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[Developmental studies on the foramen rotundum, foramen ovale and foramen spinosum of the human sphenoid bone].

For the purpose of these studies 111 cases of the fetus skulls, 25 cases of the juvenile skulls and 220 cases of the adult skulls were used and the following results were obtained; 1. The perfect ring-shaped formation of the foramen rotundum is observed in all cases of the fetuses after the 4th fetal month. The earliest perfect ring-shaped formation of the foramen ovale is observed in the 7th fetal month and the latest in 3 years after birth. The earliest perfect ring-shaped formation of the foramen spinosum is observed in the 8th month after birth and the latest in 7 years after birth. 2. The foramen rotundum is mostly oval-shaped in the fetal period and it is round-shaped in general after birth. The majority of the foramen ovale is oval-shaped and it is irregular in shape compared with the rest of two types of foramina. The majority of the foramen spinosum is round in shape. 3. The average diameter of the foramen rotundum is 3.55 mm in the adult. The average maximal length of the foramen ovale is 7.48 mm and its average minimal length is 4.17 mm in the adult. The average diameter of the foramen spinosum is 2.63 mm in the adult. The differences between the right and left and the sexual differences fail to be observed in all types of foramina.

Adolescent↗

Morphology of the temporal canal and postglenoid foramen with reference to the size of the jugular foramen in man and selected species of animals.

The jugular foramen and postglenoid foramen are the main venous foramina of the skull of placental mammals. Their mutual relations are closely related to the development of the internal and external jugular vein, depending on the given kind. On the basis of measuring studies, it was decided to investigate the relations of the size of these foramina and to quantitatively determine which of them prevails. The studies were performed with macerated human and animal skulls. Altogether 100 skulls of human adults of both sexes, 100 of macaccas, 67 of bisons, 25 of mongrel dogs, 37 of foxes and 25 of rats were examined. The jugular foramen was the outlet of the sigmoid sinus or its equivalents and the postglenoid foramen--the petrosquamous or temporal canal. The jugular foramen was always singular and characterised by a small variability in the morphology, consisting only in the occurrence of the internal division or its lack. The postglenoid foramen, on the other hand, in the majority of the studied kinds was variable and numerous. The number of foramina ranged from 1 in man to 7-10 in bisons. In the course of measurements, it was found that the area of the postglenoid foramen in relation to the area of the jugular foramen is 0.87% in man, 24% in macaccas, 30.7% in dogs, 34.4% in foxes, 53.9% in rats and 248.5% in bisons. The results obtained indicate that in bisons the system of venous sinuses, connected with the postglenoid foramina, has a decisive significance for the drainage of the cranial cavity. In contrast, the postglenoid foramen in man has a marginal significance. The remaining kinds, whose skulls have been investigated, occupy on that score an intermediate position.

Animals↗

Measurement of the local pressure of the intervertebral foramen and the electrophysiologic values of the spinal nerve roots in the vertebral foramen.

STUDY DESIGN: The intraoperative findings of the local pressure of the intervertebral foramen and the electrophysiologic values of the spinal nerve roots were evaluated. OBJECTIVE: To investigate the neurophysiologic changes of the spinal nerve roots in the vertebral foramen. SUMMARY OF BACKGROUND DATA: As far as we know, few reports have so far described the neurophysiologic changes of the spinal nerve roots in the vertebral foramen. METHODS: The local pressure of the intervertebral foramen was continuously measured while the lumbar spine posture was changed in 66 vertebral foramens. In addition, 20 L5 nerve roots were electrophysiologically evaluated using the compound muscle action potentials (CMAPs) from tibialis anterior (TA) muscle after L5 nerve root stimulation. RESULTS: The local pressure of the intervertebral foramen was significantly increased during lumbar spine extension (P < 0.001); moreover, the latency and amplitude of the CMAPs both significantly deteriorated in line with the increasing local pressure. CONCLUSIONS: Our findings suggested that a double compression of the nerve root exists in lumbar spinal stenosis with lumbar spine extension, which includes the spinal canal and the vertebral foramen.

Action Potentials↗

The mandibular lingual foramen: a consistent arterial foramen in the middle of the mandible.

The lingual foramen in the midline of the mandible causes confusion in terminology, incidence of occurrence and contents. A survey of 314 dried mandibles showed the foramen to be present in 311 specimens (99.04%). Sectioning of cadaver specimens illustrated a canal traversing the bone to approximately 50% of the buccolingual dimension of the mandible. The contents of the foramen were found to be an artery, which was an anastomosis of the sublingual branches of the right and left lingual arteries. Wire markers were placed in the foramen and the genial tubercles were covered with lead foil to illustrate the radiographic relationship between them. The radio-opacity peripheral to the foramen as seen on a radiograph is produced by the wall of the canal and not the genial tubercles as previously reported. While the foramen is not seen on many radiographs of the lower incisor region, this can be accounted for by a change in orientation of the x-ray beam. A pilot study revealed an incidence of 49% of the lingual foramen on periapical radiographs of the mandibular incisor region in an adult population, the previous reported incidence being 28%.

Arteries↗

[Proposal for the definition of "foramen magnum syndrome"--foramen magnum tumor and abnormalities].

The clinical appearance of foramen magnum tumor is protean and, even at the stage when serious neurological deficits are present, the lesions are often misdiagnosed as another disease, especially cervical spondylosis and multiple sclerosis, and patients may undergo improper concervative or even surgical treatments. The best guarantee against misdiagnosis, we believed, was to establish a definition of "Foramen Magnum Syndrome" to facilitate the recollection of its peculiar clinical findings. "Foramen Magnum Syndrome" is composed of: 1. Cape distribution of sensory loss; 2. Atrophy of the intrinsic muscles of the hands; 3. Neck or suboccipital pain; 4. Dysesthesia of the hands (numbness, tingling, and cold sensation); 5. Eleventh cranial nerve palsy; 6. Stereoanesthesia. (Remember the mnemonic CANDES or DESCAN) Among these, cape distribution of sensory loss, eleventh cranial nerve palsy and cold dysesthesia (not numbness or tingling sensation) are of great importance for topological diagnosis. We also pointed out the similarities between the clinical picture of syringomyelia and that of the advanced stage of foramen magnum tumor. The syringomyelic syndrome, often seen in Arnold-Chiari malformation and basilar impression, has been attributed to the concurrent syrinx of cervical cord. But the clinical analysis of foramen magnum tumors showed that this is not always true and that compressive lesions at the foramen magnum alone can cause syringomyelic syndrome.

Accessory Nerve↗

Foramen tympanicum, or foramen of Huschke: pathologic cases and anatomic CT study.

BACKGROUND AND PURPOSE: A persistent foramen tympanicum, or foramen of Huschke, is an anatomic variation of the tympanic portion of the temporal bone due to a defect in normal ossification in the first 5 years of life. The foramen is located at the anteroinferior aspect of the external auditory canal (EAC), posteromedial to the temporomandibular joint (TMJ). We sought to define its prevalence, location, and size on high-resolution spiral CT (HRCT). METHODS: We prospectively examined 102 consecutive HRCT studies of the temporal bone (204 ears). HRCT was performed by using 120 kV, 400 mAs, an ultra-high-resolution filter, 0.6-mm section thickness, 0.3-mm section increment, 728 x 728 matrix, and 160-mm field of view. We noted the size and location of the foramen tympanicum relative to the tympanic membrane and calculated its prevalence. Patients with focally decreased tympanic bone thickness of <1 mm at the anteroinferior EAC (between the 3- and 6-o'clock positions) were considered separately. RESULTS: We found a foramen tympanicum was found in six (4.6%) of 130 ears. Mean axial diameter was 4.2 mm, and mean sagittal diameter was 3.6 mm. Focally reduced bone thickness in the same location was found in 45 (35%) ears, with a female preponderance (P = .003). CONCLUSION: HRCT is sensitive for detection of the foramen tympanicum because of its thin sections, high spatial resolution, and multiplanar capabilities. Awareness of this anatomic entity may be useful in evaluating patients with transient otorrhea in whom no otologic cause (e.g., ear infection, TMJ disease) is identified.

Adolescent↗

[The infraorbital foramen (the position of the infraorbital foramen in man)].

The injection of the infraorbital nerve in the infraorbital canal, gives a full anesthesia to the anterior superior nerve, for a major operations in the anterior part of the upper jaw or in case which an infection precludes a local injection. In this study we describe in detail the position of the infraorbital foramen in 55 crania and in 16 cadavers. As landmarks in the cadavers, we used the lateral point of the wing of the nose, and the medial angulus oculi. As landmarks in the crania we used, the inferior orbital rim, the zygomaticoalveolar crest and the anterior nasal spine. The results of our measurements are the following: 1. The infraorbital foramen is situated in equal distance from the medial angulus oculi and the zygomaticoalbeolar crest. 2. The infraorbital foramen, the anterior nasal spine and the zygomaticoalveolar crest form the vertex of an isosceles triangle. The infraorbital foramen is situated in the vertex which corresponds to the one of the equal angles. 3. The infraorbital foramen is situated 7.19 mm below the infraorbital.

Humans↗

Trigeminal neuralgia is caused by maxillary and mandibular nerve entrapment: greater incidence of right-sided facial symptoms is due to the foramen rotundum and foramen ovale being narrower on the right side of the cranium.

Trigeminal neuralgia (TN) is the most important disease of the trigeminal nerve. Vascular compression of the dorsal root of the trigeminal nerve by aberrant loop of blood vessels is currently accepted as the most common cause of TN. The right side of the face is affected by TN twice as often as the left side, but there are no anatomical reasons for the blood vessels loop to be more frequent on the right side of the cranial fossa. Additionally, vascular compression in asymptomatic patients and in TN patients without aberrant blood vessels has been reported, thereby arguing against the idea that vascular compression alone is responsible for TN. Anatomical and radiological studies have shown that the rotundum and ovale foramens on the right side of the human cranium are significantly narrower than on the left side. The rotundum and ovale foramens are crossed by the maxillary and mandibular nerves, respectively, and are the nerves most affected in TN. Based on demographic and epidemiological data of TN patients, and on anatomical findings in the foramens, we hypothesized that entrapment of the maxillary and mandibular nerves when they cross the ovale and rotundum foramens is a primary cause of TN and accounts for the higher incidence of TN on the right sided.

Causality↗

Blocks of the foramen rotundum and the oval foramen: a reappraisal of extraoral maxillary and mandibular nerve injections.

OBJECTIVE: To present our experience of regional anaesthesia with blocks of the foramen rotundum and the oval foramen. DESIGN: Open study. SETTING: University Hospital, Beograd, Yugoslavia. SUBJECTS: 107 patients who underwent 58 maxillary and 49 mandibular nerve blocks. INTERVENTIONS: Injection of 2% lignocaine with adrenaline 1/80,000 with an 18 G venflon or 20 G spinal needle. MAIN OUTCOME MEASURES: Quality of anaesthesia and morbidity. RESULTS: 49 of the 58 maxillary (84%) and 45 of the 49 mandibular (92%) nerve blocks were successful (no sensitivity to pinprick in the distribution of the injected nerve and a painless operation). There were 17 complications (26%), 8 in the maxillary and 9 in the mandibular group. All complications were minor and transient, and 6 could be attributed to anhydrous glycerol rather than the injection technique itself. CONCLUSION: Blocks of the foramen rotundum and the oval foramen achieve good regional anaesthesia in the maxillofacial region.

Anesthetics, Local↗

Recurrent cerebrovascular events in patients with patent foramen ovale, atrial septal aneurysm, or both and cryptogenic stroke or transient ischemic attack. French Study Group on Patent Foramen Ovale and Atrial Septal Aneurysm.

Patent foramen ovale (PFO) and atrial septal aneurysm (ASA) have been identified as potential risk factors for stroke, but information about the risk of recurrent cerebral ischemia is scarce. The aim of this retrospective study was to assess the absolute risk of recurrent cerebrovascular events in 132 patients under 60 years of age with patent foramen ovale, atrial septal aneurysm (diagnosed by transesophageal echocardiography with a contrast study), or both and an otherwise unexplained stroke or transient ischemic attack (TIA). During a mean follow-up of 22.6 +/- 16 months, six patients had a recurrent stroke (n = 2) or a TIA (n = 4). No systemic embolism was observed. The actuarial risk of having a recurrent stroke was 2.3% (95% confidence interval, 0.6% to 8.2%) at 2 years, whereas the risk of having a stroke or a TIA was 6.7% (95% confidence interval, 3.1% to 14.2%) at 2 years. The average annual rates of recurrence were 1.2% and 3.4%, respectively. In patients with both PFO and ASA, the actuarial risk of a first recurrent stroke was 9.0% (95% confidence interval, 2.4% to 28.5%) at 2 years, with an average annual rate of recurrence of 4.4%. As a group, patients with patent foramen ovale, atrial septal aneurysm, or both and an otherwise unexplained stroke or TIA appear to have a low risk of recurrent stroke whatever the prophylactic antithrombotic therapy used. The association of ASA and PFO may be an indicator of a higher risk of recurrent stroke.

Adult↗

Trigeminus stereoguide: an instrument for stereotactic approach through the foramen ovale and foramen jugulare.

The author describes a new, fully stereotactic instrument for the percutaneous treatment of tic douloureux. The principle is to place the instrument in such a position around the patient's head that the foramen ovale lies at the midpoint for a spherical system consisting of a cylinder part and a 90 degrees arch with an electrode carrier. The foramen can then be reached from a suitable bone-free direction, either through the cheek or inframandibularly. The position of the foramen ovale is calculated from lateral and axial radiograms and defined with x, y, and z coordinates. The instrument can also be used for the percutaneous treatment of glossopharyngeal neuralgia.

Adult↗

Jugular foramen syndrome caused by varicella zoster virus infection in a patient with ipsilateral hypoplasia of the jugular foramen.

We report a patient with acute cranial polyneuropathy with unilateral involvement of the ninth, tenth, and eleventh cranial nerves. Although this patient lacked a typical cutaneous herpetic manifestation, elevated levels of IgM and IgG antibodies to varicella zoster virus (VZV) in both the serum and cerebrospinal fluid confirmed the clinical diagnosis of VZV infection and zoster sine herpete. Coexisting hypoplasia of the ipsilateral jugular foramen was detected using three-dimensional, surface-rendering displays reconstructed from the cranial helical CT scan. The patient recovered almost completely following treatment with an anti-inflammatory corticosteroid. Anatomical narrowing of the jugular foramen in this patient may have contributed to entrapment of the affected nerves at their passage through the foramen.

Accessory Nerve↗

The direction and location of mental foramen and incidence of accessory mental foramen in south Indian mandibles.

One hundred and forty two south Indian mandibles of unknown sex were examined for the variations of the location and direction of the mental foramen. Accessory mental foramen were also looked for. The findings have been compared with those of other studies in the literature. Topography of the mental foramen is of practical importance to the dental and maxillo-facial surgeon for purpose of anesthesia and surgical procedures.

Adult↗

Microanatomy of retia mirabilia of bowhead whale foramen magnum and mandibular foramen.

The morphology of vessels of the cervical rete mirabile near the region of the foramen magnum of the bowhead whale, Balaena mysticetus, as well as of retial vessels of the mandibular foramen was studied by light and transmission electron microscopy. A comparison of arterial and venous components of the mandibular rete revealed considerable arterial branching and arteriovenous anastomoses. Although the small arteries of bowhead retia contained the same layers found in nonretial arteries, several distinctive morphologic features were evident. These included wide separation by collagenous connective tissue and small size of individual smooth muscle cells of the tunica media. These myocytes also contained considerable perinuclear glycogen and communicated minimally with adjacent myocytes by small foot-like cytoplasmic appendages as well as branching of basement membranes. Ganglia-like neural plexuses were observed within the tunica media of arterial retia. Endothelial cells lining the intima demonstrated loose peripheral edges which frequently projected into the vessel lumen, and these cells rested upon a subjacent layer of reticular fibers. It is known for some species that the retial supply to the brain in whales largely supplants an internal carotid arterial supply and that the spinal cord is supplied by retia. The physiologic role of the bowhead mandibular retia remains unknown. The retia mirabilia of cetaceans are considered as one of the morphologic adaptations which modulate hemodynamics during diving and resurfacing. The morphologic features of these vessels in the bowhead whale, as revealed by electron microscopy, appear to reflect the capability to respond in a slow but sustained manner to diving, and the large glycogen deposits may help sustain vascular myocyte metabolism during prolonged submersion.

Animals↗

Supraorbital Notch/Foramen, Infraorbital Foramen and Mental Foramen in Thais: anthropometric measurements and surgical relevance.

OBJECTIVE: To determine the morphology and the locations of the SupraOrbital Notch/Foramen (SON/F), InfraOrbital Foramen (IOF), and Mental Foramen (MF) relative to frequently encountered surgical landmarks. MATERIAL AND METHOD: One hundred and six Thai adult skulls were investigated. RESULTS: Mean horizontal widths of SON, SOF, IOF and MF were 4.31 +/- 1.61 mm, 2.81 +/- 0.62 mm, 3.35 +/- 0.62 mm and 2.80 +/- 0.70 mm, respectively. The SON/F was situated 25.14 +/- 4.29 mm lateral to the nasal midline, 26.57 +/- 3.92 mm medial to the temporal crest of the frontal bone and 3.15 +/- 1.29 mm superior to the supraorbital rim. The IOF was 28.43 +/- 2.29 mm lateral to the maxillary midline, 9.23 +/- 2.03 mm below the infraorbital rim and 2.15 +/- 1.67 mm medial to the zygomaticomaxillary suture. Mean vertical distances from the IOF to the SOF and to occlusal plane of the upper teeth were 44.95 +/- 2.96 mm and 42.52 +/- 3.89 mm, respectively. The IOF was frequently found in the same vertical line with the second upper premolar and its usual direction of opening pointed downward medially. The MF was a mean of 28.52 +/- 2.15 mm lateral to the symphysis menti and most commonly observed in line with the second lower premolar. Its usual direction of opening was in a posterosuperior direction. CONCLUSION: The results of the present study may assist surgeons to localize important maxillofacial neurovascular bundles passing through these foramina in facilitating surgical, local anesthetic and other invasive procedures.

Adult↗

Preventing stroke recurrence in patients with patent foramen ovale: antithrombotic therapy, foramen closure, or therapeutic abstention? A decision analytic perspective.

Emphasis on the role of patent foramen ovale as a potential risk factor for ischemic paradoxical stroke has recently increased. Current therapeutic options for secondary stroke prevention include long-term antithrombotic therapies and invasive closure of the defect, but selective indications have not been evaluated. Therefore we developed a Markov-based decision analysis model for a hypothetical cohort of patients 55 years of age with presumed paradoxical embolism, measuring for each therapy the risks of stroke recurrence, treatment-related complications, and death after 5 years and the quality-adjusted life-years. Over a wide range of stroke risk recurrence (0.8% per year to 7% per year), the gain provided by closure of the defect exceeded the one obtained by other therapeutic options. When the risk exceeded 0.8% per year and 1.4% per year, respectively, this was also verified for anticoagulation and antiplatelet therapies compared with therapeutic abstention. Therapeutic abstention was the preferred strategy under 0.8% per year. Sensitivity analyses identified key parameters influencing the choice of therapy. These included estimates of stroke recurrence, bleeding rates, surgery-related case fatality rates, and age. Considering the risks of treatment and the devastating consequences of a recurrent stroke, our model suggests that if the estimated risk of paradoxical stroke recurrence is > 0.8% per year, therapeutic abstention becomes the worst option. Above this threshold secondary stroke prevention with anticoagulation therapy or surgical closure of the defect is the preferred strategy, and assessment of both the risk of stroke recurrence and the risk related to therapeutic options should guide individual therapeutic decision making.

Cardiac Surgical Procedures↗