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The influence of stimulus length on the oblique effect of contrast sensitivity.

Contrast sensitivity for grating of different orientations was measured at various stimulus lengths. The oblique effect of contrast sensitivity was observed to increase in magnitude as the length of the truncated gratings was increased from 0.5 to 5.6 deg. This finding refutes a purported distinction between the contrast sensitivity oblique effect and the orientation discrimination oblique effect. Thus, these results are consistent with the idea that the contrast sensitivity oblique effect and the orientation discrimination oblique effect share the same common underlying anisotropic basis. These results also show that grating summation differs at oblique and nonoblique orientations in terms of length summation as well as in terms of width summation.

Adult

Operation Everest II: lack of an effect of extreme altitude on visual contrast sensitivity.

Contrast sensitivity thresholds were studied over 40 d during gradual ascent to a simulated terrestrial altitude of 25,000 ft in a decompression chamber. Only ambient pressure, and thus inspired oxygen pressure, was varied, thereby eliminating many of the confounding effects of cold, dehydration, malnutrition and exhaustion, inevitably encountered on very high mountains. Contrast sensitivity thresholds measured by the Ginsburg Vistech test showed no overall impairment as altitude increased. These results are different from those of other previously reported vision studies involving shorter exposures, lower altitudes, and lower test luminances. However, our results can be explained on the basis of the higher stimulus luminances used in our contrast sensitivity testing. Compared to the luminance levels involved in previously reported testing, our higher luminance stimuli would be less likely to be affected by hypoxia.

Adult

Age differences in Vistech near contrast sensitivity.

Contrast sensitivity was measured at near using the Vistech 6000 Contrast Test System (VCTS) in 287 persons aged 4 to 87 years. Obtained data compared well with those previously reported for the Vistech charts. Results indicate an age-related loss in sensitivity to intermediate and higher spatial frequencies. This is consistent with the age trends observed using other methods for measuring contrast sensitivity functions (CSFs). However, the Vistech charts yield contrast sensitivity values which are lower than those obtained previously with the Nicolet system. These between-method differences are greatest at lower spatial frequencies, and are attributed to the small number of grating cycles in the Vistech charts. The data are used to develop provisional age norms for the Vistech charts which allow the assessment of an individual's performance relative to their age cohort. Recommendations for use and future development of the Vistech charts are also given.

Adolescent

Aging and luminance-adaptation effects on spatial contrast sensitivity.

Contrast sensitivity as a function of target luminance for four spatial frequencies (0.5, 2, 4, and 8 cycles/deg) was measured in younger (n = 12; age range, 19-35 years) and older (n = 11; age range, 68-79 years) adults in order to examine the feasibility of optical and neural explanations for the impairment of contrast sensitivity in older adults. All subjects were free from identifiable ocular disease and had good acuity. Sensitivity for each spatial frequency was measured at eight luminance levels spanning 3.5 log units in the photopic-mesopic range. When gratings were flickered at 0.5 Hz, functions for older adults were displaced downward on the sensitivity axis across all luminance levels, and the slopes of these functions were steeper than those for younger adults, suggesting that optical mechanisms alone cannot account for the vision loss in older adults. Further measurements, in which spatial targets were flickered at 7.5 Hz, indicated that this faster temporal modulation affected sensitivity as a function of luminance differentially in younger and older adults. These data imply that the neural mechanisms subserving human spatial vision undergo significant changes during adulthood.

Adaptation, Physiological

Assessment of potential contrast sensitivity. Part I: Preoperative prediction of contrast sensitivity following intraocular lens implantation.

Preoperative contrast sensitivity functions (CSFs) were determined for 15 cataract patients using laser-generated patterns that effectively bypassed the optical components of the eye. These functions were compared with postoperative CSFs determined using traditional methods by transmission through the optics of the eye. Accurate prediction of postoperative contrast sensitivity occurred in 91% of the cases (ten of 11) for patients with preoperative visual acuity of 20/200 or better and in 67% of all the cases (ten of 15). Prediction failures occurred when the laser interferometer was not able to penetrate the cataract or when postoperative complications occurred. These results suggest that preoperative measurement of laser interferometric CSF is a useful predictor of postoperative CSF for patients with mild to moderate cataracts that can be bypassed by the laser and with better than 20/200 preoperative visual acuity. The problem of assessment when lens opacity is advanced is addressed in Part II.

Aged

The common cold, pattern sensitivity and contrast sensitivity.

Results from two studies involving challenge with respiratory syncytial viruses showed that volunteers who developed colds were more sensitive to a visually distracting pattern presented prior to virus challenge than were volunteers who did not get a cold. Volunteers with sub-clinical infections reported more illusions after virus challenge than they had done before, whereas uninfected volunteers and those with colds tended to report fewer illusions on the second test. These effects did not occur when volunteers were challenged with either a coronavirus or rhinovirus. Overall, the results confirm that behavioural measures may be related to susceptibility to subsequent illness, and that viral infections may influence visual perception. They also show that the effects vary according to the nature of the infecting agent, which agrees with results from studies looking at other aspects of behaviour.

Adolescent

Spatial scaling of central and peripheral contrast-sensitivity functions.

Contrast sensitivity was measured as a function of spatial frequency at various eccentricities in the nasal visual field. Eccentricity influenced resolution more for vertical gratings than for horizontal ones, demonstrating a nasal field anisotropy. When grating apertures and spatial frequencies were varied together, by changing viewing distance, peripheral and central contrast-sensitivity functions could not be entirely superimposed by scaling the spatial-frequency stimulus parameter. However, when gratings apertures were designed to project a standard-sized patch on a hypothetical vertical surface at an angle of 9 deg to the line of sight, the superimposition of central and peripheral contrast-sensitivity functions improved. Central and peripheral contrast-sensitivity functions can be superimposed by describing the grating stimulus with reference to this putative surface in terms of cycles per surface distance. The surface-scaling approach leaves a minor effect of eccentricity on contrast sensitivity for vertical gratings but readily accommodates the vertical-horizontal anisotropy in grating resolution. These findings suggest a novel functional role for gradients in the spatial sampling of the visual field, in relation to the internal representation of the structure and geometry of visible surfaces.

Humans

Hemispheric lateralization of spatial contrast sensitivity.

Visuospatial contrast sensitivity was determined by the Arden grating chart in 23 patients with cerebral infarctions involving the primary visual cortex or visual association cortex. Subjects were classified into three groups according to their lesions: I, 6 patients with unilateral medial occipital or occipitotemporal lesions; II, 6 patients with left lateral parieto-occipital lesions; and III, 11 patients with right lateral parieto-occipital lesions. Contrast sensitivity was markedly reduced in Group III, especially in patients having hemispatial agnosia. Group I patients with hemispatial agnosia showed almost normal contrast sensitivity. Spatial contrast sensitivity appears to be more affected when the lesion has an influence on the nondominant lateral parieto-occipital cortex.

Adult

The effect of cycloplegia on the visual contrast sensitivity function.

Contrast sensitivity assessment is one of several emergent techniques being considered for inclusion in a visual standards test battery for the Army, particularly for the evaluation of Army aviators. Since a cycloplegic refraction is required for initial selection of candidates for Class I and Class IA flying duty, it is important to determine what effect, if any, cycloplegia has on the contrast sensitivity function. There were 12 subjects tested, all officers in preparation for flight training who had passed a recent Class I flight physical. Contrast sensitivity functions were obtained under normal ambient conditions and in the presence of a glare source both under manifest and cycloplegic conditions. Cycloplegia produced a small reduction in contrast sensitivity under normal ambient conditions, and a greater reduction under glare conditions. For both conditions, the cycloplegia effect was greater for the higher spatial frequency gratings than for the lower.

Aerospace Medicine

Jogging and contrast sensitivity.

Threshold contrast sensitivity was measured using sinusoidal gratings with the method of increasing contrast both before and after jogging in fresh air. The mean contrast sensitivity of 11 subjects was higher after jogging at all three spatial frequencies studied (1, 6 and 19 c/deg). The differences were statistically significant. The effect of jogging was subject to individual variation, some 'unstable' subjects responding strongly and some 'stable' subjects showing no change at all. Two 'unstable' subjects were tested several times, and their strong response proved to be repeatable.

Adult

Assessment of contrast sensitivity. Part II: The relationship between objective lens opacity and laser interferometric contrast sensitivity in the cataract patient.

The laser interferometer can effectively bypass the optics of the eye and measure retinal function in patients with immature cataracts. However, it is not known how much laser interferometric measurements are impaired by cataract density. In this study we compared objective lens opacity using the IntraOptics opacity lensmeter with contrast sensitivity (CS) measured by a Randwal He-Ne laser interferometer. Comparison of lens opacity with CS in the cataract population revealed an inverse linear relationship between objective lens opacity and retinal contrast sensitivity. Separation by cataract type showed correlation coefficients as high as -0.91 for nuclear sclerotic predominant cataracts and as low as no significant correlation for posterior subcapsular predominant cataracts. Comparisons of before and after implantation surgery contrast sensitivities (as measured by the laser interferometer) with preoperative lens opacities (as measured by the IntraOptics opacity lensmeter) quantified the extent to which laser interferometric measurements underestimated potential retinal function. We found that for all cataracts, other than posterior subcapsular predominant cataracts, potential contrast sensitivity (in decibels) was underestimated by about 0.2 to 0.3 times the opacity measured by this technique.

Adult

Population norms for edge contrast sensitivity.

The contrast sensitivity (CS) for a single edge appears to be a reliable indicator of the peak of the contrast sensitivity function (CSF). We propose that for general clinical practice and in the functional assessment of patients with low vision, the simple measurement of edge CS provides an adequate indicator of the peak of the CSF. We conducted a trial in which edge CS was measured in a routine clinic setting.

Aging

A system for controlled presentation of the Arden contrast sensitivity test.

Contrast sensitivity has been identified as a significant index of visual function, and as an indicator of visual disorders. The Arden test of contrast sensitivity has been recognized as a simple and easily administered technique for measurement of this process. However, the customary method of administration of this test involves manual manipulation and considerable individual subjectivity. The instrument described in this report was designed and developed to minimize variability in the testing procedure due to differences in individual testing techniques, and to standardize testing conditions, ambient illumination, viewing distance and rates of presentation.

Fourier Analysis

Age variations in normal human contrast sensitivity.

The visual contrast sensitivity (the reciprocal of contrast threshold) was studied as a function of age. Psychophysical measurements of binocular and monocular contrast thresholds were made for 33 normal observers at spatial frequencies within the range 0.5 to 40 cycles/degree. The observers were divided into three different age groups: young, middle-aged, and old subjects with the age ranges 6--10 years, 20--40 years, and 60--70 years, respectively. All observers had healthy eyes, normal vision, and Snellen visual acuity of 1.0 or better in both eyes. In all groups, contrast sensitivity for binocular and monocular viewing peaked at a spatial frequency around 3--5 cycles/degree and showed the typical attenuation at low and high spatial frequencies. The binocular contrast sensitivity was higher than the monocular. There was no significant difference between young and middle-aged subjects with regard to contrast sensitivity. Subjects aged 60 years or more showed significantly lower contrast sensitivity than younger subjects for most spatial frequencies above 4 cycles/degree. We may thus conclude that both the binocular and monocular contrast sensitivity seemed independent of age within the range of 6 to 40 years. For higher ages studied (above 60 years), there was a loss of sensitivity in the middle and high frequency regions.

Adolescent

Binocular contrast summation and inhibition in amblyopia. The influence of the interocular difference on binocular contrast sensitivity.

The monocular contrast sensitivity loss in amblyopia is well documented. We investigated the influence of interocular sensitivity difference on binocular contrast sensitivity in amblyopia. Monocular and binocular contrast sensitivity functions of six amblyopes (three strabismic and three anisometropic) were measured. The monocular contrast sensitivity loss depended on the type of amblyope. Anisometropic amblyopes generally showed high frequency losses. Strabismic amblyopes showed losses at both low and high spatial frequencies. Binocular performance was assessed in terms of binocular ratios (binocular/non-amblyopic). A binocular ratio greater than 1 indicates binocular summation (binocular > monocular) while a ratio less than 1 shows binocular inhibition (binocular < monocular). In all subjects, the binocular ratio depended on the difference between the amblyopic and the non-amblyopic eye. Minimal interocular difference produced binocular summation, the magnitude of which decreased as the difference between the two eyes increased. Further increases in the monocular difference produced binocular inhibition. Anisometropic amblyopes showed a greater degree of binocular summation at low spatial frequencies compared to strabismic amblyopes. Both types of amblyopes showed binocular inhibition at high spatial frequencies. Clinical implications of binocular summation and inhibition in amblyopia are discussed.

Adolescent

Effect of visual blur on contrast sensitivity. Clinical implications.

Contrast sensitivity of normal subjects was measured under conditions of refractive blur that produced specific levels of visual acuity. Measurements were made at distance (with Vistech charts), at near (with Arden gratings), and with a pinhole to control pupil size. Under all conditions, when visual acuity was reduced by spherical lenses, there was a loss of contrast sensitivity over a broad range of spatial frequencies (i.e., not just at the higher frequencies that correlate with target letter size). By inference, it may be clinically hazardous to interpret contrast sensitivity results in patients with reduced acuity (from any cause) relative only to standard contrast sensitivity values based on subjects with normal visual acuity. If the potential effects of acuity are taken into account, contrast sensitivity testing can distinguish between deficits that are roughly equivalent to the loss of acuity and those which indicate more distinctive pathology of the media, retina, or optic nerve.

Humans

[Contrast sensitivity and diabetes].

Contrast sensitivity has been assessed in 24 diabetic patients in order to test the hypothesis that contrast sensitivity is impaired in the early stages of diabetes mellitus. All patients had 20/20 vision. Some evidence of visual dysfunction was observed in 33% of the diabetics with no retinopathy and 83% of the 6 patients with retinopathy when compared to 48 age-matched controls. Contrast sensitivity was mainly reduced in the mid-range spatial frequencies and correlated with the degree of retinopathy. The accurate assessment of visual dysfunction in diabetes is very important, as new drugs (i.e. aldose reductase inhibitors) are currently under evaluation.

Contrast Sensitivity

Contrast sensitivity after penetrating keratoplasty.

Contrast sensitivity testing in the corneal transplant patient may enhance our assessment of visual performance, which is traditionally evaluated using Snellen acuity only. To evaluate contrast sensitivity function after penetrating keratoplasty, we studied 29 patients with anatomically successful corneal grafts and a best corrected visual acuity of 20/50 or better. Graft patients were compared with an age-matched control group including persons with comparable visual acuities without ocular disease. In addition to a complete ophthalmic examination, all subjects underwent contrast sensitivity testing using a computer-generated sinusoidal grating system as well as a commercially available contrast sensitivity wall chart. Data indicate that, despite comparable Snellen visual acuity, the contrast sensitivity curves for graft patients were depressed overall compared with those of normal subjects except at the lowest spatial frequency. However, comparison of grafted eyes to contralateral eyes with corneal disease in a small subset of patients with bilateral disease shows a trend toward higher contrast sensitivity values in the eyes that had been operated on. These data suggest that despite an improvement in contrast sensitivity with penetrating keratoplasty, an eye with a corneal transplant is not entirely normal from a visual standpoint. Nonacuity parameters may be important indexes for assessing real-world visual function in the graft patient, although the clinical role of these tests is not yet completely defined.

Adult