PubMed Health⌕ Search

SEARCH · PubMed Health

Results for “Double Bind Interaction”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 19 recordsLinked to original sources
PubMed1995

A case of family dysfunction and teenage suicide attempt: applicability of a family systems paradigm.

A large body of research indicates that suicidal behavior in adolescence is related to dysfunctional family processes. The purpose of this paper was to investigate this relationship focusing on the concepts of boundary transgression, double bind interactions, and the demarcation of kinship roles in the family. The possibility is explored that suicidal behavior is a double bind response to contradictions in the way roles and responsibilities are distributed in the family, and that as a response, suicide attempts may contain a simultaneous appeal for help and an assertion of independence from the family. A case vignette is presented to illustrate these processes.

Adolescent↗
PubMedDate not supplied

A survey of attitudes of burn unit nurses.

The staff of a burn unit was surveyed concerning attitudes about their patients and the treatment procedure. Previous research indicates that in such medical settings paradoxical interactions (double binds) may occur among staff, patient, and family. We hypothesized that the paradoxical environment of burn care units facilitates individuals who can change their perspective (or reframe these situations) and that this ability is related to attitudes and feelings about burn patients and their treatment. Contrary to expectation, however, reframing ability and attitudes about burn care were not related. Staff members are quite positive about burn treatment and agree that the staff instills hope. The staff's endorsement of providing accurate information, while behaving optimistically even if pessimistic about the patient's condition, does represent possible double-binding communication patterns. Nursing managers with high reframing ability may facilitate staff coping with these issues.

Attitude of Health Personnel↗
PubMed2000

A new double-stranded RNA-binding protein that interacts with PKR.

We have identified a 74 kDa double-stranded (ds)RNA-binding protein that shares extensive homology with the mouse spermatid perinuclear RNA-binding (Spnr) protein. p74 contains two dsRNA-binding motifs (dsRBMs) that are essential for preferential binding to dsRNA. Previously, dsRNA-binding proteins were shown to undergo homo- and heterodimerization, raising the possibility that regulation of activity could be controlled by interactions between different family members. Homodimerization is required to activate the dsRNA-dependent protein kinase PKR, whereas hetero-dimerization between PKR and other dsRNA-binding proteins can inhibit kinase activity. We have found that p74 also interacts with PKR, both the wild-type enzyme and a catalytically defective mutant (K296R). While co-expression of p74 and wild-type PKR in the yeast Saccharomyces cerevisiae did not alter PKR activity, co-expression of p74 and the catalytically defective K296R mutant surprisingly resulted in abnormal morphology and cell death in transformants that maintained a high level of p74 expression. These transformants could be rescued by overexpression of the alpha-subunit of wild-type eukaryotic translation initiation factor 2 (eIF2alpha), one of the known substrates for PKR. We hypothesize that competing heterodimers between p74-K296R PKR and eIF2alpha-K296R PKR may control cell growth such that stabilization of the p74-K296R PKR heterodimer induces abnormal morphology and cell death.

Amino Acid Motifs↗
PubMed1989

Interactions of the dimethyldiazaperopyrenium dication with nucleic acids. 2. Binding to double-stranded polynucleotides.

The interactions of dimethyldiazaperopyrenium dication (1) with DNA have been studied by spectroscopic methods: absorption, static and dynamic fluorescence, and linear dichroism. 1 binds strongly to DNA at 250 mM NaCl, with a higher affinity for G-C pairs as compared to A-T pairs. The dye fluorescence is enhanced when it is bound to A-T pairs, whereas the emission is quenched in the vicinity of G-C pairs. Evidence for intercalation has been obtained via energy transfer and linear dichroism measurements.

Base Composition↗
PubMed1980

Ethical problems in feeding patients with advanced dementia.

Aged patients with dementia if not stricken by an acute disease sooner or later approach a terminal phase that is distinguished by a failure of spoon feeding. This condition induces great anxiety in the workers who care for these patients. The interaction between patient and care-worker during spoon-feeding failure is described by the psychological model of double-binding. Two serious consequences of double-binding are the distancing of the care-workers from the patient and scapegoating among the care-workers. It is essential that the pressure of double-bindings in the wards should be reduced.

Aged↗
PubMed1998

TRIP: a novel double stranded RNA binding protein which interacts with the leucine rich repeat of flightless I.

A northwestern screen of a CHO-K1 cell line cDNA library with radiolabelled HIV-1 TAR RNA identified a novel TAR RNA interacting protein, TRIP. The human trip cDNA was also cloned and its expression is induced by phorbol esters. The N-terminus of TRIP shows high homology to the coiled coil domain of FLAP, a protein which binds the leucine-rich repeat (LRR) of Flightless I (FLI) and the interaction of TRIP with the FLI LRR has been confirmed in vitro . TRIP does not bind single stranded DNA or RNA significantly and binds double stranded DNA weakly. In contrast, TRIP binds double stranded RNA with high affinity and two molecules of TRIP bind the TAR stem. The RNA binding domain has been identified and encompasses a lysine-rich motif. A TRIP-GFP fusion is localised in the cytoplasm and excluded from the nucleus. FLI has a C-terminal gelsolin-like domain which binds actin and therefore the association of TRIP with the FLI LRR may provide a link between the actin cytoskeleton and RNA in mammalian cells.

Amino Acid Sequence↗
PubMed1980

Notes on the genesis of pathological splitting.

In this preliminary paper, we have concentrated on the reverberating system that may develop as parents respond to the rapprochement toddler's ambitendent communications of split objects and to some of the ways in which these interactions may become reactivated later in borderline transference phenomena. We have hypothesized that such splits in mental content underlie communication of a fixed, binary and dualistic nature, such as communication that characterizes the so-called double bind. We have further suggested that the double bind, when understood in the context of object relations, usefully highlights the process whereby parent and then therapist become unwitting participants in the toddler's or borderline's world of split-off part objects. Finally, we have touched on certain therapeutic implications, emphasizing the developmental impact of interpreting borderline transference phenomena.

Borderline Personality Disorder↗
PubMed2004

Hox transcription factor ultrabithorax Ib physically and genetically interacts with disconnected interacting protein 1, a double-stranded RNA-binding protein.

The Hox protein family consists of homeodomain-containing transcription factors that are primary determinants of cell fate during animal development. Specific Hox function appears to rely on protein-protein interactions; however, the partners involved in these interactions and their function are largely unknown. Disconnected Interacting Protein 1 (DIP1) was isolated in a yeast two-hybrid screen of a 0-12-h Drosophila embryo library designed to identify proteins that interact with Ultrabithorax (Ubx), a Drosophila Hox protein. The Ubx.DIP1 physical interaction was confirmed using phage display, immunoprecipitation, pull-down assays, and gel retardation analysis. Ectopic expression of DIP1 in wing and haltere imaginal discs malforms the adult structures and enhances a decreased Ubx expression phenotype, establishing a genetic interaction. Ubx can generate a ternary complex by simultaneously binding its target DNA and DIP1. A large region of Ubx, including the repression domain, is required for interaction with DIP1. These more variable sequences may be key to the differential Hox function observed in vivo. The Ubx.DIP1 interaction prevents transcriptional activation by Ubx in a modified yeast one-hybrid assay, suggesting that DIP1 may modulate transcriptional regulation by Ubx. The DIP1 sequence contains two dsRNA-binding domains, and DIP1 binds double-stranded RNA with a 1000-fold higher affinity than either single-stranded RNA or double-stranded DNA. The strong interaction of Ubx with an RNA-binding protein suggests a wider range of proteins may influence Ubx function than previously appreciated.

Animals↗
PubMed2000

New insight on beta-lactoglobulin binding sites by 1-anilinonaphthalene-8-sulfonate fluorescence decay.

The fluorescence time decay parameters of the beta-lactoglobulin-1-anilinonaphthalene-8-sulfonate complex have been investigated under physical and chemical perturbations (2 < pH < 8 and added electrolyte 0 < NaCl < 0.5 M) to obtain new insight on the nature of the protein binding interactions. A double exponential decay of the bound probe lifetime has been confirmed by the presence of a longer component, 11 to 14.5 ns, and a shorter component, 2.5 to 3.5 ns. The two lifetimes are ascribed to different binding modes associated also with different exposure to the solvent; in particular, the longer component is attributed to binding inside the hydrophobic beta barrel, while a "surface" site is suggested for the shorter component. A detailed analysis of the lifetime fractional intensities correlates the binding constants with ionic strength and supports the presence of electrostatic effects at both sites. A Debye-Hückel approach, applied to extrapolate the electrostatic free energy contribution vs. pH at vanishing ionic strength, gives interesting clues on the effective charge felt by the ANS ligands in the proximity of each site. In particular, binding is found to parallel the aspartate and glutamate titrations between pH 3 and pH 4.5; the "surface" site mainly responds to the presence of these local titrating charges while the "internal" site more closely follows the overall protein net charge.

Anilino Naphthalenesulfonates↗
PubMed2000

The key event in force-induced unfolding of Titin's immunoglobulin domains.

Steered molecular dynamics simulation of force-induced titin immunoglobulin domain I27 unfolding led to the discovery of a significant potential energy barrier at an extension of approximately 14 A on the unfolding pathway that protects the domain against stretching. Previous simulations showed that this barrier is due to the concurrent breaking of six interstrand hydrogen bonds (H-bonds) between beta-strands A' and G that is preceded by the breaking of two to three hydrogen bonds between strands A and B, the latter leading to an unfolding intermediate. The simulation results are supported by Angstrom-resolution atomic force microscopy data. Here we perform a structural and energetic analysis of the H-bonds breaking. It is confirmed that H-bonds between strands A and B break rapidly. However, the breaking of the H-bond between strands A' and G needs to be assisted by fluctuations of water molecules. In nanosecond simulations, water molecules are found to repeatedly interact with the protein backbone atoms, weakening individual interstrand H-bonds until all six A'-G H-bonds break simultaneously under the influence of external stretching forces. Only when those bonds are broken can the generic unfolding take place, which involves hydrophobic interactions of the protein core and exerts weaker resistance against stretching than the key event.

Amino Acid Sequence↗
PubMed1985

[Psychoanalytic approach to family therapy].

Looking at the psychoanalysis and systemic point of view like different and opposed theories seems to be erroneous. On the basis of a clinical example, the author shows that those are the two sides of the same reality: psychic reality. A so-called "metapsychoanalitic approach" leads to discuss the points of dynamic links between interactions, unconscious desires and ideas, influence of playing on secondary fantasies moulding. An hypothesis is raised about the possible reformulation of Freud's psychic trauma theory in terms of family homeostasis. Dynamic links between transfer and interpretation are outlined.

Adult↗
PubMed1977

Gregory Bateson and the mathematicians: from interdisciplinary interaction to societal functions.

An instance of fruitful cross-disciplinary contacts is examined in detail. The ideas involved include (1) the double-blind hypothesis for schizophrenia, (2) the critique of game theory from the viewpoint of anthropology and psychiatry, and (3) the application of concepts of communication theory and theory of logical types to an interpretation of psychoanalytic practice. The protagonists of the interchange are Gregory Bateson and the two mathematicians Norbert Wiener and John von Neumann; the date, March 1946. This interchange and its sequels are described. While the interchanges between Bateson and Wiener were fruitful, those between Bateson and von Neumann were much less so. The latter two held conflicting premises concerning what is significant in science; Bateson's and Wiener's were compatible. In 1946, Wiener suggested that information and communication might be appropriate central concepts for psychoanalytic theory--a vague general idea which Bateson (with Ruesch) related to contemporary clinical practice. For Bateson, Wiener, and von Neumann, the cross-disciplinary interactions foreshadowed a shift in activities and new roles in society, to which the post World War II period was conducive. Von Neumann became a high-level government advisor; Wiener, an interpreter of science and technology for the general public; and Bateson a counter-culture figure.

Anthropology↗
PubMed1988

Cytochemical detection of receptors specific for N-linked oligosaccharides of glycoproteins in the membrane of the human spermatozoon and their distribution in the different zones of that membrane.

The horseradish peroxidase (HRP), a glycoprotein rich in mannose and N-acetylglucosamine residues has been used as a ligand to detect receptors for N-glycosidic linked oligosaccharides of glycoproteins in the human spermatozoon. Specific binding of HRP occurred to the membrane and the binding sites were visualized with 3,3'-diaminobenzidine-H2O2 (DAB-H2O2) reagent, and by fluorescence when the FITC-peroxidase was used. This specific binding was suppressed by alpha-D-methyl-mannoside and human chorionic gonadotropin, decreased by follicle stimulating and luteinizing hormones and slightly diminished by N-acetylglucosamine. The distribution of the N-linked oligosaccharide specific receptors for glycoproteins in the different zones of the membrane of the spermatozoon was determined by counting the spermatozoa labeled in those zones. The pattern of the distribution is similar to that found for N-linked oligosaccharides containing glycoproteins of the same membrane. The similarity of these distributions together with the general model for cell-to-cell recognition suggest that the sperm-egg interaction mechanism could consist of dual interactions by double binding receptors.

Cell Membrane↗
PubMed1982

The double-blind situation in families of disturbed children.

The interpersonal conditions of the double-blind situation were examined in the interaction of 15 families containing a symptom-bearing child. It was found that the greatest prevalence of conflicting communication occurred between the symptomatic children and their mothers, that the symptomatic children responded to incongruous communication with more avoidance behavior than their siblings, and that extreme interpersonal closeness or distance between mother and symptomatic child was associated with greater occurrence of conflicting communication.

Adolescent↗
PubMed1976

The double-bind theory and hemodialysis.

A review of the literature on the psychosocial problems attending hemodialysis provides no coherent theory or approach to explain the high incidence of psychiatric morbidity in this medical population. The literature is characterized in the main by the assumption that the problems lie either in the patients or in the stresses consequent to the treatment. Little recognition is given the fact that hemodialysis patients, unlike patients in other medical categories, are involved in intense, ongoing, and in many cases permanent, interpersonal relationships with medical professionals. Instead of looking at the personalities, predispositions, or capacities of patients, or how these responded to handicap and stress, the focus here is on the structure or pattern of the staff-patient relationships in this context.

Adult↗
PubMed1977

The attitudes of psychiatrists toward etiological theories of schizophrenia.

This study is an analysis of psychiatrists' opinions on the etiology of schizophrenia. A random sample of members of the American Psychiatric Association uncovers a general hesitation on their part to subscribe to any particular etiological theory. Only four theories are viewed as causally related to schizophrenia: social isolation, cognitive breakdown, biochemical imbalance, and maternal deprivation. Attitudes toward etiological theories are significantly different among psychoanalysts, behaviorists, and eclectics. Attitudes also are related to the setting in which the psychiatrist practices.

Attitude of Health Personnel↗
PubMed1980

Dying or living?: The double bind.

Describing the behaviors of terminally ill patients, their families and those charged with their care has received considerable attention during the past decade. This study of comprehensive cancer treatment and research facility indicates that the prevailing theory is limited to explanation at the intra-psychic level. In her work with hundreds of terminal cases, Dr. Elizabeth Kubler-Ross found that patients typically progress through five stages: 1) denial, 2) anger, 3) bargaining, 4) depression, and 5) acceptance. She concludes that the majority of her patients die in a stage of acceptance--a state of equanimity. Recently, scholars have claimed that this five stage scheme has limited applicability and may in fact contribute to the formalization of a dying person's behavior. This preliminary report proposes that the stage theory, if it has any descriptive validity, becomes meaningful only when used to describe behaviors occurring among patients, families, and medical practitioners. A plausible explanation of these behaviors is accomplished by examination of communication patterns containing the structure of paradox or double bind. Patients are forced to perceive realities about their physical conditions not as they appear to them, but as they are defined by those in their environment. This paper explores these communication patterns in relation to the structure of social relationships and the specific contents of messages being transmitted and received.

Acute Disease↗