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At least 19 recordsLinked to original sources
PubMed2002

Risk factors for the development of accommodative esotropia following treatment for infantile esotropia.

PURPOSE: One aim of the study was to determine whether accommodative esotropia after surgical alignment in infantile esotropia occurs because a pre-existing accommodative component is unmasked at the time of surgery or whether it occurs as a sequela of infantile esotropia. A second aim of the present study was to examine risk factors for accommodative esotropia after surgery for infantile esotropia. METHODS: A total of 80 consecutive patients who were enrolled in a prospective study of infantile esotropia had been followed for more than 4 years and had achieved orthoposition were included. Twelve potential risk factors were examined: age at onset, initial esodeviation, initial refractive error, age at alignment, delay in alignment, presurgical glasses, amblyopia, additional surgical procedures, unstable alignment, increase in hypermetropia, peripheral fusion, and stereopsis. Mantel-Haenszel odds ratios were computed for each factor and were corrected to relative risks. RESULTS: Overall, 48 of 80 children (60%) developed accommodative esotropia at a mean age of 33 months. Increasing hypermetropia, delay in alignment, and poor stereopsis posed significant risks for accommodative esotropia. The remaining 9 factors were not associated with increased risk for accommodative esotropia. CONCLUSIONS: Accommodative esotropia is unlikely to be a pre-existing condition in most cases because the mean age of onset was 23 months postoperative and the prevalence of preoperative hypermetropia greater than +3.00 D was low. Both delay in alignment and stereopsis risk factors may reflect compromised binocular sensory status that allows accommodative esotropia to occur at low to moderate levels of hypermetropia. Identification of children treated for infantile esotropia who are at risk for accommodative esotropia may allow for prevention or early treatment.

Accommodation, Ocular↗
PubMed2002

Spontaneous resolution of early-onset esotropia: experience of the Congenital Esotropia Observational Study.

PURPOSE: To determine the probability of spontaneous resolution of esotropia with onset in early infancy. DESIGN: Prospective multicenter cohort study. METHODS: Eligibility criteria included age at enrollment 4 to < 20 weeks and an esotropia measuring at least 20 prism diopters (pd). The primary outcome measure was ocular alignment at 28 to 32 weeks of age. The esotropia was classified as resolved when there was a misalignment of 0 to 8 pd at the outcome examination either with or without spectacle correction. RESULTS: Outcome data were available for 170 of the 175 enrolled patients. The esotropia was classified as resolved in 46 of the 170 patients (27%, 95% confidence interval = 21% to 34%). Most of the resolved cases had an intermittent or variable deviation at enrollment. Resolution occurred in only one of 42 cases that had a constant esotropia > or = 40 pd on both the baseline and first follow-up examination and had a refractive error < or = + 3.00 diopters. In another patient, who had an esotropia of 35 pd at baseline and 40 pd at the outcome examination, the esotropia resolved subsequent to the outcome examination. CONCLUSIONS: Esotropia with onset in early infancy frequently resolves in patients first examined at less than 20 weeks of age when the deviation is < 40 pd in size and is intermittent or variable. Cases with a constant deviation > or = 40 pd presenting after 10 weeks of age have a low likelihood of spontaneous resolution. Our results can be used to define a clinical profile for which persistence of the esotropia is sufficiently likely that surgical correction at 3 to 4 months of age could reasonably be considered.

Age of Onset↗
PubMed2002

The clinical spectrum of early-onset esotropia: experience of the Congenital Esotropia Observational Study.

PURPOSE: To describe historical and presenting features of infants with the onset of esotropia in early infancy to provide a better understanding of the clinical spectrum of the disorder. DESIGN: Prospective multicenter cohort study. METHODS: Eligibility criteria included age at enrollment 4 to < 20 weeks and an esotropia at near measuring at least 20 prism diopters (pd). Historical information was elicited from the parent or guardian. The esotropia was measured at near and characterized as constant, variable, or intermittent. RESULTS: 175 infants were enrolled. Their average age at enrollment was 97 +/- 26 days. The esotropia was characterized as constant in 56% of the patients, variable in 25%, and intermittent in 19%. Forty-nine percent of the deviations were > or = 40 pd. Most of the larger angle deviations were constant whereas the majority of the smaller angle deviations were intermittent or variable. The majority of patients first seen after 12 weeks of age had constant deviations (65%), whereas the majority seen before 12 weeks of age had intermittent or variable deviations (57%). At enrollment, amblyopia was diagnosed in 19% of patients. CONCLUSION: The clinical presentation of esotropia in early infancy shows more variation in the esotropia's size and character than has been previously appreciated. Only a minority of the infants who are diagnosed to have esotropia before 20 weeks of age have the commonly accepted profile for congenital esotropia of a large-angle constant deviation. Amblyopia frequently develops, so an evaluation for amblyopia should be an integral part of the examination of an infant with esotropia.

Age of Onset↗
PubMed1988

Accommodative esotropia following surgical correction of congenital esotropia, frequency and characteristics.

This study was undertaken to look at the development of accommodative esotropia, which occurs following the surgical correction of congenital esotropia. A retrospective review was done on all congenital esotropia patients operated on by one of the authors from 1974 through mid-1984. The criterion of a minimum of 3 years postsurgical follow-up was met by 101 patients. Of these patients, 52 developed accommodative esotropia, 25 within 3 months of surgery and 27 from 3 to 60 months after surgery. The average preoperative refractive error in the early group was +3.90 and +1.95 in the later group. The average time to develop accommodative esotropia in this group with later onset was 27 months following the initial surgery. It would appear that if the preoperative refractive error is +3.00 or more, and especially if the preoperative deviation responds to spectacles with a reduction of 15 prism diopters or more, then it is very likely that glasses will be required for accommodative esotropia very soon following surgery. There appear to be no clues as to which patients will need glasses later for accommodative esotropia.

Accommodation, Ocular↗
PubMed2003

Is it possible to differentiate early-onset accommodative esotropia from early-onset essential esotropia?

PURPOSE: To determine the frequency of > or =2.50 diopter (D) hyperopia in infantile esotropia with onset up to the age of 6 months and by evaluating the treatment results of these cases retrospectively, to find the factors that may help to differentiate early-onset accommodative esotropia from early-onset essential esotropia. METHODS: The charts of 256 patients with infantile esotropia were reviewed. Thirtyseven cases, with hyperopia of > or =2.50 D, no other systemic and neurologic disease, and at least 1 year of follow-up, were included in this study. The age at the start of therapy, refractive error, deviation angle, type of therapy (antiaccommodative therapy, surgery) and the presence of amblyopia, latent nystagmus, inferior oblique overaction, dissociated vertical deviation and cross-fixation were recorded for each case. RESULTS: The prevalence of high hyperopia was found to be 14.4% (37/256) in infantile esotropia. In 18 of the cases (48.6%), antiaccommodative therapy alone was found to be adequate (Group I). In the remaining 19, although antiaccommodative therapy was found to decrease the deviation angle significantly (P<0.001), surgery was also required (Group II). Groups were compared with respect to age at the initial examination, refractive error, deviation angle, presence of amblyopia, anisometropia, and inferior oblique overaction, but no factor could be determined to predict the pure refractive ones (P>0.05). Essential infantile esotropia-associated findings did not help because they are rarely evident at the time of initial diagnosis. CONCLUSIONS: Half of the high hyperopic infantile esotropes could be corrected fully by antiaccommodative therapy alone, while the remaining ones could also benefit significantly. It is strongly recommended to try spectacles at first in the treatment of infantile esotropia with hyperopia > or =2.5 D.

Accommodation, Ocular↗
PubMed1988

Acute acquired comitant esotropia simulating late onset accommodative esotropia.

Acute acquired comitant esotropia in the older child, adolescent, and young adult may represent uncorrected accommodative esotropia. Three young patients developed spontaneous diplopia associated with acute comitant esotropia. In all cases, cycloplegic refraction revealed high uncorrected hyperopia suggesting late onset accommodative esotropia. However, for one patient an intracranial neoplasm precipitated the strabismus and for the other patients the hyperopic correction did not alter the deviation. Clinicians confronted with older children or adolescent patients with acute comitant esotropia associated with large uncorrected hyperopia should not hastily classify the deviation as being accommodative in etiology. Although the latter is possible, the hyperopia may be coincidental and masking an underlying mechanism.

Accommodation, Ocular↗
PubMed1988

Congenital esotropia vs infantile esotropia.

The term congenital esotropia has been challenged for many years. The basis of this challenge is that the deviation is not confirmed connatally. However, the term congenital esotropia is valid based on clinical observations and is easily separated from other forms of acquired esotropia.

Age Factors↗
PubMed2002

Nonaccommodative esotropia after cataract extraction in a patient with previous accommodative esotropia.

We report a case of nonaccommodative esotropia developing after bilateral cataract surgery that corrected the preexisting hyperopia in a patient with accommodative esotropia since childhood. The esotropia required surgical correction despite the good visual acuity after the cataract surgery. In patients with preexisting strabismus, there is a possibility of decompensation of adaptive binocular mechanisms after cataract surgery and refractive procedures.

Accommodation, Ocular↗
PubMedDate not supplied

Recurrent esotropia following early successful surgical correction of congenital esotropia.

A study was conducted using a group of congenital esotropes who had an adequate surgical alignment prior to 18 months of age, to determine how many of them would redevelop esotropia. In the group that redeveloped the condition, a high percentage of the esotropia was accommodative in nature and was therefore able to be corrected with spectacles. Both the initial refractive error and changes in refractive error were noted to be significant. This study emphasizes the importance of monitoring the refractive state continuously, especially in children with subnormal fusion.

Accommodation, Ocular↗
PubMed1989

Primary inferior oblique overaction in congenital esotropia, accommodative esotropia, and intermittent exotropia.

A statistical analysis of the onset and natural history of primary inferior oblique eye muscle overaction (IOOA) was conducted using the records of 456 strabismus patients. With 5 years or more of follow-up, IOOA developed in 72% of congenital esotropes (CETs), 34% of accommodative esotropes (AETs), and 32% of intermittent exotropes (X[T]s) at an average age of 3.6, 5.2, and 5.2 years, respectively. Incidence of IOOA was positively related to the number of horizontal surgeries in CETs but not in AETs or X(T)s. Incidence was not related to age of onset of strabismus, time from onset of strabismus to surgery, age at first surgery, or decompensation of ocular alignment. Mild IOOA did revert to normal in 12 patients after only horizontal surgery. The association of IOOA with dissociated vertical deviation, as well as symmetry, range of age of detection, and recurrence after surgery are also explored.

Accommodation, Ocular↗
PubMed2002

20 unusual presentations of accommodative esotropia.

PURPOSE: This paper will discuss several unusual presentations of accommodative esotropia. METHODS: A total of 20 patients with unusual case histories who presented with accommodative esotropia were studied retrospectively. These patients were separated into 3 categories. The first contained children who had their onset of accommodative esotropia after a traumatic event such as head trauma or ocular trauma. The second involved infants between 3 and 5 months of age who presented with accommodative esotropia. The third showed the onset of accommodative esotropia associated with diabetic ketoacidosis. (There were no other metabolic disorders associated with accommodative esotropia.) RESULTS: All patients resolved their esotropia with glasses initially but 2 did require surgery several years after the onset of the esotropia. CONCLUSIONS: Children under 5 months of age with intermittent esotropia and/or significant amounts of hyperopia should have the diagnosis of accommodative esotropia considered as the etiology of their esotropia. Children with the onset of esotropia associated with trauma who have significant amounts of hyperopia should also have accommodative esotropia considered as an etiology of their crossing.

Accommodation, Ocular↗
PubMed2001

The role of anisometropia in the development of accommodative esotropia.

PURPOSE: To determine whether anisometropia increases the risk for the development of accommodative esotropia with hypermetropia. METHODS: Records of all new patients with a refractive error of +2.00 D or more (mean spherical equivalent of both eyes) over a 42-month period were reviewed. Three hundred forty-five patients were thus analyzed to determine the effect of anisometropia (>or=1 D) on the relative risk of developing accommodative esotropia and of developing unsatisfactory control with spectacles once esotropia was present. RESULTS: Anisometropia (>or=1 D) increased the relative risk of developing accommodative esotropia to 1.68 (P < .05). Anisometropia (>or=1 D) increased the relative risk for esotropia to 7.8 (P < .05) in patients with a mean spherical equivalent less than +3.00 D and increased it to 1.49 (P < .05) in patients with a mean spherical equivalent of +3.00 D or more (P = .016). In patients with esotropia and anisometropia (>or=1 D), the relative risk for a deviation that was unsatisfactorily controlled with spectacles was 1.72 (P < .05) compared with patients with esotropia but without anisometropia. Unsatisfactorily controlled esotropia was present in 33% of patients with anisometropia versus 0% of patients without anisometropia, with a mean hypermetropic spherical equivalent of less than +3.00 D (P = .003); however, anisometropia did not significantly increase the relative risk of unsatisfactory control of esotropia with spectacles in patients with a hypermetropic spherical equivalent of +3.00 D or more. Although amblyopia and anisometropia were closely associated, anisometropia increased the relative risk for esotropia to 2.14 (P < .05), even in the absence of amblyopia. CONCLUSIONS: Anisometropia (>or=1 D) is a significant risk factor for the development of accommodative esotropia, especially in patients with lower overall hypermetropia (>+3.00 D). Anisometropia also increases the risk that an accommodative esotropia will not be satisfactorily aligned with spectacles.

Accommodation, Ocular↗
PubMedDate not supplied

Early-onset accommodative esotropia.

PURPOSE: To determine the frequency of accommodative esotropia with onset by 6 months of age; to determine if the presence or absence of characteristics usually associated with infantile esotropia can help in the diagnosis; and to determine if antiaccommodative therapy is adequate treatment for the esotropia. METHODS: The charts of 100 patients with infantile esotropia, seen over a 2-year period (September 1995 to September 1997), were reviewed. We identified those with at least 2.25 diopters (D) of hyperopia and determined the presence of large angle esotropia (> 30 to 40 prism diopters [delta]), amblyopia, inferior oblique overaction, dissociated vertical deviation, latent nystagmus, and cross-fixation. The success of antiaccommodative therapy, if attempted, was also evaluated. RESULTS: Of 100 patients with infantile esotropia, 15 (15%) were found to have at least +2.25 D. This represented 8% of all patients with accommodative esotropia seen over the same time period. The average age at initial examination was 21 months, although the reported age of onset in all cases was 6 months or less. Two had surgery before presenting to our institute. Eleven of 13 (84%) had 40 delta or less. Six (40%) of the 15 had amblyopia, 5 (33%) had inferior oblique overaction, 3 (20%) had dissociated vertical deviation, 1 (7%) had latent nystagmus, and 4 (27%) had cross-fixation. Of the 13, 7 were given glasses initially, with 3 being fully corrected. Six were not given glasses, all had surgery, and all were given glasses postoperatively for a residual esotropia. CONCLUSION: Fifteen percent of infantile esotropia patients and 8% of accommodative esotropia patients have infantile accommodative esotropia. Other characteristics of infantile esotropia may be present, but are less frequent, and at least 40% are fully corrected with spectacles indicating that when the hyperopia is 2.25 D or greater, antiaccommodative therapy should be instituted before surgery.

Accommodation, Ocular↗
PubMed2001

Common forms of childhood esotropia.

OBJECTIVE: To determine the most common forms of childhood esotropia. DESIGN: Prospective, consecutive, observational case series. PARTICIPANTS: All esotropic children younger than 11 years of age from a predominantly rural Appalachian region evaluated from August 1, 1995 through July 31, 1998. METHODS: Demographic and clinical data were collected for all patients. MAIN OUTCOME MEASURES: The percentage ratio of the various forms of childhood esotropia. RESULTS: Two hundred twenty-one consecutive children without prior surgical treatment were evaluated for esotropia. One hundred seventeen (52.9%) of the 221 children had some form of accommodative esotropia, 38 (17.2%) were associated with congenital or acquired abnormalities of the central nervous system, 23 (10.4%) displayed acquired nonaccommodative esotropia, 15 (6.8%) resulted from ocular sensory defects, 12 (5.4%) had confirmed congenital esotropia, seven (3.2%) had paralytic esotropia, and an unverified age at onset prevented an accurate categorization in the remaining nine (4.1%). CONCLUSIONS: Children with accommodative esotropia accounted for more than half of the study patients and were diagnosed nearly 10 times more frequently than children with congenital esotropia. Esotropic patients with central nervous system defects or with an acquired nonaccommodative deviation were also more common than children with congenital esotropia. Children with congenital esotropia or with a paralytic or sensory cause of their deviation were relatively uncommon.

Age of Onset↗
PubMed2001

Acquired nonaccommodative esotropia in childhood.

PURPOSE: Acquired nonaccommodative esotropia (ANAET) in childhood is reported to occur infrequently and is often associated with an underlying neurologic or neoplastic disorder. The primary objective of this study was to ascertain the prevalence and clinical characteristics of this form of childhood esotropia. METHODS: A cohort of all children younger than 11 years with esotropia from a predominantly rural Appalachian region was prospectively identified from August 1, 1995, through July 31, 1998. The age at onset, family history of strabismus, perinatal and medical history, ophthalmologic findings, and surgical results were reviewed for all patients with ANAET. RESULTS: Twenty-three (10.4%) of 221 consecutive children with esotropia were diagnosed with ANAET compared with 12 (5.4%) diagnosed with congenital esotropia. The median age at esotropia onset for the 23 children with ANAET was 31.4 months (range, 8-63 months) with a mean initial angle of esotropia of 24 PD. Although at least 2 children presented with diplopia, none of the 23 patients were known to have harbored intracranial tumors or other lesions of the central nervous system during the follow-up period. Fourteen of the 19 patients who underwent surgery attended follow-up visits for at least 6 months after their last surgical procedure: 13 were within 8 PD or less of orthotropia, whereas the final patient had persistent esotropia. Twelve of the 13 patients within 8 PD of orthotropia demonstrated some level of stereopsis, including 2 children with bifoveal fixation. Two (10.5 %) of the 19 operated patients later required a low hyperopic spectacle correction to control their deviation. CONCLUSIONS: ANAET was more prevalent than congenital esotropia in this cohort of children with esotropia. This clinically distinct form of strabismus typically begins between 1 and 5 years of age and appears to be infrequently associated with underlying disease. The angle of deviation is relatively small and early surgical correction is more likely to achieve bifoveal fixation for these patients than for those with congenital esotropia.

Accommodation, Ocular↗