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Results for “Fertility Control, Postcoital”

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At least 19 recordsLinked to original sources
PubMed1991

[Use of contraception among women applying for abortion].

During a period of one year (1988-89), a questionnaire was distributed to women applying for legal abortion at Frederikssund Hospital in Denmark. Two hundred and eight-eight answered the questions about why they had become pregnant. 84% of the women had used contraceptive methods. The remainder included women who regretted a planned pregnancy and women who believed they were infertile. 50% of the women had at least one intercourse without using contraceptives. Women using barrier-methods who forgot the contraceptive once or women who had stopped using the pill were mainly concerned. 23% of the women said they had used contraceptives correctly and consistently. After the abortions 75% intended to use IUD, oral contraceptives or sterilization. Suggestions to reduce the number of unwanted pregnancies are discussed. Eg. spread of the knowledge of postcoital contraception as an extraordinary measure after an unprotected coitus is suggested. This will not replace other contraceptives, but should be used in a emergency.

Abortion Applicants↗
PubMed1977

Contraception.

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Contraception↗
PubMed1990

Progesterone receptor antagonists and prostaglandins in human fertility regulation: a clinical review.

Progesterone receptor antagonists have been developed by substitutions at the 11-beta and 17 side-chain positions of the progestagen norethisterone. The most studied progesterone receptor antagonists are mifepristone (Mifegyne; Roussel-UCLAF; RU486) and ZK98734 and ZK98299 (Schering AG). These compounds bind avidly to the progesterone receptor and glucocorticoid receptor but have essentially no binding to the mineralocortocoid, oestrogen or androgen receptors. Mifepristone also binds avidly to albumin, resulting in a half-life of approximately 24 h after oral administration. Progesterone receptor antagonists can induce menstruation by a direct action upon the endometrium. They have also been shown to exert weak progesterone agonist actions in certain circumstances and to modulate pituitary hormone secretion by antagonizing the feedback actions of progesterone. Moreover, they release prostaglandin F2 alpha and E2 from human endometrium or early pregnancy decidua and reduce the metabolism of these eicosanoids. Clinically, progesterone receptor antagonists have been used in trials of menstrual regulation, abortion and induction of labour, and during treatment of breast or ovarian cancer, some forms of hypertension and meningioma. Progesterone receptor antagonists have been administered to approximately 70,000 women in 18 countries as medical abortifacients. They have been proven, especially when combined with prostaglandin analogues, to be as effective as surgical methods of termination of pregnancy. Progesterone receptor antagonists have focussed international attention on menstrual regulation, abortion and the rights of women to regulate their fertility.

Abortifacient Agents, Steroidal↗
PubMed1991

Incidence of numerical chromosome anomalies in human pregnancy estimation from induced and spontaneous abortion data.

Induced abortion data provided an estimate of 4.7% numerical chromosome anomalies for women with a clinically recognized pregnancy at the end of the 7th week after the last menstrual period (LMP). This frequency requires that 51.9% of spontaneous abortions occurring after the 7th week should be chromosomally abnormal if the frequency of numerical chromosome anomalies at term (live and stillbirths combined) is 0.53%. Cytogenetic data from surveys of spontaneous abortion suggested a lower incidence of 39.7%. However, this figure is likely to be an underestimate because chromosome anomalies are almost certainly over-represented among the many early abortuses which lack embryonic tissue and hence are not karyotyped. The frequency of numerical chromosome anomalies at conception, arising from meiotic errors, was estimated from sperm karyotype data combined with information on the relative frequencies of maternal and paternal errors in the aetiology of trisomies. This provided a minimum estimate of 20%.

Abortion, Induced↗
PubMed1979

Abortion.

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Abortifacient Agents↗
PubMed1979

Abnormalities of early conceptus: a morphological study of 500 cases.

Although MR and PT are post-conception family planning measures, a large number of women were found to be non-pregnant. In the absence of direct evidence, presence of necrosis in the placental tissue in 20.8% cases is regarded as suggestive of abnormal ova which might have ended in abortion.

Abortion, Induced↗
PubMed1991

Mifepristone (RU486) alone or in combination with a prostaglandin analogue for termination of early pregnancy: a review.

The availability of a medical mode of termination of early pregnancy by the administration of RU486, an antiprogesterone alone, or in combination with one of the PG analogues significantly reduces the maternal morbidity and mortality associated with the classical surgical abortion. RU486 given alone in early pregnancy induces complete abortion in 60% to 85% of cases, and when combined with prostaglandin analogues, gemeprost or sulprostone, reaches a success rate of 95% to 99%. RU486 may also be of potential value in the medical treatment of ectopic pregnancy. Its use as a postcoital contraception is suggested, but further research is required to determine whether RU486 can be used on a once-a-month basis for contraception.

Abortion, Induced↗