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At least 19 recordsLinked to original sources
PubMed1982

Long-term reproducibility of the intravenous fat tolerance test.

The reproducibility of the intravenous fat tolerance test (IVFTT) with Intralipid was studied in 26 healthy volunteers, in whom the test was repeated after 5-9.5 years (mean interval 6.5 years). Mean body mass, IVFTT fractional removal rate and serum TG (triglyceride) concentration were not significantly changed with time, whereas a slight increase of the serum cholesterol concentration from 5.09 +/- 0.12 to 5.54 +/- 0.19 mmol/1 (P less than 0.05) was found. The coefficient of variation intra-individually for the IVFTT k2 value was 16%. The corresponding figure for the serum TG concentration was 29%. The results suggest that the IVFTT might be a useful tool in long-term evaluation of serum TG abnormalities.

Adult↗
PubMed1980

Evaluation of the intravenous fat tolerance test in chronic renal disease.

The intravenous fat tolerance test (IVFTT) was performed on 17 controls, 25 patients with non dialyzed, non nephrotic chronic renal failure and 32 patients on hemodialysis. The fractional removal rate of triglyceride (K2) from plasma is decreased to the same degree in renal disease whether treated by hemodialysis or not. There was an inverse relationship between K2 and both serum triglyceride and fasting blood sugar, which were significantly increased compared to controls. The IVFTT also separated patients with renal disease and hypertriglyceridemia into two groups. One, where there was a low K2, suggesting that defective clearance of triglyceride was the major etiological factor in the hypertriglyceridemia and two, those patients with a normal K2 value, where other factors appear to be more important.

Adolescent↗
PubMed2000

The Pro12Ala polymorphism in the peroxisome proliferator-activated receptor gamma2 gene is not associated with postprandial responses to glucose or fat tolerance tests in young healthy subjects: the European Atherosclerosis Research Study II.

This study investigated whether the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor gamma2 (PPARgamma2) gene is associated with glucose and lipid metabolism in young healthy subjects participating in the European Atherosclerosis Research Study II. Men aged 18-28 years (n=675) were recruited from 14 university student populations in 11 European countries. At their first visit subjects had an oral glucose tolerance test and 1 week later an oral fat tolerance test. Lipid variables and genotype were measured centrally. The Ala allele frequency exhibited a clearcut north-to-south gradient through Europe, decreasing from 0.21 in Baltic countries to 0.07 in Mediterranean countries. There was no significant effect of the Pro12Ala polymorphism on fasting lipid, glucose, or insulin levels, nor on the postprandial changes in these variables after glucose and fat tolerance tests. Neither was the Pro12Ala polymorphism associated with body mass index. This study provides no evidence for a major effect of the Pro12Ala polymorphism on glucose and lipid metabolism in young healthy subjects. Since PPARgamma has a major role in adipogenesis, the differential effect of its polymorphism on weight and related metabolic disorders may become apparent only later in life.

Adolescent↗
PubMed1976

Intravenous fat-tolerance test in ischaemic heart disease and peripheral vascular disease.

1. The intravenous fat-tolerance test and serum lipid and lipoprotein measurements were carried out in ninety-three normal subjects, fifty-one patients with ischaemic heart disease and thirty patients with peripheral vascular disease. 2. The fractional turnover rate of exogenous triglyceride was significantly slower in patients with ischaemic heart disease and in patients with peripheral vascular disease than in normal men. The rate was also slower in normal men than normal women. 3. Serum triglyceride and cholesterol concentrations were higher in both vascular disease groups than in control subjects. 4. The proportion of both groups of patients who had a subnormal fractional turnover rate of exogenous triglyceride was 35%, and 32% of patients had hypertriglyceridaemia in the fasting state; 27% of patients were hypercholesterolaemic. 5. Although the intravenous fat-tolerance test did not provide significantly better discrimination between cardiovascular patients and control subjects than did measurement of serum triglyceride, the results suggest that hypertriglyceridaemia in such patients may be separable into a group in which impaired triglyceride clearance may be partly responsible, and a group in which overproduction of serum triglyceride may be the major mechanism of the hyperlipidaemia.

Adult↗
PubMedDate not supplied

[Oral fat tolerance test in obese patients].

19 adipose patients, 10 of them women, underwent an oral fat tolerance test with circa 50 g triglycerides. Before the loading test as well as 2 and 4 hours after it the serum lipids were determined. While in the cholesterol components (including the index of arteriosclerosis) no significant shiftings were the result, after 2 hours in the triglycerides a significant increase (p less than 0.05) by 21% from 1.62 +/- 0.76 to 1.96 +/- 0.91 mmol/l could be stated. The further increase after 4 hours by 10% was not significant. A standardized fat tolerance test concerning the triglycerides is apparently better suited for the estimation of the atherogenic risk than the determination of the fasting value alone.-By an additional determination of LPL and insulin as key enzyme and hormone, respectively, probably better statements could be made, which under equal conditions explain the interindividual differences of adipose persons in weight gain and weight reduction.

Adult↗
PubMed1982

Intravenous fat tolerance test with Intralipid in chronic renal failure.

The intravenous fat tolerance test with Intralipid has been used to evaluate the triglyceride (TG) removal capacity in 34 male patients with varying degree of chronic renal failure (CRF). The investigations were repeated in 10 patients after 2-3 years when the renal function had deteriorated further. The fractional removal rate of Intralipid (k2) was low compared to controls, regardless of degree of renal function, etiology of renal disease or treatment with antihypertensive drugs. The k2 value did not change in patients investigated twice, although there was a considerable decrease in renal function. Both in patients and controls there was a strong negative correlation between k2 and the very low density lipoprotein (VLDL) TG concentration. However, at the same k2 value, the VLDL TG concentration was higher in patients than in controls. These data suggest that the hypertriglyceridemia commonly seen in patients with CRF is caused both by an increased VLDL production and a decreased VLDL removal from the circulation. Furthermore, these changes in TG metabolism are induced early in the course of renal insufficiency.

Fat Emulsions, Intravenous↗
PubMed1981

[The intravenous fat tolerance test in patients with peripheral arteriosclerotic disorders of the blood supply].

Latent metabolic disturbances become evident only by specific loads. As functional test of the fat metabolism the intravenous fat tolerance test is suited in which after an injection of 0.1 g fat/kg body weight via the decreasing plasma turbidity the degradation rate K2 (%/min) may be calculated. In 29 patients with peripheral arteriosclerotic disturbances of the blood supply we did not find any changed degradation rates in comparison to 29 reference persons, so that a disturbance of the clarification system is not to be supposed in these patients. It is reported on the behaviour of other metabolic parameters. At the same time by the slight changes in the intermediary metabolism after fat injection the good tolerability of the emulsion of soya bean oil lipofundin S which is known from clinical experience is supported.

Arterial Occlusive Diseases↗
PubMedDate not supplied

Elimination of lipofundin S during the intravenous fat tolerance test in patients with low, medium, and high fasting triglyceride concentrations.

The intravenous fat tolerance test with Lipofundin S (0.5 ml of 20% emulsion/kg body weight) was performed in 22 male nondiabetic patients. According to their fasting triglycerides (TG), the patients were arranged into three groups: low (less than 2.8 mmol/liter), medium (2.8-5.7 mmol/liter), and high (greater than 5.7 mmol/liter) concentrations. Fractional elimination rates of injected Lipofundin S decreased from 11.08 in low TG to 4.57%/min in high TG; they were positively correlated with fasting levels of high-density lipoprotein cholesterol but negatively with those of TG. The same pattern of correlations was observed with fractional catabolic rates of endogenous TG as measured after injection of tritium-labeled glycerol. The intravenous Lipofundin S load effected transient TG and free fatty acid elevations which were delayed in high TG. The elimination mechanisms of injected Lipofundin S and of endogenous TG are compared.

Adult↗
PubMed1979

A simple method for the intravenous fat-tolerance test.

A simple method for measuring intravenous fat tolerance with an artificial fat emulsion (intralipid) was studied and compared with the currently used method of Carlson and Rossner [J. Lab. Invest. 29, 271-280 (1972)]. The proposed method uses as little as 3 mL of whole blood to follow, by nephelometry, the elimination of intravenously administered fat emulsions. There is a high correlation between the K2 values obtained by the current method for plasma and those obtained by the proposed method (r = 0.903). The latter is simpler, quicker, and more acceptable to patients.

Adult↗
PubMed1984

Relationship between lipoproteins including HDL subfractions and the intravenous fat tolerance test.

There is a positive relationship between the HDL cholesterol concentration and the fractional removal rate k2 of intravenously administered Intralipid, the intravenous fat tolerance test (IVFTT). This relationship was analysed in 22 female and 20 male healthy normolipoproteinaemic volunteers with regard to HDL subfractions. A positive correlation between the IVFTT k2 value and HDL cholesterol (r = 0.40, P less than 0.05) was confirmed. The k2-HDL2 cholesterol relationship was strong and positive (r = 0.56, P less than 0.001), whereas the correlation between HDL3 cholesterol and k2 was negative (r = -0.37, P less than 0.05). These findings extend other observations indicating that HDL2 seems to be the HDL fraction, directly associated with removal of TG-rich particles from the circulation.

Adult↗
PubMed1995

Use of oral and intravenous fat tolerance tests to assess plasma chylomicron clearance in dogs.

The reduced clearance of chylomicrons from plasma results in an exaggerated post prandial lipaemia and fasting hypertriglyceridaemia. This study evaluated whether oral and intravenous fat tolerance tests are appropriate for the in vivo analysis of chylomicron clearance in dogs. Plasma and chylomicron triglyceride concentrations were measured in eight beagles after the administration of a cream-based meal of 2.35 g fat kg-1 bodyweight. The changes in each parameter were determined chiefly by the activity of lipoprotein lipase, which was measured in plasma collected after the intravenous injection of heparin and did not appear to be influenced by intestinal fat absorption. The inclusion of retinyl palmitate in the meal provided additional information on the metabolic fate of chylomicron remnants. After the intravenous injection of 0.1 g Intralipid kg-1 bodyweight, there was an initial linear decay in plasma triglyceride concentrations that represented the maximal elimination rate K1. This was followed by a second exponential component so that the plasma triglyceride concentration returned to baseline by 60 minutes. Lipoprotein lipase was the major determinant of K1 and the area under the curve of plasma triglycerides.

Administration, Oral↗
PubMed1999

[Postprandial lipemia as an atherosclerotic risk factor and fat tolerance test].

Most of our lives are spent in the postprandial state, during which vessel walls are exposed to triglyceride rich lipoproteins-namely, chylomicron and chylomicron remnants. Recent studies showed that coronary artery disease patients even with normal fasting lipid levels had higher concentrations of postprandial lipoproteins than patients without coronary artery disease. Postprandial lipoprotein responses are influenced by various factors such as the postabsorptive concentrations of plasma triglycerides, lipoprotein lipase activity, polymorphisms of apolipoprotein B and apolipoprotein E, dietary fatty acid contents. Oral fat tolerance test is performed to see the postprandial lipoprotein responses. Triglycerides, apolipoprotein B, retinyl-palmitate and remnant like particles in plasma and subfractionated triglyceride rich lipoproteins are measured.

Adult↗
PubMed2000

Postprandial response to a fat tolerance test in young adults with a paternal history of premature coronary heart disease - the EARS II study (European Atherosclerosis Research Study).

BACKGROUND: The European Atherosclerosis Research Study (EARS) I had shown that fasting plasma concentrations of apolipoprotein B (apo B) and triglycerides were the most discriminant variables between offspring with a paternal history of coronary heart disease (CHD) and controls. The EARS II study was undertaken to investigate whether a paternal history of CHD was associated with differences in postprandial lipemia. DESIGN: Male subjects with a paternal history of CHD (cases, n = 407) and age-matched male controls (n = 415) were recruited from 14 European universities. All subjects had an oral fat tolerance test. RESULTS: In the sample as a whole, the postprandial triglyceride responses did not significantly differ between the two groups. However, in the upper tertile of fasting triglycerides, cases displayed a higher area under the curve (5.71 vs. 4.49 mmol.h L-1, P < 0.001), a higher peak (1.76 vs. 1.43 mmol L-1, P < 0.001) and a more delayed time to peak (3.15 vs. 2.91 h, P < 0.05) than controls. In the upper tertile, fasting apo B levels (P < 0.05) and triglyceride area under the curve (P = 0.002) significantly discriminated cases from controls in a multivariate analysis. Cases had also higher Lp C-III:B levels at 4 h than controls (11.2 vs. 9.9 mg dL-1, P < 0.01) and this difference remained significant after adjustment for apo B and triglyceride levels. CONCLUSIONS: These results indicate that in subjects with a moderate elevation of fasting triglycerides, an impaired postprandial response to a fat load constitutes an early biological expression of a paternal history of premature CHD.

Administration, Oral↗