SEARCH · PubMed Health

Results for “FACE”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 19 recordsLinked to original sources

PubMed2002

Synthetic faces, face cubes, and the geometry of face space.

To simplify the study of visual face processing, we introduce a novel class of synthetic face stimuli based upon 37 measurements (head shape, feature locations, etc.) extracted from individual face photographs in both frontal and 20 degrees side views. Synthetic faces are bandpass filtered optimally for face perception and include both line and edge information. Pilot experiments establish that subjects are extremely accurate in matching a synthetic face with the original grayscale photograph, even across views. To determine the perceptual metric of face space, we introduce face cubes in which the geometric differences between any faces in a four-dimensional face subspace can be precisely determined. Experiments on face discrimination using face cubes establish the metric of synthetic face space as locally Euclidean, with discrimination thresholds representing 4-6% total geometric variation (as a percent of mean head radius) between faces. Discrimination thresholds are lowest for face cubes constructed around the average face, thus indicating that the mean face for each gender represents a natural origin for face space. Finally, synthetic faces exhibit a pronounced inversion effect for 20 degrees side views and a characteristic "Thatcher effect" for inverted front views. Synthetic faces and face cubes thus provide a useful new quantitative approach to the study of face perception and face space.

Computer Simulation↗

PubMed1989

Electric brain potentials evoked by pictures of faces and non-faces: a search for "face-specific" EEG-potentials.

In three different experimental series, electroencephalographic responses evoked by changes in pictorial patterns were recorded in 29 adult human subjects (19 females, 10 males). Quantitative data evaluation for the evoked responses from electrodes T5, T6, Cz, Pz (10-20 system) was performed. The stimuli were projected to a 4 x 6 degree binocularly viewed field. The patterns changed within 6 ms every 2.5-4.5 s according to a random program. Paradigm (1): Identical line drawings of a face, a tree and a chair were used, either black on white (P-stimuli) or white on black (N-stimuli); in each set altogether 160 slides appeared in semi-random order. At Cz and Pz a prototypical EEG-response evoked by face stimuli was found exhibiting 3 prominent peaks, very similar for P-stimuli and N-stimuli. A P150 maximum was especially pronounced in the responses to face stimuli but absent in the evoked potentials aroused by chair or tree stimuli. The difference curves (face-chair, face-tree, chair-tree) supported the hypothesis of "face-responsive" components in these responses. Paradigm (2): 4 x 6 degree slides (black and white photographs) of 54 different human faces, 53 different vases and 53 different pairs of shoes were projected as in paradigm (1), but instruction to the subjects on a supposed post-test memory task raised their attention during the recordings. "Face-responsive" components (an early N 140-160, P 210-240, N 300) were more marked in female than in male subjects, and again most pronounced at electrode Cz. Paradigm (3): When a recognition task was included in paradigm (2)--9 out of 192 items were memorized 20 minutes before the recording session--essentially the same evoked potentials were obtained as in (2), but an additional late positive wave (450-600 ms) appeared in the responses to all stimuli. We assume that the "face-specific" components--a designation which is used cautiously considering the limited number of non-face stimuli--do not originate in the temporo-occipital cortical face region, but in limbic structures (amygdala, hippocampus) deep in the temporal lobe or in the gyrus cinguli. In the present study no significant hemispheric differences (T5, T6) in the evoked responses were found (all stimulus categories), but such differences are known to appear with highly schematic face stimuli.

Adult↗

PubMed2003

Role of face-to-face and edge-to-face aromatic interactions in the inclusion complexation of cyclobis(paraquat-p-phenylene): a theoretical study.

A B3LYP/6-31G(d,p) and MP2/6-31G(d,p)//B3LYP/6-31G(d,p) computational study of the gas-phase complexation of cyclobis(paraquat-p-phenylene) (1(4+)) with four typical aromatic guests, namely, 1,4-dimethoxybenzene (2), 1,5-dimethoxynaphthalene (3), benzidine (4), and tetrathiafulvalene (5), has been carried out. The structure of the host has been successively split into two responsible substructures, respectively, for the face-to-face and edge-to-face interactions with the guests. The sum of the two interactions calculated at the B3LYP/6-31G(d,p) and MP2/6-31G(d,p)//B3LYP/6-31G(d,p) levels for each guest proved to be in good agreement with the overall binding energy of the host calculated at the corresponding level of theory. The results show that the binding of the complexes is primarily due to London dispersion interactions which require wave function-based correlation methods for an adequate description. Face-to-face interactions are about 1 order of magnitude more important than edge-to-face interactions in determining the overall binding energy. While edge-to-face interactions essentially depend on London dispersion forces, face-to-face interactions depend about one-half on electrostatic and frontier orbital contributions (the latter being more important) and the other half on London dispersion forces.

Journal Article↗

PubMedDate not supplied

Electrophysiological studies of human face perception. I: Potentials generated in occipitotemporal cortex by face and non-face stimuli.

This and the following two papers describe event-related potentials (ERPs) evoked by visual stimuli in 98 patients in whom electrodes were placed directly upon the cortical surface to monitor medically intractable seizures. Patients viewed pictures of faces, scrambled faces, letter-strings, number-strings, and animate and inanimate objects. This paper describes ERPs generated in striate and peristriate cortex, evoked by faces, and evoked by sinusoidal gratings, objects and letter-strings. Short-latency ERPs generated in striate and peristriate cortex were sensitive to elementary stimulus features such as luminance. Three types of face-specific ERPs were found: (i) a surface-negative potential with a peak latency of approximately 200 ms (N200) recorded from ventral occipitotemporal cortex, (ii) a lateral surface N200 recorded primarily from the middle temporal gyrus, and (iii) a late positive potential (P350) recorded from posterior ventral occipitotemporal, posterior lateral temporal and anterior ventral temporal cortex. Face-specific N200s were preceded by P150 and followed by P290 and N700 ERPs. N200 reflects initial face-specific processing, while P290, N700 and P350 reflect later face processing at or near N200 sites and in anterior ventral temporal cortex. Face-specific N200 amplitude was not significantly different in males and females, in the normal and abnormal hemisphere, or in the right and left hemisphere. However, cortical patches generating ventral face-specific N200s were larger in the right hemisphere. Other cortical patches in the same region of extrastriate cortex generated grating-sensitive N180s and object-specific or letter-string-specific N200s, suggesting that the human ventral object recognition system is segregated into functionally discrete regions.

Adolescent↗

PubMed2000

Categorical perception occurs in newly learned faces, other-race faces, and inverted faces.

On the basis of findings that categorical perception (CP) is possible in complex visual stimuli such as faces, the present study tested for CP on continua between unfamiliar face pairs. Results indicate that CP can be observed for unfamiliar faces, in both familiar (same-race) and unfamiliar (other-race) groups. In addition, significant CP effects were observed in inverted faces. Finally, half-continua were tested where midpoint stimuli became endpoints. This was done to ensure that stimulus artifacts did not account for the observed CP effects. Consistent with the perceptual rescaling associated with CP, half-continua showed a rescaled CP effect. We argue that these CP effects are based on the rapid acquisition of perceptual equivalence classes.

Adult↗

PubMed1993

Cooperative face-to-face and edge-to-face aromatic interactions of tryptophan indole ring with N7-quarternized guanine and neutral cytosine bases.

In order to investigate the effect of cytosine base upon the stacking interaction of N7-quarternized guanine base with tryptophan indole ring, the X-ray crystal structure of a 1:1 complex of model compounds 1 and 2 was carried out. Contrary to the expectation of the interaction of both molecules in aqueous solution, the crystal structure showed the first example of the simultaneous recognition of the Trp indole ring by guanine and cytosine bases by the coupling of the face-to-face and edge-to-face aromatic interactions, respectively.

Cytosine↗

PubMed2002

An electrochemically controllable nanomechanical molecular system utilizing edge-to-face and face-to-face aromatic interactions.

[formula: see text] A new molecular system, 2,11-dithio[4,4]metametaquinocyclophane containing a quinone moiety, was designed and synthesized. As the quinone moiety can readily be converted into an aromatic pi-system (hydroquinone) upon reduction, the nanomechanical molecular cyclophane system exhibits a large flapping motion like a molecular flipper from the electrochemical redox process. The conformational changes upon reduction and oxidation are caused by changes of nonbonding interaction forces (devoid of bond formation/breaking) from the edge-to-face to face-to-face aromatic interactions and vice versa, respectively.

Journal Article↗

PubMed1999

Theoretical Study of the Conformations and Strain Energies of [n,n]Metaparacyclophanes: Indication of Stable Edge-to-Face and Displaced Face-to-Face Conformers for n = 4.

We have studied [n,n]metaparacyclophanes-model compounds exhibiting edge-to-face and displaced stacked aromatic-aromatic interactions-using semiempirical calculations for n = 2-5 and ab initio calculations for n = 2-4. For n = 2 and 3, the strain energies govern the conformational preference, while for n = 4 and 5 the aromatic-aromatic and strain energies are equally important. The 3,12-dithio[4,4]metaparacyclophanes exhibit edge-to-face aromatic-aromatic intereactions, while the [4,4]metaparacyclophanes and 2,11-dithio[4,4]metaparacyclophanes exhibit displaced stacked aromatic-aromatic interactions.

Journal Article↗

PubMed2000

Effects of face inversion on the structural encoding and recognition of faces. Evidence from event-related brain potentials.

It was investigated how face inversion affects face-specific components of event-related brain potentials (ERPs) which are assumed to reflect the structural encoding and the recognition of faces. ERPs were recorded to upright and inverted photographs of familiar faces, unfamiliar faces, and houses. In Part I, participants had to detect infrequently presented targets (hands), in Part II, attention was either directed towards or away from the pictorial stimuli. When compared with upright unfamiliar faces, upright familiar faces elicited an enhanced negativity between 300 ms and 450 ms ('N400f') and an enhanced positivity between 450 and 650 ms post-stimulus ('P600f'). It is suggested that these ERP modulations are generated by processes involved in the recognition of faces. Face inversion is known to disrupt face recognition processes. Accordingly, 'N400f' and 'P600f' were generally absent in response to inverted familiar and unfamiliar faces. The face-specific N170 component at lateral posterior electrodes was not affected by face familiarity, indicating that it reflects processing stages prior to face identification. N170 was delayed and enhanced for inverted relative to upright faces. While N170 enhancements were also observed for inverted relative to upright houses, the N170 latency shift caused by stimulus inversion was face-specific. Directing attention away from the faces towards a demanding primary visual task resulted in an N170 delay for inverted as well as for upright faces, suggesting that the time course of structural encoding of faces is affected by attentional factors. These results demonstrate that ERPs can be used as electrophysiological markers of specialised brain processes underlying the structural encoding and subsequent recognition of faces.

Adolescent↗

PubMed2001

How does the brain discriminate familiar and unfamiliar faces?: a PET study of face categorical perception.

Where and how does the brain discriminate familiar and unfamiliar faces? This question has not been answered yet by neuroimaging studies partly because different tasks were performed on familiar and unfamiliar faces, or because familiar faces were associated with semantic and lexical information. Here eight subjects were trained during 3 days with a set of 30 faces. The familiarized faces were morphed with unfamiliar faces. Presented with continua of unfamiliar and familiar faces in a pilot experiment, a group of eight subjects presented a categorical perception of face familiarity: there was a sharp boundary in percentage of familiarity decisions between 40% and 60% faces. In the main experiment, subjects were scanned (PET) on the fourth day (after 3 days of training) in six conditions, all requiring a sex classification task. Completely novel faces (0%) were presented in Condition 1 and familiar faces (100%) in Condition 6, while faces of steps of 20% in the continuum of familiarity were presented in Conditions 2 to 5 (20% to 80%). A principal component analysis (PCA) indicated that most variations in neural responses were related to the dissociation between faces perceived as familiar (60% to 100%) and faces perceived as unfamiliar (0 to 40%). Subtraction analyses did not disclose any increase of activation for faces perceived as familiar while there were large relative increases for faces perceived as unfamiliar in several regions of the right occipito-temporal visual pathway. These changes were all categorical and were observed mainly in the right middle occipital gyrus, the right posterior fusiform gyrus, and the right inferotemporal cortex. These results show that (1) the discrimination between familiar and unfamiliar faces is related to relative increases in the right ventral pathway to unfamiliar/novel faces; (2) familiar and unfamiliar faces are discriminated in an all-or-none fashion rather than proportionally to their resemblance to stored representations; and (3) categorical perception of faces is associated with abrupt changes of brain activity in the regions that discriminate the two extremes of the multidimensional continuum.

Adult↗

PubMedDate not supplied

Electrophysiological studies of human face perception. II: Response properties of face-specific potentials generated in occipitotemporal cortex.

In the previous paper the locations and basic response properties of N200 and other face-specific event-related potentials (ERPs) were described. In this paper responsiveness of N200 and related ERPs to the perceptual features of faces and other images was assessed. N200 amplitude did not vary substantially, whether evoked by colored or grayscale faces; normal, blurred or line-drawing faces; or by faces of different sizes. Human hands evoked small N200s at face-specific sites, but evoked hand-specific ERPs at other sites. Cat and dog faces evoked N200s that were 73% as large as to human faces. Hemifield stimulation demonstrated that the right hemisphere is better at processing information about upright faces and transferring it to the left hemisphere, whereas the left hemisphere is better at processing information about inverted faces and transferring it to the right hemisphere. N200 amplitude was largest to full faces and decreased progressively to eyes, face contours, lips and noses viewed in isolation. A region just lateral to face-specific N200 sites was more responsive to internal face parts than to faces, and some sites in ventral occipitotemporal cortex were face-part-specific. Faces with eyes averted or closed evoked larger N200s than those evoked by faces with eyes forward. N200 amplitude and latency were affected by the joint effects of eye and head position in the right but not in the left hemisphere. Full and three-quarter views of faces evoked larger N200s than did profile views. The results are discussed in relation to behavioral studies in humans and single-cell recordings in monkeys.

Animals↗

PubMedDate not supplied

Deep-plane face-lift vs superficial musculoaponeurotic system plication face-lift: a comparative study.

OBJECTIVE: To evaluate deep-plane face-lift vs superficial musculoaponeurotic system (SMAS) plication face-lift in correcting the melolabial fold, jowl, and cheek areas of the face in short-term follow-up. DESIGN: Masked, randomized review by 4 board-certified facial plastic surgeons experienced in rhytidectomy of full-face (frontal, oblique, and lateral views) before-and-after photographs of 20 patients who underwent deep-plane face-lift and 20 who underwent SMAS plication face-lift. Participants rated the melolabial fold, jowl, and cheek areas for overall correction of the deformities pertaining to the aesthetic results for deep-plane vs SMAS plication face-lift. Categories were excellent, good, average, acceptable, and poor. RESULTS: Three categories of results were determined: best, average, and poorest. Overall, SMAS plication face-lifts scored higher than deep-plane face-lifts. In the best category, there were more SMAS plication face-lifts. In the average category, there were more deep-plane face-lifts. In the poorest category, there were equal numbers of deep-plane and SMAS face-lifts. Patients were divided into the following age groups: 50 to 59, 60 to 69, and 70 to 80 years. In the 2 younger groups, SMAS face-lifts scored higher than deep-plane face-lifts. In the oldest group, deep-plane face-lifts scored slightly higher than SMAS face-lifts. CONCLUSION: Deep-plane face-lift does not seem to offer superior results over SMAS plication face-lift in patients younger than 70 years.

Aged↗

PubMedDate not supplied

Electrophysiological studies of human face perception. III: Effects of top-down processing on face-specific potentials.

This is the last in a series of papers dealing with intracranial event-related potential (ERP) correlates of face perception. Here we describe the results of manipulations that may exert top-down influences on face recognition and face-specific ERPs, and the effects of cortical stimulation at face-specific sites. Ventral face-specific N200 was not evoked by affective stimuli; showed little or no habituation; was not affected by the familiarity or unfamiliarity of faces; showed no semantic priming; and was not affected by face-name learning or identification. P290 and N700 were affected by semantic priming and by face-name learning and identification. The early fraction of N700 and face-specific P350 exhibited significant habituation. About half of the AP350 sites exhibited semantic priming, whereas the VP350 and LP350 sites did not. Cortical stimulation evoked a transient inability to name familiar faces or evoked face-related hallucinations at two-thirds of face-specific N200 sites. These results are discussed in relation to human behavioral studies and monkey single-cell recordings. Discussion of results of all three papers concludes that: face-specific N200 reflects the operation of a module specialized for the perception of human faces; ventral and lateral occipitotemporal cortex are composed of a complex mosaic of functionally discrete patches of cortex of variable number, size and location; in ventral cortex there is a posterior-to-anterior trend in the location of patches in the order letter-strings, form, hands, objects, faces and face parts; P290 and N700 at face-specific N200 sites, and face-specific P350, are subject to top-down influences.

Arousal↗

PubMed2003

Is the N170 for faces cognitively penetrable? Evidence from repetition priming of Mooney faces of familiar and unfamiliar persons.

Impoverished images of faces, two-tone Mooney faces, severely impair the ability to recognize to whom the face pertains. However, previously seeing the corresponding face in a clear format helps fame-judgments to Mooney faces. In the present experiment, we sought to demonstrate that enhancement in the perceptual encoding of Mooney faces results from top-down effects, due to previous activation of familiar face representation. Event-related potentials (ERPs) were obtained for target Mooney images of familiar and unfamiliar faces preceded by clear pictures portraying either the same photo (same photo prime), or a different photo of the same person (different photo prime) or a new unfamiliar face (no-prime). In agreement with previous findings the use of primes was effective in enhancing the recognition of familiar faces in Mooney images; this priming effect was larger in the same than in different photo priming condition. ERP data revealed that the amplitude of the N170 face-sensitive component was smaller when elicited by familiar than by unfamiliar face targets, and for familiar face targets primed by the same than by different photos (a graded priming effect). Because the priming effect was restricted to familiar faces and occurred at the peak of the N170, we suggest that the early perceptual stage of face processing is likely to be penetrable by the top-down effect due to the activation of face representations within the face recognition system.

Adult↗

PubMed2003

The functionally defined right occipital and fusiform "face areas" discriminate novel from visually familiar faces.

Neuroimaging (PET and fMRI) studies have identified a set of brain areas responding more to faces than to other object categories in the visual extrastriate cortex of humans. This network includes the middle lateral fusiform gyrus (the fusiform face area, or FFA) as well as the inferior occipital gyrus (occipital face area, OFA). The exact functions of these areas in face processing remain unclear although it has been argued that their primary function is to distinguish faces from nonface object categories-"face detection"-or also to discriminate among faces, irrespective of their visual familiarity to the observer. Here, we combined the data from two previous positron emission tomography (PET) studies to show that the functionally defined face areas are involved in the automatic discrimination between unfamiliar faces and familiar faces. Consistent with previous studies, a face localizer contrast (faces-objects) revealed bilateral activation in the middle lateral fusiform gyrus (FFA, BA37) and in the right inferior occipital cortex (OFA, BA19). Within all the regions of the right hemisphere, larger levels of activation were found for unfamiliar as compared to familiar faces. These results suggest that the very same areas involved in categorizing faces at the basic or individual level, play a role in differentiating familiar faces from new faces, showing an overlap between visual and presemantic mnesic representations of faces in the right hemisphere.

Adult↗

PubMed2003

Face versus non-face object perception and the 'other-race' effect: a spatio-temporal event-related potential study.

OBJECTIVE: To investigate a modulation of the N170 face-sensitive component related to the perception of other-race (OR) and same-race (SR) faces, as well as differences in face and non-face object processing, by combining different methods of event-related potential (ERP) signal analysis. METHODS: Sixty-two channel ERPs were recorded in 12 Caucasian subjects presented with Caucasian and Asian faces along with non-face objects. Surface data were submitted to classical waveforms and ERP map topography analysis. Underlying brain sources were estimated with two inverse solutions (BESA and LORETA). RESULTS: The N170 face component was identical for both race faces. This component and its topography revealed a face specific pattern regardless of race. However, in this time period OR faces evoked significantly stronger medial occipital activity than SR faces. Moreover, in terms of maps, at around 170 ms face-specific activity significantly preceded non-face object activity by 25 ms. These ERP maps were followed by similar activation patterns across conditions around 190-300 ms, most likely reflecting the activation of visually derived semantic information. CONCLUSIONS: The N170 was not sensitive to the race of the faces. However, a possible pre-attentive process associated to the relatively stronger unfamiliarity for OR faces was found in medial occipital area. Moreover, our data provide further information on the time-course of face and non-face object processing.

Adult↗

PubMed2003

Neural correlates of the left-visual-field superiority in face perception appear at multiple stages of face processing.

Studies in healthy individuals and split-brain patients have shown that the representation of facial information from the left visual field (LVF) is better than the representation of facial information from the right visual field (RVF). To investigate the neurophysiological basis of this LVF superiority in face perception, we recorded event-related potentials (ERPs) to centrally presented face stimuli in which relevant facial information is present bilaterally (B faces) or only in the left (L faces) or the right (R faces) visual field. Behavioral findings showed best performance for B faces and, in line with the LVF superiority, better performance for L than R faces. Evoked potentials to B, L, and R faces at 100- to 150-msec poststimulus showed no evidence of asymmetric transfer of information between the hemispheres at early stages of visual processing, suggesting that this factor is not responsible for the LVF superiority. Neural correlates of the LVF superiority, however, were manifested in a shorter latency of the face-specific N170 component to L than R faces and in a larger amplitude to L than R faces at 220-280 and 400-600 msec over both hemispheres. These ERP amplitude differences between L and R faces covaried across subjects with the extent to which the face-specific N170 component was larger over the right than the left hemisphere. We conclude that the two hemispheres exchange information symmetrically at early stages of face processing and together generate a shared facial representation, which is better when facial information is directly presented to the right hemisphere (RH; L faces) than to the left hemisphere (LH; R faces) and best when both hemispheres receive facial information (B faces).

Adult↗

PubMed2002

Effects of reversible cold block of face primary somatosensory cortex on orofacial movements and related face primary motor cortex neuronal activity.

Our previous studies have revealed that face primary somatosensory cortex (SI) as well as face primary motor cortex (MI) play important roles in the control of orofacial movements in awake monkeys, and that both face MI and face SI neurons may have an orofacial mechanoreceptive field and show activity related to orofacial movements. Since it is possible that the movement-related activity of face MI neurons could reflect movement-generated orofacial afferent inputs projecting to face MI via face SI, the present study used reversible cold block-induced inactivation of the monkey's face SI to determine if face MI neuronal activity related to a trained tongue-protrusion task, chewing or swallowing was dependent on the functional integrity of the ipsilateral face SI and if inactivation of face SI affects orofacial movements. The effects of face SI cold block were tested on chewing, swallowing and/or task-related activity of 73 face MI neurons. Both task and chewing and/or swallowing-related activity of most face MI neurons was independent of the functional integrity of the ipsilateral face SI since SI cold block affected the movement-related activity in approximately 25% of the neurons. Similarly, unilateral cold block of SI had very limited effects on the performance of the task and chewing, and no effect on the performance of swallowing. These findings suggest that movement-induced reafferentation via face SI may not be a significant factor in accounting for the activity of the majority of ipsilateral face MI neurons related to trained movements, chewing and swallowing.

Animals↗