PubMed Health⌕ Search

SEARCH · PubMed Health

Results for “GALLBLADDER NEOPLASMS”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 19 recordsLinked to original sources
PubMed1999

[Expression of P-glycoprotein in benign and malignant gallbladder neoplasms].

OBJECTIVE: To evaluate the relationship between P-glycoprotein expression and anti-cancer drug resistance of gallbladder carcinoma and the use of P-glycoprotein as a biomarker of gallbladder carcinoma, the expression of P-glycoprotein was detected in benign and malignant gallbladder neoplasms and normal gallbladder tissues. METHODS: Alkaline phosphatase anti-alkaline phosphatase (APAAP) method was used to detect the expression of P-glycoprotein in different gallbladder tissues (gallbladder carcinoma, 26 cases; benign gallbladder neoplasm, 14 cases; and normal gallbladder tissue, 9 cases). The relationship between expression of P-glycoprotein, TNM stages and other clinical data of gallbladder carcinoma was also analyzed. RESULTS: Immunohistochemical staining with a monoclonal antibody JSB-1, P-glycoprotein was positive in 76.9% (20/26) of gallbladder carcinomas, in 35.7% (5/14) of benign gallbladder neoplasms and in 33.3% (3/9) of normal gallbladder tissues (P < 0.05). With another monoclonal antibody UIC-2, the positive rates were 69.2% (18/26), 21.4% (3/14) and 11.1% (1/9), respectively (P < 0.01). There was no significant correlation between P-glycoprotein expression and gallbladder carcinoma TNM staging. CONCLUSION: The results suggest that P-glycoprotein probably plays an important role in the poor response of gallbladdar carcinoma to chemotherapeutic agents. In addition, P-glycoprotein may be used a valuable biomarker of gallbladder carcinoma.

ATP Binding Cassette Transporter, Subfamily B, Mem↗
PubMedDate not supplied

[Epidemiologic importance of gallbladder neoplasms in Belgrade].

The average standardized mortality rate caused by gallbladder neoplasms in Belgrade during the period from 1975 to 1990 amounted to 2.8 in 100,000 inhabitants. It was much higher in women -3.5/10000 than in men--1.9/10000. Considering specific age mortality rates they show low values for people to 54 years of age, and then an abrupt increase happens with the highest values recorded in the oldest group. Mortality trend caused by gallbladder neoplasms examined during these 16 years at this territory shows growth (y = 1.37 + 0.17x) which is more expressed in females (y = 1.46 + 0.24x) than in males (y = 1.35 + 0.07x).

Adult↗
PubMed1996

[Xanthogranulomatous cholecystitis simulating gallbladder neoplasm: therapeutic implications].

Xanthogranulomatous cholecystitis (XGC) is an infrequent type of chronic cholecystitis whose histologic features, in some cases, show a macroscopic appearance which may lead to suspicion of a gallbladder neoplasm with the consequent contraindication of the laparoscopic approach. The incidence of XGC was reviewed in a prospective series of 514 cholecystectomies performed in the authors' department from January 1991 to January 1996. Fourteen cases (2.7%) of XGC were identified with a male/female ratio of 1/1.8 and a mean age of 71 +/- 9 years. The most frequent form of presentation observed was hepatic cholic (43%). Echography showed cholelithiasis in 13 patients (93%). In 3 cases (21%), clinical and echographic suspicion of neoplasm was established, two being in the gallbladder, thus contraindicating the laparoscopic approach. A third patient underwent surgery for suspicion of a colon neoplasm. Xanthogranulomatous cholecystitis presents a macroscopic appearance which may be interpreted as a gallbladder neoplasm in up to 25% of the cases thus leading to treatment with laparoscopy.

Aged↗
PubMed1998

[Acute cholecystitis and gallbladder neoplasms: the experience of 2215 cases].

The authors have retrospectively analysed 2215 surgical procedures for gallbladder stones. The global incidence of gallbladder neoplasm has been 5%. This rate rises to 11% considering female patients over 60 years old. In this group, a gallbladder carcinoma was contemporary present in 17.4% of acute cholecystitis. Cholecystectomy may be suggested in every patients with gallstones, even asymptomatic, particularly if some risk factors are present.

Acute Disease↗
PubMed1991

[Prevalence of gallbladder neoplasms in cholecystectomies].

The prevalence of gallbladder cancer in 10,468 cholecystectomy patients was studied: 3.4% of the female and only 1.32% of the male population had gallbladder cancer (p < 0.001). The female population had 2.7 times more cholelithiasis, and 7.9 times more cancer than the male population. Cancer incidence increases progressively with age, specially after the 5th decade.

Adult↗
PubMedDate not supplied

[Ultrasonography aspects of primary gallbladder neoplasms].

Sixty six patients with primary gallbladder cancer were seen at the Hospital A. C. Camargo, São Paulo, Brazil, from January 1980 to December 1988 and who represent 0.14% of the total of 46,519 patients registered in the same period. Out of the 66 cases, 41 were submitted to an ultrasonographic exam. As to the other 25 patients, 20 had been submitted to a cholecystectomy at another hospital. This exam was not done in the other 5 patients for several reasons. The gallbladder cancer diagnosis was based on data obtained from surgery and confirmed by anatomopathological exam. Regarding the 20 cases operated on at another hospital there was a slide review performed at the Department of Pathologic Anatomy at the Hospital A. C. Camargo. The main ultrasonographic aspects in the 30 cases in which there was a correct diagnosis, were the following: solid mass in the gallbladder lumen in 13 cases (43.33%); solid tumour in the gallbladder area in 7 cases (23.33%); a tumour contiguous to the gallbladder reaching other organs in 6 cases (20.00%); an alteration of the gallbladder shape in 3 cases (10.00%) and an accentuated thickening of the gallbladder wall with inaccurate limits in one case (3.33%). In the sub-group in which the ultrasonographic exam was performed, cholelithiasis was observed in 31 (75.60%) of the 41 cases. There was a correct diagnosis in 18 (58.06%) of the 31 cases with cholelithiasis and in 8 (80.00%) of the 10 without cholelithiasis; not a significant difference. As to the ultrasonographic aspects of the false negative cases, in 9 (81.81%) of the 11 cases the images suggested cholelithiasis. Among these 9 cases there were 2 with an enlarged gallbladder, one case of escleroatrophic gallbladder and one case with thickened walls. The diagnosis of the other 2 cases were biliary mud in one and a probable cholelithiasis in another.

Age Factors↗
PubMed1989

Familial occurrence of anomalous pancreaticobiliary duct union associated with gallbladder neoplasms.

The authors present two cases of anomalous pancreaticobiliary duct union that occurred in a mother and her daughter; the former was associated with gallbladder adenocarcinoma, and the latter, gallbladder adenoma with high grade dysplasia. This disorder has been considered a developmental anomaly, although the true etiology has not been known. This is the first report of familial occurrence of this anomaly, and it may point to the presence of a genetic factor in its development. Another implication is the presence of histological features which suggest the possible sequence of anomalous pancreaticobiliary duct union to intestinal metaplasia to adenoma or dysplasia to cancer of the gallbladder.

Adenocarcinoma↗