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At least 19 recordsLinked to original sources
PubMed1976

Microbial formation and degradation of dimethylamine.

Dimethylamine was formed from trimethylamine in soils of different pH values. The rate of disappearance of the secondary amine from soil was affected by pH and was markedly reduced under anaerobiosis. The accumulation of dimethylamine in cultures of Micrococcus sp. provided with trimethylamine depended on the nitrogen sources available to the bacterium but was not greatly influenced by the C-N ratio of the medium. Dimethylamine and nitrite accumulated in large amounts at pH 6.0 to 8.0 in cultures containing the tertiary amine and nitrate, but dimethylnitrosamine was apparently not produced.

Anaerobiosis↗
PubMed1976

Relevance of dimethylamine to mechanism studies of DIC (DTIC, NSC 45388).

Monolayer cultures of Chinese hamster ovary (CHO) cells take up the photo-decomposition products of DIC more readily than DIC itself. Dimethylamine, an immediate product of this degradative pathway, can ultimately become associated with the DNA, RNA, and protein of the cells as demonstrated by selective enzymatic degradation of macromolecules and isopycnic centrifugation. The relevance of these observations to mechanism studies of DIC is discussed.

Animals↗
PubMed1979

Mutagenicity detection of in vivo nitrosation of dimethylamine by nitrite.

In vivo nitrosation of dimethylamine by nitrite was measured with an intrahepatic host-mediated mutagenicity assay using Salmonella typhimurium as the detecting organism. It was possible to detect the product, N-nitrosodimethylamine, at much lower doses with this system than with previously reported in vivo systems. This and other improvements made it possible to detect the formation of nitrosodimethylamine from relatively low levels of gavaged precursors.

Animals↗
PubMed1976

Experiments on the detection of the carcinogenic N-nitroso-dimethylamine in the urine of rats after oral administration of the analgesic amidopyrine and nitrite.

N-Nitroso-dimethylamine (NDMA) was excreted unchanged in the urine of rats after oral administration of the compound in amounts ranging from 0.003% at a dose of 2 mg/kg to 0.08% at a dose of 15 mg/kg. By measurement of the NDMA excreted after oral administration of amidopyrine and nitrite, the extent of nitrosation in vivo was estimated to be about 30%. For clinical investigation of NDMA formation in patients treated with amidopyrine, however, we consider this method to be too insensitive.

Aminopyrine↗
PubMed1975

Carcinogenic N-nitro-dimethylamine from the reaction of the analgesic amidopyrine and nitrite extracted from foodstuffs.

The reaction of the analgesic amidopyrine (100 mg) with nitrite extracted from cured meats and from spinach in varying degrees of spoilage was studied. Unde physiological conditions the carcinogenic dimethylnitrosamine was formed at milligram levels at nitrite concentrations as low as 4 mg (in 175 ml extracted from 100 g boiled ham). The rate of decrease in concentration in the human stomach after ingestion of amidopyrine and of nitrite contained in boiled ham or in a broth from boiled ham was also measured.

Aminopyrine↗
PubMed1977

Biochemical profile of uremic breath.

We attempted to define the substances that contribute to the characteristic "uremic breath" of patients with end-stage renal disease. Breath samples from nine patients underwent direct analysis before and after hemodialysis with use of gas chromatography and confirmation by mass spectrometry, and indirectly assessment by an organoleptic panel. Concentrations of secondary and tertiary amines, dimethylamine and trimethylamine were increased, with subsequent reduction after hemodialysis (dimethylamine from 2.00 +/- 0.19 [S.E.M.] to 0.88 +/- 0.12 microng per 30 minutes, P less than 0.001, and trimethylamine from 0.79 +/- 0.22 to 0.44 +/- 0.15 microng per 30 minutes, P less than 0.003). Treatment with nonabsorbable antibiotics in two patients reduced both serum and breath amine levels without dialysis. Loss of nitrogen via the breath was not quantitatively important. We conclude that uremic breath reflects the systemic accumulation of potentially toxic volatile metabolites, among which dimethylamine and trimethylamine have been positively identified and correlated with the classic fishy odor.

Adult↗