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At least 19 recordsLinked to original sources
PubMed1988

Elsie 4: quantitative computer analysis of sets of two-dimensional gel electrophoretograms.

We have developed and refined a system for quantitative computer analysis of two-dimensional polyacrylamide gel electrophoretograms. The system, named Elsie 4, is based on one described by Vo et al. (Anal. Biochem. 112, 258 (1981]. It is highly automated. Elsie 4 can find, and measure the intensity of, almost any spot resolvable on two-dimensional gels, including spots visible only as shoulders off larger spots and spots so close together that there is no "valley" between them. It can automatically match the spot patterns of different gels, potentially without the need for a user to provide landmark matches. The matches between paired gels let us follow the synthesis of any spot through a set of gels. Information about a group of matched spots can be obtained by referring to any spot in the group. There is generally no need for a standard or reference gel. Data for two experiments can be combined and compared by matching any gel in one experiment with any gel in the other. There are ways to automatically find possible mismatches in sets of gels. Scans and the results of the analysis can be shown on an image displayer. The programs use function libraries; this helps ensure consistency and increase portability. The programs and functions can be linked together in many ways; this lets users build custom programs for analysis of specific experiments.

Computer Systems↗
PubMed1998

A cost analysis of the tuberculosis control programme in Elsies River, Cape Town

SETTING: Four primary health care clinics located in the suburb of Elsies River in the metropolitan area of Cape Town. AIM: To measure the cost of the Tuberculosis Control Programme to the health service in Elsies River and determine the costs associated with each of the clinic, community and self-supervised methods of treatment of pulmonary tuberculosis patients. DESIGN: A cost analysis designed to assess the resource input requirements of the three alternative programmes of implementing the supervision of antituberculosis therapy. The main outcome measurement was the estimated cost per patient treated for the health services by three different supervision methods (clinic, self and community-based). RESULTS: The estimated cost per patient for a 6-month period in each of the supervision groups (clinic, self and community) was R3 600, R1 080 and R720 respectively. CONCLUSION: Directly observed therapy, short-course (DOTS), has been adopted as the recommended policy for managing tuberculosis in South Africa. The costs incurred by the variety of supervision options evaluated in this study indicate that community-based directly observed therapy by a volunteer lay health worker may be less costly to the health services than either clinic or self supervision.

Journal Article↗
PubMedDate not supplied

ELSI priorities for brain imaging.

As one of the most compelling technologies for imaging the brain, functional MRI (fMRI) produces measurements and persuasive pictures of research subjects making cognitive judgments and even reasoning through difficult moral decisions. Even after centuries of studying the link between brain and behavior, this capability presents a number of novel significant questions. For example, what are the implications of biologizing human experience? How might neuroimaging disrupt the mysteries of human nature, spirituality, and personal identity? Rather than waiting for an ethical agenda to emerge from some unpredictable combination of the concerns of ethicists and researchers, the attention of journalists, or after controversy is sparked by research that cannot be retracted, we queried key figures in bioethics and the humanities, neuroscience, media, industry, and patient advocacy in focus groups and interviews. We identified specific ethical, legal and social issues (ELSI) that highlight researcher obligations and the nonclinical impact of the technology at this new frontier.

Behavior↗