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At least 19 recordsLinked to original sources
PubMed1983

Dermographia caused by IgE mediated penicillin allergy.

A patient developed symptomatic dermographia while taking penicillin. The dermographia disappeared when the penicillin was stopped. The patient usually was negative for dermographia testing up to 400 g pressure. While taking penicillin a dermographic response occurred at 50 g pressure. Passive transfer skin testing established that the reaction was mediated by an IgE antibody to penicillin breakdown products. Interestingly, in both the subject and the passive transfer recipient skin testing to Pen G, M.D.M. and B.P.L. was negative. We concluded that the dermographia in our patient resulted from specific IgE penicillin interactions not recognized by the usual testing reagents.

Adolescent↗
PubMed1989

Inhibition of dermographia, histamine, and dextromethorphan skin tests by ketotifen. A possible effect on cutaneous vascular response to mediators.

Forty-one subjects with dermographia were studied for a 4-week period. Twenty subjects received ketotifen therapy, the other 21 received chlorpheniramine (H1) for 2 weeks, and then chlorpheniramine plus cimetidine (H1 + H2). Both groups had significant suppression of dermographia and skin wheals caused by dextromethorphan and histamine after 2 weeks. The inhibition by ketotifen of dermographia, histamine wheal, and the dextromethorphan wheal increased from week 2 to week 4. During the first 2 weeks, ketotifen's activity was comparable to chlorpheniramine. Ketotifen's activity increased during the second 2 study weeks to match the additional chlorpheniramine. These results suggest that ketotifen may have additional pharmacologic activities besides H1 antagonism, including possible inhibition of mast cell mediator release. As a consequence, cutaneous vascular hyperresponsiveness may decrease. Ketotifen appears promising as treatment for allergic skin disorders.

Adult↗
PubMed1983

Greater inhibition of dermographia with a combination of H1 and H2 antagonists.

The dermographic response was measured in eleven subjects with dermographia and chronic urticaria at baseline and after treatment with an H1 antihistamine, an H2 antihistamine and the combination. Greatest inhibition of the dermographic response occurred with a combination of the H1 and H2 blockers (P less than .01). These results support the rationale of using the combination of H1 and H2 antagonists in urticarial disease not responding to H1 blockers alone.

Chlorpheniramine↗
PubMed1952

[Dermographia].

Explore the source record for details and available documents.

Humans↗
PubMed1981

Dermo-distortive urticaria: an autosomal dominant dermatologic disorder.

A new hereditary physical urticaria, dermo-distortive urticaria (DDU), is described in a Christian Lebanese family. DDU is characterized by the appearance of pruritic, erythematosus, edematous, cutaneous swelling confined to the stimulated area in response to stimuli that vibrate or stretch the skin in a repetitive manner. The lesions appear within several minutes after stimulation and disappear within an hour. Extensive stimulation causes not only local urticaria but also a systemic response of faintness, headache, and facial erythema. Other than these annoying reactions, no other morbidity is associated with this disorder. While this disorder is certainly uncommon and its manifestations are more annoying than life threatening, it may be an important example of a heritable defect of inflammation control mechanisms. Although the mediator for the urticaria and systemic response was not isolated, a likely candidate is histamine. Computer analysis of the phenotype of 219 relatives in 6 generations shows that DDU is transmitted as an autosomal dominant trait with high penetrance. DDU is clinically distinct from hereditary angioneurotic edema, pressure urticaria, and dermographia. It is similar to vibratory angioedema (VA), but sufficient evidence to prove that DDU and VA are identical is not available.

Chromosome Aberrations↗
PubMed1974

Idoxuridine in herpes zoster: further evaluation of intermittent topical therapy.

In a randomized double-blind controlled trial of the value of intermittent topical idoxuridine in treating herpes zoster in 118 patients idoxuridine 5% in 100% dimethyl sulphoxide (DMSO), applied four-hourly for four days, significantly shortened the vesicular phase, healing time, and duration of pain; idoxuridine 25% applied two-hourly produced no greater benefit. The only side effects were transient tender erythema in three patients and "urticarial" oedema in two patients with dermographia.

Administration, Topical↗