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At least 19 recordsLinked to original sources

Effect of psoriasis heliotherapy on epidermal urocanic acid isomer concentrations.

A noninvasive Finn Chamber sampling method and HPLC analysis were used to determine epidermal urocanic acid (UCA) concentrations of psoriasis patients during 4 weeks of heliotherapy on the Spanish Canary Islands and a follow-up period of 8 weeks. During heliotherapy the epidermal cis-UCA concentration increased from a mean initial value of 0.2 nmol/cm2 to a mean final value of 2.9 nmol/cm2. The total UCA concentration decreased during the first week of heliotherapy from an initial value of 5.5 nmol/cm2 to a nadir of 2.0 nmol/cm2. Thereafter, a steady increase was recorded in the total UCA level, with a maximum of 10.2 nmol/cm2 in week 2 of the post-treatment follow-up period. Suberythemal sun exposures caused near-maximal UCA isomerization, and during heliotherapy the cis isomer constituted 63.7-74.3% of the total UCA concentration. Clinical response of psoriasis to heliotherapy, however, seemed to be independent of UCA isomer levels.

Adult

Comparison of the antipsoriatic efficacy of heliotherapy and ultraviolet B: a cross-over study.

Ten psoriasis patients who underwent a 4-week heliotherapy period in the Canary Islands were treated with ultraviolet B (UVB) phototherapy at relapse, 2-24 months later. In both settings, psoriasis improvement was monitored using a psoriasis severity index (PSI), and UV exposure was recorded with polysulphone films. In the 8 patients that could be evaluated, a median healing rate of 94% was recorded in the heliotherapy period, with a median cumulative UV dose of 46 erythemal units (EU). In the UVB phototherapy, a median improvement rate of 86% was found after a median cumulative UV dose of 112 EU. It is concluded that, on an erythemal UV dose basis, heliotherapy was more effective than UVB phototherapy in treating psoriasis.

Adult

[Heliotherapy in iridocyclitis and intermediate uveitis].

In a pilot in 1985 we treated 45 patients suffering from recurrent anterior uveitis with heliotherapy (Dead Sea, Israel), improvements were noticed in 40% of the probants during the following year. In a further clinical trial 14 patients (25 affected eyes) received treatment with heliotherapy twice for 3 weeks with a 12 months interval. The clinical findings showed a significant correlation between administration of the therapy and intermittent inflammation of the eyes.

Adolescent

[Quantitative assessment of heliotherapy in psoriasis vulgaris in high altitude climate].

At the Davos Clinic for Dermatology and Allergy (Alexanderhausklinik), patients suffering from psoriasis were treated with natural UV irradiation over 6 weeks in 1987: the average doses applied amounted to 1.042 J/cm2 UVB (= 41.7 sunburn units (SU] and 41.511 J/cm2 UVA. These doses were far below those of artificial UV sources usually required in the treatment of psoriasis. The doses were also far below those which statistically increase the incidence of non-melanotic skin cancer.

Altitude