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At least 19 recordsLinked to original sources
PubMed1987

Simple and quick gastric cancer screening method using the "Bi-Digital O-Ring Test" and its critical evaluation by standard X-ray, gastroscopic and pathological microscopic examination.

The simple, quick and non-invasive application of the "Bi-Digital O-Ring Test Cancer Screening Method" for adenocarcinoma of the stomach originally described by Y. Omura, indicated 21 out of 196 randomly selected patients who visited our hospital (114 male and 82 female with an average age of 57.2 years) to have a cancer positive response regardless of their original chief complaint. In all these 21 patients we did imaging of the outline of the stomach and localized adenocarcinoma positive area with the "Bi-Digital O-Ring Test Imaging Method." 5 out of 21 patients were confirmed to have adenocarcinoma of the stomach by microscopic examination of biopsied stomach tissue following X-ray and gastroscopic examination. Of these 5 patients with the cancer, 3 had no chief complaint indicative of stomach problems. This study indicated that simple, quick and non-invasive cancer screening method using "Bi-Digital O-Ring Test" with microscopic slide of adenocarcinoma of stomach as reference control substance, can detect stomach cancer with much greater accuracy, without giving any physical discomfort to the patient and with minimum time and expense, compared with well established standard x-ray and gastroscopic examination methods. The effectiveness and relative accuracy of mass screening of patients for gastric cancers using "Bi-Digital O-Ring Test" was well established by this study.

Adenocarcinoma↗
PubMed1991

[Comparative gastroscopic and pathologic study on "one point carcinoma" in gastric cancer--analysis of 25 cases. "One Point Carcinoma" National Cooperative Group].

Twenty-five cases of "one point carcinoma" of the stomach, collected from 14 institutes in China, diagnosed by gastroscopic biopsy and proved by regional serial sectioning of the resected specimen as having no more cancerous lesion are presented and studied. The concept, terminology and significance of "one point carcinoma" on the gastric mucosa are put forward by comparative study of the local gross findings and the histopathologic features. The gastroscopic findings showed: mucosal discoloration 3 cases; nodule-like elevation 8 cases; superficial erosion 6 cases; and superficial ulceration 8 cases. Pathologic diagnosis of mucosal biopsy material was: well and moderately differentiated adenocarcinoma 11 cases; poorly differentiated adenocarcinoma 4 cases; signet-ring cell carcinoma 1 case; cancerous change 4 cases; and carcinoma unclassifiable 3 cases. The pathologic changes in the gastric mucosa of the resected specimen were: chronic atrophic gastritis, intestinal metaplasia with superficial erosion and dysplasia 14 cases; superficial gastritis (including partial gastritis verrucosa), intestinal metaplasia with superficial erosion, superficial ulceration and dysplasia 11 cases. The concept of "one point carcinoma", its gross characteristics, biopsy technique and observations as well as other relevant problems discussed are important in the detection of micro-cancerous lesion of gastric carcinoma.

Adenocarcinoma↗
PubMed1989

Gastroscopic screening of the post-gastrectomy stomach. Relationship of dysplasia to remnant cancer.

In July 1980, an aggressive screening program for benign disease of the stomach in 163 patients at risk for carcinomatous change of the gastric remnant was instituted. All patients were at least ten years post-gastrectomy. Three gastric remnant cancers were identified during esophago-gastroduodenostomy (EGD) on 45 patients undergoing only one screening endoscopic examination during the study. One hundred and eighteen additional patients underwent two or more screening gastroscopic studies between July 1980 and July 1985. Of this group, seven patients (5.8%) had gastric biopsies showing mild to moderate dysplasia in the gastric remnant. During the period July 1985 to July 1987, these seven patients underwent two to four additional gastroscopic examinations that revealed carcinoma of the gastric remnant in two patients (28%) with progression of the dysplastic changes in three of these seven patients (42%). The post-gastrectomy interval in these seven patients ranged from 10 to 27 years with a mean of 21.5 years. This study supports the concept of neoplastic change in the gastric remnant as a function of time from initial gastric resection. EGD and biopsy are important in identifying dysplastic changes which may be harbingers of invasive carcinoma of the gastric remnant. Aggressive endoscopic screening is recommended for patients with dysplasia in order to identify gastric remnant cancer while potentially curable.

Adenocarcinoma↗
PubMed1978

Gastroscopic reduction of afferent loop intragastric intussusception.

A case is presented of afferent loop intragastric intussusception diagnosed by gastroscopy 18 years after partial gastrectomy with retrocolic gastrojejunostomy. The intussusception was successfully reduced by means of the gastroscope. The symptoms were instantly relieved, with a symptom-free follow-up of 1/2 year. Provided that the intussuscepted segment appears viable it seems justified to aim initially to reduce jejuno-gastric intussusception with the aid of the gastroscope.

Aged↗
PubMed1979

A gastroscopic and pharmacological study of the disintegration time and absorption of pivampicillin capsules and tablets.

1 An in vitro investigation showed that pivampicillin tablets disintegrated more rapidly than pivampicillin capsules. This result was demonstrated and confirmed by gastroscopy in a cross-over study in healthy volunteers. 2 There were no differences in serum levels of ampicillin obtained with the two preparations, but compared with non-gastroscoped volunteers, there was delay of 0.5--1.5 h in the appearance of peak serum ampicillin concentrations after gastroscopy. 3 Half of the volunteers receiving pivampicillin capsules developed hyperaemia, interstitial bleeding or erosions of the gastric mucous membrane. No such reactions were seen after pivampicillin tablets. 4 In one volunteer, a pivampicillin capsule was trapped in a not previously noticed hiatus hernia and local changes and pain occurred.

Adult↗
PubMed1978

The effect of metoclopramide (Primperan) on the pyloric sphincter during gastroscopic examination. A double blind investigation versus placebo.

The effect of metoclopramide and placebo on relaxation of a spasmodic pylorus during gastroscopy have been compared using a double blind technique. Metoclopramide showed a better result and the difference between its effect and the effect of placebo is statistically significant (p less than 0.01). Metoclopramide is a useful agent during gastroscopic examination in cases of spasmodic pylorus. It facilitates the passage of the gestroscope through the spasmodic pyloric sphincter. The reported relaxation and dilatation of the pyloric sphincter clarifies the amelioration of symptoms in different gastrointestinal troubles.

Adult↗
PubMed1975

Gastroscopic observations related to bioptical histology in healthy medical students.

The examinations were performed on 10 medical students, 22-23 years old, of whom 5 were women. Directed biopsies were taken from the antral mucosa and the mucosa of the greater and lesser curvatures, average number being 6.7. Gastroscopy showed a normal mucosal folding in all students. None had mucosal reddening or mucus covering of more than slight grades. The examination concluded with a normal gastric mucosa in 4 and probably normal in 2 students. In 4 students a superficial gastritis was supposed to be present. Bioptical histology showed a normal mucosa in the antrum in 6 students, at the lesser curvature in 7, and at the greater curvature in 8 students. In the others a slight superficial gastritis in the antral mucosa. There was a fairly good correlation between the gastroscopic observations and the findings by histology on directed biopsy in 6 of the students.

Adult↗
PubMed1989

[Gastroscopic mucosal biopsy and carbon ink injection marking for determination of resection line on the gastric wall in stomach cancer].

Gastroscopic mucosal biopsies and carbon ink injection marking were performed in 31 patients with gastric cancer before operation. The resection line of gastric wall was determined during operation according to the marked points. The method, dose, site, and opportunity of ink injection were studied. The results were: 1. None of these 31 patients had positive biopsies from cancer free areas. None of the resected specimens showed deep cancer infiltration beyond the site of carbon ink injection. This method is significant in recognizing the extent of intramucosal cancer infiltration; 2. None of the 31 patients marked by ink injection had residual cancer on the resected line whereas 8-10% of those unmarked had a positive margin. This result indicates that this method is significant in avoiding residual cancer on the resection line; and 3. Before surgery, the home-made carbon ink was satisfactory. The optimum dose for an ideal ink point was 0.05-0.1 ml/point which would give a marking of 0.5-1.5 cm in diameter on the serosa. The ink point was clearly shown on the anterior wall but less satisfactorily on the lesser curvature of the stomach. Injection performed as early as the fifth week before operation was valid.

Biopsy↗
PubMed1979

[Complex x-ray, gastroscopic and cytological diagnosis of malignant gastric ulcer].

Under discussion are some aspects of the diagnosis of malignant gastric ulcers established by means of a complex gastrologic examination of patients with ulcerous pathology of the stomach. Errors, difficulties and possibilities of roentgenological, gastroscopic and cytologic methods for recognition of malignant gastric ulcers are analysed. It is emphasized that cytological assay is highly efficient in ascertaining a malignant nature of the ulcer. A careful complex investigation of patient with gastric ulcer is felt to be indispensable to recognize its early stages.

Adult↗
PubMed1979

[Correlation of gastroscopic, pathohistologic, cytologic and cytochemical analysis of ulcer lesions and other pathologic changes in the gastric mucosa. Preliminary study].

This paper concerns our first experience of correlation analysis between the gastroscopic, pathohystologic, cytologic and cytochemical findings of different organic gastric lesion on gastroscopy. The authors' experience is based on 78 patients in whom 450 biopsies were performed. For an adequate analysis, 135 samples of pathohystologic anc cytological examinations were useful and only 80 samples for cytochemical analysis. From these examinations it is possible to conclude that the cytochemical reactions of the group of patients with inflammatory lesions and intestinal metaplasia showed changes in the level of enzyme aminopolypeptidase together with the presence of acid mucopolysacharides. In the group of patients with lesions showing an ulcer, carcinoma or suspect malignancies, the changes occured in the composition of enzymes such as acid phosphatase, DNP Diaphoresis and nonspecific esterases. With such combined examinations the percentage of correct diagnoses was increased in comparison with conventional method of gastroscopy and biopsy.

Gastric Mucosa↗
PubMed1987

Precise gastric secretory studies using a new fiber-gastroscope.

A system for the precise measurement of gastric secretion was devised using an endoscope produced specially for this purpose. Gastric juice was collected through the endoscope every 10 minutes before and after tetragastrin stimulation. Results were compared with those obtained by the conventional method using a nasogastric tube in the same patients (n = 24). The ratio of gastric secretory volume and acid output with the endoscopic method, to those with the conventional method ranged from 1.30 to 1.48. This difference was statistically significant (p less than 0.01). There was no significant difference in the acid concentration of gastric juice collected by the two methods. The coefficient of variation for the volume collected in six basal 10-minute fractions was significantly smaller in the endoscopic method. Gastric secretory studies can be performed by endoscopy with no more discomfort, and the result is more accurate than studies using a gastric tube. This precise method of gastric analysis should prove useful in investigating gastric physiology when accuracy and reliability are paramount.

Gastric Acidity Determination↗