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At least 19 recordsLinked to original sources

Gasoline explosions, gasoline sniffing: an epidemic in young adolescents.

One hundred twenty-two patients between the ages of 10 and 15 were admitted to the Shriners Burns Institute between July 1981 and November 1984. Seventy-five of the 122 patients sustained burns as a direct result of liquid gasoline explosions. Thirty patients had thrown gasoline on a fire and 17 others admitted to having ignited gasoline with a match. During admission interviews, none of the patients admitted to gasoline sniffing; however, 19 patients were subsequently found to have been sniffing gasoline at the time of the accident. All of the patients with gasoline burns sustained much larger burns, had longer hospitalizations, and required more surgery than did patients burned by other means. Similarly, the 19 patients who had been sniffing gasoline had larger burns, had longer hospital stays, and required more surgery than did those injured by gasoline in other accidents. The most common cause of thermal injury in the ten-to-15 year age group is a gasoline-related accident. The histories of a large number of these adolescents may be compatible with explosions related to gasoline sniffing. Educational efforts relating to the explosive nature of the substance and the dangers of gasoline sniffing are warranted.

Adolescent↗

Effects of gasoline formulation on methyl tert-butyl ether (MTBE) contamination in private wells near gasoline stations.

UNLABELLED: The extent of methyl tert-butyl ether (MTBE) contamination in private wells near gasoline stations, which lack the relative protection afforded many public waters supplies through zoning and routine testing, was examined. Samples were collected from 74 private wells near 21 randomly selected gasoline stations and from 21 control wells, one per facility. Two hypotheses are tested: (1) private wells downgradient and close (<0.5 mi) to gasoline stations (case wells) are more likely to have MTBE contamination than private wells upgradient and distant (>1.5 mi) (control wells); and (2) private wells near gasoline stations selling oxygenated gasoline are more likely to have MTBE contamination than private wells near gasoline stations selling conventional gasoline. Data on the concurrence of MTBE and other gasoline constituents are presented. RESULTS: MTBE concentrations ranged from <1.0 micro/L (microg/L) to 61 microg/L, with a mean of 12.0 microg/L. MTBE contamination of > or =1 microg/L was detected more frequently in case wells (28%) than control wells (5%) (p = 0.015). MTBE contamination of > or =1 microg/L occurred more frequently in private wells near facilities selling oxygenated gasoline (38%) than private wells near facilities selling conventional gasoline (20%) (p = 0.11). Statistical significance may have been achieved with a larger sample size. Benzene (0.5 microg/L) was found concurrently with MTBE in only one well, which also had the highest concentration of MTBE.

Benzene↗

Chemical fingerprinting of gasoline. 2. Comparison of unevaporated and evaporated automotive gasoline samples.

Analysis of the C(0)- to C(2)-naphthalene compounds present in automotive gasoline using gas chromatography-mass spectrometry with selected ion monitoring (GC-MS (SIM)) and principal component analysis (PCA) was used to discriminate between different samples of gasoline. Phase one of this study explored the ability of this method to differentiate gasoline samples at different levels of evaporation. A total of 35 random samples of unevaporated gasoline, covering three different grades (regular unleaded, premium unleaded and lead replacement), were collected in Sydney, Australia and examined. The high-boiling C(0)- to C(2)-naphthalene compounds present in the gasoline were used to chemically fingerprint each sample at different levels of evaporation. Samples of 25, 50, 75 and 90% evaporated gasoline (by weight) were generated from the 35 samples of unevaporated gasoline. Analysis of the data by PCA followed by linear discriminant analysis (LDA) showed that the 35 samples formed 18 unique groups, irrespective of the level of evaporation. Good discrimination between gasoline samples that were collected on the same day was obtained. Phase two of this study examined the change in gasoline samples over time. The C(0)- to C(2)-naphthalene composition in 96 samples of gasoline collected from three service stations over a 16-week period was examined using the method described. In most cases, it was found that the C(0)- to C(2)-naphthalene profile changed from week to week, and from station to station. In a comparison of all 96 samples together it was found that the majority could be differentiated from one another. The application of the method to forensic casework is discussed.

Journal Article↗

Combustion of gasolines in premixed laminar flames European certified and California phase 2 reformulated gasoline.

Two gasoline qualities, European unleaded certified gasoline (EUCG) and California phase 2 reformulated gasoline (P2 RFG), were analysed. EUCG contained about twice the amount of alkyl benzenes compared to P2 RFG and a large amount of cyclohexane. As a balance, P2 RFG contained higher amounts of isooctane and MTBE. The gasolines were burned in a premixed laminar flame burner at 1 atm and at about stoichiometric fuel/air ratio. The species profiles were measured using on-line GC/MS. About 40 compounds were be detected in the gasoline flames. The EUCG resulted in formation of more reactive and toxic compounds. The combustion profiles of the fuel components showed a similar slope, which suggests that the fuel components burn quite independently of each other. Ethene and propene were the dominating species produced from the two gasolines. Commonly, substantial amounts of higher alkenes were found. Combustion of P2 RFG produced higher amounts of isobutene, propene, propyne, propadiene and methanol compared to combustion of EUCG. The high amount of isobutene is reasonably a result of high concentration of isooctane and MTBE in the fuel. The high amount of methanol formed is probably due to the MTBE present in the gasoline. EUCG produced significantly higher amounts of 1,3-butadiene, which quite likely is formed from the cyclohexane in the fuel. The benzene profiles from both gasolines shows an almost constant level up to 800 microm from the burner surface; this is probably due to formation of benzene from alkyl benzenes.

Air Pollutants↗

[Effect of ethanol gasoline and unleaded gasoline on exhaust emissions of EFI vehicles with TWC].

The injectors' flow-rate of all test vehicles that each was fixed with a three-way catalytic converter (TWC) and Electronic Fuel Injection System (EFI) was tested including before and after vehicles operated on unleaded and ethanol gasoline respectively running for a long time on real road. The three main engine-out exhaust emissions (HC, CO and NOx) from vehicles operating on different fuels were also analyzed by exhaust testing procedure for the whole light-duty vehicle. Test results showed that comparing with unleaded gasoline and ethanol gasoline has a remarkable effect on decreasing engine-out exhaust emissions of CO and HC (both at about ten percent) and the exhaust emissions of CO, HC and NOx from vehicles with TWC respectively. When burning with unleaded gasoline the three main pollutants from vehicles with TWC have already or nearly reached Europe Exhaust First Standard, after changing to ethanol gasoline CO has drastically decreased at about thirty percent, while HC and NOx decreased at about eighteen and ten percent respectively, at this time which they were all above Europe Exhaust Standard First or nearly reached Europe Exhaust Second Standard; ethanol gasoline has also other better performance such as a slight cleaning function on injectors, a slower deteriorative trend of engine-out CO and HC and a longer operating life-span of TWC.

Air Pollutants↗

Reduction of post-shift traffic injuries among gasoline station workers: Are they related to the reduction of occupational gasoline vapor exposure?

AIMS: Solvents exposure is known to impair psychomotor performances. With gasoline vapor recovery devices (GVRD) installed, this study should observe a decrease of traffic injuries after shift among gasoline workers. METHODS: The occupational injury registry data of 1991-2000 in a petrochemical company containing 20,000 workers were analyzed. Cumulative injury rate (CIR) was calculated to estimate lifetime risk. The potential workday loss (PWDL) and the potential salary loss (PSL), which summed up the expected workdays and salary loss assuming a uniform retirement age of 65, were calculated for traffic injuries. Workers of gasoline sales were compared with those without gasoline exposure for commuting traffic injuries. The rate ratio (RR) was calculated based on a person-time data. RESULTS: The CIR dropped 3.14 times during 1997-2000 for commuting accidents on the way back home compared with that during 1991-1992, and the PWDL and PSL dropped 25.2 and 21.5 times, respectively, which corresponded with the time of installments of GVRD. The RRs of commuting accidents on the way back home in the exposed group significantly decreased from 2.15 to 0.53. CONCLUSIONS: The decrease of commuting injuries on journey back home for gasoline workers were probably related to the effective reduction of solvent exposure.

Accidents, Traffic↗

The EPA National Fuels Surveillance Network. I. Trace constituents in gasoline and commercial gasoline fuel additives.

A National Fuels Surveillance Network has been established to collect gasoline and other fuels through the 10 regional offices of the Environmental Protection Agency. Physical, chemical, and trace element analytical determinations are made on the collected fuel samples to detect components which may present an air pollution hazard or poison exhaust catalytic control devices. A summary of trace elemental constituents in over 50 gasoline samples and 18 commercially marketed consumer purchased gasoline additives is presented. Quantities of Mn, Ni, Cr, Zn, Cu, Fe, Sb, B, Mg, Pb, and S were found in most regular and premium gasoline. Environmental implications of trace constituents in gasoline are discussed.

Air Pollutants↗

Chemical fingerprinting of gasoline. Part 3. Comparison of unevaporated automotive gasoline samples from Australia and New Zealand.

A gas chromatography-mass spectrometry with selected ion monitoring (GC-MS (SIM)) method was used to discriminate samples of unevaporated gasoline collected from Auckland, New Zealand and Sydney, Australia. This method was applied to 28 samples of unevaporated gasoline, covering three different grades (regular unleaded, premium unleaded and premium plus unleaded), that were collected from service stations in Auckland, New Zealand in summer (February) and winter (August). The 14 samples of summer gasoline collected in New Zealand could be divided into seven unique groups. The 14 samples of winter gasoline from New Zealand could be divided into 14 unique groups. The 14 samples collected in New Zealand during February 2002 were then compared to 24 samples of unevaporated gasoline collected from service stations in Sydney, Australia during the same month. Most of the samples could be differentiated based on their country of origin.

Journal Article↗

A comparison of European High Test gasoline and PS-6 unleaded gasoline in their abilities to induce alpha 2u-globulin nephropathy and renal cell proliferation.

Male Fischer-344 rats were administered European High Test gasoline (EHT) (50-500 mg/kg), PS-6 unleaded gasoline (UG) (16-500 mg/kg) or 2,2,4-trimethylpentane (TMP) (0.95-30 mg/kg) by gavage for ten consecutive days. To measure cell replication, rats were exposed to [3H]thymidine continuously over the last 7 days of the exposure period. Twenty-four hours after the final dose, protein droplet (PD) accumulation, alpha 2u-globulin (alpha 2u) concentration and the nuclear labeling index (LI), as a measure of cell replication, were measured in the kidneys of control and treated rats. Dose-related increases in PD, alpha 2u and cell replication were detected in the kidneys of rats treated with either gasoline mixture or TMP. The accumulation of PD and the increase in alpha 2u was greater in the kidneys of UG- and TMP-treated rats than in the kidneys of rats treated with EHT. These differences were attributed to the higher composition of branched hydrocarbons in UG, which have been shown to be the biologically active components for these endpoints. The extent of renal cell proliferation was similar in both EHT-, UG- and TMP-treated rats. This suggests that other components besides the branched hydrocarbons are responsible for the increased renal cell replication in EHT-treated rats.

Administration, Oral↗

Assessment in rats of the reproductive toxicity of gasoline from a gasoline vapor recovery unit.

Gasoline (CAS 86290-81-5) is one of the world's largest volume commercial products. Although numerous toxicology studies have been conducted, the potential for reproductive toxicity has not been directly assessed. Accordingly, a two-generation reproductive toxicity study in rats was conducted to provide base data for hazard assessment and risk characterization. The test material, vapor recovery unit gasoline (68514-15-8), is the volatile fraction of formulated gasoline and the material with which humans are most likely to come in contact. The study was of standard design. Exposures were by inhalation at target concentrations of 5000, 10 000, and 20 000 mg/m(3). The highest exposure concentration was approximately 50% of the lower explosive limit and several orders of magnitude above anticipated exposure during refueling. There were no treatment-related clinical or systemic effects in the parental animals, and no microscopic changes other than hyaline droplet nephropathy in the kidneys of the male rats. None of the reproductive parameters were affected, and there were no deleterious effects on offspring survival and growth. The potential for endocrine modulation was also assessed by analysis of sperm count and quality as well as time to onset of developmental landmarks. No toxicologically important differences were found. Therefore, the NOAEL for reproductive toxicity in this study was > or =20 000 mg/m(3). The only systemic effects, in the kidneys of the male rats, were consistent with an alpha-2 u-globulin-mediated process. This is a male rat-specific effect and not relevant to human health risk assessment.

Administration, Inhalation↗

Gas chromatographic and gas chromatographic-mass spectrometric determination of gasoline in a case of gasoline vapor and alcohol poisoning.

A case of fatal poisoning due to the combined effect of alcohol and gasoline following an automobile accident is described. Toxicological analyses by means of gas chromatography and gas chromatography-mass spectrometry permitted the identification and quantitation of alcohol and several hydrocarbons in the heart blood and in the gas in the lung. Great variation was found in the estimates of blood gasoline concentration, depending on which of six constituents of gasoline was chosen for quantitation. The cause of this variation is discussed, together with the possible mechanisms leading to death.

Adult↗

The changes of gasoline compounds in blood in a case of gasoline intoxication.

A 44 year-old man, found in his gasoline vapor filled car, died of multiple organ failure on d 9. Blood samples from d 2-7 were analyzed by gas chromatography/mass spectrometry. The estimated half-lives of gasoline, toluene, ethylbenzene, m,p-xylene, and o-xylene were 16.9, 21.4, 27.5, 32.8, and 25.8 h respectively. The estimated initial gasoline concentration in blood was 247 micrograms/ml.

Acidosis↗

Recreational gasoline sniffing: acute gasoline intoxication and latent organolead poisoning. Case reports and literature review.

Gasoline is a readily obtainable intoxicant that unfortunately lends itself to habitual abuse by sniffing, a practice found particularly among children and adolescents. The concerted effects of the multiple hydrocarbon and other constituents of gasoline result in a predictable acute toxic syndrome. Organoleads, primarily tetraethyl lead (TEL), cause a separate toxicologic symptom-sign complex that overlaps with the initial acute toxic syndrome. The different clinical symptomatology, effects on hemoglobin synthesis, and response to chelation therapy are all in keeping with the view that organolead poisoning is a separate and distinct toxicologic entity from that of classical elemental lead poisoning or "plumbism".

Adolescent↗

Results of long-term experimental carcinogenicity studies of the effects of gasoline, correlated fuels, and major gasoline aromatics on rats.

Unleaded gasoline, with high aromatic content, leaded gasoline, gasoil (diesel), kerosene, toluene, xylenes, ethylbenzene, and 1,2,4-trimethyl-benzene were submitted to long-term experimental carcinogenicity bioassays. The mixtures and the compounds were administered by stomach tube, in olive oil, once daily, 4 days weekly, for 104 weeks, to male and female Sprague-Dawley rats. The animals were kept under control until the end of the experiments. With varying degrees of evidence, all the tested materials were found to increase the total number of malignant tumors and of some site-specific tumors. They must therefore be considered carcinogenic. On the basis of our results the rank of carcinogenic potency of the tested aromatic hydrocarbons increases in the following order: 1,2,4-trimethylbenzene, ethylbenzene, xylenes, toluene (benzene).

Animals↗

Neurotoxic effects of gasoline and gasoline constituents.

This overview was developed as part of a symposium on noncancer end points of gasoline and key gasoline components. The specific components included are methyl tertiary butyl ether, ethyl tertiary butyl ether, tertiary amyl methyl ether, butadiene, benzene, xylene, toluene, methyl alcohol, and ethyl alcohol. The overview focuses on neurotoxic effects related to chronic low-level exposures. A few general conclusions and recommendations can be made based on the results of the studies to date. a) All the compounds reviewed are neuroactive and, as such, should be examined for their neurotoxicity. b) For most of the compounds, there is a substantial margin of safety between the current permissible exposure levels and levels that would be expected to cause overt signs of neurotoxicity in humans. This is not the case for xylene, toluene, and methanol, however, where neurologic effects are observed at or below the current Threshold Limit Value. c) For most of the compounds, the relationship between chronic low-level exposure and subtle neurotoxic effects has not been studied. Studies therefore should focus on examining the dose-response relationship between chronic low-level exposure and subtle changes in central nervous system function.

Environmental Exposure↗

Exposure to regular gasoline and ethanol oxyfuel during refueling in Alaska.

Although most people are thought to receive their highest acute exposures to gasoline while refueling, relatively little is actually known about personal, nonoccupational exposures to gasoline during refueling activities. This study was designed to measure exposures associated with the use of an oxygenated fuel under cold conditions in Fairbanks, Alaska. We compared concentrations of gasoline components in the blood and in the personal breathing zone (PBZ) of people who pumped regular unleaded gasoline (referred to as regular gasoline) with concentrations in the blood of those who pumped an oxygenated fuel that was 10% ethanol (E-10). A subset of participants in a wintertime engine performance study provided blood samples before and after pumping gasoline (30 using regular gasoline and 30 using E-10). The biological and environmental samples were analyzed for selected aromatic volatile organic compounds (VOCs) found in gasoline (benzene, ethylbenzene, toluene, m-/p-xylene, and o-xylene); the biological samples were also analyzed for three chemicals not found in gasoline (1,4-dichlorobenzene, chloroform, and styrene). People in our study had significantly higher levels of gasoline components in their blood after pumping gasoline than they had before pumping gasoline. The changes in VOC levels in blood were similar whether the individuals pumped regular gasoline or the E-10 blend. The analysis of PBZ samples indicated that there were also measurable levels of gasoline components in the air during refueling. The VOC levels in PBZ air were similar for the two groups. In this study, we demonstrate that people are briefly exposed to low (ppm and sub-ppm) levels of known carcinogens and other potentially toxic compounds while pumping gasoline, regardless of the type of gasoline used.

Adult↗