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At least 19 recordsLinked to original sources
PubMed1999

Exploring the origins of topological frustration: design of a minimally frustrated model of fragment B of protein A.

Topological frustration in an energetically unfrustrated off-lattice model of the helical protein fragment B of protein A from Staphylococcus aureus was investigated. This G-type model exhibited thermodynamic and kinetic signatures of a well-designed two-state folder with concurrent collapse and folding transitions and single exponential kinetics at the transition temperature. Topological frustration is determined in the absence of energetic frustration by the distribution of Fersht phi values. Topologically unfrustrated systems present a unimodal distribution sharply peaked at intermediate phi, whereas highly frustrated systems display a bimodal distribution peaked at low and high phi values. The distribution of phi values in protein A was determined both thermodynamically and kinetically. Both methods yielded a unimodal distribution centered at phi = 0.3 with tails extending to low and high phi values, indicating the presence of a small amount of topological frustration. The contacts with high phi values were located in the turn regions between helices I and II and II and III, intimating that these hairpins are in large part required in the transition state. Our results are in good agreement with all-atom simulations of protein A, as well as lattice simulations of a three- letter code 27-mer (which can be compared with a 60-residue helical protein). The relatively broad unimodal distribution of phi values obtained from the all-atom simulations and that from the minimalist model for the same native fold suggest that the structure of the transition state ensemble is determined mostly by the protein topology and not energetic frustration.

Kinetics↗
PubMed1993

A longitudinal study of changes in children's thought content in response to frustration on the Children's Picture-Frustration Study.

A longitudinal design examined changes in the 11 response types on the Children's Form of the Picture-Frustration (P-F) Study. Eighty-six children were retested on the instrument after a 5-year interim. Children showed changes reflecting an increase in verbal aggression and an increase in making amends for wrongdoing. They showed decreases in unfocused emotional outbursts and apologies. The findings add to the literature on children's emotional development of aggression and guilt and on the validity of the instrument.

Adolescent↗