PubMed Health⌕ Search

SEARCH · PubMed Health

Results for “Felypressin”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 19 recordsLinked to original sources
PubMed1977

Comparative effects of adrenaline and felypressin (octapressin) on consecutive sections of the vascular bed in canine adipose tissue.

Blood flow and tissue volume were recorded in the isolated canine subcutaneous adipose tissue, enclosed in a plethysmography. Adrenaline and felypressin (octapressin) were infused intra-arterially at doses producing a blood flow reduction of approximately 60%. Adrenaline (4.6-23 ng/min) caused an initial reduction in tissue volume, indicating a constriction of capacitance vessels. Octapressin (0.46-9.2 ng/min) had no effect on tissue volume. Neither adrenaline or octapressin caused appreciable filtration or absorption, suggesting that the pre- to postcapillary resistance ration remained unchanged. In contrast to sympathetic stimulation and noradrenaline, adrenaline significantly reduced the capillary filtration coefficient (CFC) by 34%, the change in CFC being related to the flow reductions, while octapressin did not reduce CFC sffect of adrenaline on precapillary sphincter sections and on capacitance vessels is greater than that of octapressin in doses producing similar flow reductions.

Adipose Tissue↗
PubMed1977

Effects of adrenaline and felypressin (octapressin) on blood flow and sensory nerve activity in the tooth.

The present investigations in cats were designed to study the effects of local anaesthetics containing adrenaline and felypressin (octapressin) on dental pulp function. Intradental sensory nerve excitability was measured using electrodes placed in dentinal cavities in canine teeth. Changes in pulp blood flow were measured using the disappearance rate of a radioactive tracer placed in the same cavities. Injections (0.5 ml) of lidocaine (20 mg/ml) - adrenaline (12.5 microng/ml) or prilocaine (30 mg/ml) - octapressin (0.54 microng/ml) were given supraperiosteally in the apical area of the tooth. Adrenaline either alone or with lidocaine caused almost complete inhibition of pulp blood flow within a few minutes. This effect was followed by a total inhibition of the sensory nerve activity. In most cases there was a recovery of both functions after 3 hours. Octapressin, on the other hand, had no inhibitory effects on pulp blood flow or sensory nerve activity. Lidocaine and prilocaine were also without effect. These findings indicate a different mode of action of the two vasoconstrictors and suggest that octapressin may be preferred in infiltration anaesthesia during treatment of the vital tooth.

Action Potentials↗
PubMed1988

Local anaesthetic with vasoconstrictor combinations in septal surgery.

Local anaesthetic with vasoconstrictor combinations are often used to reduce bleeding and hence improve the operating field in septal surgery. Two commonly used combinations are lignocaine with adrenaline and prilocaine with felypressin (citanest with octapressin). Most surgeons prefer to use lignocaine with adrenaline but because of the risks of cardiac dysrhythmias when used with halothane anaesthetists prefer prilocaine with felypressin. In a trial with lignocaine 2 per cent and adrenaline 1 in 200,000 against prilocaine 3 per cent and felypressin 0.03 international units/ml in 18 patients undergoing septal surgery with local anaesthesia alone there was significantly less blood loss in the lignocaine with adrenaline group, p less than 0.01. The mean blood loss in the adrenaline group was 7.5 ml. and 32.7 ml. with felypressin. Both combinations were equally effective in producing adequate local anaesthesia. It is concluded that lignocaine with adrenaline is superior to prilocaine with felypressin in achieving a dry operating field in septal surgery under local anaesthesia.

Anesthetics, Local↗
PubMed1991

Postoperative pain experience after gingivectomies using different combinations of local anaesthetic agents and periodontal dressings.

The present study examines postoperative pain experience following 243 gingivectomies in Norwegian patients using possible combinations of 3 local anaesthetics (lidocaine-adrenalin, prilocaine-felypressin or mepivacaine) and 3 periodontal dressings (Coe-pak, Wondrpak or Nobetec). When Coe-pak was used, the mean pain score was higher (P less than 0.05) in the group treated with lidocaine-adrenalin 4 to 6 h after gingivectomy than the groups treated with prilocaine-felypressin or mepivacaine. There was no significant difference between the groups treated with prilocaine-felypressin or mepivacaine. When Wondrpak or Nobetec were used, there was no significant difference between any of the local anaesthetics used. The present finding shows that the local anaesthetic combination of lidocaine-adrenalin (1:80,000) gives rise to a higher mean postoperative pain experience after gingivectomy than prilocaine-felypressin or mepivacaine. However, the relative difference in pain experience seen after gingivectomy when using the present local anaesthetic agents is masked when using an eugenol-containing periodontal dressing. Thus, the higher pain experience reported after lidocaine-adrenalin may only be clinically important when using periodontal dressings without local anaesthetic components such as eugenol.

Adult↗
PubMed1978

The use of mixtures of octapressin and adrenaline in local anaesthetic solutions to obtain more effective vasoconstriction.

The synergistic effects of felypressin with adrenaline have been studied using the isolated central artery of the rabbit ear as a vascular model. Sub-constrictor doses of felypressin were shown to increase adrenaline's vasoconstrictor effect on this vessel. It is therefore suggested that a mixture of felypressin and adrenaline be used in local anaesthetic solutions in order to provide more effective vasoconstriction.

Anesthetics, Local↗
PubMed1990

Local anaesthesia in elderly patients. An experimental study of oral infiltration anaesthesia.

The proportion of elderly people is increasing. Normal ageing causes a reduced physiological capacity and ability to meet challenges. In future more elderly people will have functioning natural dentitions and undergo routine dental procedures for which local anaesthesia is required. In this experimental investigation the effect of infiltration anaesthesia from 3 commonly used agents was compared in healthy elderly and young subjects. The subjects comprised 40 volunteers and the anaesthetic agents tested were lidocaine (20 mg/ml) with epinephrine (12.5 micrograms/ml), prilocaine (30 mg/ml) with felypressin (0.54 microgram/ml) and mepivacaine (30 mg/ml). The elderly subjects had a highly significantly shorter onset time compared to the young group. There was no statistically significant difference in duration of tooth anaesthesia between lidocaine with epinephrine and prilocaine with felypressin. Because elderly people have lower drug tolerance, prilocaine with felypressin is therefore recommended for routine dentistry.

Adolescent↗