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At least 19 recordsLinked to original sources
PubMed1978

On temporal structure of human hiccups: ethology and chronobiology.

During a study on the phylogeny and ontogeny of human hiccups, essentially all hiccups to occur over continuous periods of 3m - lly were recorded from 20 healthy people of either sex and various ages. Hiccups displayed considerable structure in time. If more than a few occurred together, they became "established" and a hiccup bout ensued, which did not stop until a certain "minimum" number of hiccups had occurred. For many subjects, two or more bouts frequently occurred on the same hiccup day, even though days on which bouts occurred were weeks apart. Number of hiccups was correlated with age, sex, reproductive status and stage of menstrual cycle, time of day, length of time since previous hiccup day, length of time since previous hiccup bout, and length of hiccup-hiccup intervals within a bout. Findings support the hypothesis that human hiccup is a "fixed action pattern" (FAP)--a central theoretical concept in ethology--and provide leads for further studies aimed at learning the biological function(s) of human hiccup and its possible homologues in other species.

Adult↗
PubMed1979

Hoquet diabolique: intractable hiccups as a manifestation of multiple sclerosis.

In three patients, intractable hiccups occurred as part of the symptomatology of multiple sclerosis. In one patient intractable hiccups were the presenting complaint, and in another patient exacerbations of symptoms were almost always heralded by intractable hiccups. Intractable hiccups occur in a variety of diseases, including many that affect the brainstem and cervical cord, but have not been reported in multiple sclerosis. The hiccup may be a "primitive" gastrointestinal reflex that is disinhibited by lesions such as multiple sclerosis plaques. Carbamazepine was successful in arresting the hiccups in one of the cases presented.

Adolescent↗
PubMed1992

Treatment of intractable hiccup with baclofen: results of a double-blind randomized, controlled, cross-over study.

Four patients with intractable hiccup were treated in a double-blind, randomized, placebo, cross-over study with an analogue of gamma-aminobutyric acid, Baclofen. There was a consistent and statistically significant (p = 0.03) improvement in hiccup severity with Baclofen, both subjectively (p = 0.03) and by hiccup-free periods (p = 0.003). The actual frequency of hiccup was not significantly altered by the medication. We propose that the mechanical aspects of hiccup are reduced by Baclofen, leading to a perceptual blockage and a decrease in the reflex severity induced by the gamma-aminobutyric acid analogue. We conclude that this medication may be useful for the treatment of intractable hiccup.

Aged↗
PubMedDate not supplied

The effect of ketamine in patients with refractory hiccup in the postoperative period. Preliminary report.

In 5 cases of refractory postoperative hiccup the authors observed a favourable effect of a single dose of ketamine administered intravenously. Earlier applied procedures and drugs failed to control hiccup or alleviated it for only a short time. In all cases the overfilling of the stomach was ruled out as a cause of hiccup by routine preliminary examination. The doses of ketamine used (0.5 mg/kg of body weight) caused no central nervous system disturbances in postoperative patients. In view of the small number of observed cases the authors regard this report as a preliminary communication and as an encouragement for further investigations on the usefulness of ketamine in the treatment of postoperative hiccup and also in treatment of hiccup in patients in other medical specialities.

Drug Evaluation↗
PubMed1992

[A case of multiple sclerosis with intractable hiccups and sleep apnea syndrome].

A 48-year-old female with multiple sclerosis (MS) accompanied by intractable hiccups of over one month' duration and the sleep apnea syndrome was reported. This MS patient had been well controlled until September 16, 1991 when she experienced nausea, vomiting and hiccups. The patient was admitted to Kawasaki Medical School Hospital on October 9, 1991. A physical examination revealed intractable hiccups. T1-weighted MRI showed a low and T2-weighted image disclosed a high signal intensity area in the tegmentum of the medulla oblongata. The intractable hiccups and vomiting improved with intravenous high dose methylprednisolone injection therapy. The following day, she complained of insomnia and her family observed severe snoring and apnea during the night. These symptoms and the results of a breathing monitor were compatible with the sleep apnea syndrome. These symptoms disappeared following the administration of amitriptyline. There have been few reports of the combination of intractable hiccups and the sleep apnea syndrome in MS. The MRI findings suggest that the causative lesion of these symptoms is in the tegmentum of the medulla oblongata.

Amitriptyline↗
PubMed1992

Hiccups. A case presentation and etiologic review.

Hiccups (singultus) usually present as a common annoyance lasting for short periods. Rarely, they may be the harbinger of a serious disease. We present the case of a 19-year-old man in which intractable hiccups was the first and most prominent symptom of a serious underlying neurologic disorder. The patient had been examined by his pediatrician, and despite multiple medical regiments and physical maneuvers, his symptoms persisted. A thorough head and neck examination revealed a right-sided vocal cord paralysis. This finding prompted obtaining a magnetic resonance imaging scan, which demonstrated a type I Arnold-Chiari malformation associated with a large cervicothoracic syringomyelia. The patient was referred to the neurosurgical service and subsequently underwent a ventriculoperitoneal shunt placement. There was considerable initial improvement in his neurologic status and cessation of the hiccups. However, the symptoms recurred within 1 month. The case report as well as a brief review of the relevant pathophysiologic and etiologic considerations and several treatment modalities for hiccups is presented.

Adult↗
PubMed1992

[Chronic hiccups].

We report 18 cases of chronic hiccup (defined as lasting for more than 48 hours) in adults. Among the numerous possible causes, reflux esophagitis proved to be by far the most frequent (50% of the cases). However, hiccup often initiated a self-perpetuating vicious circle. This is possibly because hiccup per se can give esophageal dyskinesia, which in turn leads to gastro-esophageal reflux. The treatment was difficult and whenever possible has been directed chiefly towards the cause. However hiccup remained intractable in many cases even after a possible cause had been adequately cured (e.g., successful Nissen procedure in reflux cases). Central nervous system depressants and myorelaxing drugs were not very helpful, except for baclofen (initial response rate = 60%).

Adult↗
PubMed1979

Hiccups: an unusual manifestation of an abdominal aortic aneurysm.

A patient with hiccups was found to have an abdominal aortic aneurysm that subsequently ruptured. We believe that a leaking abdominal aortic aneurysm led to an ileus-induced distention of the splenic flexure of the colon with consequent diaphragmatic irritation and phrenic nerve stimulation. This led to persistent hiccups as a result of repetitive stimulation of the reflex arc mediating hiccups. Persistent hiccups require investigation for an underlying organic etiology, and a leaking abdominal aortic aneurysm should be included in the differential diagnosis.

Aged↗
PubMed1992

Lidocaine pretreatment effectively decreases the incidence of hiccups during methohexitone administration for dilatation and curettage.

The efficacy of lidocaine 1 mg.kg-1 for prevention of methohexitone-induced hiccups was assessed in a double-blind fashion in 200 patients undergoing dilatation and curettage for pregnancy interruption. The patients were randomly assigned to receive either lidocaine 1% or saline 0.9% in a similar way (1 ml for every 10 kg of body weight). The incidence of hiccups was 16% in the control group compared to 6% in the lidocaine group. We speculate that this reduction in the methohexitone-induced hiccup ratio is related to lidocaine's membrane-stabilizing properties, which decrease the excitability of all the nervous structures involved in this reflex.

Abortion, Induced↗
PubMedDate not supplied

[Droperidol in the treatment of hiccup of central origin].

Persistent intractable hiccup (over 24 hours) was observed in four patients. Administration of 2.5 mg droperidol intravenously stopped the hiccup for some hours (4-12). This dose was repeated every 4-12 hours for some days. The hiccup stopped completely.

Adrenergic alpha-Antagonists↗
PubMedDate not supplied

[Hiccup caused by epigastric compression in a hemiplegic patient].

The authors report the case of a patient with permanent, refractory hiccup, resistant at all classical treatment methods. Hiccup was due to compression of the epigastric region by the left fist of the patient immobilised by a spastic hemiplegia. Passive mobilisation of the diseased upper limb resulted in the disappearance of hiccup.

Abdomen↗
PubMed1978

Hiccup and ephedrine.

Twelve patients who developed hiccup during anaesthesia and surgery were treated successfully with an intravenous injection of ephedrine 5 mg (eleven cases) or 10 mg (one case). In nine patients ephedrine was successful after traditional methods had been tried and failed, and in three patients ephedrine was the only agent given. We conclude that ephedrine is a safe and easy mode of treatment for intractable hiccup during anaesthesia and surgery.

Adult↗
PubMed1975

Metoclopramide in hiccup.

Metaclopramide has been observed to induce dramatic relief of intractable hiccup in 14 patients with diverse serious illnesses. When given orally or parenterally the effect was observed within 30 minutes, the relief lasting up to 8 hours, indicating a direct relation to the duration of action of the drug. This drug is recommended for symptomatic relief of hiccup associated even with serious organic illnesses, without any fear of undesirable effects.

Administration, Oral↗
PubMed1977

Management of intractable hiccup.

A patient who developed hiccups after laparotomy was treated with numerous drugs with limited success. A left phrenic nerve crush was eventually successful. A review of published work showed that the drugs most likely to succeed were chlorpromazine and metoclopramide, and that phrenic nerve injection and crush should be considered if these failed.

Adult↗
PubMed1992

About the mechanism of hiccup.

Every new empiric observation made over two millenia fueled the dispute as to whether hiccup (Hc) is a digestive or a respiratory reflex. A review of the literature, focusing attention on the probable mechanism of Hc, shows Hc as a neurogenic dysfunction of the 'valve function' between the inspiratory complex and the glottis closure complex.

Glottis↗
PubMed1977

Fetal hiccups.

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Female↗