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Results for “Dermatologic Agents”

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At least 19 recordsLinked to original sources
PubMed1979

[Radiation lesions of the skin and mucous membrane and their treatment (author's transl)].

The therapy of mucocutaneous lesions in the course of radiation therapy of malignant tumors is most important for lasting recovery in a successful combat against the primary tumor. The application of the different dermatological agents and of adjuvant therapy has to conform to the principles of dermatotherapy because of the necessary adaptation to the pathophysiology of the injured organ. Underlying principles and the requisite instructions for the combination of preparations are specified.

Animals↗
PubMed1979

Updated in vivo methods for evaluating topical antimicrobial agents on human skin.

Updated and expanded in vivo quantitative testing procedures to determine the efficacy of topical antimicrobial agents are presented. The occlusion test measures the ability of an agent to prevent the expansion of the resident microflora which occurs when an impermeable dressing is applied to the forearm. Measurements are made at 24 and 48 hr. The expanded flora test measures the ability of an agent to suppress a dense population of micro-organisms produced by expansion of the resident flora of the forearm by prior application of an impermeable occlusive dressing. Measurements are made at 6, 24 and 48 hr or after 10 min in the case for agents designed for immediate degerming. The persistence test measures the ability of an agent to establish a reservoir in skin and exert an antimicrobial effect up to 3 days after the last application of the test material. The ecological shift test determines any major alteration in cutaneous microbial ecology following several applications of the material under occlusive dressings. The serum inactivation test determines whether the presence of serum proteins interferes with antimicrobial activity.

Adult↗
PubMed1977

[Skin reactions to topical agents].

The author desires to attract attention to the disadvantages of drugs for external use which are more and more widely used. The two main reactions observed are contact dermatitis and photosensitisation, but practically all skin lesions may be produced. She then rapidly recapitulates the various responsible agents insisting on dermo-corticoids and the precautions which should be taken in their use.

Administration, Topical↗