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At least 19 recordsLinked to original sources
PubMed1975

Dreams and dementia: a laboratory exploration of dream recall and dream content in chronic brain syndrome patients.

Seventeen (seven mild and ten severe) chronic brain syndrome patients were testes in the sleep laboratory for dream recall and content. The mildly organic patients had 57 per cent recall while the severely organic patients had 35 per cent recall. We also studied four aged severely organic patients. These patients showed a recall rate of 8 per cent. The difference between the recall rates in mildly and severely organic middle-aged patients was not statistically significant. The difference between the recall rates of the aged severely organic patients and either or both of the middle-aged groups was statistically significant (p smaller than .001). In addition, we found dream content differences between the mildly and severely organic middle-aged groups and between the combined group and normal young men.

Age Factors↗
PubMed1977

The brain as a dream state generator: an activation-synthesis hypothesis of the dream process.

Recent research in the neurobiology of dreaming sleep provides new evidence for possible structural and functional substrates of formal aspects of the dream process. The data suggest that dreaming sleep is physiologically determined and shaped by a brain stem neuronal mechanism that can be modeled physiologically and mathematically. Formal features of the generator processes with strong implications for dream theory include periodicity and automaticity of forebrain activation, suggesting a preprogrammed neural basis for dream mentation in sleep; intense and sporadic activation of brain stem sensorimotor circuits including reticular, oculomotor, and vestibular neurons, possibly determining spatiotemporal aspects of dream imagery; and shifts in transmitter ratios, possibly accounting for dream amnesia. The authors suggest that the automatically activated forebrain synthesizes the dream by comparing information generated in specific brain stem circuits with information stored in memory.

Animals↗
PubMed1978

The single-mindedness and isolation of dreams.

Dreams are descirbed as "single-minded," meaning that they tend to be unaccompanied by other, simultaneous streams of thought and imagery. Four manifestations of single-mindedness are discussed: (1) the absence of a reflective awareness that one is dreaming while the dream is in progress; (2) the absence of alternative images and thoughts while attending to the primary dream content; (3) the tendency for dream content to stay on a single thematic track; (4) the absence of a set to remember the dream while it is in progress. This isolation of dream content, from other thought systems is then considered as but one manifestation of a more generalized relative isolation of dream content, which includes isolation from presleep stimuli, contemporaneous stimuli, organismic state, and autonomic and motor activity. Some of the implications of dream isolation for dream psychophysiology and theories of dreaming are outlined.

Arousal↗
PubMed1978

Frightening dreams and dosage schedule of tricyclic and neuroleptic drugs.

One previous study reported that psychiatric inpatients on bedtime-only doses of tricyclic or neuroleptic drugs reported more frequent frightening dreams than did those on divided daily doses. As a further test of this hypothesis, and in order to see whether differences in frequency of frightening dreams were a function of differences in total dream recall, we administered a questionnaire to outpatients in a Veterans Administration Hospital Mental Hygiene Clinic, asking about frequency of dream recall, frequency of frightening dream recall, and doses and times of any medications taken. Questionnaire reports of medications were checked with the medical record of the patient; for 48 patients on tricyclic or neuroleptic drugs the reports agreed, and the data of these patients were analyzed. Our findings corroborated the previous report of more frequent frightening dreams in patients on bedtime-only dosage schedules (p less than .01). In addition, we found no significant difference between the two groups with respect to frequency of dream recall; thus a difference in the affect of dreams, rather than a difference in quantity of dream recall, constituted the difference between the two groups. When a patient on bedtime doses of tricyclic or neuroleptic drugs has undesirable frightening dreams, the clinician should consider a change to divided daily doses.

Adult↗
PubMed1979

Home and laboratory dreams: four empirical studies and a conceptual reevaluation.

Four empirical studies were presented on how the setting in which dreams are collected may influence the reporting and content of dreams of children on REM awakenings. In these studies it was shown that (1) with constant dream-sampling procedures, home and laboratory did not differ in the degree to which dream reports could be elicited from 4/5 year old children; (2) the rate of truly spontaneous reporting of dreams at home by 6/7 year olds is so minimal as to render these dreams an unfit base for generalization to typical dream life at these ages; (3) with constant dream sampling procedures, home and laboratory reports were not significantly different in content for 10/11 year olds; (4) results typically observed in uncontrolled home versus laboratory studies are replicable at the child level (ages 12/13), but probably reflect biased recall at home rather than effects of REM-monitoring procedures in the laboratory. The extant literature on home versus laboratory dream differences was reviewed, and it was concluded that even for normative dream studies, the REM-monitoring procedure is the method of choice.

Adolescent↗
PubMed1977

Dreaming, fenfluramine, and vitamin C.

The effect of increasing doses of fenfluramine on dream patterns was studied in 20 patients receiving a reducing diet with or without a controlled dietary intake of vitamin C daily. The dream pattern was unchanged in six patients and dreams disappeared in another who normally dreamed often. In 13 patients dreams increased in frequency and intensity, and in five the dreams assumed frightening proportions. There was a significant straight-line relation between response and the size of the dose. When placebo tablets were given to four patients their dreams disappeared or assumed their pretreatment normal pattern. Absence of vitamin C from the diet did not significantly affect the dream pattern. That fenfluramine has dose-related cerebral effects should be remembered in patients with a history of mental illness.

Ascorbic Acid↗
PubMed2025

The DREAM complex links somatic mutation, lifespan, and disease.

The DREAM complex has emerged as a central repressor of DNA repair, raising questions as to whether such repression exerts long-term effects on human health. Here we establish that DREAM activity significantly impacts lifetime somatic mutation burden, and that such effects are linked to altered lifespan and age-related disease pathology. First, joint profiling of DREAM activity and somatic mutations across a single-cell atlas of 21 mouse tissues shows that cellular niches with lower DREAM activity have decreased mutation rates. Second, DREAM activity predicts the varied lifespans observed across 92 mammals, with low activity marking longer-lived species. Third, reduced DREAM activity in Alzheimer's patients predicts late disease onset and decreased risk for severe neuropathology. Finally, we show DREAM knockout protects against mutation accumulation in vivo, reducing single-base substitutions by 4.2% and insertion/deletions by 19.6% in brains of mice. These findings position DREAM as a key regulator of aging.

Journal Article↗
PubMed1975

The characteristics of EEG activity and the subjective estimation of time during dreams of different structure.

During dreams evoked by stimuli of a certain duration, the EEF was studied in healthy subjects and in patients with implanted electrodes (EEG, ESCoG (electrosubcorticogram), unit activity). Estimation of the temporal structure of the dream was made from the verbal account of the subject. In the case of an unformed dream the duration of the dream was shown to be adequately estimated, the EEF and ESCoG patterns to be rather variable, and correlation between the bioelectric activities of different structures to be nearly absent. Apparently, in these cases, only some of the structures participate in the formation of dreams, which accounts for their unstructure, with no disorder of temporal and spatial relationships, is accompanied by certain orderly rhythms, similar EEG and ESCoG patterns, and a high correlation between bioelectric processes occurring in the structures under study. Dreams with a complex structure, with simultaneous action in different aspects and with major overestimation of their duration, are accompanied by polymorphous EEG and ESCoG patterns. Almost no correlation is observed between bioelectric processes in different structures. Apparently these dreams are associated with independent activities in different structures and, in the verbal account, the subject tends to place the events in a certain temporal order which creates the effect of considerable acceleration of the time flow.

Alpha Rhythm↗
PubMed1977

Neuroticism and dreaming sleep: a case for interactionism in personality research.

The value of a trait approach to sleep and dreaming characteristics is evaluated by reviewing recent research on differential patterns and interactions manifest by high and low neuroticism subjects. Differential patterning of dream content and REM sleep characteristics under positive and negative presleep conditions suggest a qualitative difference in experience and behavior, and a quantitative difference in "importance" attributable to the dreaming sleep process. It is hypothesized that, under "normal" conditions, low neuroticism individuals make more exclusive use of the dreaming period, while under "artificial" conditions, they demonstrate a greater motivation to compensate for restricted REM by intensification of the REM process (shortened REM onset latencies, greater REM rebound, intensified dream experiences). Finally, it is suggested that theories of dreaming sleep should recognize the importance of traits, as well as situational factors to the psychology of dreaming sleep.

Affect↗
PubMed1979

Symbolism in the dreams of the blind.

The present study compared a group of visually handicapped adults and normally-sighted college students with respect to extent of symbolic content in nocturnal dreams. The visually handicapped group comprised individuals who were partially sighted, congenitally blind and adventitiously blind. Each subject was required to keep a dream-diary for a period of two or four months. These diaries were then content-analyzed for frequency of symbolic instances, with symbols being identified in line with the criteria suggested by Hall (1966) and Hall and Nordby (1972). Although individual differences were marked and some visually handicapped subjects reported highly symbolic dreams, this group, on the whole, revealed less symbolism in dreams than did the normally sighted subjects. There was also a tendency for individuals blinded later in life (after age seven) to manifest more symbolic content in dreams than subjects blinded earlier (before age five). However, for the partially sighted subjects in the study, there emerged no clear relationship between age of onset of visual impairment and amount of symbolism in dreams. In general, the present findings were congruent with those of Blank (1958).

Adult↗
PubMedDate not supplied

The relationship of small limb movements during REM sleep to dreamed limb action.

Ten adult subjects, selected for good dream recall and ability to produce spontaneously fine limb movements in the laboratory, reported their last dream experience after awakenings from REM sleep during various limb movement and no movement conditions. The reports were rated for amount and girdle location of dreamed actions by judges blind to the awakening condition. There was a significant correlation between the number of girdles moving before awakening and the amount of dreamed action. Also, when dreams from single girdle movement awakening conditions were examined, the girdle active before awakening was dreamed as moving to a significant degree.

Adult↗
PubMed2026

Distal Recirculation of Enteral contents Augmented Mechanically (DREAM) Promotes Intestinal Adaptation and Restores Enterohepatic Signaling in Short Bowel Syndrome.

BACKGROUND & AIMS: Short bowel syndrome (SBS) leads to malabsorption and intestinal failure-associated liver disease. Intestinal adaptation (IA) driven by sustained enteral nutrition (EN) is essential, but EN delivery is limited after major resection. We developed DREAM (Distal Recirculation of Enteral contents Augmented Mechanically), which enables complete EN despite SBS, and enhances IA. We evaluated its efficacy in a translational large-animal model. METHODS: The study randomized 20 neonatal pigs to EN (control), SBS (75% resection), or DREAM. Growth, serum biochemistry, cytokines, intestinal morphology, barrier integrity, hepatic histology, and gene expression (quantitative polymerase chain reaction, RNA sequencing, Kyoto Encyclopedia of Genes and Genomes, and Gene Ontology enrichment) were analyzed. RESULTS: DREAM prevented hepatic and intestinal injury seen in SBS. Serum bilirubin (0.11 vs 5.14 mg/dL, P = .0008), &#x3b3;-glutamyl transferase (23.2 vs 114.6 IU/L, P < .0001), and bile acids (9.7 vs 39 &#x3bc;mol/L, P = .0026) were significantly lower. Inflammatory cytokines (interferon-&#x3b3;, P = .0296; interleukin 1&#x3b2;, P = .0349; and interleukin 6, P = .0189) and portal lipopolysaccharide (P = .0130) markedly improved. DREAM enhanced IA, increasing linear gut density (0.38 vs 0.209 g/cm, P < .0001), villus-to-crypt ratio (P = .0026), glucagon-like peptide 2 (P < .0001) and restored occludin and E-cadherin (P < .001). Hepatic bile salt export pump and cholesterol 7&#x3b1;-hydroxylase regulation were preserved (P = .0373 and P = .0034), and intestinal farnesoid X receptor, Takeda G-protein-coupled receptor 5, and epidermal growth factor signaling were reactivated (P < .01). Transcriptomic analysis confirmed improvements in metabolic, absorptive, and immune pathways. DREAM effluent demonstrated >80% macronutrient absorption within 6 hours (P < .0001). CONCLUSION: DREAM enables full EN in SBS, restoring absorption, mucosal integrity, and gut-liver homeostasis while preventing intestinal failure-associated liver disease. This approach represents a promising translational advance in SBS therapy.

Gut Atrophy↗
PubMed1977

Dream report following commissurotomy.

This paper addresses the question of right hemisphere involvement in the visual components of dreaming. The rationale derives from an observed relation between reports of visual agnosia accompanied by dream cessation and the literature on right hemisphere specialization for visuo-spatial processes. All night sleep EEGs were recorded from subjects with partial or complete section of the corpus callosum and anterior commissure. Upon entering a EEG-, EOG- and EMG-defined REM episode, the subjects were awakened and questioned about dream content. All subjects examined in this fashion were able to recount some visual dream content. This result fails to support any notion of selective right hemisphere visual dream mediation.

Corpus Callosum↗
PubMed1979

Effect of certain cerebral hemispheric diseases on dreaming.

Dreaming may be altered by cerebral hemispheric disease. A woman who sustained a probable left posterior cerebral artery thrombosis, with right homonymous hemianopsia and alexia, had virtual cessation of dreaming for at least 9 months. Four individuals with temporal lobe epilepsy experienced recurrent painful (frightening) dreams, which in two patients showed features identical to seizures. Sleep recordings showed abnormalities in all four, including rhythmic temporal epileptiform activity during REM sleep. Lesions in parieto-occipital loci may interfere with production of the visual imagery required for dreaming (negative symptom in the Jacksonian sense) while epileptic activity in temporal loci may produce painful repetitive dream imagery (positive symptom).

Adult↗