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Results for “Granuloma, Plasma Cell”

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PubMed2001

Gingival plasma cell granuloma.

Plasma cell granulomas (pseudotumors) are rare benign, tumor-like proliferations composed chiefly of plasma cells that manifest primarily in the lungs, but may occur in various anatomic locations. We report this case of a 54-year-old male who presented with an unusual maxillary anterior gingival overgrowth treated by excisional biopsy. Histological examination revealed a dense inflammatory cell infiltrate containing mainly plasma cells. Immunohistochemistry for kappa and lambda light chains showed a polyclonal staining pattern confirming a diagnosis of plasma cell granuloma. Intraoral plasma cell granuloma is exceedingly rare, although case reports documenting such lesions have been reported. This case highlights the need to biopsy unusual lesions to rule out potential neoplasms.

Diagnosis, Differential↗

PubMed2001

A hard thyroid mass due to plasma cell granuloma.

Plasma cell granuloma involving the thyroid is very rare. A 29-year-old man with type 1 diabetes mellitus presented with a one-week history of fever, sore throat, neck tenderness and dysphagia. Antibiotics were given but over the next two weeks a hard 8 cm mass in the left lobe of the thyroid developed. Fine needle aspiration was not diagnostic and surgical exploration revealed an inflammatory process arising from the left lobe of the thyroid involving the left sternothyroid muscle and parapharyngeal spaces. Histology of multiple biopsies showed plasma cell granuloma. Immunoperoxidase staining demonstrated the presence of IgG, IgM and IgA with predominance of IgG. The residual mass resolved and was impalpable after four weeks. Plasma cell granuloma should be suspected when there is a rapidly developing hard thyroid mass. Open biopsy/removal and histological confirmation are mandatory and residual disease may resolve within weeks.

Adult↗

PubMed2000

Intracranial plasma cell granuloma.

Plasma cell granulomas (PCGs) are benign, inflammatory masses of unknown etiology composed of polyclonal mature plasma and lymphoid cells. The lung is their most common location, and occurrence within the cranial cavity is extremely rare. We report the case of an 11-year-old girl who presented with seizures and was diagnosed as having a dural-based right frontal tumor that extended toward the sagittal sinus and the falx. The lesion was totally excised, together with the abnormal dura. A limited cortical excision was also performed using electrocorticographic guidance. Histopathologic diagnosis of intracranial plasma cell granuloma was reached after extensive immunohistochemical tests and electron microscopy. This is the third case of PCG with description of changes in the neighboring cerebral tissue. Although PCGs are well-circumscribed lesions, lymphoplasmocytic inflammation, neuronal loss, and reactive gliosis occur within the adjacent cortex. Disturbed cortical lamination, as we have observed, appears to be a histological finding that has not been described previously.

Adolescent↗

PubMed1991

Evolution of a case of lung plasma cell granuloma.

Plasma cell granuloma, on lung inflammatory pseudotumour, is a localized benign proliferation of plasma cells and mesenchymal cells. We report the case of a 45 yr old male, who first presented with mild pain in the left side of the chest. Chest radiography was normal. Eight weeks later he had more pain and an opacity in the left and lower zones of his left chest. After another 7 weeks he had fever and cough with yellowish-green sputum. Chest X-ray then showed a round density in the left upper lobe. The final diagnosis was established after thoracotomy histological examination.

Granuloma, Plasma Cell↗

PubMed1983

Experimental production of pulmonary granulomas: III. Plasma-cell granulomas in mice.

Endobronchial instillation of Freund's complete adjuvant (FCA) induced plasma-cell granulomas in the lungs of DD strain mice. One week after administration, plasma cells appeared in monolayered cell clusters around pulmonary arterioles running along the bronchial tree. The plasma cells increased in number with time to form granulomas consisting mainly of well developed plasma cells with an admixture of lymphocytes and macrophages. At the peak of production of granulomas (4-10 weeks), the plasma cells piled up around the arterioles and infiltrated the connective tissues surrounding the bronchioles. Germinal-centre-like foci could be demonstrated in the granulomas. The lymph nodes draining the treated lobe showed marked proliferation of plasma cells in the medullary cord, suggesting that the plasma cells passed through alveolar walls into the lung and migrated to periarteriolar connective tissue.

Animals↗

PubMed1995

[Intracranial plasma cell granuloma: a case report].

Plasma cell granuloma occurs most frequently in the lung and upper respiratory tract; fewer than ten cases have been reported to occur in the central nervous system. A case of intracranial plasma cell granuloma in a 69-year-old male was reported. He visited our clinic, complaining of progressive visual disturbance. The CT in this patient showed a suprasellar mass, diagnosed as a tuberculum sellae meningioma. Over a 10-year observation period the tumor grew remarkably and, when finally removed, it proved to be a plasma cell granuloma. This report presents CT scans and MR images and a review of the literature relevant to this rare intracranial lesion. The most common preoperative diagnosis in these cases, as reported here, was meningioma. Although plasma cell granuloma rarely occurs intracranially, the existence of this entity should be borne in mind in the differential diagnosis of meningioma.

Aged↗

PubMed1999

[A case of pulmonary plasma cell granuloma with a cavity].

Plasma cell granuloma of the lung is an uncommon and non-malignant neoplasm that may present difficulties in both diagnosis and management. We report a 52-year-old male who was admitted to our hospital due to fever and an abnormal shadow on chest roentgenography. Chest computed tomography revealed a tumor shadow with a cavity in the left upper lobe. However, neither bronchofiberscopy nor serum examinations suggested a diagnosis. Video-assisted thoracoscopic surgery (VATS) was performed and postoperative pathological examination of the resected specimen showed plasma cell granuloma. The postoperative course was uneventful. No recurrence was observed 10 months after the operation. As plasma cell granuloma of the lung is histologically benign, surgery should be performed to preserve the maximal residual lung with no lesion. VATS is the method of choice for treatment of pulmonary plasma cell granuloma.

Humans↗

PubMed1992

Plasma cell granuloma of the lung.

Plasma cell granuloma is an uncommon, nonneoplastic pulmonary lesion. An 11-year retrospective review of resected pulmonary tumors yielded six patients with plasma cell granulomas. Fine needle aspiration biopsy results were falsely positive for carcinoma in one patient. Adherence or invasion of the mediastinum was present in three patients. Granuloma in one patient, who underwent two operative procedures, was deemed unresectable at the initial thoracotomy. For both diagnostic and therapeutic reasons, early surgical excision is recommended for plasma cell granulomas of the lung.

Adult↗

PubMed1984

Plasma cell granuloma of the tonsil.

Plasma cell granuloma (inflammatory pseudotumor) has been described most commonly in the lung. Review of the English literature fails to reveal occurrence of such a lesion in the tonsil. We are reporting such a case presenting as a unilateral tonsillar mass in a 63-year-old man. A more typical case of plasma cell granuloma of lung is also presented to illustrate the similarity between the tonsillar and pulmonary lesions.

Adult↗

PubMed2004

Primary plasma cell granuloma of petrous bone.

Plasma cell granulomas are rare intracranial lesions that can mimic a variety of intracranial tumours. As they are usually benign lesions, their identification assumes importance. We report a case of plasma cell granuloma in a 52-year-old man presenting with features of left sided V, VII and bilateral VIII nerve involvement who underwent subtotal excision of the lesion. The relevant literature is reviewed.

Bone Diseases↗

PubMedDate not supplied

Variable CT appearance of plasma cell granuloma of the lung.

Plasma cell granuloma of the lung is an uncommon benign inflammatory pseudotumor. Although it typically presents as a solitary mass on chest radiography, several chest film appearances have been described. Three cases are presented that illustrate the variable range and nonspecificity of CT appearances of plasma cell granuloma of the lung. Computed tomography is useful in the evaluation of these lesions primarily to establish important anatomic relationships associated with each of the various manifestations.

Adult↗

PubMed2002

Plasma cell granuloma of the thyroid.

Plasma cell granuloma of the thyroid is an uncommon lesion; only 6 cases have been reported in the English literature to date. All reported cases occurred in women, mostly after the age of 50 years. We report a case of plasma cell granuloma of the thyroid in a 46-year-old woman with a 20-year history of euthyroid goiter and a positive family history of goiter in 3 close relatives. The lesion was composed of sheets of plasma cells involving the entire parenchyma that histologically resembled plasmacytoma. Plasmacytoma was excluded by demonstration of polyclonal kappa/lambda light chain immunostaining and by lack of evidence of clonal bands by polymerase chain reaction for immunoglobulin heavy-chain gene rearrangement. Similarly, the predominant histologic pattern in all previously reported cases is that of marked plasma cell infiltration. A family history of thyroid disease (goiter, thyroiditis) was associated with diffuse involvement of the thyroid. Prognosis after surgery is excellent, and to our knowledge no cases of malignant transformation or recurrence have been described.

Antigens, CD↗

PubMed1985

[Plasma cell granuloma of the lung].

Plasma cell granuloma is a rare, benign and usually solitary round tumour of the lung. Although uncommon, it is found relatively more frequently among children and adolescents. The lack of symptoms and absence of characteristic features make diagnosis difficult. In adults, the differentiation from bronchial carcinomas is particularly difficult because of their radiological similarity. Consequently, thoracotomy and excision of the tumour is the treatment of choice.

Aged↗

PubMed1985

Plasma cell granuloma of the thyroid.

Plasma cell infiltrates in the thyroid are rare. They may represent several processes, such as localized plasmacytoma, multiple myeloma, or plasma cell granuloma (PCG). It may be difficult to distinguish these disorders on the basis of morphologic features in sections stained with hematoxylin-eosin. All may be composed of mature plasma cells, without admixed macrophages or lymphocytes, that infiltrate the thyroid and adjacent connective tissue. The identification of the uncommon, but benign, PCG is facilitated by immunohistochemical staining to demonstrate an admixture of plasma cells with cytoplasmic kappa and lambda light chains. The polyclonal nature of the plasma cell infiltrate distinguishes PCG from neoplastic plasma cell proliferation.

Female↗

PubMed1994

[CT findings of pulmonary inflammatory pseudotumors (plasma cell granulomas)].

Pulmonary inflammatory pseudotumor (plasma cell granuloma) is not a true neoplastic lesion, but is composed of a variety of inflammatory cells, predominantly plasma cells. The chest X-ray features resemble those of malignant lung tumors; therefore, CT is often necessary for further evaluation. We report the CT features of five cases with histologically proved pulmonary inflammatory pseudotumor, which can be summarized as follows: a solitary round or oval parenchymal mass with regular or irregular margin, and with or without calcifications. The calcifications are useful for differential diagnosis if present, but they are usually non-specific in shape and configuration. The mean CT attenuation value of the major portion of the mass was increased from 41 HU to 78 HU by the injection of contrast material. In one case, a linear extension of the lesion was seen from the mass to the lung hilum. In three cases, satellite lung nodules were seen. One of these nodules was also proved histopathologically to be inflammatory pseudotumor. The biopsy specimens obtained by using a 20 gauge cutting-needle and an automated biopsy gun were satisfactory for histopathological diagnosis.

Adult↗

PubMed1996

Plasma cell granuloma of the temporal bone.

Plasma cell granulomas are uncommon, benign tumors comprised primarily of mature plasma cells and are a distinct entity, separate from plasmacytomas. They are rarely found in the head and neck, and have never been reported in the temporal bone. This case represents the first report of a plasma cell granuloma originating in the temporal bone. Treatment options include surgical removal and radiation therapy.

Audiometry↗

PubMedDate not supplied

Plasma cell granuloma of the thyroid gland.

Plasma cell granuloma is a tumor-like lesion consisting of mature plasma cells, sometimes with Russell bodies and reticuloendothelial cells, supported by a stroma of granulation tissue. These tumors are most common in the lungs and were sporadically reported in extrapulmonary sites. A rare case of plasma cell granuloma of the thyroid is reported. The value of immunohistochemical staining is demonstrated.

Female↗

PubMed2003

Intracranial plasma cell granuloma with genetic analysis.

BACKGROUND: Plasma cell granuloma of the central nervous system is rare and less than 30 cases have been reported in literature. METHOD/FINDINGS: A 64-year-old woman complained of headache, and computed tomography (CT) and magnetic resonance (MR) imaging of the brain revealed a tumour at the right anterior-third parasagittal region which led us to diagnose a parasagittal meningioma. We performed total resection of the tumour and the pathological diagnosis was plasma cell granuloma. Polymerase chain reaction (PCR) analysis of immunoglobulin heavy chain (IgH) gene rearrangements produced no monoclonal band. This patient underwent no supplementary treatment and no recurrent tumour was observed for 3 years. INTERPRETATION: A case of plasma cell granuloma which is diagnosed with genetic analysis is presented. An analysis of the clonality using the PCR procedure would play an important role in supporting the pathological and clinical diagnosis.

Brain Diseases↗