PubMed Health⌕ Search

SEARCH · PubMed Health

Results for “Guided Tissue Regeneration, Periodontal”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 19 recordsLinked to original sources
PubMed1997

Treatment of gingival recession using guided periodontal tissue regeneration.

Gingival recession is an apical displacement of the gingival margin and involves loss of connective tissue attachment and the supporting alveolar bone. Various treatment modalities have been utilized in the treatment of gingival recession in order to eliminate etiologic factors, achieve root coverage, regenerate the lost periodontal attachment, and prevent perpetuation of the disease. During the past two decades, the broad concept of guided tissue regeneration has become specific, identifying the specific treatment involved as guided bone regeneration and guided periodontal tissue regeneration. The learning objective of this article is to review the literature and principles of guided periodontal tissue regeneration in the treatment of gingival recession and to describe the surgical technique for clinical application of these principles. Several cases are utilized to illustrate the detailed clinical presentation of selective cell repopulation of gingival tissue defects.

Adult↗
PubMed1995

The importance of periodontal pathogens in guided periodontal tissue regeneration and guided bone regeneration.

Although guided tissue regeneration (GTR) procedures in periodontitis lesions and around endosseous dental implants represent exciting new therapeutic modalities in periodontics, these treatments can fail because of shortcomings in surgical techniques, restriction in the size and shape of the defect, anatomic features interfering with surgery, or infectious complications. Our studies show that optimal tissue regeneration cannot be expected for a nonbioabsorbable barrier membrane placed in a site infected by periodontopathic microorganisms. Our data also indicate that treatment failure is most frequent in patients who harbor high levels of periodontal pathogens and show evidence of severe periodontitis in numerous teeth. To decrease the risk of infection and to ensure proper healing, periodontal therapy should precede insertion of the barrier membrane for GTR. Recently, we have studied the effect of the pathogens on periodontal GTR and guided bone regeneration around dental implants and the results are reviewed in this article.

Biofilms↗
PubMed1991

[Periodontal treatment after the method of guided periodontal tissue regeneration].

Results of studies on animal models have shown that only guided periodontal tissue regeneration (GTR) will induce growth of new connective tissue fibers attached to new zement and bone tissue when the root surface had been exposed to plaque or pocket organisms. Studies of various authors suggest that it is exclusively the progenitor cells in the still existing periodontal ligament that permit regeneration. The development of GTR is based on biological principles. In the beginning its application was limited to periodontal surgery and has meanwhile expanded to include other areas such as implantology and oral surgery. Best results can be achieved in the periodontological treatment of three-walled bone defects and class II furcation involvements according to the data of several studies.

Animals↗
PubMed1997

Clinical comparison of resorbable and non-resorbable barriers for guided periodontal tissue regeneration.

The purpose of this study was to compare the clinical results of guided periodontal tissue regeneration (GPTR) using a resorbable barrier manufactured from a copolymer of polylactic and polyglycolic acids (Resolut Regenerative Material) with those of non-resorbable e-PTFE barrier (Gore-Tex Periodontal Material). 12 subjects participated, 6 with similarly paired class II furcations and 6 with 2 similar 2, 3-wall periodontal lesions. The resorbable and non-resorbable barriers were randomly assigned to 1 defect in each subject. Non-resorbable barriers were removed in six weeks. Plaque index (PlI), gingival index (GI), probing depth (PD), clinical attachment level (CAL) and gingival recession (R) were recorded at baseline, (i.e., immediately prior to surgery) and at 12 months postsurgically. The clinical healing was similar and uneventful in both groups. Intrabony pockets depicted significant changes from baseline (p < 0.05) for probing depth reduction and gain in clinical attachment levels. No differences were found between treatments. Class II furcations showed significant improvements from baseline (p < or = 0.05) for probing depth reduction and clinical attachment gain. No differences were detected between treatments. It is concluded that the resorbable barrier tested is as effective as the nonresorbable e-PTFE barrier for the treatment of class II furcations and intrabony defects.

Adult↗
PubMed1997

Guided periodontal tissue regeneration in interproximal intrabony defects following treatment with a synthetic bioabsorbable barrier.

This study evaluated guided periodontal tissue regeneration (GPTR) wound healing in interproximal intrabony periodontal defects following surgical treatment with a synthetic bioabsorbable barrier made from a copolymer of glycolide and lactide. Periodontal lesions were induced around the mandibular central incisor teeth of 10 adult male rhesus monkeys using orthodontic elastics. Once similar contralateral interproximal defects had been created, the elastics were removed and an oral hygiene program was initiated and maintained until completion of the study. Three weeks after commencing oral hygiene, flap surgery was performed in the mandibular incisor region and the root surfaces were thoroughly scaled and root planed to the apical portion of the defects. On the test sites, a bioabsorbable barrier was placed over the entire interproximal periodontal defect. Control sites did not receive a barrier. Five months after surgery, the animals were sacrificed and the teeth with their supporting periodontium were processed for light microscopic evaluation. Postoperative clinical healing progressed uneventfully and was similar in both control and test sites. Histologic observations from control specimens indicated reparative healing characterized by a long junctional epithelium with limited cementum and bone formation. Test specimens exhibited significantly more new connective tissue attachment, cementum deposition, and bone formation than the control sites (P < 0.001). The barriers had been completely resorbed with no apparent adverse effect on periodontal wound healing. It was concluded that this bioabsorbable barrier facilitated GPTR wound healing in interproximal intrabony periodontal defects.

Alveolar Bone Loss↗
PubMed1996

Guided periodontal tissue regeneration (GPTR): an update.

Periodontal therapy has three primary objectives--elimination of etiologic factors, repair or regeneration of the lost attachment apparatus, and prevention of further periodontal breakdown. Significant progress has occurred in the area of surgical periodontal therapy during the last two decades. Periodontal regeneration has become a viable treatment option utilizing the principles of guided tissue regeneration. The learning objective of this article is to review the biologic rationale, the various barrier materials currently available, and the surgical techniques for guided periodontal tissue regeneration procedures using nonresorbable and resorbable barriers, with and without bone grafting materials.

Alveolar Bone Loss↗
PubMed1997

Guided periodontal tissue regeneration in Class II furcation defects following treatment with a synthetic bioabsorbable barrier.

The purpose of this study was to evaluate guided periodontal tissue regeneration (GPTR) wound healing in Class II furcation defects following surgical treatment with a synthetic bioabsorbable barrier manufactured from a copolymer of glycolide and lactide. Periodonal lesions were induced in four adult male rhesus monkeys around the mandibular first, second, and third molar teeth using orthodontic elastics. After obtaining approximately 30% bone loss, the elastics were replaced by a stainless steel wire which had a projection extending into the furcation. Once similar contralateral Class II furcation defects had been created, the wires were removed, and an oral hygiene program was initiated and maintained until completion of the study. Three weeks after commencing oral hygiene, flap surgery was performed in the mandibular molar region and the root surfaces were thoroughly scaled and root planed to the apical portion of the defects. A bioabsorbable barrier was then placed to cover the furcation defects on one side of the jaw (i.e., test sites). No barriers were placed on the contralateral molars (i.e., control sites). Five months after surgery, the animals were sacrificed and the teeth with their supporting periodontium were processed for light microscopic evaluation. Clinical healing progressed normally and was similar in both groups. Histologic observations from control specimens indicated repair with epithelium and connective tissue occupying the majority of the furcation defects. Test specimens exhibited definitive evidence of regeneration with significantly greater new connective tissue attachment, cementum deposition, and bone formation than the control sites (P < 0.001). It was concluded that this bioabsorbable barrier facilitated GPTR wound healing in Class II furcation defects.

Alveolar Bone Loss↗
PubMed2002

Connective tissue and bacterial deposits on rubber dam sheet and ePTFE barrier membranes in guided periodontal tissue regeneration.

The aim of this study was to compare the connective tissue and bacterial deposits on rubber dam sheets and expanded polytetrafluoroethylene membranes used as barrier membranes in guided tissue regeneration for periodontal treatment. Twenty patients having intrabony defects and/or furcation defects were surgically treated by guided tissue regeneration employing either rubber dam sheets (10 patients) or expanded polytetrafluoroethylene membranes (10 patients) as barrier membranes. Four to six weeks after the first operation, membranes were retrieved from the lesion sites and processed for scanning electron microscopy. The lesion-facing surfaces of membranes were examined for the presence of connective tissue and bacterial deposits. The differences between the numbers of fields and the distributions of connective tissue and bacteria on both types of membranes were analysed by the Chi-square test at the level of 0.05 significance. The results showed a lot of fibroblasts with their secreted extracellular matrices, known as components of the connective tissue on rubber dam sheets and expanded polytetrafluoroethylene membranes. There was no significant difference in the total number of connective tissue on both types of membranes (P = 0.456). Many bacterial forms including cocci, bacilli, filaments and spirochetes with the interbacterial matrices were identified. The total number of bacteria on rubber dam sheets was statistically less than that on expanded polytetrafluoroethylene membranes (P < 0.001). The comparable number of connective tissue on both types of membranes suggests that the healing process under both types of membranes was also comparable. Therefore, the rubber dam sheet might be used as a barrier membrane in guided tissue regeneration.

Alveolar Bone Loss↗
PubMed1993

Electron microprobe analysis in periodontal guided tissue regeneration.

Electron microprobe analysis was used to determine the evolution of Ca, P and S in regenerated tissue surrounding incisors roots after periodontal treatment with guided tissue regeneration. Our results, which showed increased Ca and P, and decreased S are discussed in relation to the process of mineralization electron probe microanalysis with potentially provided an accurate means of assessing the degree of mineralization in extremely small tissue samples.

Calcium↗
PubMed1998

[Periodontal guided tissue regeneration with a rubber dam: short term clinical study].

BACKGROUND: The guided regeneration of periodontal tissues demonstrated to represent a therapeutical technique with predictable results. It has been observed that different materials, used as regenerative membranes, offer very similar results. Unconventional materials too, like the rubber dam, seem to be useful in the guided tissues regeneration technique. The object of the present study has been to comparatively evaluate the effectiveness of Gore-Tex and rubber dam-made membranes in the therapy of intra-osseous periodontal defects. MATERIALS AND METHODS: Six patients with two similar intra-osseous defects, participated in the study; one defect has been treated using, during the surgical intervention, a Gore-Tex membrane, while the other has received, a fragment of sterile rubber dam membranes. The principal clinical parameters of the periodontal health (probing depth -PD- and attachment loss -AL-) has been evaluated in both the defects before and 6 months after the periodontal surgery. RESULTS AND CONCLUSIONS: The results have showed that there are not statistically significant differences (p > 0.05) in the healing of the intra-osseous defects treated by rubber dam or Gore-Tex. The conclusion is drawn that the rubber dam can represent a valid and cheap alternative to the materials traditionally used in the regenerative surgery of the periodontal tissues.

Humans↗
PubMed2002

[Histological evaluation of domestic poly-DL-lactic acid membranes for periodontal guided tissue regeneration].

OBJECTIVE: To evaluate the possibility of domestic poly-DL-lactic acid membranes as barriers during periodontal guided tissue regeneration. METHODS: Two-wall intrabony defects were made by artificially removing buccal and distal alveolar bone from the distal roots of the second, third and fourth mandibular premolars as well as the first mandibular molars of dogs. These experiment defects received four membranes (PDLLA, ePTFE, COL, Vicryl ) respectively for GTR, the control treated without membrane. Animals were sacrificed for histological evaluation and histometric analysis 2,4,8 weeks after surgery. RESULTS: Domestic poly-DL-lactic acid membranes for periodontal guided tissue regeneration only induce a non-specific inflammation, which began its bioresorption at 4 weeks after surgery. Just like the other GTR materials including Vicryl mesh,domestic poly-DL-lactic acid membrane acts as barrier preventing the apical downgrowth of gingival epithelium and prompting periodontal tissue regeneration. As compared with the control, PDLLA exhibited its more effects 4 weeks after surgery, there is statistically difference between them. CONCLUSION: Domestic poly-DL-lactic acid membranes exhibit excellent biocompatibility, as a guided tissue regenerative materials, it may have beneficial effects in the treatment of 2-wall periodontal intrabony defects.

English Abstract↗
PubMed2003

[Biocompatibility of chitosan-carboxymethylchitosan as membrane for periodontal guided tissue regeneration].

OBJECTIVE: To investigate the biocompatibility of chitosan-carboxymethylchitosan as membrane for periodontal guided tissue regeneration (GTR). METHODS: Chitosan-carboxymethylchitosan blending membrane was prepared by freeze-drying and tests including cytotoxicity test, inserting the membrane into the rabbits, muscles, were employed to investigate its biocompatibility. RESULTS: Chitosan-carboxymethylchitosan blending membrane showed no toxicity. In early period after the insertion of the membrane, inflammatory processes with macrophages were observed, but the processes reduced with the membrane degradation. CONCLUSION: Chitosan-carboxymethylchitosan blending membrane has desirable biocompatibility.

Animals↗
PubMed1998

[Is periodontal guided tissue regeneration a reproducible technic? A review of the literature].

Guided tissue regeneration (GTR) has been developed as a surgical technique enabling the complete regeneration of the periodontal attachment apparatus. Among various periodontal tissues, the root, cementum and the alveolar bone, as well the Sharpey collagenic fibers linking the cementum to the bone, are of particular interest. As demonstrated in this literature review, we could globally conclude to date, that most of the publications confirm the biological and clinical potential of GTR, although in some publications, this opinion is not being shared. A number of factors influence the outcome of the regenerative therapy, some relating to the patient such as the smoking habits and the level of oral hygiene, others relating to the type of implanted biomaterial or the surgical technique. A better understanding of the periodontal healing mechanisms as well as the continuous research and progress in the field of biomaterials, chemical mediators and growth factors, are likely to further increase the predictibility of the periodontal regenerative treatments.

Alveolar Process↗
PubMed1996

Quantitative digital subtraction radiography for assessment of bone density changes following periodontal guided tissue regeneration.

OBJECTIVES: The quantitative assessment of alveolar bone density changes in periodontal defects following guided tissue regeneration (GTR). METHODS: Twelve patients with 30 intrabony lesions and 16 furcation defects took part. Standardized radiographic and clinical examinations were carried out immediately before and then 5 and 13 months after surgery. Intra-oral radiographs were evaluated by means of digital subtraction radiography (DSR). Within the subtraction images, a window ('experimental region') was defined covering the visible density changes in the defect area. Background noise was measured by using a similarly sized window ('control region') located in an area not affected by GTR. Bone density changes were quantitatively evaluated by calculation of the mean, standard deviation and maximum and minimum values of the grey-level histogram within these windows. RESULTS: DSR revealed significant bone density gain after GTR in intrabony and furcation defects. While a continuous increase was observed over the 13 month period in intrabony defects, changes in furcation defects occurred mostly in the 5-13 month period. Clinically, a distinct vertical and horizontal attachment gain was found. The correlation coefficients between changes in radiographic density and clinical parameters were low, indicating a difference in the information obtained by the two diagnostic methods. CONCLUSION: Quantitative DSR is a valuable, non-invasive, objective method to obtain information on density changes in intrabony and furcation defects treated by GTR. However, a full assessment of soft and hard tissue changes requires both clinical evaluation and DSR.

Alveolar Bone Loss↗
PubMed2003

[Study on cyto-compatibility of PGLA film for periodontal guided tissue regeneration].

This study was aimed to evaluate the cyto-compatibility of PGLA film for periodontal guided tissue regeneration (GTR) and their degradable products. Different extraction temperature, time and ratio were used to assess the cell relative growth rate (RGR) for PGLA. The degradable solution were brought into contact with cultured cells in vitro to observe the effects of cytotoxicity at 2, 4, 6, 8 and 10 weeks. The results showed when the extraction ratio was 0.1 g/ml, the extraction time has no effects on cytotoxicity at 37 degrees C. When the ratio was 0.1 cm2/ml, slight cytotoxic reaction appeared with the increase of extraction temperature (50 degrees C or 70 degrees C). When the extraction ratio was 0.5 cm2/ml in contract with the degradable solution at 37 degrees C for 72 h, the cell growth rate decreased. When the ratio was 6 cm2/ml, the cytotoxicity existed in some degree even if the temperature was at 37 degrees C for 24 h. After 2-4 w, the degradable solution had no obvious toxic effects on cells. However, the RGR gradually decreased as the degradation period increased. In conclusion, the effects of the extraction temperature, time, ratio and the degradation products accumulating in solution on RGR may exist. PGLA film has a good cytocompatibility.

Animals↗
PubMed2001

[Surface characteristic of domestic poly-DL-lactic acid membrane for periodontal guided tissue regeneration].

OBJECTIVE: To evaluate the surface characteristic of domestic poly-DL-lactic acid membrane for periodontal guided tissue regeneration. METHODS: Three guided tissue regeneration membranes (PDLLA, ePTFE, COL)were implanted in rats subcutaneously, then they were removed 2,4,8 weeks after surgery for examination under scanning electron microscope. The membranes in vitro served as control. RESULTS: The surface of PDLLA membrane was characterized by unorganized smooth film structure. After 2 weeks implanted subcutaneously, its surface became rough with numerous oval micropores in it. These oval micropores were 5 microm in size.The micropores increased gradually in size and number 4, 8 weeks after implantation,there were many shindle shaped cells inlayed. CONCLUSION: Domestic Poly-DL-lactic acid membrane exhibits excellent biocompatibility,which meets the criterion for GTR.

English Abstract↗