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At least 19 recordsLinked to original sources
PubMed1992

[Local compressibility of denture foundation--evaluation of denture foundation in relation to impression pressure].

The viscoelastic character of the denture foundation is different in each individual or site. The character of the mucosa and the appropriate impression procedure should be examined. However, few investigations concerning the relation between the compressibility of the denture foundation and the impression pressure have been reported. The purpose of this study was to discuss the objective evaluation of the denture foundation in relation to the impression pressure. In this report, the local compressibility of the denture foundation of 20 upper edentulous patients was measured with the 20 MHz B-Mode ultrasonic diagnostic equipment. The Compressible Index was defined to analyze the compressibility of the denture foundation quantitatively as against the impression pressure. The main results were as follows: 1. The compressible amount of the denture foundation against 100 gw/cm2 pressurization was an average of 0.32-0.61 mm. 2. The compressible rate of the denture foundation against 100 gw/cm2 pressurization was an average of 13.5-20.7%. 3. The Compressible Index was confirmed to represent the compressibility of the denture foundation accurately as against the impression pressure. 4. It was suggested that the Compressible Index was useful for the clinical simple evaluation of the denture foundation.

Aged↗
PubMed1994

[About the relationship between medicine and social sciences: the French Foundation for the Study of Human Problems or Carrel Foundation (1941-1945)].

Nobel Prize winner for medicine in 1912, author of a widely acclaimed best seller which was published in English and in French in 1935, Man, the Unknown, Alexis Carrel was Regent of the French Foundation for the Study of Human Problems from 1942 to 1944, during the Second World War in France. The Foundation, known as the "Carrel Foundation", was created as a financially autonomous public establishment with full legal status and had a dual mission: to stkudy "all possible means of safeguarding, improving and developing the French population" (1) and to "synthesize efforts undertaken by its own members or by others and to develop the science of man" (2). Considering its short official existence and the exceptional circumstances of the period, the scientific work of the Foundation is impressive: the demographical analyses undertaken by R. Gessain, P. Tincent, and J. Bourgeois; the pioneer work of J. Sutter in nutrition; J. Merlet's work on group settings; the Gallup polls undertaken by J. Stoetzel's team; and the work and publications of the F. Perroux Department of Bio-Sociology, without failing to mention the study carried out on a group of one hundred thousand children. Amongst the effects of the Foundation, one must mention the National Institute of Demographic Studies (INED) and with it, the establishment of one of the most active and productive research groups in the Social and Human Sciences in France. There are other initiatives and activities which form part of the Foundation's inheritance: the creation in 1947 by Dr A. Gros, former Vice-regent of the Foundation, of the group of "Advisers in Synthesis"; the jkoint creation ten years later by D Gros and G. Berger of the group and the publication "Prospective"; the wide multidisciplinary study undertaken by the (DGRST) "Délégation Générale à la Recherche Scientifique et Technique" undertaken in 1960 thanks to the initiative of R. Gessain and of J. Sutter; and the Monaco Forums on Social Sciences, not to mention the contribution of former Foundation members to the establishment at the international level of medicine of work and the encouragement given to ergonomic studies.

Eugenics↗
PubMed1982

The Rockefeller Foundation, the China Foundation, and the development of modern science in China.

Two powerful foundations, with interlocking directorates, were the most important media for transmitting American science to China and for making its development possible: In the 1920s and 1930s, the Rockefeller Foundation's China Medical Board and the China Foundation for the Promotion of Education and Culture recognized that transmission and development required much more than the transplantation of whole scientific institutions. This essay shows that, in their most mature form, the foundations' strategies were informed by a rational and coherent set of policies. Their premise was that the practice and development of advanced scientific medicine and bio-medical or natural scientific research all require an infrastructure of education, communication, physical plant, and equipment. This infrastructure did not exist before the foundations began to foster it in China. In this essay the foundations' China policies are outlined and detailed examples are given to show they built the science infrastructure amidst debate over the appropriateness of the dominant 'Johns Hopkins' institutional model and the norm of 'pure science'. In China, the 'Hopkins' model for medical training and practice featured a combination of clinical practice with sophisticated scientific laboratory research. This model and the 'pure science' norm were seriously challenged by the political and economic exigencies of the 1930s.

China↗
PubMed1999

[The Rockefeller Foundation, the Carlsberg Foundation and Danish medical biology in the interwar years. Effects on research and education throughout the 20th century].

Three large scientific institutes were built in Copenhagen, Denmark, between 1928 and 1938 supported by the Rockefeller Foundation in New York. The three institutes were: the Rockefeller Institute of Copenhagen, Juliane Mariesvej, the Biological Institute of the Carlsberg Foundation, and the Institute of Human Genetics, both on Tagensvej (The Carlsberg Foundation in Copenhagen participated in the financing of the two first ones.) In the same period the Rockefeller Foundation supported the construction of a cyclotron at Niels Bohr's Institute of Theoretical Physics. These institutes in Copenhagen sent many co-workers both to the Rockefeller University in New York and to other places in the world for further education supported by stipends from the Rockefeller Foundation. The scientific nucleus around which these activities crystallized included: the physiologist (and Nobel Prize winner) Aug. Krogh, the physicist (and Nobel Prize winner) Niels Bohr, the chemist S.P.L. Sorensen, the geneticist W. Johannsen, the plant physiologist Peter Boysen Jensen, and the cell culturist Albert Fischer. The international co-operation between the two foundations began early in the 20th century and it can be traced in Danish medical/biological science through the rest of that century.

Academies and Institutes↗
PubMed2000

Evidence for Scattering Resonances in the H+D(2) Reaction We thank Donald G. Truhlar, Patrick Brown, Zee Hwan Kim, and Stephen Cho for careful and critical reading of the manuscript prior to publication. We also thank Andrew J. Alexander for his assistance in the preparation of the polar plots. Elf-Atochem (B.D.B.), the Hertz Foundation and Stanford University (J.D.A.), and the National Science Foundation (A.E.P.) are gratefully acknowledged for their support in the form of Graduate Fellowships. This work was supported at Stanford University by the U.S. National Science Foundation under Grant Number CHE-99-00305 and at Universidad Complutense by DGCYT PB98-0762-C03-01.

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Journal Article↗
PubMed2001

A Novel Polynuclear Gold-Sulfur Cube with an Unusually Large Stokes Shift V.W.-W.Y. acknowledges financial support from the Research Grants Council and The University of Hong Kong, and the receipt of a senior research fellowship from the Croucher Foundation. E.C.-C.C. acknowledges the receipt of a postgraduate studentship (1997-1999) and a Croucher Foundation scholarship (1999-2000), administered by The University of Hong Kong and the Croucher Foundation, respectively. N.Z. acknowledges the receipt of a postdoctoral fellowship from The University of Hong Kong.

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Journal Article↗
PubMed2001

The Novel Open-Framework Vanadium Silicates K(2)(VO)(Si(4)O(10)) small middle dotH(2)O (VSH-1) and Cs(2)(VO)(Si(6)O(14)) small middle dot3 H(2)O (VSH-2) We thank the National Science Foundation (DMR-9805881) and the Robert A. Welch Foundation for support. This work made use of MRSEC/TCSUH Shared Experimental Facilities supported by the National Science Foundation under Award Number DMR-9632667 and the Texas Center for Superconductivity at the University of Houston.

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Journal Article↗
PubMed2001

Silynes (RC identical with SiR') and Disilynes (RSi identical with SiR'): Why Are Less Bonds Worth Energetically More? The research is supported by an Israel Science Foundation (ISF) and a Niedersachsen grant (to S.S.), by a U.S.-Israel Binational Science Foundation (BSF) grant (to Y.A.) and by the Minerva Foundation. S.S. and F.O. thank the European Union for a Marie Curie Fellowship (Contract number: MCFI-1999-00145). S.S. and D.D. thank P. C. Hiberty for the helpful advice.

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Journal Article↗
PubMed1997

National Kidney Foundation report on dialyzer reuse. Task Force on Reuse of Dialyzers, Council on Dialysis, National Kidney Foundation.

The Council on Dialysis of the National Kidney Foundation convened an expert panel to evaluate the current practice and literature related to the reuse of hemodialyzers. The panel reviewed and evaluated literature related to reuse since the last report of the National Kidney Foundation recommendations on reuse was published in 1988. The group sought to develop a consensus concerning the effect of reuse of hemodialyzers on mortality; the efficiency of delivered hemodialysis when reused hemodialyzers are used in the clinical setting; the clinical effects of reused dialyzers as compared with dialyzers not reused on intradialytic symptoms; infections in patients using reused dialyzers; and the effect of reused dialyzers on complement activation, cytokine production, and beta2-microglobulin metabolism and clearance. In addition, the panel reviewed the literature on the potential toxicity of germicides used in the processing of dialyzers for reuse as well as recent changes in federally mandated regulations concerning labeling of dialyzers for reuse, the monitoring of the reuse process, and the effectiveness of reused dialyzers to achieve a prescribed delivered clearance as estimated by urea kinetic modeling or by percent urea reduction. The National Kidney Foundation takes no position for or against dialyzer reuse. The principal reason for the practice of reuse is economical. In view of the uncertainties related to the safety and biological impact of reuse procedures, the task force recommends that a full discussion of the issue of reuse and its potential beneficial and detrimental effects be undertaken with each patient. There is no conclusive evidence to substantiate the notion that either morbidity or mortality associated with single use or reuse is different. Microbial contamination of the water used for dialyzer reprocessing increases patient morbidity. The chemical quality of water used for dialyzer reprocessing should, at least, fall within the same standards as those recommended for product water intended for hemodialysis. Dialyzers should not be reprocessed from patients who have tested positive for hepatitis B surface antigen. The effects of reprocessing high-flux dialyzers on beta2-microglobulin clearance are dependent on the reprocessing technique, the number of reuses, and the nature of the dialyzer membrane used. There are insufficient data on the effects of reuse on beta2-microglobulin behavior to make uniform recommendations. Untoward effects of reused dialyzers may still occur in spite of rigorous adherence to the AAMI guidelines. For example, use of the total cell volume method for assessing changes in small molecule clearances will not show the loss of performance attributable to dialysate shunting. For this reason, the measurement of Kt/V for urea as recommended by the AAMI or the determination of the urea reduction ratio (URR) is strongly recommended at least monthly to gauge the adequacy of the dialysis procedure. Given the significant fall in dialyzer efficiency for urea removal that can occur after repeated uses of a dialyzer, dialysis prescriptions in units practicing reuse should be designed to deliver a Kt/V or URR value that exceeds the dose used for patients treated with single-use dialyzers to make allowance for any possible reuse-induced reduction in dialyzer efficiency. Technicians and other personnel responsible for the reprocessing of dialyzers should receive proper training. These health care providers should be certified in reprocessing by an examining body so that professional competency can be assured.

Bacterial Infections↗
PubMed1999

Quality of life in patients with vertebral fractures: validation of the Quality of Life Questionnaire of the European Foundation for Osteoporosis (QUALEFFO). Working Party for Quality of Life of the European Foundation for Osteoporosis.

Vertebral fractures may be minor or lead to pain, decreased physical function, immobility, social isolation and depression, which together contribute to quality of life. A Working Party of the European Foundation for Osteoporosis has developed a specific questionnaire for patients with vertebral fractures. This questionnaire, QUALEFFO, includes questions in the domains pain, physical function, social function, general health perception and mental function. QUALEFFO was validated in a multicenter study in seven countries. The study was done in 159 patients aged 55-80 years with clinical osteoporosis, i.e., back pain and other complaints with at least one vertebral fracture and lumbar bone mineral density T-score <-1. Patients with a recent vertebral fracture were excluded because of unstable disease. Controls were age- and sex-matched, and did not have chronic back pain or vertebral fractures. Subjects with conditions exerting a major influence on quality of life were excluded. The QUALEFFO was administered twice within 4 weeks and compared with a generic questionnaire, the Short Form 36 of the Medical Outcomes Study (SF-36). Standard spinal radiographs were made for assessment of vertebral height. Seven questions were removed from the analysis because of low response rate, linguistic ambiguities or redundancy. The 41 remaining questions were analyzed for repeatability, internal consistency and the capacity to discriminate between patients with vertebral fractures and controls. Comparison with the SF-36 was performed within similar domains by conditional logistic regression and by receiver operating characteristic (ROC) curves. The repeatability of QUALEFFO was good (kappa statistics 0.54-0.90) and 26 of 41 questions had a kappa score >/=0.70. The internal consistency of the five domains was adequate, with Crohnbach alpha around 0.80. All except five questions discriminated significantly between patients and controls. The median scores of QUALEFFO were significantly higher in patients with vertebral fractures than in controls in all five domain (p<0. 001), which is consistent with decreased quality of life in patients with osteoporosis. Spinal radiographs were assessed using the McCloskey-Kanis algorithm. According to this, 124 patients (78%) had vertebral fractures of >/=3 SD severity, in contrast with 7 controls (4%). Significant correlations existed between scores of similar domains of QUALEFFO and the SF-36, especially for pain, physical function and mental function. All five domains within each questionnaire discriminated significantly between fracture cases and controls. The odds ratios for pain and social function were greater for QUALEFFO, while general health perception was more discriminating using the SF-36. The ROC curve analysis of QUALEFFO indicated that all five domains were significantly predictive of vertebral fractures. When comparing similar domains of the two questionnaires, QUALEFFO domains demonstrated significantly better performance for pain, physical function and social function. The QUALEFFO total score and SF-36 physical composite score showed similar performance. In conclusion, QUALEFFO is repeatable, coherent and discriminates well between patients with vertebral fractures and control subjects. The results of this study confirm the decreased quality of life in patients with vertebral fractures.

Aged↗
PubMed1989

Gene testing in autosomal dominant polycystic kidney disease: results of National Kidney Foundation workshop. Scientific Advisory Board of the National Kidney Foundation.

Until recently the diagnosis of hereditary disorders was dependent on the phenotypic manifestation of those disorders. This created considerable obstacles for effective genetic counseling and family planning in late onset disorders, such as polycystic kidney disease. Moreover, in autosomal dominant disorders there is sufficient clinically variability that diagnosis could not always be established with certainty. For example, in autosomal dominant polycystic kidney disease clinicians were appropriately reluctant to confirm the diagnosis in a 20-year-old, at-risk family member with only a few scattered renal cysts. Moreover, they were equally unwilling to definitively remove any risk of development of the disease from a 20-year-old with normal, noncystic kidneys. Within the last decade, gene linkage and other gene identification techniques have provided new methodologies to surmount these dilemmas. However, these techniques also have produced new questions. In order to provide some guidance to clinicians and investigators utilizing the methodologies of recombinant DNA, genetic linkage, and gene identification the American Society of Genetics commissioned a panel to provide initial guidelines regarding DNA banking. The National Kidney Foundation task force is in agreement with the concepts this group has outlined. However, specific guidelines for the use of genetic linkage techniques in autosomal dominant polycystic kidney disease appeared necessary with the commercial availability of this diagnostic test.

Adult↗
PubMed1995

Screening and management of microalbuminuria in patients with diabetes mellitus: recommendations to the Scientific Advisory Board of the National Kidney Foundation from an ad hoc committee of the Council on Diabetes Mellitus of the National Kidney Foundation.

All individuals with diabetes mellitus should be screened yearly with a spot urine albumin:creatinine ratio to identify those who are at increased risk for the development of complications of diabetes mellitus, including nephropathy, retinopathy, and cardiovascular disease. Once these high-risk individuals are appropriately identified, it is recommended that therapy with an angiotensin-converting enzyme (ACE) inhibitor be initiated. In addition, cardiovascular risk factors should be investigated, and when appropriate, therapeutic interventions should be initiated according to existing recommendations.

Albuminuria↗