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At least 19 recordsLinked to original sources

Hyaluronan, cartilage destruction and hydrarthrosis in traumatic arthritis.

The concentrations of hyaluronan (HA) and chondroitin sulfate (CS) in synovial fluids from patients with traumatic arthritis (TA) with and without hydrarthrosis were measured. The CS in synovial fluids was determined as a marker of cartilage destruction by high performance liquid chromotography. The concentration of HA in synovial fluids was lower in patients with hydrarthrosis than in healthy volunteers and patients with TA without hydrarthrosis, whereas the total amounts of HA and CS and the concentration of CS were higher in patients with hydrarthrosis. To investigate the relation between hydrarthrosis and production of HA in synovial tissues, TA synovial tissue biopsies were stained for HA with biotinylated HA binding region. The intensity of HA staining was higher in specimens from patients with hydrarthrosis than in normal and TA without hydrarthrosis specimens. Thus, there may be a correlation between hyperproduction of HA, cartilage destruction and increase in fluid volume in TA.

Adolescent↗

Comparison between clinical evaluation and ultrasonography in detecting hydrarthrosis of the knee.

OBJECTIVE: To assess the validity of the clinical detection of knee hydrarthrosis compared to ultrasonography (US). To assess the differences of results for both clinical and US tests when they are done by independent investigators. To assess the effect of a previous clinical evaluation on the US diagnosis. METHOD: The clinical and US examinations were scored using a 3 point scale. In 50 symptomatic patients, 82 knees underwent clinical and US evaluations by the same physician. Two independent observers clinically and echographically tested 22 other knees (11 patients). Finally, in another series of 20 knees (10 patients), the first investigator performed clinical testing before the US evaluation, while the other did the US with no previous clinical evaluation. RESULTS: Between the clinical and US evaluations, agreement was moderate (kappa = 0.508), but statistically significant (p<0.001). The relationship between the 2 investigators for clinical evaluation was slightly weaker (kappa = 0.446, p = 0.032). Possible (score 1) or definite (score 2) clinical knee hydrarthrosis sensitivity was 79/100% and specificity 25/78%, respectively. In contrast, US studies from 2 independent observers were strongly related (kappa = 0.902) and were not modified by a previous clinical evaluation. CONCLUSION: Clinical knee hydrarthrosis detection is less accurate and reproducible than US detection.

Humans↗

The treatment of idiopathic and secondary hydrarthrosis of the knee by intra-articular Rifamycin SV.

Fifty-three patients, 28 females and 25 males, aged from 21 to 68 years, affected with mono- and bilateral intermittent hydrarthrosis of the knee and of a non-inflammatory nature, were included in an open study. All of the knees involved were treated with intra-articular infiltrations with Rifamycin SV. The weekly dosage of Rifamycin SV was 500 mg; the average duration of treatment was 6 weeks. Follow-up 1 year after the end of treatment showed a decrease or regression in joint effusion in all of the knees treated.

Adult↗

Analysis of synovial fluid components of hydrarthrosis in long-term hemodialysis patients.

The synovial fluid components in long-term hemodialysis patients (HD; 43 knees in 43 patients) were investigated and compared with those in patients with osteoarthritis (OA; 21 knees in 21 patients) and rheumatoid arthritis (RA; 26 knees in 26 patients). The average ages in the three groups were, respectively, 60.7 years (range, 34-79 years), 63.2 years (range, 48-88 years), and 59.7 years (range, 37-76 years). The duration of hemodialysis in the HD group averaged 14.0 years (range, 4-24 years). The concentrations of hyaluronic acid, protein, and isomers of chondroitin sulfate (chondroitin 6-sulfate [C6S] and chondroitin 4-sulfate [C4S]) in the synovial fluid, and its viscosity were measured. Differences in each of the parameters were investigated according to disease clinical stage, roentgenological grade, and periods of dialysis in the HD group. The viscosity of the synovial fluid and the concentration of hyaluronic acid in HD patients were similar to those in OA patients; however, the C6S/C4S ratio in the synovial fluid of HD patients was similar to that in RA patients. The latter finding suggests that synovitis may be present in the hydrarthrosis of HD patients. The cause of this synovitis in HD patients remains to be elucidated.

Adult↗