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Proximal strain distribution in the loaded femur. An in vitro comparison of the distributions in the intact femur and after insertion of different hip-replacement femoral components.

The distribution of strain in the proximal part of loaded cadaver femora was measured in vitro using strain gauges applied to the cortex. The loading conditions simulated single-limb stance and the strains were recorded first with the femora intact and then with the femoral components of six different designs inserted. Each femur served as its own control. After insertion of a femoral component, the pattern of strain in the proximal part of the femur was reversed compared with that in the intact femur, in that the maximum strain occurred around the tip of the prosthesis rather than at the calcar femorale. A massive decrease in stress in the region of the calcar femorale was found when the implants were in place, and it was concluded that this decrease could contribute substantially to the calcar femorale resorption sometimes observed in patients after total hip replacement. Transfer of load directly to the calcar femorale through a larger collar in direct contact with the cortical bone restored 30 to 40 per cent of the normal strain to the calcar femorale and shifted the strain pattern toward normal. Compared with the less stiff stems tested, the larger, stiffer stems, which provide more protection against fatigue failure, did not affect the strain pattern adversely.

Aged

Necrosis of the proximal epiphyseal plate cartilage of the femur following detachment of the perichondral ring. Its relationship to the etiology of proximal epiphysiolysis of the femur.

A histological study of the proximal epiphyseal plate cartilage of rabbit femurs following detachment of the perichondral ring was performed. 15 animals were used, 5 of which being controls. Slight to severe necrotic changes in the plate were present in 9 out of 10 animals. In severe necrosis there was formation of fissures similar to those seen in human femoral epiphysiolysis. The necrosis was considered ischemic in nature and due to the detachment of the perichondral ring with involvement of the blood supply for the femoral epiphysis. Also the epiphyseal and metaphyseal bone marrow and bone tissue, as well as the articular cartilage, presented necrotic changes in a few animals. Such necrosis of the epiphyseal plate may be a factor in the pathogenesis of human proximal epiphysiolysis of the femur.

Animals

The use of Kiton Fast Green to measure the viability of the head of the femur after fractures of the neck of the femur.

An intravital staining method was used to predict the viability of the femoral head at operation in 36 patients with fractures of the neck of the femur. Life was predicted in 18 heads, death in 16 and in 2 there was some doubt. In the group which was predicted to be live, 15 fractures united uneventfully, 1 developed late collapse and 2 became infected and died. Of the heads predicted to be dead, 3 united without evidence of necrosis, four had radiological changes suggesting that necrosis had been followed by revascularization and 10 required further operations. Histological evidence was later obtained in 19 cases. Of 6 heads predicted to be live, 4 had united without evidence of necrosis, 1 showed necrosis and collapse and 1 was infected and dead. Of the heads predicted to be dead, 8 were dead, 4 showed revascularization taking place and 1 showed no evidence of bone necrosis. Intravital staining is a relatively easy technique but has limitations as a means of predicting the clinical outcome.

Adult

Effect of glucocorticoids and zinc deficiency on femur and liver zinc in rats.

Male weanling rats were fed diets containing less than 1, 3, 6 oor 13 ppm zinc or stock rat diet for 3 weeks. Each dietary group was subdivided into a control group and a prednisolone-treated group (5 mg pred/kg body weight). Femur and liver zinc contents were determined by flame atomic absorption spectrophotometry. Prednisolone caused growth retardation at all levels of dietary zinc. A marked increase was seen in femur zinc content of prednisolone-treated rats fed zinc-deficient diets. No such increase was seen in rats fed diets adequate in zinc. No significant change was seen in liver zinc content of zinc-deficient rats due to prednisolone. By comparing femur zinc in rats fed zinc-deficient diets with femur zinc in weanling rats, it appears that prednisolone causes an increase in femur zinc in rats fed deficient diets by (a) preventing bone resorption, and (b) increasing femur uptake of dietary zinc. Because the effects of glucocorticoids in rats appear to differ from effects in man, similar studies in other species are recommended.

Animals

Total femur and total knee replacement. A preliminary report.

Osteogenic sarcoma, a highly malignant tumor of bone, is generally treated by amputation. This is a report of 19 cases of excision of the entire femur because of skip areas which are occasionally seen. The femur usually has the lowest cure rate according to site of involvement. In total femur replacement, the whole bone is removed while the limb is saved. The operation consists of isolating the neurovascular bundle and removing the knee joint and femur including some surrounding normal tissue for margin of safety. The femur and knee replacements are made entirely of metal. The resultant extremity is weak, but functional. The patients can walk without support, but their gait is better using a cane and/or an ischial weight bearing brace.

Adolescent

[Malrotation of distal femur (author's transl)].

Malrotation of the distal femur could be important for the pathogenesis of the accidental dislocation of the patella. Most difficulties aries in the impossibility to prove and determine torsion deviations of the femur just as torsion deviations of the femur just as torsion deviations of other human bones with the methods at present available. With the syndrom of accidental dislocation of the patella often a series of promoting factore is combined. In animal experiences the consecutive alterations after producing artificial patella alta at the distal femur and at the patella bed with growing rabbits have been examined. It is found out that a real pathological torsion (inward torsion of the distal femur) is following.

Animals

The measurement of blood flow in mouse femur and its correlation with 239Pu deposition.

The concentration of 18F was measured in three parts of the femur and in the blood of 36 mice killed at intervals of from 1 min to 2 h after intravenous injection. Blood supply to the bone sections, calculated by dividing the increase in 18F concentration in bone by the integral of 18F concentration in blood between selected time intervals, was shown to be unaffected by the return of 18F from bone to blood at times earlier than 90 min following injection. The supply of blood per unit mass of bone was greatest in distal end of the femur, less in proximal end and least in shaft. In whole femur average blood flow was 230 mm3 per gram fresh bone per min. The deposition of 239Pu in three parts of the mouse femur was shown to be linearly related to blood flow and the nature of the relationship is discussed.

Animals

Methods for testing the mechanical properties of the rat femur.

A modular apparatus to measure the bending and torsional properties of the rat femur is presented. Both intact femur diaphyses and diaphyseal fractures in different phases of healing can be tested. It is also possible to measure the bending-strength of the distal femur metaphysis and the epiphyseal plate. The apparatus can be used to investigate the effect of drugs and hormones on the remodelling of the rat femur.

Animals

Treatment of fractures of the hip and ipsilateral femur with the Zickel device: a report of three cases.

Three case reports demonstrate the successful management of patients with fractures of the hip and ipsilateral femur using the Zickel device. The hip fractures were base of the femoral neck, trochanteric and substrochanteric. The ipsilateral femur fractures consisted of 2 shaft fractures and 1 supracondylar femur fracture. These 3 cases, added to those previously reported in the literature, suggest that this form of intramedullary fixation should be considered for fractures of the hip combined with fractures of the shaft of the femur and possibly even supracondylar region.

Adult

Femur-bending properties as influenced by gravity: III. Sex-related weakness after 4-G mouse growth.

Optimum gravitational intensity for growth stimulation depends upon the type of growth measurement. Although the 4-G field resulted in relatively weaker male bones, relative bone size increased. The more moderate 3-G field is known to stimulate relative bone-strength as well. Femurs from 36 male white mice demonstrated no growth of load-supporting ability Fu after 1 to 8 weeks of chronic centrifugation at 4-G from the fifth week of age. Although measurable with 35 female mice, this growth intended to fall below the control rate. When compared to 82 younger control femurs of the same cross-sectional geometry, experimental female femurs could sustain comparable moments Mu while experimental male femurs could not.

Age Factors

Changes in the upper femur after low friction arthroplasty.

In 169 low friction arthroplasties, an extension to 10 years of the radiological appearances, noted at 4 years after acrylic cement had been in the medullary cavity of the femur, there was no grossly visible evidence of deterioration. An increased number of femora showed hypertrophy with normal bone texture. The number showing atrophy remained the same at about 4.8%. Absorption of the medial neck of the femur averaged 5.5 mm over the whole study and was often preceded by small cystic areas. Evidence of demarcation of cement from the endosteal surface of the femur was absent in 66%. When demarcation did occur, in most cases it was confined to the tip or below the midlevel of the stem. In only 2.4% did it reach slightly above the midlevel. No tendency could be found for the radiological appearances of medial femoral neck absorption or cement demarcation to predominate in patients with lower grade levels of function. Improved techniques, by which more perfect fixation between cement and bone in the upper level of the prosthetic stem is achieved, may eliminate instances of loosening and localized bone erosion encountered elsewhere.

Absorption

[Fascicular nailing of the femur and tibia. 14 years' experience. Report of 275 cases (author's transl)].

The use of the fascicular four-pin nail has been introduced to correct certain inadequacies revealed by the rigid nailing according to Kuntscher's method; made up of four tiny pins soldered at each end, it fits the curve of the bone; its elasticity allows a much greater resistance to repeated strain as compared to other nails; an experimental study which compares the stability of fresh femurs cut then nailed according to different methods, reveals a definite superiority for the fascicular nail. The clinical use for 14 years (275 nailings among which 92 cases werefresh closed fractures of the femur) confirms that such a method provides the advantage of nailing without reaming as well as the possibility of immediate weight bearing ambulation for most patients (75% in the cases of resh femur or tibia fractures).

Biomechanical Phenomena

A new power tool for removal of methylmethacrylate from the femur.

An air turbine drill will remove methylmethacrylate from the medullary canal of the proximal femur in cases of failed total hip replacement and from the distal femur in cases of failed long stem total knee replacement. This power tool is expensive, but the high cost is partially offset by multiple other uses: cutting burr holes in the skull, doing osteotomies, cutting bone grafts and making windows in the femur. The power of the instrument and effectiveness of the burrs make it important to have instruction and direct experience in its proper use prior to use in the operating room.

Femur

Coxa vara, avascular necrosis and osteochondritis dissecans complicating solitary bone cysts of the proximal femur.

In 2 children with cysts in the upper end of the femur, there were 3 complications: coxa vara, avascular necrosis and osteochondritis dissecans. Coxa vara occurred in both cases and was due in 1 case to pathological fracture, and in the other case to growth disturbance. Avascular necrosis of the femoral head, a hitherto unreported complication of bone cyst of the upper end of the femur occurred in 1 patient following pathological fracture and resulted in osteochondritis dissecans of the femoral head.

Bone Cysts

Two-plane fixation of acute supracondylar and intracondylar fractures of the femur.

In 37 cases of supracondylar and intracondylar fractures of the femur treated by open reduction and internal fixation, a two-plane compression device, affording firm fixation in either the sagittal or frontal plane, was used with excellent results. Certain anatomic factors and associated injuries to the musculoskeletal system deserve classification, to enable the orthopedic surgeon to accurately evaluate and treat such fractures in the distal third of the femur. A negative attitude has been perpetuated concerning the ability of the trained orthopedic surgeon to reduce these fractures and adequately maintain the reduction for early mobilization. In 97% of our cases, results were good to excellent, and complications were infrequent. The purpose of this paper is, first, to describe a practicable classification of supracondylar and intracondylar fractures of the femur and, second, to describe the results in our series of cases treated a compression device specifically designed for these types of fractures.

Adolescent

A reduction apparatus for femur fractures.

The majority of femur fractures are closed fractures in the mid-third of the femoral shaft. A very well known fixation technique is the one using an intramedullary pin, which is inserted from the hip side. Open reduction of the fracture is mostly applied but the majority, between 85 and 93%, of the fractures are closed and therfore a more logical and safer technique would be closed reduction. However, this technique, also called blind-nailing, is more difficult. Besides an x-ray scanner with a monitor it also requires experience of the surgeon and some special tools to supply the necessary reduction forces to the proximal and distal parts of the femur. This publication describes a new designed reduction apparatus (1), that primarily simplifies blind-reduction of femur fractures, but can also be used for any other operation technique where a good grip on bones has to be provided with a minimum of tissue damage. The apparatus is designed to be used with standard Kirschner-wires and is easy to apply in combination with the existing operation techniques, and does not require special skill.

Femoral Fractures

Fat embolism as a cause of idiopathic necrosis of the head of the femur. Review of forty five cases of post traumatic fat embolism.

It has been postulated in recent years that idiopathic necrosis of the head of the femur may possibly be caused by arteriolar obstruction by fat emboli emanating from a fatty liver, which would act as a reservoir, due to various causes such as alcoholism and prolonged steroid therapy. A similar situation has been found in human pathology in post traumatic fat embolism. The writers have reviewed forty five cases of post traumatic fat embolism which had passed the pulmonary filter. All the cases were reviewed after a minimum of two years, since this is considered the minimum time within which necrosis can manifest itself radiologically. In none of these cases was there any evidence of necrosis of the head of the femur. These findings, supported by other critical considerations. do not lend support to the theory of fat embolism as a case of idiopathic bone necrosis.

Embolism, Fat