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At least 19 recordsLinked to original sources
PubMed1978

Hodgkin's disease treated by chemotherapy and large field irradiation. Hematologic effects.

The hematologic effects of combined chemotherapy and irradiation were analyzed in 70 patients with Hodgkin's disease stage I and II. The schedule used was as follows: one cycle of 15--21 days of chemotherapy immediately followed by irradiation, including mantle and lumboaortic fields. After a rest of one month, another cycle of the same chemotherapy was applied. The erythrocytes varied slightly; the leukocytes decreased during chemotherapy and were stable or increased slightly during irradiation. Platelets decreased slightly during chemotherapy and more markedly during irradiation. No major side effects were observed, and the regimen appeared well tolerated.

Adolescent↗
PubMed1977

Hematologic effects of a single dose of methylnitrosourea.

The hematological effects of a single dose of 50 mg/kg Methylnitrosourea (MNU),administered i.v. to CBA/J mice, are described. Special emphasis was given to the number of pluripotent (CFUS) and granulocytic committed (CFUc) stem cells found in the bone marrow and spleen. In the peripheral blood a decreased number of reticulocytes, granulocytes, lymphocytes and thrombocytes was seen. This was followed by a rapid return of reticulocytes and a very slow return of thrombocytes. The bone marrow cellularity was below normal for at least 2 weeks with a markedly reduced number of lymphocytes. A rapid decrease in bone marrow and splenic CFUS and CFUc to 20-50% of control values was observed within 3 hours in mice injected with MNU. Seven days after MNU treatment, CFUS was about 10% of normal in both tissues. Contrary to this, CFUc had undergone significant regeneration. After 3 weeks CFUS returned to normal levels. At no stage could colony stimulating activity be detected in the serum.

Animals↗
PubMed1978

Comparative studies of pulsatile and nonpulsatile flow during cardiopulmonary bypass. I. Pulsatile system employed and its hematologic effects.

A new, commercially available roller pump system able to deliver pulsatile and nonpulsatile flow has been studied in patients undergoing elective open-heart surgical procedures. The pulsatile pump (Stöckert Instrumente) may be used with standard extracorporeal circuit equipment and consistently produces a peripheral arterial pulse pressure of 25 to 30 mm. Hg at mean flow rates of 3.5 to 4.0 L. per minute. Twenty patients, arbitrarily allocated to pulsatile or nonpulsatile groups, have been studied. There were no significant differences between the groups in respect of age, weight, bypass time, pump flow, or mean arterial pressure during bypass. Comparative studies of the hematologic effects of pulsatile and nonpulsatile perfusion were carried out. There was no evidence of increased hemolysis with pulsatile flow, nor was there increased depletion of red blood cells (RBC's) or platelets in the pulsatile group. This pulsatile pump system may therefore be used to produce pulsatile perfusion during cardiopulmonary bypass without the fear of producing excessive blood cell trauma.

Adult↗
PubMed1977

Studies on the hematologic effects of long-term, low-dose microwave exposure.

Hematologic and morphologic investigations were carried out in order to discover changes during and after prolonged exposure to microwave radiation. A 12-cm wavelength CW microwave generator was used as a source of radiation and the mean power density was 5 mW/cm2. The rats were exposed to microwaves for a period of 90 d for 1 h/d. Before, during, and after the irradiation period, hematologic examinations were carried out. The histological examinations of various organs and tissues of irradiated rats were carried out after the experimental period. No significant difference in any of the observed biological parameters was detected in experimental animals in comparison with control. It was concluded that these results indicate that it is unlikely that prolonged microwave exposure to low-intensity (around 5 mW/cm2) will cause marked changes in the peripheral blood counts of the irradiated organism.

Animals↗
PubMedDate not supplied

[Hematological effects produced on horses and sheeps pasturing upon Brachiaria radicans Napper (Tanner grass) in winter time (author's transl)].

Hematological studies were developed on two mares and twelve adults castrate sheeps of "Ideal" breed. The animals had been on a pasture formed with Brachiaria radicans Napper for one and two months respectively. This experiment was developed in winter time, so the leaves of the graminea had a yellow-green color. Clinical and hematological observations were made weekly. The typical symptoms of intoxication failed to present as observed in the former investigation when the plant was green (3). The hematological exames showed only for ovines a slight anemia, it was also characterized as being macrocytic and hypochromic. Some red blood cells with basophillic stippling and the occurrence of anisocytosis was observed in the blood of anemic animals, but no methemoglobin and Heinz bodies were found. The Brachiaria radicans Napper, had a low level of nitrate (2) therefore the animal poisoning must be attributed to another plant component, not nitrate as admited in the first hematological study (12).

Anemia, Hypochromic↗
PubMed1975

The hematological effects of irradiation on the Indian desert gerbil (Meriones hurrianae Jerdon).

Male adult gerbils were irradiated with a whole-body dose of 600 R with gamma-rays. The animals were studied for their hematological response on days, 1, 2, 3, 7, 14, and 28 post irradiation. No significant change was noted in erythrocyte number after irradiation. There was a slight fall in hemoglobin and hematocrit values in the early post-irradiation periods. A transient leukocytosis was observed on day 1 after irradiation followed by a sharp fall on day 2 which continued up to day 3. A recovery in leukocyte value was noted after a week of irradiation. Abnormal leukocytes were noted in the peripheral blood on day 2 after irradiation. The results show that the gerbil is radioresistent and is comparable to the rabbit at this dose-level.

Animals↗
PubMed1977

Hematologic effects of xylazine when used for restraint of Bactrian camels.

Xylazine was found to be a safe and reliable drug for chemical restraint of Bactrian camels (Camelus bactrianus). Dosages of 0.27 to 0.51 mg/kg of body weight provided adequate sedation for the performance of various procedures (e.g., tuberculin testing, lymph node biopsy, and electroejaculation). Hematologic and serum biochemical values for camels restrained manually were compared with those for camels restrained with xylazine. Xylazine-treated camels had significantly lower values for RBC, hemoglobin, and packed cell volume, and significantly higher blood glucose concentrations. Venous blood gas analyses did not reveal any major acid-base disturbances resulting from the use of xylazine. Rapid arousal from the sedative effects of xylazine occurred after the intravenous administration of doxapram hydrochloride in dosages of 0.05 to 0.13 mg/kg of body weight.

Animals↗
PubMed1978

Hematologic effects of phenytoin therapy during pregnancy.

Serum folate and plasma phenytoin concentrations were measured in 10 epileptic gravidas who did not receive folate supplementation. Mean serum folate concentration averaged 5.0 ng/ml during the second and third trimesters of pregnancy but significantly decreased to 2.9 ng/ml during nonpregnant evaluation 1 to 12 months following delivery. No patient exhibited anemia or macrocytosis suggestive of cellular folate deficiency either during or following pregnancy. Although phenytoin dosage remained relatively constant, plasma phenytoin concentrations during pregnancy were significantly lower than nonpregnant concentrations. The improvement in folate status observed during pregnancy may be related to lowered plasma phenytoin concentrations.

Carotenoids↗
PubMed1979

[Absorption and hematologic effect of streptokinase-streptodornase (varidase) after intracavital or oral administration].

A series of patients who received intracavitary streptokinase/streptodornase after thoracotomy or laparotomy were compared with a control group. They showed a highly significant increase in plasma streptokinase tolerance, indicating absorption of the streptokinase from the cavity. Changes in blood coagulation, plasma cell count and immunoglobulins were not observed. In a series of patients with leg ulcers treated with streptokinase/streptodornase by mouth, no increase in plasma streptokinase tolerance was observed, indicating that orally administered streptokinase is not absorbed from the gastro-intestinal tract.

Abdomen↗
PubMed1979

Hematological side effects from antihypertensive drugs.

To sum up, some hematological side effects are seen after antihypertensive drugs. They are, however, few, usually not severe and furthermore reversible. And so, from the viewpoint of the hematologist, there are no contraindications against antihypertensive treatment. The prevalence of side effects on blood and blood-forming organs from antihypertensive drugs is low. Of certain interest are 1) the tendency of modern diuretics (thiazides) to cause a moderate and reversible thrombocytopenia and 2) the positive antiglobulin reaction (Coomb's test) sometimes seen after alpha-methyldopa therapy and in a few cases causing autoimmune hemolytic anemia. Even though case reports have appeared on leukopenia/agranulocytosis related to almost all drugs used in the treatment of hypertension, none of these drugs seem to be especially prone to cause any damage to leukocytes and/or leukocyte production.

Agranulocytosis↗
PubMed1978

The non-hematological side effects of levamisole in the treatment of rheumatoid arthritis--a review.

The non-hematological side effects of levamisole include (1) sensorineural reactions, the most common of which is alterating of taste and smell; (2) idiosyncratic or allergic reactions such as rash and a febrile, influenza-like illness; and (3) gastro-intestinal symptoms. The sensorineural reactions are seldom of sufficient severity to require discontinuation of treatment. Rash and febrile illness have resulted in withdrawal of levamisole in 7% and 1.5% of cases, respectively, but usually remit spontaneously within a brief interval and are not hazardous except when associated with agranulocytosis. Rash due to levamisole occurs more frequently in rheumatic disease patients than in other conditions. Gastro-intestinal symptoms are mild, quickly reversible, and possibly dose-related; some controlled trails have shown a similar frequency of gastro-intestinal symptoms in the placebo group.

Arthritis, Rheumatoid↗