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Chronic toxicity of dextran sulphate in rabbits.
The chronic toxicities of two samples of low molecular dextran sulphate from different sources were studied in rabbits. Both samples caused retardation in weight gain, cachexia and general osteoporosis with spontaneous fractures and epiphyseolyses. Heparin-treated controls were used to exclude the possibility that the toxic effects could be connected with prolonged anticoagulant treatment. It is concluded that prolonged administration of dextran sulphate causes systemic toxic effects which are not related to its anticoagulant activity.
On fluid and electrolytic balance in toxaemia of late pregnancy, in dehydration caused by 10 per cent salt-free macrodex.
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[Effects of isonicotinic acid hydrazide on the formalin inflammation and the dextran edema].
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Allergic reaction to dextran; case history report.
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[Dextran and anaphylatoxin].
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[The toxicity of dextran sulfate, a synthetic anticoagulant of the heparin type].
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The effects of antihistaminic agents on the reaction of the rat to dextran.
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[Symptomatology and pathogenesis of the edematous syndrome produced by dextran in the rat].
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[The inhibitory action of promethazine and adrenalin on dextran edema in the rat].
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[Experimental ascites produced by osmotic effect of highly concentrated solutions of dextrose, polyvinylpyrroldon and dextran. Animal experiments on Buerger's osmotherapy].
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