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At least 19 recordsLinked to original sources
PubMed2004

[Quality of life and occupational dermatoses--development and evaluation of a questionnaire assessing quality of life with in patients with occupational dermatoses (LIOD--Life Quality Index Occupational Dermatoses)].

BACKGROUND: Quality of life (QOL) is an established parameter in dermatology; it is known that skin diseases can affect QOL adversely. There are no specific questionnaires that consider the consider the effect of occupational factors as triggers for work-related diseases, even though such a questionnaire could link QOL specifically with the work situation. PATIENTS AND METHODS: Based on a literature search and the analysis of existing study instruments, a questionnaire reflecting "Life Quality Index Occupational Dermatoses (LIOD)" was developed and studied in four different groups of persons (N = 228) with and without dermatological diseases. RESULTS: Using the "Guidelines for QOL-assessment in dermatological studies", a test comparing LIOD to established instruments showed a reliability quotient of 0.804. Cronsbach's alpha was 0.898. The logical and discriminate validity were tested and found to be significant. Hypotheses that had been devised while developing the test were confirmed. CONCLUSIONS: The validated LIOD questionnaire is a valuable addition to existing instruments in dermatology. LIOD may be used to gain data reflecting the efficacy of therapeutic strategies comparable to medical data.

Data Collection↗
PubMed1997

Penicillamine-induced degenerative dermatoses: report of a case and brief review of such dermatoses.

We describe a case of elastosis perforans serpiginosa with additional findings of degenerative skin changes. A 20-year-old man with hepatolenticular degeneration, under prolonged treatment with D-penicillamine, presented with a circular or serpiginous arrangement of nuchal papules. Histopathologically, transepidermal channels were accompanied by granulomatous reactions, with several giant cells engulfing elastic fibers. In addition to these findings of a typical elastosis perforans serpiginosa, we observed scar-like skin changes inside the circular arrangement of the papules. At the scar-like tissue, we found electron-microscopical evidence of randomly aggregated thin collagen fibers with no tendency toward systemic combined bundle formation, which is a characteristic feature of normal collagen fiber formation. Pseudoxanthoma-elasticum-like changes were observed on his neck. On his axillae and groin, slight skin thickening and wrinkling were detected. The diagnosis of elastosis perforans serpiginosa does not represent all of the manifestations or the pathological background described above. The skin manifestations described here represent not only an elastosis but also a total degenerative dermatosis with overhealed collagenosis. Thus, those dermatoses should be summarized as one entity, penicillamine-induced degenerative dermatosis. After considering the pathogenic background and clinical similarities, we further propose to simplify the penicillamine-induced skin manifestations to three categories: acute sensitivity reactions, bullous dermatoses, and degenerative dermatoses.

Adult↗