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Results for “Endocrine System Diseases”

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At least 19 recordsLinked to original sources
PubMed1984

Increased deaths due to endocrine system diseases and allergies among mothers of dizygotic twins.

To test the hypothesis that mothers of DZ twins, who seem to represent a separate population from mothers of singletons in terms of levels of pituitary gonadotropins, height and weight, and reproductive and menstrual characteristics, have different patterns of disease and mortality, causes of non-cancer deaths were examined. Study subjects were 3,982 mothers of unlike-sexed (DZ) twins and other polyzygous multiple births, and a matched comparison group of 3,982 mothers of singletons only. A significantly increased risk of death due to diseases in ICD Group III, Allergic Endocrine System, Metabolic and Nutritional Diseases, was found among mothers of DZ twins (relative risk (RR) = 2.4, exact two-tail P = 0.024, exact 95% confidence limits 1.11 to 5.62). Of the 24 deaths among mothers of DZ twins, 18 were due to diabetes, 2 to diseases of the adrenal glands, 1 to a thyroid gland and, 3 to asthma. Of the ten deaths in the comparison group, nine were due to diabetes and one to asthma. Excluding the asthmas, the RR for endocrine system diseases is 2.33, exact two-tail P = 0.042, exact 95% CL 1.02 to 5.79. These observations are consistent with evidence in the literature which shows an association between endocrine system diseases and twinning, and between gonadotropic hormones and diabetes.

Connecticut↗
PubMed1990

[The renin-angiotensin-aldosterone (RAA) system in endocrine diseases].

Modern, views are presented on the pathogenesis of arterial hypertension in certain diseases of endocrine glands. In patients with phaeochromocytoma, virilizing tumours, acromegaly, in Cushing's disease, and in Conn's syndrome at the present state of knowledge it is not possible to formulate unequivocal conclusions concerning the effects of renin-angiotensin-aldosterone system on the mechanism of arterial hypertension development in these endocrinopathies.

Adrenal Gland Neoplasms↗
PubMed1994

Accuracy of admission and pre-autopsy clinical diagnoses in the light of autopsy findings: a study conducted in Budapest.

Pre- and post-autopsy diagnoses of underlying cause of death were compared in consecutive autopsies on persons aged 30 to 80 years; 1000 from each of two pathology departments in Budapest. Data on admission diagnoses and on contributory causes of death were also analysed. At autopsy, the percentages of deaths by underlying cause were neoplasms (any site) 34.9%, diseases of the circulatory system 40.2%, digestive system 13.8%, endocrine, nutritional, metabolic or immune systems 2.7%, and respiratory system 2.2%. For these five disease groupings, the percentages of cases diagnosed clinically as the underlying cause of death which were confirmed at autopsy were, respectively, 90.9%, 84.0%, 82.9%, 55.2% and 32.5%. Although, out of 697 cases with an autopsy diagnosis of neoplasia as the underlying cause, there were only 61 (8.8%) where neoplasms were not diagnosed clinically as the underlying cause, this conceals the fact that in 130 (18.7%) the two diagnoses differed as to the site of the primary neoplasm (ICD 3 digit code). The fact that 43% of post-mortem diagnoses (ICD major category) of underlying cause are missed on admission, and that 19% are missed clinically, indicates that improved clinical diagnostic procedures have not diminished the need for high autopsy rates. Morbid anatomy needs to be better resourced.

Adult↗
PubMed2002

Autoimmune endocrine disease.

The immune system can attack almost any given organ in a very specific and directed fashion. The endocrine system appears to be particularly vulnerable to this kind of insult. Which endocrine organs are most susceptible and why? Genetic studies and animal models have revealed some commonalities for these diseases. The MHC locus appears to help control not only susceptibility to disease but also which endocrine organs are attacked. Autoimmune thymectomy models have revealed suppressor cell populations, which are being intensely sought after as a protective mechanism against endocrine autoimmunity. Finally, the recent cloning of the causative gene for autoimmune polyglandular syndrome type I, called AIRE, has brought central tolerance back into focus as an important mechanism in these endocrine diseases.

Animals↗