PubMed Health⌕ Search

SEARCH · PubMed Health

Results for “EPILEPSY/metabolism”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 19 recordsLinked to original sources
PubMed1961

Epileptogenic cerebral electrical activity and serotonin levels.

Chronically epileptic cats and monkeys showed marked activation of paroxysmal electrographic abnormalities both in the original focus and in a number of structures with secondarily altered functional states after intraperitoneal injection of the serotonin precursor 5-hydroxytryptophan (10 to 25 mg/kg) plus vitamin B6. Much less 5-hydroxytryptophan was required to produce such epileptogenic activation if the animals had previously been treated with Marsilid, a monoamine oxidase inhibitor. Marked paroxysmal activity in epileptic animals was also produced by injection of Marsilid alone or of Marsilid in combination with reserpine. Since all of the activating agents used have been shown by others to elevate brain serotonin levels, the epileptogenic activation may be correlated with such high levels. Since the effects were at least partially blocked by atropine, such "serotonin-induced" activation may possibly involve some cholinergic mechanism.

5-Hydroxytryptophan↗