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At least 19 recordsLinked to original sources
PubMed1979

Morphologic and functional effects of esophageal cryotherapy.

With advances in equipment design, cryotherapy has been applied increasingly in the management of various integumentary disorders. Recently, endobronchial cryotherapy has been utilized in the treatment of acquired tracheal strictures. To evaluate the effects of cryotherapy upon the esophagus, we cooled the distal esophagus of 12 cats to -70 degrees to -80 degrees C. for 2 minutes with a specially constructed cryoprobe. The animals were put to death in pairs 90 minutes, 4 days, 10 days, 14 days, 28 days, and 42 days following cryotherapy. Immediately prior to sacrifice, all animals were studied with esophageal cinefluoroscopy and esophageal manometrics. All animals tolerated this degree of cryotherapy and gained weight on an ad libitum diet. Manometric studies demonstrated diminished amplitude of peristalsis immediately following cryotherapy, but prompt return to a normal manometric pattern. There was no evidence of esophageal dysfunction on esophageal cinefluoroscopy. Morphologic examination demonstrated superficial ulceration between 4 and 10 days following cryotherapy, with subsequent healing. The esophagus in animals put to death 28 and 42 days following cryotherapy appeared histologically normal. These studies demonstrate the safety of cryotherapy to -70 to -80 degrees C. upon the esophageal wall and suggest investigation of the usefulness of this modality in the treatment of local esophageal webs and strictures.

Animals↗
PubMed1977

Comparison of cryotherapy and surgery for treatment of spontaneous mouse tumour.

Spontaneous mammary adenocarcinoma was implanted subcutaneously into the flank or leg of inbred C3H/HeJ mice. Excision or cryotherapy of flank tumours was followed by cure in 47 and 52% respectively. Amputation or cryotherapy of tumours of the hind leg resulted in a cure in 70% for each method. Rechallenge of surviving mice resulted in initial delay of growth in mice treated by cryotherapy, but final host acceptance and survival were the same for each method of treatment. The tumour was grown in tissue culture; significant antibody levels after cryotherapy could not be detected by a mixed antiglobulin technique. It is concluded that cryotherapy can destroy the tumour, but this method offers little immunologic advance for weakly antigenic tumours. Careful monitoring of temperature is essential for successful cryotherapy. In the same series of experiments barbiturate anesthesia and tumour exploration did not alter tumour growth or mortality.

Adenocarcinoma↗
PubMed1979

Cryotherapy of Pseudomonas keratitis and scleritis.

Three cases of perforated Pseudomonas corneal ulcers with scleral extension were treated with keratoplasty and cryotherapy to the remaining cornea and sclera. All three cases showed dramatic improvement. Cryotherapy of Pseudomonas keratitis in guinea pigs has been shown to be effective. Pseudomonas organisms seem to be susceptible to cryotherapy in vivo; there is no effect in vitro. Cryotherapy may prove to be a new tool in the treatment of Pseudomonas keratitis.

Adult↗
PubMed1977

Palliative cryotherapy in inoperable prostate carcinoma.

Cryotherapy was applied by us as a palliative in 91 cases of carcinoma of the prostate. 1. Disobstruction was achieved in 87% of patients. 2. Results proved stable over time. 3. Operating mortality, survival curve, number of deaths, etc. was not statistically different in patients treated with cryotherapy compared with patients undergoing other treatments. 4. Precutions are required to combat infection of cryotherapy patients in the first few weeks. We feel authorized to pursue cryotherapy in the future exploiting all its immunologic possibilities.

Aged↗
PubMed1975

Alterations of alpha2-globulin and the clinical response in patients with prostatic cancer following cryotherapy.

Evaluation of alterations in the level of alpha2-globulin in the serum of 18 patients with prostatic cancer prior to and following cryotherapy of their primary prostatic tumor and the clinical response of these patients disclosed: (1) a progressive increase in the level of alpha2-globulin and the incidence of patients with significantly elevated levels of alpha2-globulin, i.e., greater than or equal to 1.30 g/100 ml, with a progression of the stage of their malignancy; (2) a decrease in the levels of alpha2-globulin in the serum of 14 of 18 (78%) patients following cryotherapy, and (3) a favorable clinical response in 11 of 14 (79%) patients with prostatic cancer showing a decrease in alpha2-globulin following cryotherapy. While limited to the study of a relatively small patient population, the present results suggest a prognostic potential for alpha2-globulin, particularly as applied to stage identification in prostatic cancer. Pending confirmation by evaluation of a larger patient population, it may even provide objective criteria for monitoring the clinical response of an individual following cryotherapy of the prostate.

Alpha-Globulins↗
PubMed1978

Cryotherapy of herpes simplex keratitis.

Twenty-one cases of epithelial herpetic keratitis were treated with cryotherapy and 14 cases were treated with Iodoxouridine (IDU). Cryotherapy was found statistically superior to IDU. The average healing time was 2.4 days for cryotherapy and 6.2 days for IDU. The advantages of cryotherapy are emphasized.

Child↗
PubMed1976

Experimental inhibition of prostaglandin-like inflammatory response after cryotherapy.

To determine the effect of aspirin as an inhibitor of the prostaglandin-induced inflammatory reaction that follows cryotherapy, 12 rabbits were pretreated with aspirin and 12 were controls. The aspirin-pretreated animals showed less inflammatory reaction after cryotherapy and significantly less protein in the aqueous humor than did the control animals (P less than .01). We believe that the conjunctival hyperemia and chemosis, and the increase in protein concentrations in the aqueous humor that follow cryotherapy, are prostaglandin-related, because pretreatment with aspirin inhibited these phenomena.

Animals↗
PubMed1977

Cryotherapy in the treatment of ameloblastoma of the mandible: report of cases.

Two cases of ameloblastoma treated in part by cryotherapy have been presented. The first case was of particular interest because of the extensive intraoral involvement and history of recurrences. The second case evolved as an example of the rare peripheral ameloblastoma. In both cases, cryotherapy was used as an adjunctive modality to conserve mandibular bone without compromising the primary objective of adequately treating the tumor. We contend that the judicious use of cryotherapy offers the advantage of treating a broad area of bone without destruction of the basic structural matrix of this tissue.

Ameloblastoma↗
PubMed1976

[Recommendations for the use of cryotherapy in gynecology].

Bases on the experiences with the application of cryotherapy to 393 patients with 440 cryosurgical operations, special and general experiences concerning the cryotherapy in gynaecology are presented. Accordingly, the cryotherapy is suitable to increase the number of the conventional methods of medical attendance to the vulva, the vagina, and to the cervix uteri. The main possibilities of application are those to the sanitation indications of the portio, to the removal of acute condylomes, and to the pallative as well as to the curative therapy of the vulva carcinomes.

Cervix Uteri↗
PubMed1978

[New trocar housing with an interchangeable cryotherapy sound for after-treatment of bladder outlet tumors].

The cryotherapy of tumours of the urinary bladder hitherto used by means of transurethrally introduced sounds with or without optics made necessary the development of an irrigation trocar casing with exchangeable cryotherapy sound for the entire therapeutic comprehension of all parts of the wall of the urinary bladder, particularly in the region of the outlet of the urinary bladder from 7 till 17 o'clock. The optic control is performed by means of a simultaneously suprapubically introduced trocar cystoscope. Thus also extremely localised tumorous changes in the region of the outlet of the urinary bladder (dead angle) are optically established and rendered accessible to cryotherapy.

Cryosurgery↗
PubMed1976

[Microflora and its antibiotic sensitivity in chronic pharyngitis treated by cryotherapy].

Antibiotic sensitivity of the pharynx mucosa microflora in patients with chronic pharyngitis subjected to cryotherapy was studied. Examination of 36 patients showed that cryotherapy at a temperature of -1950 markedly decreased the number of the grown colonies, their qualitative characteristics being changed. In 10 days both the quantitative and the qualitative characteristics of the flora completely reduced. The cryotherapy did not change the virulence of the flora and its sensitivity to antibiotics.

Anti-Bacterial Agents↗
PubMed1977

[Microflora of the nasal cavity and its sensitivity to antibiotics in patients with chronic rhinitis treated by cryotherapy].

Cryotherapy is used in treatment of chronic rhinitis and pharyngitis. The effect of cryotherapy on the qualitative and quantitative composition of the microflora was studied. Staphylococci prevailed in the rhinitis patients, streptococci, Clebsiella and Neisseria being registered more rarely. The staphlococcal isolates were highly sensitive to monomycin, neomycin, erythromycin and levomycetin. The results of the dynamic study showed that the flora composition did not significantly change during cryotherapy and the sensitivity level of the staphylococcal isolates to the antibodies remained unchanged.

Anti-Bacterial Agents↗
PubMed1979

Cryotherapy for experimental Pseudomonas keratitis.

The effectiveness of cryotherapy alone and in combination with topical tobramycin sulfate therapy for experimental Pseudomonas keratitis was determined in guinea pigs and rabbits. Results were evaluated quantitatively by determining numbers of viable bacteria surviving in corneas. A brass probe cooled to--79 degrees C and applied directly to infected corneas for six seconds resulted in an immediate 99.9% reduction in bacteria. One freeze-thaw cycle followed by topical tobramycin therapy was significantly more effective than tobramycin therapy alone in five of six strains tested. None of the corneas treated with tobramycin alone demonstrated no growth, whereas 24 of 42 of these infected corneas showed no growth after the combination treatment. We conclude that cryotherapy alone had a rapid bactericdal effect on experimental Pseudomonas keratitis and that it significantly potentiated topical antibiotic therapy for most strains.

Animals↗
PubMed1976

Cryotherapy of basal cell carcinoma in oculoplastic surgery.

Cryotherapy was an effective modality in the treatment of basal cell carcinoma in the eyelid and periorbital area and cured 93% of the 29 lesions in 25 patients. This method was especially advantageous in patients with blood clotting disorders; those with medical contraindications to, or who refused, classical surgery; patients who had prior radiation or surgery; patients with the basal cell nevus syndrome or xeroderma pigmentosa; and in patients with medial canthal tumors. Experimental cryotherapy in the albino rabbit showed their lacrimal system is not adversely affected by freezing in the temperature range required for tumor death.

Animals↗
PubMed1976

Repair and adhesion mechanisms of the cryotherapy lesion in experimental retinal detachment.

Cryotherapy to the pigment epithelium and retina induced a proliferation and metaplasia of pigment epithelial cells, Mueller cell hypertrophy, and proliferation of astrocytes. When cryotherapy was applied to the pigment epithelium and to the retina during retinal detachment surgery, a strong adhesion developed, characterized by the occurrence of true cell junctions between pigment epithelium and retinal cells. When only the pigment epithelium was treated, the adhesion appeared weak due to the absence of microvillous interdigitations normally present between pigment epithelium and retina.

Animals↗
PubMed1977

Late complications following cryotherapy of lattice degeneration.

We observed 341 patients who had received cryotherapy for lattice degeneration in order to identify possible late complications. Sequelae such as retinal tears posterior to an operculum or flap tears within treated areas showed that treatment did not necessarily prevent subsequent vitreous traction. Moreover, the newly created flap tears may extend beyond the treated area and can cause retinal detachment. Even scleral buckling did not necesserily prevent further traction. Therefore, we concluded that when cryotherapy is used to treat lattice degeneration, an adequate margin of surrounding retina should be treated and the treatment should extend to the ora serrata.

Cryosurgery↗
PubMed1977

Endobronchial cryotherapy in the treatment of tracheal strictures.

Modern advances in ventilatory support systems have introduced a patient population requiring long term endotracheal intubation or tracheostomy. The formation of tracheal strictures in such patients remains a very significant clinical problem despite new modifications in endotracheal tube design and materials. Dissatisfied with standard modalities of treatment for these lesions, we have explored the usefulness of endobronchial cryotherapy for the treatment of such stricture. Cervical tracheal strictures were produced in 11 sheep. In six animals a prototype cryosurgical probe was passed through the bronchoscope and these lesions frozen to -80 degrees C. Respiratory epithelial regeneration was complete, but significant reduction in strictures was not noted. Utilizing the cryosurgical probe in conjunction with the endobronchial resection of tracheal strictures in three animals did, however, produce significant reduction in stricture size. Healing following cryonecrosis was associated with minimal fibrosis. Endobronchial cryotherapy is easily performed and has been well tolerated by these animals.

Animals↗