PubMed Health⌕ Search

SEARCH · PubMed Health

Results for “Empiricism”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 19 recordsLinked to original sources

Feminist empiricism as a method for inquiry in nursing.

Feminist empiricism may provide a valuable approach for the acquisition, evaluation, and integration of biological knowledge in nursing epistemologies. This article discusses feminist empiricism as a method for inquiry in nursing. Proponents of feminist empiricism strive to work within the current political, social, and scientific structures while acknowledging that all three of these structures must change if less distorted epistemologies are to emerge. Hypertension in women is used to illustrate how feminist empiricism could be used to modify the traditional scientific approach. The argument is made that the androcentricism of the traditional scientific approach must be changed in order to include the problematics of women. Moreover, women must have a central role in determining the problematics of both health and illness in women. A philosophical stance embracing holism cannot deny biological phenomena or preclude research on these phenomena. Theorists and scientists in nursing have a unique opportunity to reconceptualize biological phenomena, from a holistic perspective, in the development of epistemologies for nursing. An argument for the use of basic research as a quantitative methodology, from a feminist perspective, is made. The appropriateness, for nursing, of basic research methodologies to generate knowledge about biological processes, which are within nursing's scientific domain, are discussed.

Female↗

Fight the power: the limits of empiricism and the costs of positivistic rigor.

A summary of the influence of positivistic philosophy and empiricism on the field of psychology is followed by a critique of the empirical method. The dialectic process is advocated as an alternative method of inquiry. The main advantage of the dialectic method is that it is open to any logical argument, including empirical hypotheses, but unlike empiricism, it does not automatically reject arguments that are not based on observable data. Evolutionary and moral psychology are discussed as examples of important fields of study that could benefit from types of arguments that frequently do not conform to the empirical standards of systematic observation and falsifiability of hypotheses. A dialectic method is shown to be a suitable perspective for those fields of research, because it allows for logical arguments that are not empirical and because it fosters a functionalist perspective, which is indispensable for both evolutionary and moral theories. It is suggested that all psychologists may gain from adopting a dialectic approach, rather than restricting themselves to empirical arguments alone.

Biological Evolution↗

Expanding the use of empiricism in nursing: can we bridge the gap between knowledge and clinical practice?

The philosophy of Aristotle and its impact on the process of empirical scientific inquiry has been substantial. The influence of the clarity and orderliness of his thinking, when applied to the acquisition of knowledge in nursing, can not be overstated. Traditional empirical approaches have and will continue to have an important influence on the development of nursing knowledge through nursing research. However, as nursing is primarily a practice discipline, the transition from empirical and syllogistic reasoning is problematic. Other types of inquiry are essential in the application of nursing knowledge obtained by empirical scientific approaches and to understand how that knowledge can best be used in the care of patients. This paper reviews the strengths and limitations of syllogistic reasoning by applying it to a recently published study on temperature measurement in nursing. It then discusses possible ways that the empirical knowledge gained from that study and confirmed in its reasoning by logical analysis could be used in the daily care of critically ill patients. It concludes by highlighting the utility of broader approaches to knowledge development, including interpretative approaches and contemporary empiricism, as a way to bridge the gap between factual empirical knowledge and the practical application of that knowledge in everyday clinical nursing practice.

Critical Care↗

From total empiricism to a rational design of metronomic chemotherapy phase I dosing trials.

'Metronomic chemotherapy' represents a novel anti-angiogenic strategy whereby low-dose chemotherapy is utilized in a continuous fashion in order to target tumor endothelium. There are many potential advantages of this strategy and clinical trials are already underway. However, although the scheduling of metronomic chemotherapy is relatively unequivocal, metronomic dosing principles are at present poorly defined. Arbitrarily, 10-33% of the maximum tolerated dose comprises 'the dose range'. We argue that this is too empirical and propose a set of phase I metronomic chemotherapy dosing strategies based on a principled approach which may help to reduce the problem of empiricism in dosing for metronomic chemotherapy trials.

Angiogenesis Inhibitors↗

The rationale of combination antifungal therapy in severely immunocompromised patients: empiricism versus evidence-based medicine.

PURPOSE OF REVIEW: Despite expansion of the antifungal armamentarium over the past decade, the mortality rate for invasive fungal infections remains high in severely immunocompromised patients. Furthermore, in recent years, difficult-to-treat invasive infections caused by rare molds and yeasts have emerged in high-risk patients receiving antifungal prophylaxis or empirical treatment. Antifungal combinations are increasingly used in clinical practice to improve outcomes for refractory mycoses because of the suboptimal efficacy of current antifungal agents. Herein we review recent advances in the area of antifungal combinations in high-risk patients to separate empiricism from evidence-based medicine. RECENT FINDINGS: Thus far, the benefits of combination antifungal therapy have been difficult to prove for invasive fungal infections other than cryptococcal meningitis. The recent introduction of a new class of antifungal agents (the echinocandins) and extended-spectrum triazoles has rejuvenated interest in studying those combinations for difficult-to-treat aspergillosis, as recent observational studies show promise. SUMMARY: In view of the evolving epidemiology of invasive fungal infections, combination antifungal therapy could be most valuable in preemptive management of carefully selected high-risk patients; however, this should be studied in appropriate trials.

Antifungal Agents↗

Concept empiricism: a methodological critique.

Thanks to Barsalou's, Damasio's, Glenberg's, Prinz' and others' work, neo-empiricism is gaining a deserved recognition in the psychology and philosophy of concepts. I argue, however, that neo-empiricists have underestimated the difficulty of providing evidence against the amodal approach to concepts and higher cognition. I highlight three key problems: the difficulty of sorting out amodal predictions from neo-empiricist predictions, the difficulty of finding experimental tasks that are not best solved by imagery and the difficulty of generalizing findings concerning a given cognitive process in a given context to other cognitive processes or other contexts. Finally, solutions to these three problems are considered.

Empirical Research↗

Two dogmas of conceptual empiricism: implications for hybrid models of the structure of knowledge.

Concepts seem to consist of both an associative component based on tabulations of feature typicality and similarity judgments and an explanatory component based on rules and causal principles. However, there is much controversy about how each component functions in concept acquisition and use. Here we consider two assumptions, or dogmas, that embody this controversy and underlie much of the current cognitive science research on concepts. Dogma 1: Novel information is first processed via similarity judgments and only later is influenced by explanatory components. Dogma 2: Children initially have only a similarity-based component for learning concepts; the explanatory component develops on the foundation of this earlier component. We present both empirical and theoretical arguments that these dogmas are unfounded, particularly with respect to real world concepts; we contend that the dogmas arise from a particular species of empiricism that inhibits progress in the study of conceptual structure; and finally, we advocate the retention of a hybrid model of the structure of knowledge despite our rejection of these dogmas.

Association Learning↗

Empiricism versus science in the teaching of nephrology.

Recent changes in medical courses in Italy reflect a recognition that both theoretical education and clinical practice are essential components of a doctor's training. These two parallel branches of medical education find their origins in the beliefs of Galen, mentor of medicine as a pure science, and of Alexander of Aphrodisias, promoter of the predominant role of empiricism. Neither a dogmatic nor an empiric approach to the study of medicine, however, is sufficient on its own.

Education, Medical↗

Philosophical inquiry in nursing: an argument for radical empiricism as a philosophical framework for the phenomenology of addiction.

Philosophical inquiry involves examination of the meaning of a phenomenon within the larger framework of the human condition and a particular view of reality. Argumentation is the method. In this study, the author argues that the metaphysics of radical empiricism enhances the understanding of the immediate subjective experience or phenomenology of addiction. When applied to subjective narratives of the addiction experience from literature, this metaphysics confers meaning to the changes in consciousness that occur in the immediate subjective experience of addiction. Conclusions revealed from the application of this perspective highlight novel feelings, the will and changing sense of self, and the human values of belonging and freedom. This study also revealed the value of the philosophical method of inquiry: to temporize our moral judgments and enrich our perspective of the human values within the addiction phenomenon. These values support and clarify the belief system of nursing.

Consciousness↗

Logic and empiricism in the selection of antiarrhythmic agents. The role of drug combinations.

Advances in investigative techniques of cardiac arrhythmias through invasive procedures (clinical electrophysiology) or through ambulatory electrocardiographic monitoring provide a better understanding of the mechanism responsible for these disturbances and a better assessment of therapeutic efficacy. Yet, it cannot be inferred that the selection of antiarrhythmic agents is orientated in all cases by logical reasoning. Too many factors are unknown, especially those regarding the spontaneous mechanism of initiation of clinical arrhythmias. Patient management very often remains mainly empirical. The problem becomes even more complex when dealing with arrhythmias resistant to single-agent therapy. Drug combinations are then used, often successfully, particularly those combining membrane-stabilising agents with amiodarone or beta-adrenergic blocking agents or combining amiodarone with verapamil. Explanations of the efficacy of these combinations at reduced doses become less certain, but it is more important to achieve efficacy than to understand its mechanism, which does not always amount to a simple increase in plasma drug levels. When attempting to determine the reasons behind the theoretically logical selection of an antiarrhythmic agent, it appears that, in spite of advances in electrophysiology and pharmacology, the logic of this selection owes more to chance than to reason. The problem becomes further complicated when drug combinations are to be used which, in clinical practice, are often the therapeutic solution in difficult cases. Advances made in recent years bring up the question of knowing whether or not logic is near to replacing empiricism.

Anti-Arrhythmia Agents↗

Freeze-drying: from empiricism to predictability. The significance of glass transitions.

The physical and chemical principles which govern the behaviour of aqueous solutions during freezing and subsequent drying are discussed. They include undercooling, nucleation and growth of ice, the concomitant freeze concentration of the residual solution and its secondary effects, the role of water as plasticizer in amorphous organic materials, the removal of such water, and the over-riding importance of the glass/rubber transition. An understanding of the basic principles can remove most of the empiricism from freeze-drying and lead to more efficient process cycles and to products of superior quality and stability.

Biological Products↗

[Physical medicine--a field between empiricism and science].

Physical Medicine is more deeply rooted in empiricism than most other medical fields. This causes problems and the demand for scientific testing of its methods. Selected examples are given relating to prevention, therapy and rehabilitation. They show that scientific testing is possible also in Physical Medicine and can lead to positive results.

Arterial Occlusive Diseases↗

EMPIRICISM IN LATTER-DAY BEHAVIORAL SCIENCE.

Let me recapitulate. I am not happy with developments in the behavioral sciences. I wonder whether science does actually stand divorced from the intention, motive, and character of the scientist. I suspect that some of our current philosophies in science, whether so conceived or not, encourage and abet a science of the trivial. I believe we should recognize that, as epistemology, the empirical rule cannot stand alone. The great advances in science are associated with its grand conceptions even more than with its discoveries. We often mistakenly assume that the rule of objectivity has traditionally divided the character of science from that of the scientist. This is far from true. The objectivity of 18th- and 19th- century science was believed to be a function not so much of methodology and procedure as of the honesty and integrity of the scientist. Michael Faraday had this to say about the matter (3, p. 233): It puzzles me greatly to know what makes the successful philosopher [scientist]. Is it industry and perseverance, with a moderate proportion of good sense and intelligence? Is not a modest assurance or earnestness a requisite? Do not many fail because they look rather to the renown to be acquired than to the pure acquisition of knowledge, and the delight which the contented mind has in acquiring it for its own sake? I am sure I have seen many who would have been good and successful pursuers of science, and have gained themselves a high name, but that it was the name and the reward they were always looking forward to-the reward of the world's praise. In such there is always a shade of envy or regret over their minds, and I cannot imagine a man making discoveries in science under these feelings. As to Genius and its Power, there may be cases; I suppose there are. I have looked long and often for a genius for our own laboratory, but I have never found one. But I have seen many who would, I think, if they submitted themselves to a sound self-applied discipline of mind, have become successful experimental philosophers. Are these issues native only to behavioral science? Earlier, I laid at Skinner's door much of the blame for an unreasonable complacency regarding the disposition of modern behavioral science. In all fairness to Skinner, however, it is only correct to acknowledge that the same problem is evident in other areas of science. Skinner appears to be a spokesman, in the behavioral sciences, for one of those famous "Zeitgeists." Let me quote a series of observations by Paul Weiss, a biologist at the Rockefeller Institute, New York City, from a paper entitled "Experience and experiment in biology" (5): Without imagination one can contrive infinite variations of experimental set-ups, all of them novel, yet utterly uninteresting, inconsequential, insignificant. The mere fact that something has not been done or tried before is not sufficient reason for doing or trying it. . . . But is not scientific history full of instances of accidental discovery of the unexpected? True again, but he who does expect something will be on the alert even for the unexpected, while he who just ambles, looking for nothing in particular, is prone to miss even the obvious. . . . We see instruments turning from servants into tyrants, forcing the captive scientist to mass-produce and market senseless data beyond the point of conceivable usefulness-a modern version of the Sorcerer's Apprentice. . . . Finally, I recommend study of N. W. Storer's article "The coming changes in American science" (6). Storer, a sociologist at Harvard University, feels that prior to 1940 the basic currency in science was professional recognition. This in turn reinforced certain fundamental values-a high emphasis on communication; dedication of the individual and a tendency to work in small, select groups; a spurning of worldly gain and a proclivity for basic research. Today, professional recognition is being replaced by more common currencies-money, power, and worldly prestige. The result is a shift of values in science: numbers are no longer small or groups select; communication and professional recognition are viewed as means to gain money, power, and prestige rather than as ends in themselves; basic research is giving way to a kind of imposter with a thinly disguised commercial goal. I do not know how to resolve the issues in modern science. It seems to me we may be troubled by the embarrassments of too much success. Will we continue to succeed if we do not change our ways? Maybe, but not as magnificently I am sure as we could if we did change them. We cannot do anything about our numbers-nor would I want us to forswear all worldly possessions. We can examine critically and revise certain of our guiding philosophies. We can follow a suggestion of P. H. Abelson (7) and alter granting procedures so that institutions, as well as individuals, are given support. In the end, however, the major force for change resides in the minds and hearts of scientists who share a concern about science.

Behavioral Sciences↗