PubMed Health⌕ Search

SEARCH · PubMed Health

Results for “Curio”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

16 recordsLinked to original sources
PubMed2025

Spatial Genomic Approaches to Investigate HOX Genes in Mouse Brain Tissues.

Spatial transcriptomic tools are an upcoming and powerful way to investigate targeted gene expression patterns within tissues. These tools offer the unique advantage of visualizing and understanding gene expression while preserving tissue integrity, thereby maintaining the spatial context of genes. Curio is a robust spatial transcriptomic tool that facilitates high throughput comprehensive spatial gene expression analysis across the entir e transcriptome with high efficiency. Here, we present a bioinformatics protocol for performing whole transcriptome gene expression analysis of mouse brain tissue using Curio. Specifically, we demonstrate using computational techniques to visualize expression patterns of various HOX genes in the mouse brain.

Animals↗
PubMed1990

Annoyance and health risk caused by military low-altitude flight noise.

Effects of noise of low-flying military jet aircraft were investigated from demoscopic and epidemiological points of view. Areas with different low-altitude flight noise exposure were compared with one another as to subjective annoyance, casual blood pressure and ear symptoms. With the same energy equivalent sound pressure level (Leq), the subjective disturbance caused by military low-altitude flight noise was essentially greater than that due to ordinary flight noise (in the neighbourhood of civil airports). A comparison of several areas revealed that frequencies of ear symptoms (tinnitus lasting more than one hour and permanent hearing threshold shifts of greater than 30 dB) were higher only in areas where maximal flight noise levels considerably exceeded 115 dB (A) accompanied by rapid noise level increases. Blood pressure measurements yielded significantly higher values (group difference 9 mm Hg systolic) in girls living in these highly exposed areas. Acoustic limits are proposed with respect to public health.

Adolescent↗
PubMed1987

Peripheral origin of BAEP wave II in a case with unilateral pontine pathology: a comparison of intracranial and scalp records.

In a patient with unilateral hearing impairment due to a predominantly ipsilateral pontine pathology, BAEP peak II in a vertex to ipsilateral mastoid derivation (BAEP-II) was preserved on stimulation of the affected ear. All later activity was lost. Intracranial recording from electrodes intraoperatively placed over both cochlear nuclei on the floor of the IVth ventricle showed potentials with size and wave form comparable to the scalp records. Thus only peripheral sources, distant from the ventricular electrode, seem to contribute to scalp BAEP-II. Upon stimulation of the unaffected ear considerably larger intracranial activity was seen with peak 2-4 wave shapes obviously different from the scalp BAEP II-IV. It is concluded that intracranial electrodes sense a complex field distribution predominantly originating in structures to which they are in close electrical connection. This activity, however, need not necessarily project to the scalp.

Brain Neoplasms↗
PubMed1988

Intraparenchymatous ponto-mesencephalic field distribution of brain-stem auditory evoked potentials in man.

Brain-stem auditory evoked potentials (BAEPs) were recorded simultaneously from scalp electrodes and intraparenchymatous sites along a ponto-mesencephalic stereotactic penetration path in a patient with the unique condition of a brain-stem tumour which therapeutically necessitated radionuclide implantation but did not grossly affect scalp BAEPs. The data suggest major contributions to scalp peak III from the pons ipsilateral to the stimulated ear, to peak IV from both ipsi- and contralateral sources, and to peak V mainly from contralateral, more rostral sites. Some local activities evidently did not project to the scalp.

Adult↗
PubMed1991

Exploratory mapping of evoked neuromagnetic activity from human peripheral nerve, brachial plexus and spinal cord.

Upon conventional median nerve stimulation at the wrist early magnetic fields were recorded using a SQUID magnetometer. At the upper arm, mono- and biphasic compound nerve action fields were detected, depending on the subject's distribution of single fiber conduction velocities. At the upper thorax, brachial plexus fields reversed polarity at the level of Erb's point; their distribution was asymmetric, probably due to volume currents. At the upper lateral neck, fields from proximal plexus, spinal cord (P13m) and the primary somatosensory cortex contralateral to the sensor position were detected. The observed P13m field distribution agrees with the electrophysiological concept of a sagittal segmental dorsal horn generator.

Brachial Plexus↗
PubMedDate not supplied

Intra-ponto-mesencephalic recording of binaural interaction in human brain-stem auditory evoked potentials.

Brain-stem auditory evoked potentials (BAEPs) were recorded at intraparenchymatous sites along a ponto-mesencephalic stereotactic penetration path in a patient with the rare condition of a ponto-medullary lesion which required biopsy but did not grossly alter scalp BAEPs. Click stimuli were applied either monaurally (with contralateral masking noise against acoustic cross-talk; conditions 'R,' 'L') or binaurally (condition 'RL'). A binaural interaction trace ('BI') was derived by subtracting the sum of the monaural from the binaural responses: BI = (RL)-(R + L). Despite failure to obtain significant BI components above noise level for scalp BAEPs, at the lower pons clearly discernible, multiphasic BI activity could be recorded beginning at the peak latency of scalp wave III and extending over approximately the next 4 msec. Its amplitude rapidly fell off with distance toward more rostral, mesencephalic recording sites. In relation to this positive finding, the equivocality among some of the previous studies on the detection of BI components in human scalp BAEPs is tentatively rephrased in terms mainly of a low signal-to-noise ratio and of functional peculiarities introduced by the respective stimulation protocols.

Adult↗
PubMed1975

[Selection of strays from the group by predators during prey].

Equally sated three-spined sticklebacks (Gasterosteus aculeatus) that had a free view of stray individuals and of a swarm of Daphnia magna preferentially preyed upon the strays; the resulting risk to the strays increased with swarm density (a leads to c leads to e in Fig. 1). This applied also to situations with constant swarm numbers but varied density (a leads to b, d leads to e). The results from two experiments with equal swarm density (b/e, c/d) suggest selection to be affected also by swarm number and/or volume.

Animals↗
PubMed1991

[Evaluating the validity of short witness reports using behavioral and psychophysiologic parameters].

Within the context of credibility assessment, the impact of behavioral and physiological adaptation and response patterns of truly and falsely testifying eyewitnesses was examined in a laboratory study. It was further examined statements concerning characteristics of the delict and the experimental situation itself. 20 subjects were instructed to truly or falsely testify after having witnessed a willful destruction. Eye movements, respiration, heart rate and skin conductance were recorded and analyzed by computer. Witnesses instructed to falsely testify showed elevated skin conductance responses and an increased variability of horizontal eye movements at the beginning of the session. Additionally, they also showed stronger responses in eye-blink rate, respiration rate and variability of skin conductance and heart rate to questions related to the behavior in the experimental situation. Reactivity to questions concerning the culprit was less pronounced. Results are discussed in terms of their application within the German law system.

Adult↗
PubMed1990

Integrin (alpha 6/beta 4) expression in human lung cancer as monitored by specific monoclonal antibodies.

In this study, the expression of the alpha 6/beta 4 integrin complex was analyzed in human lung carcinomas both in vitro and in vivo, using two monoclonal antibodies which recognize the integrin subunits alpha 6 (Mab 135-13C) and beta 4 (Mab 439-9B). Immunoprecipitation patterns obtained from established human lung carcinoma cell lines demonstrated that the alpha 6 and the beta 4 subunits were differentially expressed in carcinomas of different types. The alpha 6 subunit was expressed in all the cell lines tested (squamous cell carcinoma A431, adenocarcinoma A549, large cell carcinoma DG3, and small cell carcinoma AE2). The beta 4 subunit was expressed in non-small cell cancer lines but was not detectable in the small cell cancer line tested. Using a quantitative two-site assay, we measured the concentration of the alpha 6/beta 4 integrin in matched biopsies from primary lung tumors and from normal lung. These studies confirmed that the complex was differentially expressed in non-small versus small cell lung cancers and that it was also detectable in lysates from normal lung at low levels. The highest levels of alpha 6/beta 4 were found in moderately differentiated squamous cell carcinomas. By immunohistochemistry, the beta 4 subunit was detectable in all the squamous cell carcinoma and adenocarcinomas tested (a total of 59), but not in 10 small cell cancers. The patterns of immunoreactivity were consistent with the expected distribution of membrane glycoproteins and, in some squamous cell carcinomas, were suggestive of the localization displayed by molecules involved in carcinoma-stroma interaction. Immunohistochemical staining indicated that beta 4 was also expressed in specific types of nonrespiratory pulmonary epithelial cells.

Adenocarcinoma↗