[Tumors of the cutaneous annexa; epithelioma adenoides cysticum; sebaceous epithelioma; sudoriparous epithelioma].
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The presence of plasminogen activator (PA) with a Mr of about 35,000 was detected by SDS-PAGE in extract from Guerin epithelioma. The activator, which is a serine proteinase, was partially purified on Sephadex G-50 followed by Lys-Sepharose. Rat plasma, both of healthy and epithelioma-bearing animals, inhibited the activity of such isolated PA. However, the difference between these plasmas in their antiactivator action was observed after inactivation of plasma proteinase inhibitors. In such conditions, the control plasma lost the ability to inhibit the examined PA, whereas the plasma of epithelioma bearing rats retained this ability.
A case of carcinomatous transformations of an intraepidermal epithelioma is presented by the authors. The rarity of this transformation is emphasized.
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