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At least 19 recordsLinked to original sources
PubMed1979

Neutrophil chemotaxis in patients with Staphylococcus aureus furunculosis.

Neutrophil chemotaxis was evaluated in patients with staphylococcal furunculosis using a modified Boyden chamber assay. Neutrophil chemotactic response to Staphylococcus aureus-derived chemotactic factor was compared with response to Escherichia coli-derived chemotactic factor and zymosan-activated serum. Twenty-one patients with active furunculosis were compared with 29 patients with a history of furunculosis but no recent infection and with 29 healthy control subjects. Chemotactic response to the staphylococcal chemotactic factor was significantly higher in patients with active furunculosis (mean 61.6) than in patients with a history of furunculosis (mean 36.4) or controls (mean 31.4), P less than 0.001. Neutrophils from patients with active staphylococcal infections also had higher chemotactic activity toward E. coli chemotactic factor, but not significantly so (P = 0.09). Chemotactic response to zymosan-activated serum and background neutrophil motility was comparable among the three groups. The increased neutrophil chemotactic response of patients with active infection to bacterial factors, but not zymosan-activated serum, may represent a specific neutrophil response to products of infecting organisms. The differential response of the patients' neutrophils to these attractants supports evidence for the presence of separate categories of chemotaxin receptor on the surface of neutrophils.

Chemotactic Factors↗
PubMed1979

A cure for recurrent furunculosis.

A therapy for recurrent boils using antibiotic ointment over the entire integument is described herein. Rather than eradicating the individual nidus of infection, the skin is allowed to muster its own defenses, resulting in fewer, and eventually no, eruptions.

Anti-Bacterial Agents↗
PubMed1979

Furunculosis of salmonids: vaccination attempts in rainbow trout (Salmo gairdneri) by formalin-killed germs.

Two immunization trials were performed in rainbow trout, using a formalin killed Aeromonas salmonicida suspension. In the first experiment, 200 g fish were administered orally or intraperitoneally. Circulating antibodies were elicited in injected animals only, but no protection was found when they were challenged with a highly virulent strain. Rough and smooth bacteria have provided similar agglutinins titers. In the second study, fingerlings were vaccinated by injection, but experimental disease was reproduced through IP or IM inoculations. Protection was effective in the second case. In the IP injected group the mortality was the same in vaccinated fish and controls, and carriers were detected among survivors 3 months later. The surprising fact is that serum agglutinins did not always provide a protection. This last one depends on different factors such as pathogenicity of strains and route of penetration of the challenge bacteria. So, experimental challenge has to be improved.

Administration, Oral↗
PubMed1979

Beneficial effect of granulocyte transfusions in patients with defects in granulocyte function and severe infections.

A 3-year-old boy (patient A) with a congenital and a 24-year-old man (patient B) with an acquired granulocyte function defect received supportive granulocyte transfusions for the management of severe infections. The boy had suffered from recurrent infections since bith. His granulocytes showed in vitro almost no chemotactic responsiveness, an impaired phagocytosis and reduced intracellular killing of Candida albicans. Family studies suggested that it was an inherited autosomal recessive defect. The child developed a Pseudomonas pneumonia at the age of 3 years, which did not respond to antibiotic therapy. Granulocyte transfusions were then started and soon after the fever and pneumonia disappeared. Patient B showed the haematological signs of a preleukaemic state. He had 3 recurrent episodes of furunculosis which led each time to cellulitis and septic temperatures accompanied by symptoms of an enterocolitis. Tests of granulocyte function in vitro showed reduced intracellular killing of Staphylococcus aureus. Granulocyte transfusions were started, since no clinical improvement could be attained by antibiotics. With transfusion therapy, fever, cellulitis and enterocolitis disappeared each time.

Adult↗
PubMed1975

Brown- and red-pigmented Pseudomonas aeruginosa: differentiation between melanin and pyorubrin.

The pigment produced by three clinically isolated strains of Pseudomonas aeruginosa has been shown to by pyomelanin. The pigment is also produced by three strains of the same species labelled as "var. erythrogenes" by the National Collection of Type Cultures, and by Aeromonas salmonicida. Melanin and pyorubrin may be distinguished by the differential effects of tyrosine and glutamate on their production in minimal salts medium; Furunculosis Agar is a suitable medium for differentation of these pigments.

Anti-Bacterial Agents↗
PubMed1979

The Papillon-Lefèvre syndrome: keratosis palmoplantaris with periodontopathy. Report of a case and review of the cases in the literature.

The Papillon-Lefévre syndrome (PLS) is an autosomal recessive trait characterized by diffuse transgredient palmar-plantar keratosis (PPK) and premature loss of both the deciduous and permanent teeth. In most cases, the PPK is noted within the first 3 years of life. The periodontal lesions begin shortly after the start of both the primary and the permanent dentitions. The teeth are affected in the order of their eruption, exhibiting inflammation of the periodontal tissue, bleeding of the gums, pocket formation, loosening, and finally spontaneous exfoliation without showing definite signs of root resorption. After an edentulous interval, the same process begins anew shortly after the second dentition. Ectopic intracranial calcifications, mental retardation, and increased susceptibility to infections have often been seen in PLS patients and may thus be regarded as facultative signs.

Child↗
PubMed1979

Acute bone marrow necrosis caused by streptococcal infection.

An 8 year old boy with a furuncle on the dorsum of the right foot, high fever, severe pain in the right knee joint, slight hepatosplenomegaly, leukopenia and thrombocytopenia was admitted with the working diagnosis of acute leukemia. However, an abundance of necrotic cells, together with clusters of streptococci, could be demonstrated in the bone marrow aspirate. After antibiotic therapy the boy recovered completely.

Bone Marrow↗