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At least 19 recordsLinked to original sources
PubMed1991

Nitrous oxide and formiminoglutamic acid: excretion in surgical patients and anaesthetists.

We have investigated the possible toxicity of nitrous oxide on vitamin B12 and its sequelae upon folic acid metabolism using the urine formiminoglutamic acid excretion test, an index of the functional state of folate metabolism. Ten control subjects not exposed to nitrous oxide and five patients receiving limb surgery under local anaesthesia excreted normal amounts of formiminoglutamic acid in urine for 6 days. Fifty patients received nitrous oxide anaesthesia for similar surgery and, of these, 22 had a dose-dependent increase in excretion on the first 2 days after operation. There were large individual variations. Exposure to 70% nitrous oxide appeared to cause abnormal metabolism of folate when exposure was greater than 90 min. Ten anaesthetists demonstrated normal excretion of formiminoglutamic acid; their exposure to nitrous oxide was typical of that in other studies of theatre environmental pollution.

Adult↗
PubMed1970

Factors affecting formiminoglutamic acid excretion in vitamin B 12 deficiency.

1. Formiminoglutamic acid, a product of the catabolism of histidine, is excreted in abnormally large amounts in the urines of vitamin B(12)-deficient rats and of vitamin B(12)-deficient sheep; the excretion is reduced to negligible amounts after administration of vitamin B(12). 2. After administration of certain methyl donors to vitamin B(12)-deficient rats or sheep urinary excretion of formiminoglutamic acid is temporarily decreased. 3. Irrespective of the pteroylglutamic acid status of the animals neither vitamin B(12)-deficient rats nor vitamin B(12)-deficient sheep have the ability to deal efficiently with histidine. 4. In sheep, urinary excretion of formiminoglutamic acid is increased after administration of aminopterin; treatment with pteroylglutamic acid restores the ability of the animal to deal with the catabolic products of histidine. 5. The possible functions of vitamin B(12) and methionine in relieving a virtual deficiency of pteroylglutamic acid are discussed.

Aminopterin↗
PubMed1961

Conventional voltage electrophoresis for formiminoglutamic-acid determination in folic acid deficiency.

A new method for the determination of urinary formiminoglutamic acid (FIGLU) using conventional electrophoresis at 200 to 500 v. on cellulose acetate strips is reported. Experience in 166 determinations on 137 patients shows the method to be a simple, practical, and apparently sensitive one for the determination of FIGLU in the urine. Results of the application of the measurement of urinary FIGLU with histidine loading as a test for folic acid deficiency are also reported.

Cellulose↗
PubMed1980

[Biochemical and hematological parameters for the estimation of folate status in man. 3. Importance of formiminoglutamic acid excretion in the urine in comparison to other measurements].

In a study on 250 industrial workers the amount of the formiminoglutamic acid excretion in urine was measured by an enzymatic spectrophotometric method. For the estimation of the folacine status the vitamine concentration in serum and erythrozytes was determined as well as the segmentation of the neutrophilic granulocytes. As shown in previous studies these parameters indicate the degree of folate supply. A correlation between the FIGLU excretion in urine and other folate dependent parameters could not be demonstrated. Criterial to judge the folate supply are the radioimmunological determination of folacine concentration in serum and erythrocytes as well as the estimation of the segmentation of the neutrophilic granulocytes.

Female↗