The role of teleology in higher nervous activity.
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The effect of streptomycin on recovery of the higher nervous activity during the postanesthesia period was studied on 3 dogs with the method of the conditioned reflexes. It was found that streptomycin sulphate administered in a dose of 25 mg per 1 kg body weight induced no changes in the conditioned reflexes of the non-anesthetized animals. After ether anesthesia disorders in the conditioned and unconditioned reflexes, as well as differentiation was observed during the postanesthesia period. On an average they normalized in 7, 6 and 2 days respectively from the moment of anesthesia. When streptomycin sulphate was used during the post anesthesia period, both the strength and the character of the disorders in the conditioned reflexes changed. In this case recovery of the conditioned and unconditioned reflexes was registered in 2 days, while that of the differential inhibition was registered in 3--7 days from the moment of anesthesia.
Functional changes of higher nervous activity were found in the rats after a 22-day flight in the biosatellite "Cosmos-605". The ability to retain and restore the habit of searching food in the maze deteriorated. The number of refusals to go through the maze increased with an enhancement of the functional load on the central nervous system. This resulted not only from reduced alimentary excitability or muscular weakness developed during the flight, but also from a weakening of the basic nervous processes in the higher parts of the central nervous system.
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A preliminary study involving 80 paid subjects, 40 of each sex, investigated the usefulness of motor response-time tasks as measures of three neo-Pavlovian properties of higher nervous activity, excitatory strength, dynamism, and mobility. Six independent factors were extracted from a set of variables measuring those properties. These factors demonstrated the independence of the three properties, of the excitatory and inhibitory processes in dynamism and mobility, and of strength and sensitivity at least when such tasks are used as measures of properties in the auditory modality. These findings are promising, however, further investigation is required to validate these tasks against the classical tests of properties of higher nervous activity.
The effect of a 22-day hypokinesia study on the labyrinthine behavior of white rats was investigated. The test animals showed certain behavioral changes which developed throughout 22 days. However, significant changes occurred only during the first 6--7 days. Later, the changes diminished but retained their trend. It is believed that the behavioral changes are mainly associated with inhibition of the nervous processes of higher cerebral compartments responsible for the higher nervous activity.
The corpuscular blood composition, ALP activity and glucose level of 20 E+ and 20 E- adult male Wistar rats were measured without stress. We wanted to find differences due to the specific reaction type--emotive/non-emotive--of the animals. E+ animals had higher counts of small erythrocytes and a higher total number of leucocytes than E- rats. When the compositions of the blood of several inbred strains were compared, the composition of the red blood, total number of leucocytes and lymphocytes of E- -Wistar rats and E- -Sprague-Dawley rats were most similar. Differences in the activity of the ALP and in the glucose levels we found are similar to those in literature on this topic. When measured in a condition of inactivity the lower glucose values of E+ Wistar rats correspond to the excretion of smaller amounts of urinary catecholamines. Our findings, as well as those mentioned in the literature, confirm the assumption that the reaction type--which corresponds to the type of higher nervous activity--influences all functions of the organism including the composition of the blood.
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