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Results for “Gingivitis, Necrotizing Ulcerative”

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At least 19 recordsLinked to original sources
PubMed1979

[Acute necrotizing-ulcerative gingivitis in young men].

Acute necrotizing ulcerative gingivitis is a disease in which the bacilli of the flora normally found in the buccal cavity (fusiform bacilli and spirochetae) play a role. This type of gingivitis occurs relatively frequently in young men. The frequency of the disease tends to peak in the winter. We examined 72 young men between the ages of eighteen and twenty-one with acute necrotizing ulcerative gingivitis, fever and swelling of the regional lymph nodes for possible noxas. All of the individuals were smokers: approximately 3/4s of the group smoked more than 60 cigarettes per day. Roughly half of the individuals examined showed extremely poor oral hygiene or underlying psychological or physical stress at the onset of the disease. Dentitio difficilis and alcohol abuse however appeared to be less important factors. Symptomatic measures, such as mouthwash and oral hygiene, proved to be effective therapy. Diseases and disorders of internal structures of the body could not be diagnosed in any of these individuals.

Adolescent↗
PubMed1991

Pathogen-related spirochetes identified within gingival tissue from patients with acute necrotizing ulcerative gingivitis.

The purpose of this investigation was to determine whether monoclonal antibodies against pathogen-restricted antigens of Treponema pallidum subsp. pallidum could be used as probes for spirochetes in diseased gingival tissue from subjects with acute necrotizing ulcerative gingivitis. A biotin-streptavidin system was used to identify spirochetes bound by monoclonal antibodies in cryostat sections of tissue. Twelve of 16 tissue samples from diseased sites, but none of 8 tissue specimens from healthy sites, reacted with pathogen-restricted antibodies. Organisms were found in intact epithelium and connective tissues adjacent to ulcers. Staining intensity was often high in perivascular locations and around vesicular spaces. Monoclonal antibodies to Bacteroides gingivalis and Treponema denticola were each reactive with diseased gingival tissues, but staining was usually restricted to ulcerated areas. These studies extend recent observations that showed that subjects with acute necrotizing ulcerative gingivitis had both pathogen-related spirochetes in dental plaque and serum immunoglobulin G to pathogen-restricted antigens on T. pallidum subspecies, suggesting that pathogen-related spirochetes may be associated with the pathogenesis of certain periodontal diseases.

Adolescent↗
PubMed1975

The relationship of 17-hydroxycorticosteroid to acute necrotizing ulcerative gingivitis.

Eleven patients presenting with acute necrotizing ulcerative gingivitis (ANUG) collected 24-hour urine samples during and after the course of their ANUG. The Porter-Silber technique was used to determine the 17-hydroxycorticosteroid concent of the urine, a physiological measure of stress. All of the patients had significantly higher levels of 17-hydroxycorticosteroid during the course of their ANUG than after it had resolved.

17-Hydroxycorticosteroids↗
PubMed1991

Acute necrotizing ulcerative gingivitis is associated with attachment loss.

Acute necrotizing ulcerative gingivitis (ANUG) has been generally considered as a gingivitis. However, clinical impressions suggest that periodontal attachment loss is one of the sequelae of the disease. This study was designed to investigate the extent of probing attachment loss detectable following resolution of the acute phase of the disease. 13 patients (3 male, 10 female) aged on average 22.7 years were studied. The presence of interdental soft tissue cratering was used to determine whether a site was previously affected by ANUG. ANUG sites were compared with other sites using a paired Student t-test (N = 13). Patient mean probing attachment level was greater for ANUG sites (2.2 +/- 0.9) than for the mean of all other sites (0.8 +/- 0.7). It is concluded that greater loss of probing attachment is associated with sites affected by ANUG than with other sites studied.

Acute Disease↗
PubMed1991

The treatment of acute necrotizing ulcerative gingivitis.

The destruction of the interdental papillae and formation of permanent gingival craters are common sequelae of acute necrotizing ulcerative gingivitis. These craters can be disfiguring, especially in the anterior gingiva, and can act as a nidus for recurrent episodes. Traditional therapy has emphasized a surgical approach for elimination of these defects, often increasing the esthetic problems. The purpose of this paper is to review the treatment modalities of acute necrotizing ulcerative gingivitis and illustrate an alternative treatment approach of periodic scaling, root planing, and antimicrobial rinses with 0.12% chlorhexidine. With this therapeutic regimen, the disease process can be reversed and damaged papillae may regenerate.

Chlorhexidine↗
PubMed1990

Spirochetes in early lesions of necrotizing ulcerative gingivitis experimentally induced in beagles.

The presence of spirochetes and other bacteria during the induction of necrotizing ulcerative gingivitis (NUG) in beagle dogs was studied by transmission electron microscopy. NUG was induced by application of dental debris from diseased dogs to 4 beagles treated with corticosteroid. Biopsies of interdental papillae were collected during a period of 7 weeks. Spirochetes and other bacteria were observed in enlarged intercellular spaces between non-keratinized epithelial cells. Intracellular bacteria were found with and without surrounding vesicular spaces. The invasive spirochetes were mainly intermediately sized and of flagellar "4-8-4" configuration or higher. Bacterial invasion of the sulcular epithelium occurred before clinical evidence of NUG could be observed. It is concluded that invasion by intermediate spirochetes and other bacteria plays a role in initiating ulcerative gingivitis in beagles.

Animals↗
PubMed1991

[Acute necrotizing ulcerative gingivitis (ANUG) in HIV antibody-positive subjects].

The paper reports five cases of acute ulcero-necrotic gingivitis in AbHIV-positive subjects and stresses that the frequency of this pathology in the AbHIV-positive population is 0.67% (3.3% if only the homosexual population is taken into consideration) compared to 0.02-0.08% in the normal population. These findings may therefore suggest an association between AUNG and HIV-1 infection.

AIDS-Related Complex↗
PubMed1975

Necrotizing ulcerative gingivitis in children: a 9 year clinical study.

Twenty-eight children with ANUG and nine children with noma were studied over the past 9 years. It is concluded that these entities occur only in children from low socioeconomic groups and have a multifactorial etiology consisting of poor oral hygiene and malnutrition. In the case of noma, a prior infection with a viral agent or intestinal parasitism appears to be important predisposing factors.

Adolescent↗
PubMed1991

Identification of spirochetes related to Treponema pallidum in necrotizing ulcerative gingivitis and chronic periodontitis.

BACKGROUND: Spirochetes are commonly associated with periodontal disease, but it is not known whether these treponemes are pathogenic or merely opportunistic. We sought to determine whether spirochetes present in periodontal disease share antigens thought to be unique to spirochetes that are known pathogens. METHODS: We examined dental plaque from 24 healthy subjects, from ulcerative sites in 17 patients with ulcerative gingivitis, and from areas of involvement in 19 patients with chronic periodontitis, using an immunocyto-chemical technique with monoclonal antibodies against pathogen-specific determinants on 47-kd and 37-kd molecules from Treponema pallidum subspecies pallidum. Serum was tested against T. pallidum by immunoblotting and by serologic assays for syphilis. RESULTS: Spirochetes with a pathogen-specific epitope on a 47-kd molecule were not found in plaque samples from any of the 24 healthy subjects, but they were identified in plaque samples from 11 of 17 patients with ulcerative gingivitis (P less than 0.001) and from 10 of 19 patients with periodontitis (P less than 0.01). Monoclonal antibodies directed against a 37-kd molecule reacted with spirochetes in plaque samples from 1 of 14 controls, from all 11 patients with gingivitis from whom samples could be obtained (P less than 0.001), and from 14 of 19 patients with periodontitis (P less than 0.001). Five of 18 normal subjects had IgG against 47-kd and 37-kd molecules, but none had IgG against 14-kd or 12-kd molecules from T. pallidum subspecies pallidum. Among 19 patients with ulcerative gingivitis, IgG was identified against 47-kd molecules in 15, against 37-kd molecules in 12, against 14-kd molecules in 4, and against 12-kd molecules in 15. CONCLUSIONS: The spirochetes found in dental plaque from patients with ulcerative gingivitis or chronic periodontitis have antigens that are thought to be unique to pathogenic treponemes. This close antigenic relation suggests that T. pallidum or a closely related organism may be involved in the pathogenesis of periodontal disease.

Adult↗