PubMed Health⌕ Search

SEARCH · PubMed Health

Results for “Ganglia, Spinal”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 19 recordsLinked to original sources
PubMed1978

[Effect of nerve growth factor and amizil on the viability and metabolism of cultured spinal ganglia].

Spinal ganlia of a 9-day chick embryo were cultivated by the method of "floating rafts" in common medium (control) and in the medium containing amizyl (100 microgram/ml) or a neuregrowth factor (50 microgram/ml). With the action of amizyl there proved to be an increase in the number of surviving neurons; the majority of these neurons contained monoaminoxidase; there was a rise of NAD-diaphorase activity, and, to a lesser extent, of lactic dehydrogenase and isocitric dehydrogenase activities. The neurogrowth factor caused an increase in the number of nerve cells with acetylcholinesterase; there was an elevation of NAD-diaphorase and some rise of malic dehydrogenase activities; the activity of lactic dehydrogenase became maximal; as to succinic dehydrogenase--its activity was somewhat suppressed.

Animals↗
PubMed1978

Substance P-like immunoreactivity in cultured spinal ganglia from chick embryos.

The localization of substance P (SP) or a SP-like peptide in cultured ganglia from chick embryos was studied by the indirect immunofluorescence technique. Ganglia from 8-16 days old chick embryos and from newly hatched chickens were cultured in a control medium or in the presence of nerve growth factor (NGF). Addition of colchicine and exposure to different explanted peripheral tissues were also tried. Ganglia from the younger embryos (8-12 days) cultured for 24 h with added NGF showed a weak SP-like immunoreactivity (SPLI) in some cell bodies and strong specific immunofluorescence in nerve fibres growing out from the ganglia. In spinal ganglia of the older embryos (14 and 16 days) and newly hatched chickens cultured with and without NGF the concentration of SPLI in the cell bodies was considerably higher. Addition of colchicine to spinal ganglia cultured 12 h in NGF-medium, resulted in retraction of nerve fibres and strongly fluorescent, expanded nerve fibres were observed in peripheral parts of the ganglia. Explants of skin placed near the spinal ganglia stimulated the outgrowth of fibres, some of them containing SPLI. A few fluorescent fibres were also seen within the skin explants. Also heart tissue explants stimulated outgrowth of nerve fibres, but innervation of these explants with SPLI-containing nerves could not be observed. Nerve fibre-extension from the spinal ganglia was not stimulated by spinal cord explants. The present results support the existence of SP-containing primary sensory neurons in chickens.

Age Factors↗
PubMed1977

[Connections between spinal ganglia in the pathogenesis of reflex-distant pain syndromes].

Using the complex of the neurohistological research methods the author studied spinal ganglia, spinal cord (37 dogs) following the removal of groups of the spinal ganglia in the cervical and thoracic sections. Widely spread distant receptor-reflex systems of the connections between spinal ganglia accompanied by dendrites and axones were revealed. The fibres of these systems pass in the Bechterew intermediate regions of the posterior columns of the spinal cord. The straight interneuronal connections between the cervical and lumbar spinal ganglia were found. On the basis of the obtained data the author conducted analysis of the mechanism of the occurrence of reflex-distant pain syndromes in patients with ganglio-radiculoneuralgia in degenerative diseases of the vertebral column. The reflex-distant syndrome occurs due to irritation of spinal ganglion neurons accomplishing distant ganglion connections.

Animals↗
PubMed1977

[Routes of blood flow away from human spinal ganglia].

Blood outflow from the spinal ganglia is accomplished along the deferent veins of the lateral part of the ganglia into the intravertebral veins (for most of cervical ganglia--into the veins surrounding the spinal cord artery), from the medial part of the ganglia--along the deferent veins into the longitudinal veins of the interal spinal plexus. Analysing total cross section area of the deferent veins of the spinal ganglia, we were able to reveal a gradual increases in cross section area from the cervical towards the lumbar veins, and a decrease towards the sacral veins. A ratio of total cross section area of the deferent veins to the volume unit of the ganglia substance characterizes capacitance density of the deferent venous bed of the spinal ganglia and is 0.01--0.014 mm2 per 1 mm3.

Adult↗
PubMed1975

Pathology of the human spinal ganglia in varicella-zoster virus infection.

Spinal ganglia from a patient who died on the 6th day of varicella infection were examined by immunofluorescence and electron microscopy, and were compared with spinal ganglia from a patient dying on the 17th day of herpes zoster infection. In herpes zoster, typical intranuclear inclusion bodies were found in neurons, satellite cells and fibroblast-like cells of the ganglia, which contained numerous naked virus particles. In varicella, few changes were found by light microscopy but viral antigen was detected in a few neurons and satellite cells by immunofluorescence. Electron microscopy revealed scattered virus particles near the nuclear membrane of a neuron, satellite cells and capsular cells and enveloped particles in the cytoplasm of satellite cells. The particles in the nuclei were mostly naked virions with specific crescent-like inner-nuclear structure; those in the cytoplasm had complete and incomplete envelopes and showed pleomorphism. A "virus-like" intranuclear filament found in mononuclear cells in herpes zoster and a "plexiform vermicellar array" found in the nuclei of neurons in varicella are at present considered to be non-specific nuclear changes caused probably by viral infections.

Adult↗
PubMedDate not supplied

Pseudo-intracellular collagen tangles in human spinal ganglia.

A new structure was found in the spinal ganglia of 6 out of 215 human autopsy cases with various disorders. It was composed of ballooned cells fully packed with fibrillar structures showing the same staining properties as collagen. Ultrastructurally the fibrillar structures were bundles of collagen fibres with a striation of about 70nm periodicity, and they were enclosed by the cell membrane invaginated in a very complex manner into the cytoplasm. This structure, which we named 'pseudo-intracellular collagen tangle', was considered to result from a disturbance in the releasing process of collagen fibre from fibroblasts. The aetiology of the structure is unknown, but it might represent one of regressive or senile changes in human spinal ganglia.

Aged↗
PubMed1975

Quantitative relationships between nerve and satellite cells in spinal ganglia: an electron microscopical study. II. Reptiles.

In the spinal ganglia of two species of reptiles (gecko and lizard) the volume of the perikaryal satellite cell sheath was found directly proportional both to the volume and surface area of the related neuronal body. This result agrees with that obtained in a previous research on two species of mammals (cat and rabbit). A quantitative balance between neuronal bodies and their associated glial tissue therefore exists also in the spinal ganglia of zoological species phylogenetically quite distant from mammals. The quantitative relationship between glial and nerve tissue was found to be lower in the gecko and lizard than in the cat and rabbit. This difference could have a phylogenetic significance, and/or it could be explained by the lower metabolic rate in the nervous system of the poikilotherms in respect to mammals.

Animals↗
PubMed1975

Uptake of tritium labelled chloroquine into organized cultures of rat spinal ganglia. An electron microscope autoradiographic study.

Cultured spinal ganglia of the rat treated with 3-3H-chloroquine led to the formation of numerous multilamellated bodies (MLB) in the perikarya of neurons, satellite cells, and fibroblasts. Electron microscope autoradiography showed label over and near a considerable proportion of MLB. The action of chloroquine in MLB is discussed with regard to its effect upon lysosomes.

Animals↗
PubMed1976

Cytochemical investigations of proteins and RNA in spinal motoneurons and neurons of spinal ganglia of the rat after space flight.

The content of RNA and cytoplasmic protein was assayed by methods of quantitative cytochemistry in motoneurons of anterior horns of the spinal cord and neurons of spinal ganglia of rats flown for 22 d. It was shown that the 22-d space flight did not change the RNA content in motoneurons of anterior horns of the spinal cord and reduced the RNA content in large neurons of spinal ganglia. The protein content in the cytoplasm of motoneurons and neurons of spinal ganglia was significantly lowered as compared with the control. The RNA content 27 d postflight in motoneurons of anterior horns of the spinal cord was significantly reduced and in neurons of spinal ganglia it did not differ from the control. On the 27th postflight day the protein content in the cytoplasm of motoneurons returned to the preflight level and in the cytoplasm of large neurons of spinal ganglia remained lowered.

Animals↗
PubMed1978

Quantitative histomorphological studies on the spinal ganglia of the Indian buffalo (Bubalus bubalis).

Spinal ganglia of C3, C7, T5, T12, L2 and L5 spinal dorsal roots were studied. These ganglia vary in their size. Their greatest cross-sectional area was at C7 (2.12 cm2) in the cervical region and at L5 (1.39 cm2) in the lumbar region. The neurons were either spherical or oval in contour. The smallest neurons (mean size 68.50 X 55.64 micrometer) were located in the T5 ganglion, while some of the largest neurons (mean size 79.17 X 63.34 micrometer) were noticed in the C3 ganglion. As for their cross-sectional area, the ganglionic neurons at the L5 level were the largest (3,713.16 micrometer2), while the least value (2,994.60 micrometer2) was noted in T5 ganglionic cells. The amphicytes (satellite cells) were clearly defined. The neuronal cytoplasm revealed finely granular Nissl material. The neurons exhibit a pale-staining, centrally located vesicular nucleus with a prominent nucleolus. Few multipolar cells with eccentric nuclei were noted in the L5 ganglion.

Animals↗
PubMed1976

Freeze-fracture aspects of the perineurium of spinal ganglia.

The internal portion of the capsule of the spinal ganglia of rabbit is composed of continuous superimposed layers of flattended cells (perineurium). In replicas, extensive meshworks of strands, presumably forming zonulae occludentes, are found between the perineurial cells of the same layer. Adjacent layers are joint by maculae occludentes located on the lateral processes of the perineurial cells. Occasionally small gap junctions lie within the meshes of the zonulae occludentes.

Animals↗
PubMed1977

[State of the nerve cells of the cat spinal ganglia transplanted into the mesentery].

The survival of the mature differentiated neurons from the spinal ganglia under the conditions of autotransplantation into the colon mesentery of the cat was studied in chronic experiments. For two months, one-third of the neurons from the peripheral parts of the grafts survived and, as the normal ones, had a pseudounipolar form. However, their initial glomeruli had excessive overgrowth in the form of perivascular plexus, in its formation both the main axonal segment with its fine lateral branches and the finest offshoots from the neuronal bodies take part. These regenerating nerve fibres together with growth cones make terminals in the form of buttons, rings and loops. Such terminal structures in the capsular plexus around the neurons and in numerous Nageotte's cells present receptor terminals which are abundantly produced under the condition of the spinal ganglia transplantation.

Animals↗
PubMedDate not supplied

[Topographo-anatomic interrelationships between the branches of the lumbar arteries and the spinal ganglia, nerves and roots].

By using a complex of investigation methods variants of branchingout of the spinal cord and spinal ganglia blood supply sources and their anatomo-topographic interrelations were discerned in 140 preparations of lumbar spinal ganglia obtained from human cadavers of both sexes and different age. With the help of anastomoses these sources form a specific arterial circle around the ganglion. The radicular arteries are noted to be non-equivalent. The annular architectonics of the blood vessels is considered as a morphological manifestation of a functionally reliable blood supply to the border area between the central and peripheral divisions of the nervous system.

Arteries↗
PubMed1977

[Separation of ionic currents responsible for action potential generation in isolated neurons of frog spinal ganglia].

The technique was developed for isolating neurons from the frog spinal ganglia. The isolated cells completely preserved electrical excitability and were investigated under intracellular dialysis conditions. Fast and slow inward current components were found. They were separated by TTX and cadmium: the fast inward current component was blocked by TTX, while the slow inward current was blocked by cadmium. Slow inward current diminished in Na-free solution and calcium ions are supposed to participate in its transfer.

Action Potentials↗
PubMed1977

Long-term unit recording from somatosensory neurons in the spinal ganglia of the freely walking cat.

A new technique has been developed for stable, long-term recording from groups of individual primary afferent neurons in the freely walking cat. A number of fine, flexible wires are inserted into dorsal root ganglia via a small laminotomy in the lumbar spine. The cut end of each wire can record stable and separable action potentials from one to three dorsal root ganglion neurons; each unit has typically held for 1 to 4 days. A broad range of myelinated somatosensory afferent (conduction velocities of 30 to 120 meters per second) have been studies during locomotion. Most cutaneous and proprioceptive afferent studied have been sensitive monitors of complex combinations of step-cycle components, and their firing patterns would often have been difficult to predict from existing information.

Action Potentials↗