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Results for “ERYTHROCYTE AGGREGATION, INTRAVASCULAR”

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At least 19 recordsLinked to original sources
PubMed1980

[Effect of trypsin on intravascular erythrocytes aggregation].

The role of proteolytic enzymes in intravascular aggregation of red cells was studied in experiments on rats by intravital microscopy. Intravenous injection of trypsin (40--50 mg/kg) combined with heparin (1000 units/kg) produces marked intravascular aggregation of red cells. Preliminary infusion of pentoxyphyllin (20 mg/kg) or acetylsalicylic acid (100 mg/kg) blocked this process. A conclusion is made about an important role of proteolytic enzymes play in the development of microcirculatory disorders. A possible mechanism of the aggregating action of trypsin and approaches to its correction are discussed.

Animals↗
PubMed1980

[Effect of acetylsalicylic acid and pentoxifylline (trental) on intravascular erythrocyte aggregation stimulated by arachidonic acid].

The role of arachidonic acid (3--5 mg/kg animal body weight) in the intravascular red cell aggregation was studied on rats by intravital microscopy. It has been established that intravenous injection of arachidonic acid leads to aggregation and red cell hemolysis, and animals' death. Preliminary injection of acetylsalicylic acid or pentoxyphylline prevents the initiation of aggregation and lysis of red cells but does not avert the animals' death because of arachidonic acid. It is concluded that arachidonic acid plays an important role in aggregation and lysis of red cells. It is recommended that reasons for animals' death because of arachidonic acid in the absence of microcirculatory disorders be studied.

Animals↗