development of OCs containing a progestin with the least potential for androgenically mediated side effects appears to be advisable.

Cardiovascular Diseases↗
PubMed1977

[Investigations on the contraceptive action of the Graefenberg ring. Historical review (author's transl)].

The biological activity of 2 Graefenberg rings was tested in vitro by electrone microscopy and X-ray microanalysis. The investigation showed that Graefenberg rings made of silver contain a varying amount of copper. The Graefenberg rings showed dissociation of copper in vitro which probably also occurred in the uterine cavity. The effect of the copper on the endometrium was probably a factor in the good contraceptive effectiveness of the Graefenberg silver ring compared for the silk thread intrauterine pessaries.

Copper↗
PubMed1992

A condom sense approach to AIDS prevention: a historical perspective.

Condoms have come a long way since their use in ancient Egypt three millennia ago. Their benefit is well established for the prevention of both contraception and STDs. Although AIDS has revitalized the condom, we must remember that condoms do not prevent the spread of HIV infection, people do. Everyone must take personal responsibility to avoid high risk behavior (e.g.; IV drug use, promiscuous sex, casual sex, etc). If one does engage in high risk sexual behavior, he/she should at least use condom sense.

Acquired Immunodeficiency Syndrome↗